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5. PLANT DIVERSITY AND COMMUNITY COMPOSITION ALONG THE PREVAILING ENVIRONMENTAL CONDITIONS IN WADI MURR AL-ZAHRAN, SOUTHWESTERN SAUDI ARABIA.

Author

OSMAN, H. E., SOLIMAN, M. A., EL-MORSY, M. H., ELAIDAROUS, A. A., and GALAL, T. M.

Subjects
PLANT communities, WATERMELONS, PRINCIPAL components analysis, SPECIES diversity, BOTANY
Abstract

Desert wadis serve as essential ecosystems for socioeconomic development because of their biological value, physiographic heterogeneity, and environmental gradients. The study aims to evaluate Wadi Murr, the largest wadi ecosystem in Makkah, as a plant diversity hotspot regarding floristic diversity and vegetation along the prevailing environmental gradients. Data were collected from 102 stands across 17 sampling sites, representing the vegetation physiognomy along the wadi. About 118 species related to 81 genera and 35 families have been recognized, the Poaceae family notably prevailing in dominance. Therophytes prevailed among other life forms, and biregional taxa exhibited dominance among other chorotypes. The Two-way indicator species analysis (TWINSPAN) revealed 13 distinct vegetation groups (VGs) segregation along the two Detrended Correspondence Analysis (DECORANA) axes. Seven VGs (D, F, H, I, K, L, M) were dominated by halophytic species of family Zygophyllaceae, while VG (A) was dominated by the rocky community Capparis decidua, and VG (B and G) was dominated by the tree's communities Vachellia seyal and Senna italica. Besides, VG (E) is dominated by a grass community (Aristida pennei), and VG (J) is dominated by the medicinal herb Citrullus colocynthis. The Principal Component Analysis (PCA) ordination explained that Cl-, SO4 2-, pH, EC, fine sand, silt, and gravel significantly influenced the plant communities. Furthermore, certain plant communities, such as Capparis decidua and Senna italica exhibited positive responses to the following soil variables: Ca2+, Mg2+, and Na+. In contrast, others, such as Tribulus pentandrus were negatively affected by gravels, coarse sand, and fine sand. The species richness ranged from 1.3 species stand-1 in Capparis decidua-Cenchrus divisus group (VG A) to 13.1 species stand-1 in Senna italica-Stipagrostis hirtigluma (VG: G). The limited species diversity observed in certain plant communities implies the eradication of the original vegetation, emphasizing the pressing need for habitat rehabilitation. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Supplementary Figure 6 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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8. Supplementary Figure 24 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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9. Supplementary Figure 5 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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10. Supplementary Figure 17 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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11. Supplementary Tables S1-S12 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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12. Supplementary Figure 9 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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13. Supplementary Figure 7 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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14. Supplementary Data 1 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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15. Data from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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16. Supplementary Figure 4 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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17. Supplementary Data 2 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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18. Supplementary Figure 8 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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19. Supplementary Figure 3 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
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30. REMOTE SENSING AND MULTIVARIATE ANALYSIS FOR ASSESSING THE IMPACT OF PLANT DIVERSITY ON LAND SURFACE TEMPERATURE OF WADI AL-SHARAEA, MAKKAH REGION, SAUDI ARABIA.

Author

EL-MORSY, M. H., ABD EL-HAMID, H. T., OSMAN, H. E., and ELAIDAROUS, A. A.

Subjects
LAND surface temperature, PLANT diversity, NORMALIZED difference vegetation index, REMOTE sensing, MULTIVARIATE analysis, CARYOPHYLLACEAE
Abstract

Nowadays, studying the macrophytes distribution climatic change reducing effect through land surface temperature is vital. 17 locations with 102 stands were randomly chosen to illustrate the vegetation physiognomy in Wadi Al-Sharaea, Makkah Province, Saudi Arabia. A total of 110 species from 77 genera and 33 families were detected during the field study, with the Poaceae family predominant. Therophytes were the dominant life form (38.2% of the total species), followed by chamaephytes (30.0%), and bioregional elements were the dominant chorotype. Remote sensing data were acquired to evaluate land surface temperature (LST), normalized difference built-up index (NDBI), and normalized difference vegetation index (NDVI) from 2002 and 2018. The study assesses the relationship between organic matter, plant diversity species, vegetation cover, and LST. Principal component analysis (PCA) was applied, and the obtained data showed that PCA1 and PCA2 represent about 25.29% and 16.34%, respectively. Cluster analysis was used to identify the commonality of the groups among the data from points clustered into four significant clusters. On the other hand, LST correlated with the distribution of some families, such as Caryophyllaceae, Boraginaceae, Euphorbiaceae, and Molluginaceae. The families that correlated to LST show the tolerance of these families to high temperatures. Results showed that Limeaceae, Poaceae, and Zygophyllaceae families grow in soil with high organic matter. These findings indicated fundamental advances in understanding the temperature response of organic matter and plant diversity. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Gastrointestinal: A rare case of concurrent vulvar Crohn's disease and pyoderma gangrenosum.

Author

Bommireddipally, J, Broussard, K, Osman, H, Uhlhorn, A, and Loganantharaj, N

Subjects
CROHN'S disease, PYODERMA gangrenosum, VULVAR cancer, VULVAR diseases, INFLAMMATORY bowel diseases
Abstract

This article discusses a rare case of concurrent vulvar Crohn's disease (CD) and pyoderma gangrenosum (PG). CD is a chronic inflammatory condition that affects the gastrointestinal tract, and vulvar involvement is a rare extraintestinal manifestation. PG is an autoinflammatory dermatitis that is infrequently seen in patients with CD. The article presents the case of a 33-year-old female with vulvar CD and PG, describing her symptoms, physical exam findings, and treatment. The article emphasizes the need for a multidisciplinary approach to care and mentions various treatment options for vulvar CD and PG. [Extracted from the article]

Published
2024
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33. Pulmonary Adenocarcinomas of Low Malignant Potential

Author

Yambayev, Ilyas, Sullivan, Travis B., Suzuki, Kei, Zhao, Qing, Higgins, Sara E., Yilmaz, Osman H., Litle, Virginia R., Moreira, Paulo, Servais, Elliot L., Stock, Cameron T., Quadri, Syed M., Williamson, Christina, Rieger-Christ, Kimberly M., and Burks, Eric J.

Abstract

Supplemental Digital Content is available in the text.Lung cancer screening has improved mortality among high-risk smokers but has coincidentally detected a fraction of nonprogressive adenocarcinoma historically classified as bronchoalveolar carcinoma (BAC). In the National Lung Screening Trial (NLST) the majority of BAC—comprising 29% of computed tomography–detected stage I lung adenocarcinoma—were considered overdiagnosis after extended follow-up comparison with the control arm. In the current classification, adenocarcinoma in situ and minimally invasive adenocarcinoma have replaced BAC but together comprise only ∼5% of stage I lung adenocarcinoma. Lepidic and subsets of papillary and acinar adenocarcinoma also infrequently recur. We, therefore, propose criteria for low malignant potential (LMP) adenocarcinoma among nonmucinous adenocarcinoma measuring ≤3 cm in total, exhibiting ≥15% lepidic growth, and lacking nonpredominant high-grade patterns (≥10% cribriform, ≥5% micropapillary, ≥5% solid), >1 mitosis per 2 mm2, angiolymphatic or visceral pleural invasion, spread through air spaces or necrosis. We tested these criteria in a multi-institutional cohort of 328 invasive stage I (eighth edition) and in situ adenocarcinomas and observed 16% LMP and 7% adenocarcinoma in situ/minimally invasive adenocarcinoma which together (23%) approximated the frequency of overdiagnosed stage I BAC in the NLST. The LMP group had 100% disease-specific survival. The proposed LMP criteria, incorporating multiple histologic parameters, may be a clinically useful “low-grade” prognostic group. Validation of these criteria in additional retrospective cohorts and prospective screen-detected cohorts should be considered.

Published
2024
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34. 335P Transition in Duchenne muscular dystrophy: understanding healthcare providers' roles in an international context.

Author

Friedrich, S., Langer, T., Reeskau, G., Rodger, S., Willems, J., de Angelis, F., Brigliadori, B., Guastafierro, E., Leonardi, M., Marcassoli, A., Moroni, I., Nardocci, N., Fournier, A., Frei, J., Gutierrez Rojas, R., Kraus De Camargo, O., Pozniak, K., Swain, A., Gorter, J., and Osman, H.

Subjects
*TRANSITIONAL care, *PATIENTS, *DUCHENNE muscular dystrophy, *MEDICAL personnel, *PATIENTS' families
Abstract

Duchenne muscular dystrophy (DMD) is a rare X-linked disorder characterized by progressive muscle degeneration. The period of transition from pediatric to adult care is particularly challenging for adolescents with DMD, with the disease progressing at a time when youth typically strive for greater independence. With life expectancies increasing over the last years, health care providers are in need for better concepts to meet patients' and families' needs when going through this challenging period. Within the context of the GrowDMD study (http://www.growdmd.org), we aim to explore which measures and strategies are currently implemented in Canada, Germany and Italy to support and facilitate the transition of care for adolescents with DMD. We conduct semi-structured interviews with healthcare providers involved in the transition process, the total number being n=30 (10/country). In follow-up interviews healthcare providers are presented with two case vignettes that have been developed in collaboration with adolescents with DMD and their caregivers. Qualitative data are categorized across three countries and four languages. Data collection is ongoing, with the analysis of the first interviews having started. Preliminary results point toward the importance of roles (of patients, caregivers and healthcare providers), the existence and lack of support for these groups and several specific enablers and barriers for the transition process. Transitioning from pediatric to adult care is a challenge for patients and caregivers around the world. Findings from this international study will help to inform healthcare providers on how to navigate this process, delivering support for patients and families where needed and better understanding of their own role. [ABSTRACT FROM AUTHOR]

Published
2024
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35. 334P GrowDMD: an international study on transition of youth with Duchenne muscular dystrophy (DMD).

Author

Friedrich, S., Langer, T., Reeskau, G., Rodger, S., Willems, J., de Angelis, F., Brigladori, B., Guastafierro, E., Leonardi, M., Marcassoli, A., Moroni, I., Nardocci, N., Fournier, A., Frei, J., Gutierrez Rojas, R., Kraus De Camargo, O., Pozniak, K., Swain, A., Gorter, J., and Osman, H.

Subjects
*TRANSITIONAL care, *TRANSITION to adulthood, *YOUNG adults, *DUCHENNE muscular dystrophy, *MEDICAL personnel
Abstract

Care pathways for transition from childhood to adulthood are a well-described phenomenon. However, the transition of patients with Duchenne muscular dystrophy (DMD) is still neither defined nor implemented at national or international levels. DMD is a rare X-linked disorder characterized by progressive muscle degeneration, making it a chronic debilitating disease. The period of transition from pediatric to adult care is particularly challenging for adolescents with DMD, with the disease progressing at a time when youth typically strive for greater independence. The study GrowDMD (http://www.growdmd.org) aims to explore the diverse experiences of young people living with DMD and their families, as well as healthcare providers, in Canada, Germany, and Italy, addressing the following research questions: 1. How do patients with DMD and their caregivers experience the transition to adult care? 2. What measures and strategies are currently implemented in the care organizations of participating countries to support and facilitate the transition of care? 3. How can the transition of care be improved? This study utilizes an integrated knowledge translation process in which researchers, knowledge users, Patient Advocacy Organisations (PAOs) representatives, and patient partners collaborate across all stages of the research process. Following a systematic review of the literature; we conduct semi-structured interviews with 1) adolescents living with DMD and their parents/caregivers, 2) healthcare providers involved in the transition process, as well as qualitative surveys and focus groups. Together with youth with DMD and caregivers we aim to identify potential solutions and develop knowledge translation products. The integrated nature of this project will facilitate the co-creation of general recommendations, tailored to local contexts that can serve as a model for the transition care path for youth with DMD and other rare disease in participating countries and around the world. [ABSTRACT FROM AUTHOR]

Published
2024
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36. 379P A qualitative study on people with Duchenne muscular dystrophy and caregivers' experiences during the transition process from pediatric to adult healthcare.

Author

Marcassoli, A., Moroni, I., Guastafierro, E., Brigliadori, B., Nardocci, N., Leonardi, M., De Angelis, F., Langer, T., Rodger, S., Willems, J., De Camargo, O. Kraus, Frei, J., Swain, A., Ringer, D., Gorter, J., Pozniak, K., Rajapakse, N., Fournier, A., Gutierrez, R., and Osman, H.

Subjects
*YOUNG adults, *DUCHENNE muscular dystrophy, *PATIENT experience, *NEUROMUSCULAR diseases, *PATIENTS' attitudes
Abstract

Transition from pediatric to adult-centered healthcare involves both medical and psychological needs of adolescents and young adults. This process can be especially complex in rare neurological diseases, including neuromuscular disorders. Duchenne Muscular Dystrophy (DMD) is a rare X-linked disorder characterized by progressive muscle degeneration, causing the loss of independent ambulation and severe multisystem complications. Over the past few years, the survival perspectives for people with DMD have improved, leading to the need for a transition process from pediatric to adult healthcare. The present study aims to explore the experiences of adolescents and young adults with DMD and their families in three countries, identifying the challenges and supportive factors encountered during the transition process. This will help to understand how to improve health care, including rehabilitation systems, for individuals with DMD and other rare diseases. People with DMD aged 15-25 years and their caregivers undergo semi-structured interviews on their transition experiences and daily life challenges and facilitators. This study is included in the project "Growing into Adulthood with DMD - Comparing Patient Experiences and Systems to Optimize Care", funded by the European Joint Programme on Rare Diseases 2020 (N°825575), and involved German, Italian, and Canadian research centers. Data collection and qualitative synthesis of data from interviews are ongoing. The themes that emerge most from interviews include the need for transition policies, help from public institutions and the lack of information on transition for patients and caregivers. Without structured guidelines, young people and their families feel left alone during this process. The experiences of people with DMD and families across various countries will inform recommendations to improve the knowledge and development of transition programs from pediatric to adult care systems. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Irreversible Electroporation Margin Accentuation in Pancreaticoduodenectomy: A Propensity Score Matching Analysis.

Author

Lim JS, Heard J, Brant N, Malo J, Kong J, Osman H, Buell J, and Jeyarajah DR

Subjects
Humans, Male, Female, Aged, Survival Rate, Middle Aged, Follow-Up Studies, Prognosis, Retrospective Studies, Neoplasm Recurrence, Local pathology, Pancreaticoduodenectomy methods, Pancreatic Neoplasms surgery, Pancreatic Neoplasms pathology, Propensity Score, Margins of Excision, Electroporation methods, Adenocarcinoma surgery, Adenocarcinoma pathology
Abstract

Background: Margin accentuation using irreversible electroporation (MA-IRE) improves recurrence and overall survival (OS) in pancreatic cancer patients; however, there have been limited outcome comparisons to similarly risked patients who did not receive MA-IRE., Methods: Patients with borderline resectable or locally advanced pancreatic adenocarcinoma who underwent a pancreaticoduodenectomy (PD) between 2017 and 2022 were included. Those who did not receive neoadjuvant chemotherapy for major vessel involvement were excluded. One-to-one propensity score matching (PSM) was used to match the MA-IRE group with the corresponding non-MA-IRE control group with similar risk factors., Results: A total of 36 patients were included in this study. Seventeen (47.2%) patients who underwent MA-IRE matched with 19 control patients (52.8%) with similar risk factors who did not have MA-IRE. Before matching, OS and disease-free survival (DFS) were comparable between the MA-IRE and non-MA-IRE groups. After matching, the MA-IRE group showed improved OS (746 vs. 509 days, hazard ratio 0.313; p = 0.034) compared with the non-MA-IRE group. DFS (p = 0.768), negative margin status (p = 0.317), and 30-day complication rates (p = 1.000) remained statistically different between the groups., Conclusions: MA-IRE in PD results in longer OS but does not impact margin status, DFS, or postoperative complication rates in our cohort. These findings suggest that MA-IRE is safe and potentially promotes immune cell activation rather than upfront margin mitigation., (© 2024. Society of Surgical Oncology.)

Published
2024
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40. Incipient Intracholecystic Papillary Neoplasm of the Gallbladder Without Dysplasia.

Author

Lim JS, Dominguez A, Kidd N, Mudaliar K, Buell JF, Jeyarajah DR, and Osman H

Subjects
Humans, Female, Carcinoma, Papillary surgery, Carcinoma, Papillary pathology, Carcinoma, Papillary diagnosis, Male, Middle Aged, Gallbladder Neoplasms surgery, Gallbladder Neoplasms pathology, Gallbladder Neoplasms diagnostic imaging, Gallbladder Neoplasms diagnosis, Cholecystectomy
Abstract

Intracholecystic papillary neoplasm (ICPN) of the gallbladder is a rare tumor described as a mucosal exophytic neoplastic lesion that projects into the gallbladder lumen. In regards to the size, lesions that did not make the arbitrary 1cm cutoff are described as "incipient" ICPN. Not much is known about these incipient ICPNs, as they are often excluded in ICPN studies, given the attempted adherence to the traditional 1cm cutoff. We present the youngest reported case of incipient, non-mucinous gastric-pylorus type ICPN who underwent cholecystectomy. Resection with negative margin for ICPN appears to be sufficient treatment and post resection imaging surveillance could be of value but further studies are required., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr Jeyarajah is a consultant for AngioDynamics, Ethicon, and Sirtex.

Published
2024
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42. Risk factors for acute appendicitis among adult patients with indeterminate ultrasound.

Author

Doubova M, Cortel-LeBlanc MA, Mckinnon M, Osman H, Nemnom MJ, Macdonald B, and Thiruganasambandamoorthy V

Abstract

Objectives: Abdominal ultrasound is used for diagnosing appendicitis in patients with right lower quadrant abdominal pain. Between 45 and 82% of radiology performed ultrasounds are indeterminate for appendicitis and computed tomography is required for diagnostic confirmation. Our study aims to determine predictors to rule out appendicitis when ultrasound is indeterminate., Methods: We performed a health records review of adult emergency department (ED) patients presenting with symptoms suspicious for appendicitis and indeterminate ultrasound to two academic EDs between June 2019 and July 2020. The outcome was appendicitis diagnosis within 30 days of the index ED visit. We used multivariable logistic regression, identifying a cut-off threshold for continuous variables with cubic spline, and chose the parsimonious model to develop a binary decision rule. We report Odds ratios (OR) and diagnostic performance with 95% confidence intervals (CI)., Results: Overall, 463 patients (mean age 30.3 years (SD 10.5 years), 74.9% female) were included. Appendicitis was diagnosed in 45 patients (9.7% [95% CI 7.2-12.8%]). After ultrasound, computed tomography was performed in 227 patients (49.0%) and 39 patients (17.2%) were diagnosed with appendicitis. Among the 236 patients who did not have a subsequent computed tomography, 6 (2.6%) patients had appendicitis. Neutrophil count > 5.5 × 10 9 /L (OR 1.21 [95% CI 1.12-1.30]) and secondary signs of inflammation on ultrasound (OR 2.16 [1.07-4.37]) were associated with a higher likelihood of appendicitis (C-statistic 0.77 [95% CI 0.70-0.84]). The absence of both predictors had a sensitivity of 88.9% (95% CI 76.0-96.3%), specificity of 45.7% (95% CI 40.8-50.6%) and a negative predictive value of 0.97 (95% CI 0.94-0.99) to rule out appendicitis., Conclusion: For patients suspected of appendicitis and indeterminate ultrasound, the absence of an elevated neutrophil count and secondary signs of inflammation are associated with a low probability of appendicitis., (© 2024. The Author(s), under exclusive licence to the Canadian Association of Emergency Physicians (CAEP)/ Association Canadienne de Médecine d'Urgence (ACMU).)

Published
2024
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43. Effectiveness of biofeedback on blood pressure in patients with hypertension: systematic review and meta-analysis.

Author

Jenkins S, Cross A, Osman H, Salim F, Lane D, Bernieh D, Khunti K, and Gupta P

Subjects
Humans, Female, Middle Aged, Treatment Outcome, Male, Adult, Hypertension therapy, Hypertension physiopathology, Hypertension diagnosis, Biofeedback, Psychology, Blood Pressure
Abstract

Hypertension is the leading modifiable risk factor for cardiovascular disease, but less than 50% have their blood pressure controlled. A possible avenue to support hypertension management is a holistic approach, using non-pharmacological interventions. Since hypertension is mediated in part by dysregulation of the autonomic nervous system (ANS), biofeedback may help improve hypertension management by targeted self-regulation and self-awareness of parameters that regulate the ANS. This systematic review aimed to assess the effectiveness of biofeedback on blood pressure in hypertensive patients. The review was pre-registered on PROSPERO and followed the PICO strategy. A total of 1782 articles were retrieved, 20 met the inclusion criteria. Sample sizes ranged from 15 to 301 participants; with a median age of 49.3 (43.3-55.0) years and 45% were female. There was a significant effect of biofeedback on systolic (-4.52, Z = 2.31, P = 0.02, CI [-8.35, -0.69]) and diastolic blood pressure (-5.19, Z = 3.54, P = 0.0004, CI [-8.07, -2.32]). Six different biofeedback modalities were used, with biofeedback delivered by psychologists, trained therapists and research assistants. There was no publication bias, heterogeneity was rated as substantial and data quality was rated to be poor. This review demonstrated that biofeedback had a significant effect on blood pressure. However, this should be viewed in the context of included studies being limited by heterogeneity and dated literature, meaning the research does not reflect the current biofeedback technology such as wearable devices. Future research should incorporate these technologies with robust methodology to fully understand the effect of biofeedback on hypertension., (© 2024. The Author(s).)

Published
2024
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44. Exploring the thermoluminescence characteristics of smartphone screen safety glasses for retrospective dosimetry applications.

Author

Muslima U, Khandaker MU, Lam SE, Mat Nawi SN, Abdul Sani SF, Ung NM, Osman H, Hanfi MY, Sayyed MI, Alzimami K, Alqahtani A, and Bradley DA

Subjects
Humans, Retrospective Studies, Radiation Protection instrumentation, Radiation Protection methods, Radiation Dosage, Thermoluminescent Dosimetry instrumentation, Thermoluminescent Dosimetry methods, Smartphone
Abstract

In clinical settings, standard dosimeters might miss radiation mishaps. Retrospective dosimeters could help to track personnel (such as patients and other staff who don't wear dosimeters) exceeding safe limits and assess long-term exposure trends. This study has investigated key thermoluminescence (TL) dosimetric characteristics, including the glow curve structure, dose-response, energy dependence, sensitivity and fading of various safety glasses that are used as screen protectors of smartphones subjected to photon irradiation. Among the studied glasses, the HD Anti-Peep safety glass for iPhone has been found to exhibit a linear dose-response with a regression coefficient of 99% within the dose range of 2-10 Gy. Moreover, all the safety glasses showed independence with respect to photon energy of 6 MV and 10 MV. The TL glow curves of the samples showed a broad glow peak between 125 °C and 325 °C at 10 Gy. The TL kinetic parameters of the safety glasses were also studied by analyzing the glow curves using the peak shape and initial rise method. The geometric factor (μ g ) is found to be within the range of 0.43-0.53, which indicates the suitability of applying Chen's general-order formula to calculate the kinetic parameters such as activation energy, frequency factor and trap lifetime. The activation energy (E) and frequency factor (s) are found in the range of 0.31-0.54 eV and 4.55 × 10 3 to 2.12 × 10 6 s -1 respectively obtained via the peak shape method. The relatively long trap lifetime and observed thermoluminescence features indicate that the HD Anti-Peep safety glass offers a better option to estimate dose retrospectively to ensure the safety of human health., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Published
2024
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45. Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats.

Author

Kovács Á, Zhazykbayeva S, Herwig M, Fülöp GÁ, Csípő T, Oláh N, Hassoun R, Budde H, Osman H, Kaçmaz M, Jaquet K, Priksz D, Juhász B, Akin I, Papp Z, Schmidt WE, Mügge A, El-Battrawy I, Tóth A, and Hamdani N

Subjects
Animals, Male, Female, Rats, Sex Factors, Connectin metabolism, Disease Models, Animal, Calcium-Calmodulin-Dependent Protein Kinase Type 2 metabolism, Echocardiography, Phosphorylation, Muscle, Smooth, Vascular metabolism, Muscle, Smooth, Vascular physiopathology, Heart Failure physiopathology, Heart Failure metabolism, Hypertension metabolism, Hypertension physiopathology, Rats, Transgenic, Ventricular Remodeling physiology, Myocytes, Cardiac metabolism
Abstract

Introduction: The prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women often hypertensive and/or obese or diabetic. Indeed, there is evidence on sex differences in the development of HF. Hence, we studied cardiovascular performance dependent on sex and age as well as pathomechanisms on a cellular and molecular level., Methods: We studied 15-week- and 1-year-old female and male hypertensive transgenic rats carrying the mouse Ren-2 renin gene (TG) and compared them to wild-type (WT) controls at the same age. We tracked blood pressure and cardiac function via echocardiography. After sacrificing the 1-year survivors we studied vascular smooth muscle and endothelial function. Isolated single skinned cardiomyocytes were used to determine passive stiffness and Ca 2+ -dependent force. In addition, Western blots were applied to analyse the phosphorylation status of sarcomeric regulatory proteins, titin and of protein kinases AMPK, PKG, CaMKII as well as their expression. Protein kinase activity assays were used to measure activities of CaMKII, PKG and angiotensin-converting enzyme (ACE)., Results: TG male rats showed significantly higher mortality at 1 year than females or WT male rats. Left ventricular (LV) ejection fraction was specifically reduced in male, but not in female TG rats, while LV diastolic dysfunction was evident in both TG sexes, but LV hypertrophy, increased LV ACE activity, and reduced AMPK activity as evident from AMPK hypophosphorylation were specific to male rats. Sex differences were also observed in vascular and cardiomyocyte function showing different response to acetylcholine and Ca 2+ -sensitivity of force production, respectively cardiomyocyte functional changes were associated with altered phosphorylation states of cardiac myosin binding protein C and cardiac troponin I phosphorylation in TG males only. Cardiomyocyte passive stiffness was increased in TG animals. On a molecular level titin phosphorylation pattern was altered, though alterations were sex-specific. Thus, also the reduction of PKG expression and activity was more pronounced in TG females. However, cardiomyocyte passive stiffness was restored by PKG and CaMKII treatments in both TG sexes., Conclusion: Here we demonstrated divergent sex-specific cardiovascular adaptation to the over-activation of the renin-angiotensin system in the rat. Higher mortality of male TG rats in contrast to female TG rats was observed as well as reduced LV systolic function, whereas females mainly developed HFpEF. Though both sexes developed increased myocardial stiffness to which an impaired titin function contributes to a sex-specific molecular mechanism. The functional derangements of titin are due to a sex-specific divergent regulation of PKG and CaMKII systems., (© 2024. The Author(s).)

Published
2024
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46. Radionuclides transfer from soil-to-tea leaves and concomitant doses to the Malaysian populace.

Author

Khandaker MU, Mokhrizal NFB, Shuaibu HK, Sani SFA, Alzimami K, Bradley DA, Issa SAM, Osman H, Naseer KA, and Hanfi MY

Subjects
Malaysia, Thorium analysis, Radium analysis, Radiation Monitoring methods, Humans, Radioisotopes analysis, Food Contamination, Radioactive analysis, Potassium Radioisotopes analysis, Spectrometry, Gamma, Radiation Dosage, Soil chemistry, Plant Leaves chemistry, Soil Pollutants, Radioactive analysis, Tea chemistry
Abstract

One of the most well-liked energizing drinks is now tea, which is primarily used in Malaysia. The natural radioactivity in the associated soils where tea plants are cultivated plays a major role in determining the presence of radionuclides in tea leaves. The present study assesses the transfer of radionuclides from soil-to-tea leaves and then estimates the committed effective doses through tea consumption. Tea leaves and the associated soils were obtained from the largest tea plantation area, which is located in the Cameron Highlands, Malaysia. The marketed tea leaves in powdered form were obtained from the supermarkets in Kuala Lumpur. HPGe gamma-ray spectrometry was used to determine the prevailing concentrations of long-lived radioactive materials in tea leaves. Activity concentrations of 226 Ra, 232 Th, and 40 K in tea soils ranged from 49 to 101.7 Bq kg -1 , 74.5-124.1 Bq kg -1 and 79.6-423.2 Bq kg -1 , respectively, while the respective values in tea leaves are 14.4-23.8 Bq kg -1 , 12.9-29.5 Bq kg -1 and 297-387.5 Bq kg -1 . Transfer factors of radionuclides showed typical values (<1.0) except for the 40 K. The threshold tea consumption rates suggest that one should not consume more than 67 g of tea leaves per day (around 4 g of tea leaves are needed for making 1 cup of tea, so 17 cups per day) to avoid negative health effects. Committed effective doses due to tea consumption are found to be lower (5.18-6.08 μSv y -1 ) than the United Nations Scientific Committee on the Effects of Atomic Radiation (2000) reference dose guidance limit of 290 μSv y -1 for foodstuffs; however, it should be noted that the guidance limit is recommended for all foodstuffs collectively. Providing data on natural radioactivity in tea leaves grown in Malaysia, this study may help people manage a healthy lifestyle., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Published
2024
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47. Exploring PKG signaling as a therapeutic avenue for pressure overload, ischemia, and HFpEF.

Author

Zhazykbayeva S, Budde H, Kaçmaz M, Zemedie Y, Osman H, Hassoun R, Jaquet K, Akin I, El-Battrawy I, Herwig M, and Hamdani N

Abstract

Introduction: Heart failure (HF) is a complex and heterogeneous syndrome resulting from any diastolic or systolic dysfunction of the cardiac muscle. In addition to comorbid conditions, pressure overload, and myocardial ischemia are associated with cardiac remodeling which manifests as extracellular matrix (ECM) perturbations, impaired cellular responses, and subsequent ventricular dysfunction., Areas Covered: The current review discusses the main aspects of the cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) pathway (cGMP-PKG) pathway modulators and highlights the promising outcomes of its novel pharmacological boosters., Expert Opinion: Among several signaling pathways involved in the pathogenesis of pressure overload, ischemia and HF with preserved ejection fraction (HFpEF) is cGMP-PKG pathway. This pathway plays a pivotal role in the regulation of cardiac contractility, and modulation of cGMP-PKG signaling, contributing to the development of the diseases. Ventricular cardiomyocytes of HF patients and animal models are known to exhibit reduced cGMP levels and disturbed cGMP signaling including hypophosphorylation of PKG downstream targets. However, restoration of cGMP-PKG signaling improves cardiomyocyte function and promotes cardioprotective effects.

Published
2024
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48. Redefining at-risk patients undergoiong pancreaticoduodenectomy: Impact of socioeconomic factors including Area Deprivation Index and distance traveled.

Author

Lim JS, Lozano V, Heard J, Malo J, Kong J, Karumuri J, Osman H, Buell JF, and Jeyarajah DR

Abstract

Background: The Whipple procedure for pancreatic adenocarcinoma frequently is referred to surgeons at high-volume centers, which requires that patients travel long distances, potentially impacting patient outcomes. Furthermore, patients with pancreatic cancer from underserved areas often have poor outcomes. There are limited data on Whipple outcomes on the basis of both socioeconomic and distance traveled., Methods: This retrospective cohort study examined patients who underwent the Whipple procedure for pancreatic adenocarcinoma at a tertiary care center from 2019 to 2021. Patients who lived in areas with an Area Deprivation Index national percentile of >50% and ≥100 miles away from the care center were labeled as "at-risk" patients., Results: Seventy-eight patients were included, with 22 (28.2%) patients determined to be at risk. The preoperative characteristics were comparable between the patients in the at-risk and standard-risk groups. Postoperatively, patients in the at-risk group were more likely to require reoperation (13.6% vs 0%; P = .020) and less likely to undergo adjuvant chemotherapy (73.2% vs 50%; P = .034) than patients in the standard-risk group; pathologic staging and frequency of previous use of neoadjuvant chemotherapy were not significantly different between the groups. At-risk status did not influence overall survival or recurrence rate., Conclusions: Through the integration of distance traveled and Area Deprivation Index, we have redefined the characterization of at-risk patients with pancreatic adenocarcinoma, who are at greater risk of undergoing reoperation and not receiving adjuvant chemotherapy. By addressing these intersecting challenges, providers can mitigate disparities and improve the care of these patients with pancreatic adenocarcinoma., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Published
2024
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49. Cardiovascular medication adherence testing in patients living with HIV: A single-centre observational study.

Author

Nazareth J, Adebayo A, Fahad M, Karim H, Pan D, Sze S, Martin CA, Minhas JS, Bernieh D, Osman H, Elverstone P, Stephenson I, Gupta P, and Pareek M

Abstract

Introduction: People with HIV (PWH) are at an increased risk of developing cardiovascular disease (CVD) compared to HIV-negative individuals. We sought to evaluate the adherence to medications for CVD in PWH and identify factors associated with non-adherence to these medications., Methods: We conducted a cross-sectional study at the University Hospitals of Leicester NHS Trust between 16 April 2019 and 8 November 2022. We recruited consecutive PWH, who were attending a routine follow-up outpatient appointment and were prescribed at least one medication for CVD. In addition, we included urinary adherence results of patients with samples collected as part of routine clinical care. We used liquid chromatography-tandem mass spectrometry (LC-MS/MS) to assess if their prescribed medications (antihypertensives, diuretics, beta-blockers, lipid-lowering agents, antiplatelets, anticoagulants, antidiabetic medications) were present in the participant's urine sample. Multivariable models were used to identify demographic or clinical features that were associated with non-adherence., Results: A total of 162 PWH were included in the analysis. Median age was 55 [interquartile range (IQR): 50-61] years, 63% were male, average time living with HIV was 15 years (IQR: 11-19) and the majority (98%) had an undetectable HIV viral load. In approximately one-third of patients (59/162), at least one prescribed medication of interest was not detected in urine. Non-adherence to lipid-lowering agents was common (35/88, 40%). On multivariable logistic regression, the number of prescribed cardiovascular medications, was associated with medication non-adherence [medication non-adherence, per one medication increase: adjusted odds ratio (95% confidence interval) = 1.78 (1.34-2.36); p < 0.001]., Conclusion: We found sub-optimal adherence to medications for CVD in PWH. In order to maximize the clinical benefit of statin therapy in PWH, factors requiring consideration include: improved medication adherence, awareness of polypharmacy, educational interventions and quantitative assessment of sub-optimal adherence through chemical adherence testing., (© 2024 The Author(s). HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.)

Published
2024
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50. Ensuring radiation safety: Evaluating dose and compliance among medical staff at King Faisal Medical Complex, Saudi Arabia.

Author

Hassan WB, Osman H, Alosaimi M, AbuRkbah A, AlQurashi A, Elkhader BA, Alzahrani A, Alshehri M, Faizo NL, and Khandaker MU

Subjects
Saudi Arabia, Humans, Female, Male, Adult, Radiation Exposure analysis, Thermoluminescent Dosimetry, Surveys and Questionnaires, Middle Aged, Radiation Protection, Occupational Exposure prevention & control, Occupational Exposure analysis, Radiation Dosage, Medical Staff statistics & numerical data
Abstract

Background: Radiation is an integral part of routine medical practice, but it carries a risk to the health of medical staff. Hence, it should be assessed periodically. The study's goal was to quantify the levels of radiation exposure for medical staff at King Faisal Medical Complex (KFMC), Taif City Saudi Arabia, and to assess their radiation protective procedures in practice., Methods: The study looked at the thermoluminescence dosimeters (TLDs) records of 50 medical professionals who were exposed to radiation while working at KFMC from 2019 to 2020 in Taif city, Saudi Arabia. In Riyadh, radiation exposure is read from skin TLDs using Harshaw model 6600 plus detectors. The Excel software was utilized to process the obtained data for calculating effective doses. A questionnaire was also distributed to the medical staff to assess their radiation protection procedures. The Statistical Package for Social Sciences (SPSS) program version 23 was used to analyze the obtained data., Results: The mean annual effective doses of the medical staff in 2019 and 2020 were determined to be 1.14 mSv and 1.4645 mSv, respectively, with no significant difference in effective doses between males and females in either year. The socio-demographic features of the medical personnel were examined, and the findings revealed that the majority of participants were male radiological technologists. The rate of adherence to radiation protection techniques was 68%, with a normally distributed dispersal. The amount of adherence varied significantly depending on nationality, occupation, and academic qualification., Conclusion: According to the research, the mean annual effective dosage for medical professionals at KFMC was significantly below the recommended level, indicating satisfactory compliance with the ALARA radiation safety concept., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Published
2024
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