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Introduction: Mental disorders are highly prevalent among children, yet access to timely and effective treatment remains limited. Untreated or poorly managed mental disorders in children are associated with significant functional deterioration and long-term consequences. The validation of reliable assessment tools is crucial for identifying functional impairments and guiding interventions in this population. This study aimed to assess the utility and psychometric properties of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in evaluating functional impairment among children and adolescents receiving specialized mental health care in Mexican psychiatric hospitals. Method: A cross-sectional analytical study was conducted from January 2018 to February 2020 in two psychiatric public hospitals in Mexico. The Spanish version of the WHODAS 2.0 was adapted for the pediatric population, and its psychometric properties were evaluated among 390 children and adolescents receiving psychiatric care. Data were analyzed using descriptive statistics, exploratory and confirmatory factor analyses, and tests of internal consistency and validity. Results: The WHODAS 2.0 demonstrated high internal consistency (α =.92) and convergent validity, with significant correlations observed between WHODAS scores and clinical variables. Exploratory factor analysis revealed a six-dimensional structure, with gender-specific differences identified in functional impairment patterns. Discussion: The study provides robust evidence supporting the utility and psychometric properties of the WHODAS 2.0 for assessing functional impairment in children and adolescents with mental disorders in Mexican psychiatric hospitals. These findings have implications for clinical practice, policy-making, and future research aimed at improving outcomes for this vulnerable population. [ABSTRACT FROM AUTHOR]

The Cayo Santiago rhesus macaque colony is a renowned primate population that has experienced significant natural and anthropogenic ecological variation in their 85-year history. Demographic and familial information is also tracked and collated for the majority of monkeys. Thus, the health history of rhesus macaques at Cayo Santiago should reflect the impacts of both environmental and genetic factors. In this study, we utilized a sample of skeletal remains comprised of 2787 individuals (1571 females, 1091 males), born between 1938 and 2017 from the derived skeletal collection of the primate colony to assess variation in survivorship, pathology, bone mineral density (BMD), and dental eruption status, in the context of hurricane impacts, nutritional fluctuations, and matriline genealogy. Results demonstrated that rhesus macaques at Cayo Santiago exhibit a range of skeletal pathologies that encompass biomedical and archaeological significance, multiple etiologies, severities, locations, and types, in addition to a secular trend of declining BMD that is hypothesized to reflect decreasing physical activity levels under increasing population densities. Specifically, hurricane impacts were found to increase the rate of systemic disease, decrease BMD in young adults, and delay eruption of the primary dentition. Certain matrilines exhibited heightened levels of systemic disease at early ages while others exhibited greater rates of congenital disease. Early-life adversity, through the experience of major hurricanes, may enhance inflammatory pathways, heightening the risk of disease and accelerating the aging process leading to reduced BMD. Such impacts may underly greater levels of observed infection post-hurricane through intensification of pathogen transmission and disease rates brought on by hurricane-adaptive social strategies that favor closer proximity. Familial susceptibility to disease indicates heritable host genetic factors are likely influencing disease patterning in the population. A cluster of congenital diseases may most convincingly illustrate this, or alternatively reflects low levels of genetic diversity in the population., (© 2025 Wiley Periodicals LLC.)