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Abstract The physical characterization of proteins in terms of their sizes, interactions, and assembly states is key to understanding their biological function and dysfunction. However, this has remained a difficult task because proteins are often highly polydisperse and present as multicomponent mixtures. Here, we address this challenge by introducing single-molecule microfluidic diffusional sizing (smMDS). This approach measures the hydrodynamic radius of single proteins and protein assemblies in microchannels using single-molecule fluorescence detection. smMDS allows for ultrasensitive sizing of proteins down to femtomolar concentrations and enables affinity profiling of protein interactions at the single-molecule level. We show that smMDS is effective in resolving the assembly states of protein oligomers and in characterizing the size of protein species within complex mixtures, including fibrillar protein aggregates and nanoscale condensate clusters. Overall, smMDS is a highly sensitive method for the analysis of proteins in solution, with wide-ranging applications in drug discovery, diagnostics, and nanobiotechnology.

Abstract Estimates of radar attenuation in the shallow Martian subsurface are retrieved from RIMFAX soundings along the Perseverance rover traverse. Specifically, analyzed data is from the Hawksbill Gap area during the rover's first drives onto the Jezero Western Fan Front. The centroid frequency‐shift method is employed to quantify attenuation in terms of the constant‐Q approximation. Results are then compared with the amplitude decay method, which—in order to calculate attenuation—requires propagation velocities retrieved from radargram analysis. By verifying that results from two separate analyses are consistent, we ensure that quantified radar properties are well constrained. First estimate of constant‐Q is 78.8 ± 11.6. For a subsurface propagation velocity of 0.113 m/ns, that equals an attenuation of −2.1 ± 0.4 dB/m at the RIMFAX 675 MHz center frequency. Results are consistent with dry sedimentary rocks, and are distinguishable from the magmatic lithologies on Jezero Crater Floor.

Polygamy is the practice of marriage to multiple partners. Approximately 6-11% of households in Uganda and 4-11% of households in Kenya are polygamous. The complex families produced by polygamous marriage customs give rise to additional considerations for healthcare providers and public health messaging around HIV care. Using 27 in-depth, semi-structured qualitative interviews with participants in two studies in rural Kenya and Uganda, we analysed challenges and opportunities that polygamous families presented in the diagnosis, treatment and prevention of HIV, and provider roles in improving HIV outcomes in these families. Overall, prevention methods seemed more justifiable to families where co-wives live far apart than when all members live in the same household. In treatment, diagnosis of one member did not always lead to disclosure to other members, creating an adverse home environment; but sometimes diagnosis of one wife led not only to diagnosis of the other, but also to greater household support.

The debate about the interdependence or the dichotomy between the church and the state or politics is not new. The discourse is neither over nor something that will pass any soon. Both perspectives provide concrete reasons depending on the viewpoint from which an individual is writing and arguing. Both the ecclesia and the state or politics enjoy social capital. Of the two, however, the Church’s social capital is resilient and consistent, unlike the political capital which is seasonal and only rigorous in the pursuit for political position. In recent years, there is an immense emergence of Christianity that blend charismatic practices and African religiosity. An increased pursuit of political leadership is being witnessed by the church leadership and the secular community. One of the motivations has been the derivatives from the positions, which are mainly monetary and honourability. This can be linked to a struggle to meet a status threshold set and determined by a postmodern society which the clergy and the political leader must uphold. Anyone who lives below that ‘standard’ does not fit that position. It is for this reason that both the church and state or politics has been commercialised. The commercialisation aspect resulted in the two competitive entrepreneurial enterprises. Thus justice has been retailed to commercialisation and consumerism. This article therefore firmly holds the possibility that church and state or politics have common elements that, if reworked, can become tools in the mission of God. The assumption is that both institutions are reviewed as organs and not organisations because, as organisms, they are both fit for transformation into suitable instruments for the mission of God. Institutional reforms are dictated by the reformed human resource. This article leans towards the interrelationship between the Pentecostal tradition and the state or politics in viewing their role in doing justice to the mission of God. Thus a comparative framework fits this work. Contribution: The interdependence of the church and political enterprise is exposed to a constructive critique and further writing. It has advanced affirmed the comparative methodology as a ongoing study alternative.

Perseverance traversed the eastern, northern, and western margins of the Séítah formation inlier on the rover’s western fan front approach. Mapping the stratigraphy and extent of the Máaz and Séítah formations is key to understanding the depositional history and timing of crater floor resurfacing events. Perseverance's rapid progress across the Jezero crater floor between the Octavia E. Butler landing site and the western fan front resulted in limited contextual images of the deposits from the Navigation Camera and Mast Camera Zoom. By combining the limited surface images with continuous subsurface sounding by the Radar Imager for Mars’ Subsurface Experiment (RIMFAX) ground-penetrating radar, Jezero crater floor stratigraphy was inferred along this rapid traverse. We produced the first subsurface map of the Máaz formation thickness and elevation of the buried Séítah formation for 2.3 km of the rapid traverse. Three distinct reflector packets were observed in RIMFAX profiles interspersed with regions of low-radar reflectivity. We interpret these reflector packets with increasing depth to be the Roubion member of the Máaz formation (covered in places with regolith), the Rochette member, and the Séítah formation. We found a median permittivity of 9.0 and bulk density of 3.2 g cm ^−3 from hyperbola fits to RIMFAX profiles, which suggests a mafic composition for Máaz and Séítah. The low-radar reflectivity regions within each reflector packet could indicate potential depositional hiatuses where low-density material like sediment or regolith could have accumulated between successive Máaz formation lava flows and the Séítah formation at depth.

Estimates of radar attenuation in the shallow Martian subsurface are retrieved from RIMFAX soundings along the Perseverance rover traverse. Specifically, analyzed data is from the Hawksbill Gap area during the rover's first drives onto the Jezero Western Fan Front. The centroid frequency‐shift method is employed to quantify attenuation in terms of the constant‐Q approximation. Results are then compared with the amplitude decay method, which—in order to calculate attenuation—requires propagation velocities retrieved from radargram analysis. By verifying that results from two separate analyses are consistent, we ensure that quantified radar properties are well constrained. First estimate of constant‐Q is 78.8 ± 11.6. For a subsurface propagation velocity of 0.113 m/ns, that equals an attenuation of −2.1 ± 0.4 dB/m at the RIMFAX 675 MHz center frequency. Results are consistent with dry sedimentary rocks, and are distinguishable from the magmatic lithologies on Jezero Crater Floor. Plain Language Summary: This study presents first estimates of radar attenuation at the Jezero Western Fan Front. Measurements were made with the RIMFAX payload instrument on the Mars 2020 Perseverance rover mission, acquired along the rover drive path. Results indicate low signal losses in the subsurface that are consistent with dry sedimentary rocks, as observed on the surface by other payload instruments. Maximum imaging depths increase compared to imaging over magmatic lithologies on Jezero Crater Floor. By using separate methods of analysis (the centroid frequency‐shift method and the amplitude decay method), we reliably quantify attenuation and maximum penetration depths at the Western Fan Front, and observe differences to the Crater Floor lithologies. Key Points: The first estimate of radar attenuation at the Jezero Western Fan Front is on average −2.1 dB/mFor an average propagation velocity of 0.113 m/ns, returned power and time‐frequency analyses yield similar resultsRadar properties are consistent with dry sedimentary rocks and are distinguishable from the magmatic lithologies on Jezero Crater Floor [ABSTRACT FROM AUTHOR]

Revenue decentralization represents a framework that facilitates enhanced fiscal autonomy for subnational governments, thereby enabling the tailoring of services to meet local needs and potentially fostering economic growth. In Kenya, the ratification of the 2010 constitutional formalized novel revenue frameworks aimed at supporting the operations, management, and sustainability of devolved county governments. However, there remains a paucity of empirical analysis examining the relationship between the revenue decentralization reforms and county‐level economic growth. We begin by identifying the main sources of county revenues within the decentralization frameworks, then investigate the dynamic interrelation with county economic growth. Through panel vector autoregression estimation techniques, our analysis reveals a positive and statistically significant association between own‐source revenue and conditional grants with county‐level economic growth. We discuss the implications of our findings and call for policymakers to reassess the fiscal instruments with the aim of strengthening the roles and responsibilities of counties. Key Takeaways: Revenue decentralization, in conjunction with fiscal instruments that facilitate the collection of own‐source revenue, has the potential to stimulate economic growth at the county level.Conditional grants, while partially significant, demonstrate their capacity to promote economic growth in historically marginalized counties.Our analysis reveals no substantial evidence that the equitable share of revenue significantly contributes to county‐level economic growth.This paper highlights the necessity of ongoing restructuring of decentralization frameworks to enhance the autonomy and sustainability of county governments. [ABSTRACT FROM AUTHOR]

Polygamy is the practice of marriage to multiple partners. Approximately 6-11% of households in Uganda and 4-11% of households in Kenya are polygamous. The complex families produced by polygamous marriage customs give rise to additional considerations for healthcare providers and public health messaging around HIV care. Using 27 in-depth, semi-structured qualitative interviews with participants in two studies in rural Kenya and Uganda, we analysed challenges and opportunities that polygamous families presented in the diagnosis, treatment and prevention of HIV, and provider roles in improving HIV outcomes in these families. Overall, prevention methods seemed more justifiable to families where co-wives live far apart than when all members live in the same household. In treatment, diagnosis of one member did not always lead to disclosure to other members, creating an adverse home environment; but sometimes diagnosis of one wife led not only to diagnosis of the other, but also to greater household support. Plain Language Summary: Clinical implications of HIV treatment and prevention for polygamous families in Kenya and Uganda Polygamy is the practice of marriage to multiple partners. Approximately 6-11% of households in Uganda and 4-11% of households in Kenya are polygamous. The complex families produced by polygamous marriage customs give rise to additional considerations for healthcare providers and public health messaging around HIV care. [ABSTRACT FROM AUTHOR]

Electrochemistry plays a pivotal role in a vast number of domains spanning from sensing and manufacturing to energy storage, environmental conservation, and healthcare. Electrochemical applications encompassing gaseous or organic substrates encounter shortcomings ascribed to high mass transfer/internal resistances and low solubility in aqueous electrolytes, resulting in high overpotentials. In practice, strong acids and expensive organic electrolytes are required to promote charge transfer in electrochemical cells, resulting in a high carbon footprint. Liquid-liquid (L-L) and gas-liquid (G-L) dispersions involve the dispersion of a nano/micro gas or liquid into a continuous liquid phase such as micelles, (macro)emulsions, microemulsions, and microfoams stabilised by surface-active agents such as surfactants and colloidal particles. These dispersions hold promise in addressing the drawbacks of electrochemical reactions by fostering the interfacial surface area between immiscible reagents and mass transfer of electroactive organic and gas reactants and products from/to the bulk to/from the electrode surface. This tutorial review provides a taxonomy of liquid-liquid and gas-liquid dispersions for applications in electrochemistry, with emphasis on their assets and challenges in industrially relevant reactions for fine chemistry and depollution.

Herein we report an electrochemical deconstructive functionalization approach for the synthesis of C(sp 3 )-rich heterocycles. The reaction proceeds via the mesolytic cleavage of anodically generated aromatic radical cations and the trapping of formed carbocation intermediates with internal nucleophiles. The method has been demonstrated across various arylalcohol substrates to access a diverse range of C(sp 3 )-rich heterocycles including tetrahydrofuran, tetrahydropyran, and pyrrolidine scaffolds (26 examples). The electrochemical method was demonstrated on a 5 mmol scale via single pass continuous flow, which utilized lower supporting electrolyte concentration and exhibited increased productivity in relation to the batch process.

Introduction: An adequate health workforce (HWF) is essential to achieving the targets of the Sustainable Development Goals (SDG), including universal health coverage. However, weak HWF planning and constrained fiscal space for health, among other factors in the WHO Africa Region, has consistently resulted in underinvestment in HWF development, shortages of the HWF at the frontlines of service delivery and unemployment of qualified and trained health workers. This is further compounded by the ever-evolving disease burden and reduced access to essential health services along the continuum of health promotion, disease prevention, diagnostics, curative care, rehabilitation and palliative care., Methods: A stock and flow model based on HWF stock in 2022, age structure, graduation and migration was conducted to project the available stock by 2030. To estimate the gap between the projected stock and the need, a population needs-based modelling was conducted to forecast the HWF needs by 2030. These estimations were conducted for all 47 countries in the WHO African Region. Combining the stock projection and needs-based estimation, the modelling framework included the stock of health workers, the population's need for health services, the need for health workers and gap analysis expressed as a needs-based shortage of health workers., Results: The needs-based requirement for health workers in Africa was estimated to be 9.75 million in 2022, with an expected 21% increase to 11.8 million by 2030. The available health workers in 2022 covered 43% of the needs-based requirements and are anticipated to improve to 49% by 2030 if the current trajectory of training and education outputs is maintained. An increase of at least 40% in the stock of health workers between 2022 and 2030 is anticipated, but this increase would still leave a needs-based shortage of 6.1 million workers by 2030. Considering only the SDG 3.c.1 tracer occupations (medical doctors, nurses, midwives, pharmacists and dentists), the projected needs-based shortage is 5.3 million by 2030. In sensitivity analysis, the needs-based shortage is most amenable to the prevalence of diseases/risk factors and professional standards for service delivery CONCLUSIONS: The WHO African Region would need to more than double its 2022 HWF stock if the growing population's health needs are to be adequately addressed. The present analysis offers new prospects to better plan HWF efforts considering country-specific HWF structure, and the burden of disease., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)

Introduction: Avulsion fractures of the ischial tuberosity (AFIT) are uncommon injuries that sometimes require operative fixation with screws, suture anchors, or cortical suspensory buttons. This study reviewed a series of surgically managed AFITs at a single institution and compared outcomes among fixation strategies. We hypothesized there would be no difference in outcomes between fixation types., Methods: We conducted a retrospective review of all patients treated operatively at a single institution from 2010 to 2022 for AFIT identified by CPT code (27215). We collected patient demographics, injury characteristics, Revised Modified Oxford Bone Score, radiographic measures, fracture classification (type 1-lateral vs. type 2-complete), surgical fixation technique, postoperative complications (Modified Clavien-Dindo-Sink [M-CDS] Complication Classification), and time to return to sport (RTS). Descriptive statistics and univariate analyses were performed., Results: Study criteria identified 16 patients with surgically treated AFITs during the study period. Patients were predominantly male (88%) with a mean age of 14.8±0.8 years. Injured patients most commonly participated in soccer (38%), with the most common mechanism of injury being running/sprinting (50%). The avulsed fracture fragments were a mean of 42.6 mm in size, with an average maximal displacement of 21.1 mm and predominantly type 1-lateral (75%). Surgical constructs included: screws (4), suture anchors (5), cortical suspensory buttons (6), and combined (1, screw and suture anchor). Postoperative complications occurred in 8 patients (50%) including 7 type 1 and 1 type 3 M-CDS. No statistically significant difference was found between fixation types among the studied outcome variables; however, re-fracture (1 case [M-CDS type 3]) was only observed with a combined (screw and suture anchor) construct., Conclusions: This retrospective cohort study demonstrated that postoperative complications after ORIF for AFIT were not infrequent but were largely low in severity. Refracture occurred only with a combined screw and suture anchor construct. Consistent return to sport was achieved across all fixation types, with no significant difference in complication rate between constructs, although the available study sample limited robust analysis. This study is also, of note, one of the first to report outcomes from cortical suspensory buttons (CSB)-a relatively novel intervention for AFIT. Findings from this retrospective case series of multiple surgical techniques serve to bolster the limited literature base regarding the operative treatment of AFITs in adolescents., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Objective: To explore and describe the experiences of Haitians/Haitian Americans in Miami-Dade County, Florida during the COVID-19 pandemic, including their attitudes and practices towards vaccination., Design: We interviewed 15 community members and 15 stakeholders in the Haitian/Haitian American community in Miami-Dade County, Florida using a semi-structured interview guide. The qualitative interviews were conducted between February 4, 2021, and October 1, 2021. They were conducted in both English and Haitian Creole, audio recorded transcribed/translated, and coded using thematic content analysis., Results: The analyses revealed 9 major themes: (1) thoughts about the pandemic, (2) concerns about the COVID-19 vaccines, (3) healthcare access, February-October 2021, (4) intrapersonal relationship dynamics, (5) thoughts about individuals diagnosed with COVID-19, (6) thoughts about prevention measures (e.g., wearing masks, hand hygiene, social distancing, vaccination), (7) mental health struggles and coping, (8) food insecurity, and (9) overall experiences of the pandemic. The findings reveal that the COVID-19 public health emergency negatively affected Haitians/Haitian Americans across several domains, including employment, healthcare access, personal relationships, and food security., Conclusion: This research echoes the compounding negative experiences reported by multiple disadvantaged groups during the COVID-19 pandemic. From loss of employment to healthcare barriers, the pandemic forced many Haitians/Haitian Americans into greater economic and social instability. Interventions addressing these issues should recognize how these factors may interact and compound the experiences of this group. Health and public health agencies should work alongside community partners to build trust so that preventive efforts will be more readily accepted during public health emergencies., Competing Interests: AF was employed by Family Action Network Movement. MT is the President/CEO of the Community Health and Empowerment Network. SD is a co-investigator on a Merck & Co. funded project on “A Qualitative Study to Explore Biomedical HIV Prevention Preferences, Challenges and Facilitators among Diverse At-Risk Women Living in the United States” and has served as a workgroup consultant on engaging people living with HIV for Gilead Sciences, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Sternberg, Richard, Daniel, Chery, Beauvoir, Marcelin, Francois, Titus, Mann, Alcaide and Dale.)

Amphiphilic Janus silica particles, tunable with oleophobic-oleophilic properties and low fluorine content (8 wt % F), exhibited prominent foamability for a variety of aromatic alcohols at low particle concentrations (<1 wt %) compared to randomly functionalized silica particles. When selectively loaded with Pd nanoparticles on the oleophilic hemisphere, the particles displayed more than a 2-fold increase in catalytic activity for the aerobic oxidation of benzyl alcohol compared to nonfoam bulk catalysis under ambient O 2 pressure. The particles were conveniently recycled with high foamability and catalytic activity maintained for at least five consecutive runs., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

Background: Androgen signaling is central to prostate cancer and men's health. Prior data indicates that increasing body fat is unfavorable in the localized setting yet associated with favorable outcomes in men with metastatic disease. Understanding the biological links between adiposity and prostate cancer may optimize the therapeutic index with ASI. We hypothesized that host adiposity and androgen synthesis are linked to the efficacy and toxicity of ASI for men with metastatic castration-resistant prostate cancer (mCRPC)., Methods: A post-hoc analysis was done of NCT02703623 where men with mCRPC (n = 186) were treated for 8 weeks with abiraterone acetate, prednisone, and apalutamide (AAPA), and a satisfactory response was defined as a PSA decline >50%. Body composition was measured on baseline CT scans. Germline DNA WES was performed with a focus on variants in steroidogenic genes. Adipokine levels were measured in pre-treatment plasma., Results: Germline polymorphisms in 3 genes involved in androgen synthesis (AKR1C3 rs12529, CYP17A1 rs6162, SRD5A2 rs523349) were associated with differences in body composition at baseline on ADT alone (prior to receipt of AAPA). Elevated subcutaneous adipose tissue index (SATi, p = 0.02), visceral adipose tissue index (VATi, p = 0.03), and BMI (p = 0.04) were associated with satisfactory response to AAPA. Leptin had positive correlation with VATi (r = 0.47) and SATi (r = 0.48)., Conclusion: Inherited polymorphisms in androgen synthesis correlated with differences in body composition after exposure to ADT and warrant further investigation as candidate markers for body composition toxicity. Elevated subcutaneous and visceral adiposity were associated with improved response to ASI., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)

Gas-liquid-solid catalytic reactions are widespread in nature and man-made technologies. Recently, the exceptional reactivity observed on (electro)sprayed microdroplets, in comparison to bulk gas-liquid systems, has attracted the attention of researchers. In this perspective, we compile possible strategies to engineer catalytically active gas-liquid-(solid) interfaces based on membrane contactors, microdroplets, micromarbles, microbubbles, and microfoams to produce commodity chemicals such as hydrogen peroxide, ammonia, and formic acid. In particular, particle-stabilized microfoams, with superior upscaling capacity, emerge as a promising and versatile platform to conceive high-performing (catalytic) gas-liquid-(solid) nanoreactors. Gas-liquid-(solid) nanoreactors could circumvent current limitations of state-of-the-art multiphase reactors (e.g., stirred tanks, trickle beds, and bubble columns) suffering from poor gas solubility and mass transfer resistances and access gas-liquid-(solid) reactors with lower cost and carbon footprint.

α,β-Unsaturated aldehydes are important building blocks for the synthesis of a wide range of chemicals, including polymers. The synthesis of these molecules from cheap feedstocks such as alkenes remains a scientific challenge, mainly due to the low reactivity of alkenes. Here we report a selective and metal-free access to α,β-unsaturated aldehydes from alkenes with formaldehyde. This reaction is catalyzed by dimethylamine and affords α,β-unsaturated aldehydes in yields of up to 80 %. By combining Density Functional Theory (DFT) calculations and experiments, we elucidate the reaction mechanism which is based on a cascade of hydride transfer, hydrolysis and aldolization reactions. The reaction can be performed under very mild conditions (30-50 °C), in a theoretically 100 % carbon-economical fashion, with water as the only by-product. The reaction was successfully applied to non-activated linear 1-alkenes, thus opening an access to industrially relevant α,β-unsaturated aldehydes from cheap and widely abundant chemicals at large scale., (© 2024 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)

Nonaqueous foams in low-surface tension solvents (<25 mN·m -1 ) are highly desired for applications in fire extinguishers and detoxification gels. However, their formation is a Holy Grail of the chemical industry due to the need for stabilizers with low surface energy and high recyclability. Herein, we disclose a new strategy to generate abundant foams in ethanol and a variety of low-surface tension solvents relying on the interfacial coadsorption of two different particles. The particles consist of surface-active fluorinated silica particles, used as a stabilizer, and a novel amphiphilic polyhedral oligomeric silsesquioxane (POSS) decorated with isobutyl cage substituents, used as a frother. The interaction between POSS and fluorinated particles at the ethanol-air interface was thoroughly investigated by combining physicochemical methods (contact angle, dynamic surface tension, and dynamic light scattering methods) and catalytic tests using the model aerobic oxidation reaction of benzyl alcohol. Both particles could be conveniently recycled for at least 5 consecutive runs with high foamability and catalytic activity.

Traditional on-site missions of plastic surgeons from "high-income countries" in "low- and middle-income countries" are often limited in time and lack proper follow-up. Regular digital collaboration could lead to a more impactful and durable exchange of knowledge for plastic surgeons and residents in both settings. The aim of this study was to evaluate the satisfaction of the first twelve months of weekly digital meetings, explore advantages/disadvantages, and to provide tools for similar initiatives. Weekly meetings started from August 2021. An encrypted digital connection allowed residents and plastic surgeons from Uganda and the Netherlands to discuss cases for educational purposes, where treatment options were considered. After twelve months, a survey was sent to participants from both countries to indicate the meetings' strengths, weaknesses, and possible improvements. A total of 18 participants responded to the questionnaire (ten plastic surgeons, six residents, and two researchers). The strengths of the meetings were the accessibility of the meetings, knowledge exchange and practice for residents' final exams. Possible improvements included having a clear format for patient discussion, a session moderator and better internet connectivity. Moreover, a database to assess the impact of the given intervention on the patient cases by evaluating postoperatively (e.g. three months), could further improve clinical care. Virtual patient discussions subjectively contributed to medical education at both locations. Improved digital infrastructure and a collaborative database could further maximize learning capacity. Furthermore, digital proctoring is a promising way to establish sustainable collaborations between high- and low-resource countries. [ABSTRACT FROM AUTHOR]

In this study, we investigated the effect of the pore volume and mesopore size of surface-active catalytic organosilicas on the genesis of particle-stabilized (Pickering) emulsions for the dodecanal/ethylene glycol system and their reactivity for the acid-catalyzed biphasic acetalization reaction. To this aim, we functionalized a series of fumed silica superparticles (size 100-300 nm) displaying an average mesopore size in the range of 11-14 nm and variable mesopore volume, with a similar surface density of octyl and propylsulfonic acid groups. The modified silica superparticles were characterized in detail using different techniques, including acid-base titration, thermogravimetric analysis, TEM, and dynamic light scattering. The pore volume of the particles impacts their self-assembly and coverage at the dodecanal/ethylene glycol (DA/EG) interface. This affects the stability and the average droplet size of emulsions and conditions of the available interfacial surface area for reaction. The maximum DA-EG productivity is observed for A200 super-SiNPs with a pore volume of 0.39 cm 3 ·g -1 with an interfacial coverage by particles lower than 1 (i.e., submonolayer). Using dissipative particle dynamics and all-atom grand canonical Monte Carlo simulations, we unveil a stabilizing role of the pore volume of porous silica superparticles for generating emulsions and local micromixing of immiscible dodecanal and ethylene glycol, allowing fast and efficient solvent-free acetalization in the presence of Pickering emulsions. The micromixing level is interrelated to the adsorption energy of self-assembled particles at the DA/EG interface., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

This document is a correction notice for an article titled "Deformation-Induced Planar Defects in Immm Ni2(Cr, Mo, W) Strengthened HAYNES® 244® Superalloy" published in the journal Metallurgical & Materials Transactions. The correction involves updating Figure 13 in the article to improve the color scheme and enhance readers' understanding of the colored precipitates in relation to the plotted data. The corrected figure includes a graph showing interactions with different types of matrix dislocations and DFT calculations of slip pathways. The publisher, Springer Nature, maintains a neutral stance on jurisdictional claims and institutional affiliations. [Extracted from the article]

Background: The development of Artificial Intelligence (AI) is one of the most revolutionary changes in modern history. The combination of AI and Robotic surgery can be used positively for better patient outcomes. Methods and Results: We aimed to conduct a review of AI and its role in robotic radical prostatectomy in modern day surgical practice. We conducted a literature review on this topic with specific discussion about whether the surgeon can be replaced by robots with AI capabilities based on latest studies available in the literature. We have presented a comprehensive overview of AI in robotic surgery. Conclusion: We conclude that AI capabilities are to assist the surgeon and the team to improve patient outcomes. Robots cannot replace the surgeon in the near future. Robots with AI capabilities can be only used as an adjuvant to complement the surgical team and not replace them. [ABSTRACT FROM AUTHOR]

The importance of fundamental basic research in the quest for much needed clinical treatments is a story that constantly must be retold. Funding of basic science in the USA by the National Institutes of Health and other agencies is provided under the assumption that fundamental research eventually will lead to improvements in healthcare worldwide. Understanding how basic research is connected to clinical developments is important, but just part of the story. Many basic science discoveries never see the light of day in a clinical setting because academic scientists are not interested in or do not have the inclination and/or support for entering the world of biotechnology. Even if the interest and inclination are there, often the unknowns about how to enter that world inhibit taking the initial step. Young investigators often ask me how I incorporated biotech opportunities into my otherwise purely academic research endeavors. Here I tell the story of the foundational basic science and early events of my career that led to forming the biotech companies responsible for the development of unique cardiac drugs, including mavacamten, a first in class human β-cardiac myosin inhibitor that is changing the lives of hypertrophic cardiomyopathy patients. [ABSTRACT FROM AUTHOR]

Industrial chemical producers and formulators are increasingly conscious of their responsibility in stewarding planetary resources and minimizing harm to the environment. In 2019, the Royal Society of Chemistry (RSC) engaged an industry task force from across the value chain to drive technical research to classify a new class of polymer—polymers in liquid formulation (PLFs). Building on this, the task force called for step change in sustainability practices for PLFs and instigated a design and development process to identify research themes and priorities that could accelerate innovation in this area. However, a key challenge was that as a novel classification, PLFs were largely unknown outside the chemistry community and entirely absent from the mainstream research agenda. To establish the demand-pull requirements of the value chain for sustainable PLFs, the RSC used a 'mission-oriented' innovation framework to enable the taskforce to co-design an ideal-type portfolio of research and innovation projects, and to set out a realistic roadmap for transition. This perspective article presents a summary of the activities carried out by the task force in its pursuit of mission-oriented innovation for PLFs and describes the strategic design method used to enable cross-value chain consensus on action for PLF sustainability, build system-wide innovation ecosystems and explore common-good scenarios. This article is part of the discussion meeting issue 'Green carbon for the chemical industry of the future'. [ABSTRACT FROM AUTHOR]

Lysosomes are important cellular structures for human health as centers for recycling, signaling, metabolism and stress adaptation. However, the potential role of lysosomes in stress‐related emotions has long been overlooked. Here, it is found that lysosomal morphology in astrocytes is altered in the medial prefrontal cortex (mPFC) of susceptible mice after chronic social defeat stress. A screen of lysosome‐related genes revealed that the expression of the mucolipin 1 gene (Mcoln1; protein: mucolipin TRP channel 1) is decreased in susceptible mice and depressed patients. Astrocyte‐specific knockout of mucolipin TRP channel 1 (TRPML1) induced depressive‐like behaviors by inhibiting lysosomal exocytosis‐mediated adenosine 5′‐triphosphate (ATP) release. Furthermore, this stress response of astrocytic lysosomes is mediated by the transcription factor EB (TFEB), and overexpression of TRPML1 rescued depressive‐like behaviors induced by astrocyte‐specific knockout of TFEB. Collectively, these findings reveal a lysosomal stress‐sensing signaling pathway contributing to the development of depression and identify the lysosome as a potential target organelle for antidepressants. [ABSTRACT FROM AUTHOR]

To achieve sustainable and energy‐efficient CO2 capture processes, it is imperative to develop membranes that possess both high CO2 permeability and selectivity. One promising approach involves integrating high‐aspect‐ratio nanoscale fillers into polymer matrices. The high‐aspect‐ratio fillers increase surface area and improve interactions between polymer chains and gas molecules passing through the membrane. This study focuses on the integration of cellulose nanocrystals (CNCs) with an impressive aspect ratio of around 12 into rubbery polymers containing polyethylene oxide (PEO), namely PEBAX MH 1657 (poly[ether‐block‐amide] [PEBA]) and polyurethane (PU), to fabricate mixed‐matrix membranes (MMMs). By exploiting the interfacial interactions between the polymer matrix and CNC nanofillers, combined with the surface functionalities of CNC nanofillers, the rapid and selective CO2 transport is facilitated, even at low filler concentrations. This unique feature enables the development of thin‐film composites (TFCs) with a selective layer around 1 μm. Notably, even at a filling ratio as low as 1 weight percent, the resulting membranes exhibit remarkable CO2 permeability (>90 Barrer) and CO2/N2 selectivity (>70). These findings highlight the potential of integrating CNCs into rubbery polymers as a promising strategy for the design and fabrication of highly efficient CO2 capture membranes. [ABSTRACT FROM AUTHOR]