1. IFNγ: Priming for death.
- Author
-
Vince JE
- Subjects
- Caspase 8 physiology, Tumor Necrosis Factors physiology, Cell Death, Signal Transduction, Interferon-gamma physiology
- Abstract
TNF signaling does not result in cell death unless multiple inhibitory signals are overcome, which can be accomplished by simultaneous signaling through IFNγ. In this issue, Deng and colleagues (http://doi.org/10.1083/jcb.202305026) dissect the mechanisms by which IFNγ signaling combines with TNF to mediate cell death through caspase-8, discussed by James E. Vince., (© 2024 Vince.)
- Published
- 2024
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