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1. Measurement of Electron Antineutrino Oscillation Amplitude and Frequency via Neutron Capture on Hydrogen at Daya Bay

Author

Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. -C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Subjects
High Energy Physics - Experiment
Abstract

This Letter reports the first measurement of the oscillation amplitude and frequency of reactor antineutrinos at Daya Bay via neutron capture on hydrogen using 1958 days of data. With over 3.6 million signal candidates, an optimized candidate selection, improved treatment of backgrounds and efficiencies, refined energy calibration, and an energy response model for the capture-on-hydrogen sensitive region, the relative $\overline{\nu}_{e}$ rates and energy spectra variation among the near and far detectors gives $\mathrm{sin}^22\theta_{13} = 0.0759_{-0.0049}^{+0.0050}$ and $\Delta m^2_{32} = (2.72^{+0.14}_{-0.15})\times10^{-3}$ eV$^2$ assuming the normal neutrino mass ordering, and $\Delta m^2_{32} = (-2.83^{+0.15}_{-0.14})\times10^{-3}$ eV$^2$ for the inverted neutrino mass ordering. This estimate of $\sin^2 2\theta_{13}$ is consistent with and essentially independent from the one obtained using the capture-on-gadolinium sample at Daya Bay. The combination of these two results yields $\mathrm{sin}^22\theta_{13}= 0.0833\pm0.0022$, which represents an 8% relative improvement in precision regarding the Daya Bay full 3158-day capture-on-gadolinium result.

Published
2024

2. Search for a sub-eV sterile neutrino using Daya Bay's full dataset

Author

An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Subjects
High Energy Physics - Experiment
Abstract

This Letter presents results of a search for the mixing of a sub-eV sterile neutrino with three active neutrinos based on the full data sample of the Daya Bay Reactor Neutrino Experiment, collected during 3158 days of detector operation, which contains $5.55 \times 10^{6}$ reactor \anue candidates identified as inverse beta-decay interactions followed by neutron-capture on gadolinium. The analysis benefits from a doubling of the statistics of our previous result and from improvements of several important systematic uncertainties. No significant oscillation due to mixing of a sub-eV sterile neutrino with active neutrinos was found. Exclusion limits are set by both Feldman-Cousins and CLs methods. Light sterile neutrino mixing with $\sin^2 2\theta_{14} \gtrsim 0.01$ can be excluded at 95\% confidence level in the region of $0.01$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.1 $ eV$^2$. This result represents the world-leading constraints in the region of $2 \times 10^{-4}$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.2 $ eV$^2$., Comment: 7 pages, 4 figures, 1 table

Published
2024

3. Neutron radius determination of 133Cs and its impact on the interpretation of CEvNS-CsI measurement

Author

Huang, Y., Xia, S. Y., Li, Y. F., Tu, X. L., Zhang, J. T., Shao, C. J., Yue, K., Ma, P., Niu, Y. F., Li, Z. P., Kuang, Y., Liu, X. Q., Han, J. F., Egelhof, P., Litvinov, Yu. A., Wang, M., Zhang, Y. H., Zhou, X. H., and Sun, Z. Y.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Proton-$^{133}$Cs elastic scattering at low momentum transfer is performed using an in-ring reaction technique at the Cooler Storage Ring at the Heavy Ion Research Facility in Lanzhou. Recoil protons from the elastic collisions between the internal H$_2$-gas target and the circulating $^{133}$Cs ions at 199.4 MeV/u are detected by a silicon-strip detector. The matter radius of $^{133}$Cs is deduced by describing the measured differential cross sections using the Glauber model. Employing the adopted proton distribution radius, a point-neutron radius of 4.86(21) fm for $^{133}$Cs is obtained. With the newly determined neutron radius, the weak mixing angle sin$^2 \theta_W$ is independently extracted to be 0.227(28) by fitting the coherent elastic neutrino-nucleus scattering data. Our work limits the sin$^2 \theta_W$ value in a range smaller than the ones proposed by the previous independent approaches, and would play an important role in searching new physics via the high precision CE$\nu$NS-CsI cross section data in the near future.

Published
2024

4. Orbital Ingredients and Persistent Dirac Surface State for the Topological Band Structure in FeTe0.55Se0.45

Author

Li, Y-F, Chen, S-D, García-Díez, M, Iraola, MI, Pfau, H, Zhu, Y-L, Mao, Z-Q, Chen, T, Yi, M, Dai, P-C, Sobota, JA, Hashimoto, M, Vergniory, MG, Lu, D-H, and Shen, Z-X

Subjects
Physical Sciences, Condensed Matter Physics, Astronomical and Space Sciences, Quantum Physics, Physical sciences
Abstract

FeTe0.55Se0.45 (FTS) occupies a special spot in modern condensed matter physics at the intersections of electron correlation, topology, and unconventional superconductivity. The bulk electronic structure of FTS is predicted to be topologically nontrivial due to the band inversion between the dxz and pz bands along Γ-Z. However, there remain debates in both the authenticity of the Dirac surface states (DSSs) and the experimental deviations of band structure from the theoretical band inversion picture. Here we resolve these debates through a comprehensive angle-resolved photoemission spectroscopy investigation. We first observe a persistent DSS independent of kz. Then, by comparing FTS with FeSe, which has no band inversion along Γ-Z, we identify the spectral weight fingerprint of both the presence of the pz band and the inversion between the dxz and pz bands. Furthermore, we propose a renormalization scheme for the band structure under the framework of a tight-binding model preserving crystal symmetry. Our results highlight the significant influence of correlation on modifying the band structure and make a strong case for the existence of topological band structure in this unconventional superconductor.

Published
2024

5. First measurement of the yield of $^8$He isotopes produced in liquid scintillator by cosmic-ray muons at Daya Bay

Author

Daya Bay Collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

Daya Bay presents the first measurement of cosmogenic $^8$He isotope production in liquid scintillator, using an innovative method for identifying cascade decays of $^8$He and its child isotope, $^8$Li. We also measure the production yield of $^9$Li isotopes using well-established methodology. The results, in units of 10$^{-8}\mu^{-1}$g$^{-1}$cm$^{2}$, are 0.307$\pm$0.042, 0.341$\pm$0.040, and 0.546$\pm$0.076 for $^8$He, and 6.73$\pm$0.73, 6.75$\pm$0.70, and 13.74$\pm$0.82 for $^9$Li at average muon energies of 63.9~GeV, 64.7~GeV, and 143.0~GeV, respectively. The measured production rate of $^8$He isotopes is more than an order of magnitude lower than any other measurement of cosmogenic isotope production. It replaces the results of previous attempts to determine the ratio of $^8$He to $^9$Li production that yielded a wide range of limits from 0 to 30\%. The results provide future liquid-scintillator-based experiments with improved ability to predict cosmogenic backgrounds.

Published
2024

6. Charged-current non-standard neutrino interactions at Daya Bay

Author

Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

The full data set of the Daya Bay reactor neutrino experiment is used to probe the effect of the charged current non-standard interactions (CC-NSI) on neutrino oscillation experiments. Two different approaches are applied and constraints on the corresponding CC-NSI parameters are obtained with the neutrino flux taken from the Huber-Mueller model with a $5\%$ uncertainty. For the quantum mechanics-based approach (QM-NSI), the constraints on the CC-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ are extracted with and without the assumption that the effects of the new physics are the same in the production and detection processes, respectively. The approach based on the weak effective field theory (WEFT-NSI) deals with four types of CC-NSI represented by the parameters $[\varepsilon_{X}]_{e\alpha}$. For both approaches, the results for the CC-NSI parameters are shown for cases with various fixed values of the CC-NSI and the Dirac CP-violating phases, and when they are allowed to vary freely. We find that constraints on the QM-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ from the Daya Bay experiment alone can reach the order $\mathcal{O}(0.01)$ for the former and $\mathcal{O}(0.1)$ for the latter, while for WEFT-NSI parameters $[\varepsilon_{X}]_{e\alpha}$, we obtain $\mathcal{O}(0.1)$ for both cases., Comment: 25 pages, 16 figures, 6 tables; 36 pages, format changed, references added

Published
2024

7. Charged-current non-standard neutrino interactions at Daya Bay

Author

An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y.-C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Morales Reveco, C., Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W.-H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Published
2024
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11. Search for a Sub-eV Sterile Neutrino Using Daya Bay's Full Dataset.

Author

An FP, Bai WD, Balantekin AB, Bishai M, Blyth S, Cao GF, Cao J, Chang JF, Chang Y, Chen HS, Chen HY, Chen SM, Chen Y, Chen YX, Chen ZY, Cheng J, Cheng YC, Cheng ZK, Cherwinka JJ, Chu MC, Cummings JP, Dalager O, Deng FS, Ding XY, Ding YY, Diwan MV, Dohnal T, Dolzhikov D, Dove J, Dugas KV, Duyang HY, Dwyer DA, Gallo JP, Gonchar M, Gong GH, Gong H, Gu WQ, Guo JY, Guo L, Guo XH, Guo YH, Guo Z, Hackenburg RW, Han Y, Hans S, He M, Heeger KM, Heng YK, Hor YK, Hsiung YB, Hu BZ, Hu JR, Hu T, Hu ZJ, Huang HX, Huang JH, Huang XT, Huang YB, Huber P, Jaffe DE, Jen KL, Ji XL, Ji XP, Johnson RA, Jones D, Kang L, Kettell SH, Kohn S, Kramer M, Langford TJ, Lee J, Lee JHC, Lei RT, Leitner R, Leung JKC, Li F, Li HL, Li JJ, Li QJ, Li RH, Li S, Li S, Li SC, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin S, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu JC, Liu JL, Liu JX, Lu C, Lu HQ, Luk KB, Ma BZ, Ma XB, Ma XY, Ma YQ, Mandujano RC, Marshall C, McDonald KT, McKeown RD, Meng Y, Napolitano J, Naumov D, Naumova E, Nguyen TMT, Ochoa-Ricoux JP, Olshevskiy A, Park J, Patton S, Peng JC, Pun CSJ, Qi FZ, Qi M, Qian X, Raper N, Ren J, Morales Reveco C, Rosero R, Roskovec B, Ruan XC, Russell B, Steiner H, Sun JL, Tmej T, Tse WH, Tull CE, Tung YC, Viren B, Vorobel V, Wang CH, Wang J, Wang M, Wang NY, Wang RG, Wang W, Wang X, Wang YF, Wang Z, Wang Z, Wang ZM, Wei HY, Wei LH, Wei W, Wen LJ, Whisnant K, White CG, Wong HLH, Worcester E, Wu DR, Wu Q, Wu WJ, Xia DM, Xie ZQ, Xing ZZ, Xu HK, Xu JL, Xu T, Xue T, Yang CG, Yang L, Yang YZ, Yao HF, Ye M, Yeh M, Young BL, Yu HZ, Yu ZY, Yuan CZ, Yue BB, Zavadskyi V, Zeng S, Zeng Y, Zhan L, Zhang C, Zhang FY, Zhang HH, Zhang JL, Zhang JW, Zhang QM, Zhang SQ, Zhang XT, Zhang YM, Zhang YX, Zhang YY, Zhang ZJ, Zhang ZP, Zhang ZY, Zhao J, Zhao RZ, Zhou L, Zhuang HL, and Zou JH

Abstract

This Letter presents results of a search for the mixing of a sub-eV sterile neutrino with three active neutrinos based on the full data sample of the Daya Bay Reactor Neutrino Experiment, collected during 3158 days of detector operation, which contains 5.55×10^{6} reactor ν[over ¯]_{e} candidates identified as inverse beta-decay interactions followed by neutron capture on gadolinium. The analysis benefits from a doubling of the statistics of our previous result and from improvements of several important systematic uncertainties. No significant oscillation due to mixing of a sub-eV sterile neutrino with active neutrinos was found. Exclusion limits are set by both Feldman-Cousins and CLs methods. Light sterile neutrino mixing with sin^{2}2θ_{14}≳0.01 can be excluded at 95% confidence level in the region of 0.01  eV^{2}≲|Δm_{41}^{2}|≲0.1  eV^{2}. This result represents the world-leading constraints in the region of 2×10^{-4}  eV^{2}≲|Δm_{41}^{2}|≲0.2  eV^{2}.

Published
2024
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12. [Research on the status and development of medical and public health informatization in China, from the perspective of medical and preventive integration].

Author

Wu YL, Li KM, Guo YQ, Lin F, Li YF, and Wang LP

Subjects
China, Humans, Public Health Informatics, Delivery of Health Care, Public Health
Abstract

Medical and preventive integration effectively bridges the gap between "treating diseases" and "preventing diseases". Over the years, medical and preventive integration research has focused on chronic and chronic infectious diseases, with insufficient attention to acute ones. Confronting newly emerging infectious diseases establishing continuous monitoring, early warning, emergency response, and appropriate treatment will be a key focus for developing and reforming the healthcare system. Interoperability and sharing of medical and health data are essential prerequisites for bridging the gap between medical treatment and disease prevention and are also important for promoting intelligent surveillance and early warning of infectious diseases. Informatization is necessary to achieve efficient collaboration between medical treatment and disease prevention. Reviewing the development of medical and health informatization in the United States and Europe, this paper compares and discusses the problems and challenges in developing medical and health informatization in China. The aim is to provide references for the development of medical and health informatization and the innovation of medical and preventive integration mechanisms in the country.

Published
2024
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13. Single-Shot Diagnosis of Electron Energy Evolution via Streaked Betatron X Rays in a Curved Laser Wakefield Accelerator.

Author

Ma Y, Cardarelli JA, Campbell PT, Fourmaux S, Fitzgarrald R, Balcazar MD, Antoine AF, Beier NF, Qian Q, Hussein AE, Kettle B, Klein SR, Krushelnick K, Li YF, Mangles SPD, Sarri G, Seipt D, Senthilkumaran V, Streeter MJV, Willingale L, and Thomas AGR

Abstract

We report on an experimental observation of the streaking of betatron x rays in a curved laser wakefield accelerator. The streaking of the betatron x rays was realized by launching a laser pulse into a plasma with a transverse density gradient. By controlling the plasma density and the density gradient, we realized the steering of the laser driver, electron beam, and betatron x rays simultaneously. Moreover, we observed an energy-angle correlation of the streaked betatron x rays and utilized it in diagnosing the electron acceleration process in a single-shot mode. Our work could also find applications in advanced control of laser beam and particle propagation. More importantly, the angular streaked betatron x ray has an intrinsic spatiotemporal correlation, which makes it a promising tool for single-shot pump-probe applications.

Published
2024
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14. [Effect of peripheral blood inflammatory indicators on the efficacy of immunotherapy in patients with advanced non-small cell lung cancer and chronic obstructive pulmonary disease].

Author

Bi ZK, Xu Y, Guo L, Zhang WJ, You YT, Li JW, Zhao CL, Shan YF, Xia TT, Li YF, Xu Z, Fan Y, and Bai L

Subjects
Humans, Male, Female, Middle Aged, Aged, Retrospective Studies, Adult, Inflammation, Interleukin-8 blood, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung therapy, Pulmonary Disease, Chronic Obstructive therapy, Pulmonary Disease, Chronic Obstructive blood, Lung Neoplasms therapy, Lung Neoplasms blood, Immunotherapy, Interleukin-6 blood, Tumor Necrosis Factor-alpha blood
Abstract

Objective: To investigate the impact of peripheral blood inflammatory indicators on the efficacy of immunotherapy in patients with advanced non-small cell lung cancer (NSCLC) complicated with chronic obstructive pulmonary disease (COPD). Methods: A retrospective cohort study was performed to include 178 patients with Ⅲ-Ⅳ NSCLC complicated with COPD who received at least 2 times of immunotherapy in Xinqiao Hospital of the Army Medical University from January 2019 to August 2021. Baseline peripheral blood inflammatory indicators such as interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) were collected within 2 weeks before the first treatment, with the last one being on or before February 7, 2022. X-tile software was used to determine the optimal cut-off value of peripheral blood inflammatory indicators. The Cox multivariate regression models were used to analyze the factors affecting progression free survival (PFS) and overall survival (OS). Results: Among the 178 patients, there were 174 males (97.8%) and 4 females (2.2%); the age ranged from 42 to 86 (64.3±8.3) years old.There were 30 cases (16.9%) of immunotherapy monotherapy, 114 cases (64.0%) of immunotherapy combined with chemotherapy, 21 cases (11.8%) of immunotherapy combined with antivascular therapy, and 13 cases (7.3%) of immunotherapy combined with radiotherapy. The median follow-up period was 14.5 months (95% CI : 13.6-15.3 months). The objective response rate (ORR) and disease control rate (DCR) were 44.9% (80/178) and 90.4% (161/178) for the whole group, the median PFS was 14.6 months (95% CI : 11.6-17.6 months), and the median OS was 25.7 months (95% CI : 18.0-33.4 months). The results of Cox multivariate analysis showed that IL-6>9.9 ng/L ( HR =5.885, 95% CI : 2.558-13.543, P <0.01), TNF-α>8.8 ng/L ( HR =3.213, 95% CI : 1.468-7.032, P =0.003), IL-8>202 ng/L ( HR =2.614, 95% CI : 1.054-6.482, P =0.038), systemic immune inflammatory index (SII)>2 003.95 ( HR =2.976, 95% CI : 1.647-5.379, P <0.001) were risk factors for PFS, and advanced lung cancer inflammation index (ALI)>171.15 was protective factor for PFS ( HR =0.545, 95% CI : 0.344-0.863, P =0.010). IL-6>9.9 ng/L( HR =6.124, 95% CI : 1.950-19.228, P <0.002), lactate dehydrogenase (LDH)>190.7 U/L ( HR =2.776, 95% CI : 1.020-7.556, P =0.046), SII>2 003.95 ( HR =4.521, 95% CI : 2.241-9.120, P <0.001) were risk factors for OS, and ALI>171.15 was a protective factor for OS ( HR =0.434, 95% CI: 0.243-0.778, P =0.005). Conclusion: Baseline high levels of IL-6, TNF-α, IL-8, SII, LDH, and low levels of ALI are risk factors for poor prognosis in patients with advanced NSCLC-COPD receiving immunotherapy.

Published
2024
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16. [Long-term outcome of patients with rectal cancer who achieve complete or near complete clinical responses after neoadjuvant therapy: a multicenter registry study of data from the Chinese Watch and Wait Database].

Author

Zhao YM, Wang WH, Zhang W, Wang L, Li S, Wang JW, Liao LE, Yu GY, Sun Z, Qu YL, Gong Y, Lu Y, Wu T, Li YF, Wang Q, Zhao GH, Xiao Y, Ding PR, Zhang Z, and Wu AW

Subjects
Adult, Aged, Female, Humans, Male, Middle Aged, China, Cross-Sectional Studies, Databases, Factual, East Asian People, Registries, Retrospective Studies, Treatment Outcome, Neoadjuvant Therapy, Rectal Neoplasms therapy, Watchful Waiting
Abstract

Objective: To report the long-term outcomes of Chinese rectal cancer patients after adopting a Watch and Wait (W&W) strategy following neoadjuvant therapy (NAT). Methods: This multicenter, cross-sectional study was based on real-world data. The study cohort comprised rectal cancer patients who had achieved complete or near complete clinical responses (cCRs, near-cCRs) after NAT and were thereafter managed by a W&W approach, as well as a few patients who had achieved good responses after NAT and had then undergone local excision for confirmation of pathological complete response. All participants had been followed up for ≥2 years. Patients with distant metastases at baseline or who opted for observation while living with the tumor were excluded. Data of eligible patients were retrospectively collected from the Chinese Wait-and-Watch Data Collaboration Group database. These included baseline characteristics, type of NAT, pre-treatment imaging results, evaluation of post-NAT efficacy, salvage measures, and treatment outcomes. We herein report the long-term outcomes of Chinese rectal cancer patients after NAT and W&W and the differences between the cCR and near-cCR groups. Results: Clinical data of 318 rectal cancer patients who had undergone W&W for over 2 years and been followed up were collected from eight medical centers (Peking University Cancer Hospital, Fudan University Shanghai Cancer Center, Sun Yat-sen University Cancer Center, Shanghai Changhai Hospital, Peking Union Medical College Hospital, Liaoning Cancer Hospital, the First Hospital of Jilin University, and Yunnan Cancer Hospital.) The participants comprised 221 men (69.4%) and 107 women (30.6%) of median age 60 (26-86) years. The median distance between tumor and anal verge was 3.4 (0-10.4) cm. Of these patients, 291 and 27 had achieved cCR or near-cCR, respectively, after NAT. The median duration of follow-up was 48.4 (10.2-110.3) months. The 5-year cumulative overall survival rate was 92.4% (95%CI: 86.8%-95.7%), 5-year cumulative disease-specific survival (CSS) rate 96.6% (95%CI: 92.2%-98.5%), 5-year cumulative organ-preserving disease-free survival rate 86.6% (95%CI: 81.0%-90.7%), and 5-year organ preservation rate 85.3% (95%CI: 80.3%-89.1%). The overall 5-year local recurrence and distant metastasis rates were 18.5% (95%CI: 14.9%-20.8%) and 8.2% (95%CI: 5.4%-12.5%), respectively. Most local recurrences (82.1%, 46/56) occurred within 2 years, and 91.0% (51/56) occurred within 3 years, the median time to recurrence being 11.7 (2.5-66.6) months. Most (91.1%, 51/56) local recurrences occurred within the intestinal lumen. Distant metastases developed in 23 patients; 60.9% (14/23) occurred within 2 years and 73.9% (17/23) within 3 years, the median time to distant metastasis being 21.9 (2.6-90.3) months. Common sites included lung (15/23, 65.2%), liver (6/23, 26.1%), and bone (7/23, 30.4%) The metastases involved single organs in 17 patients and multiple organs in six. There were no significant differences in overall, cumulative disease-specific, or organ-preserving disease-free survival or rate of metastases between the two groups (all P >0.05). The 5-year local recurrence rate was higher in the near-cCR than in the cCR group (41.6% vs. 16.4%, P <0.01), with a lower organ preservation rate (69.2% vs. 88.0%, P <0.001). The success rates of salvage after local recurrence and distant metastasis were 82.1% (46/56) and 13.0% (3/23), respectively. Conclusion: Rectal cancer patients who achieve cCR or near-cCR after NAT and undergo W&W have favorable oncological outcomes and a high rate of organ preservation. Local recurrence and distant metastasis during W&W follow certain patterns, with a relatively high salvage rate for local recurrence. Our findings highlight the importance of close follow-up and timely intervention during the W&W process.

Published
2024
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17. A factorial-analysis-based Bayesian neural network method for quantifying China's CO 2 emissions under dual-carbon target.

Author

Wang Z, Li YP, Huang GH, Gong JW, Li YF, and Zhang Q

Abstract

Energy-structure transformation and CO 2 -emission reduction are becoming particularly urgent for China and many other countries. Development of effective methods that are capable of quantifying and predicting CO 2 emissions to achieve carbon neutrality is desired. This study advances a factorial-analysis-based Bayesian neural network (abbreviated as FABNN) method to reflect the complex relationship between inputs and outputs as well as reveal the individual and interactive effects of multiple factors affecting CO 2 emissions. FABNN is then applied to analyzing CO 2 emissions of China (abbreviated as CEC), where multiple factors involve in energy (e.g., the consumption of natural gas, CONG), economic (e.g., Gross domestic product, GDP) and social (e.g., the rate of urbanization, ROU) aspects are investigated and 512 scenarios are designed to achieve the national dual carbon targets (i.e., carbon peak before 2030 and carbon neutrality by 2060). Comparing to the conventional machine learning methods, FABNN performs better in calibration and validation results, indicating that FABNN is suitable for CEC simulation and prediction. Results disclose that the top three factors affecting CEC under the dual‑carbon target are GDP, CONG, and ROU; energy, economic and social contributions are 43.5 %, 34.6 % and 21.9 %, respectively. CEC reaches its carbon peak during 2027-2032 and achieve carbon neutrality during 2053-2057 under all scenarios. Under the optimal scenario (S 195 ), the CO 2 -emission reduction potential is about 772.2 million tonnes and the consumptions of coal, petroleum and natural gas can be respectively reduced by 3.1 %, 9.9 % and 23.0 % compared to the worst scenario (S 466 ). The results can provide solid support for national energy-structure transformation and CO 2 -emission reduction to achieve carbon-peak and carbon-neutrality targets., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Published
2024
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18. [Clinical and electrophysiological characteristics and treatment outcomes of anti-neutrophil cytoplasmic antibody ANCA-associated vasculitic neuropathy].

Author

Li YF, Li M, Yang F, Wang HF, Xu F, Chen SY, Sun B, Chen ZH, and Huang XS

Subjects
Humans, Antibodies, Antineutrophil Cytoplasmic, Retrospective Studies, Treatment Outcome, Granulomatosis with Polyangiitis diagnosis, Churg-Strauss Syndrome complications, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis complications, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis therapy, Microscopic Polyangiitis complications, Microscopic Polyangiitis diagnosis, Peripheral Nervous System Diseases complications
Abstract

Objective: To investigate the clinical and electrophysiological characteristics of ANCA-associated vasculitic neuropathy (VN) and analyze the predictors of treatment outcomes. Methods: Retrospective case series. In all, 652 consecutive patients with ANCA-associated vasculitis were admitted to the First Medical Center of the Chinese PLA General Hospital between January 2006 and December 2022. Peripheral neuropathy occurred in 91 patients. Patients were excluded if other known causes of neuropathy were present. Sixty-one patients were eventually enrolled, including 17 with eosinophilic granulomatosis with polyangiitis (EGPA), 11 with granulomatosis polyangiitis (GPA), and 33 with microscopic polyangiitis (MPA). Their clinical data were collected and clinical characteristics, VN manifestations, electrophysiological findings (including interside amplitude ratio [IAR]), and treatment outcomes were compared among the three subsets of AAV. Then, factors influencing the treatment outcomes were analyzed using multivariable logistic regression analysis. Results: Peripheral neuropathy occurred in 62.1%(18/29) of EGPA, 8.3%(15/180) of GPA, and 13.1%(58/443) of MPA patients. The age at onset and examination was higher in patients with MPA than those with EGPA or GPA ( P <0.01). The occurrence of VN was later in patients with GPA than those with EGPA ( P <0.01), and the GPA group had fewer affected nerves than the other two groups ( P <0.016). The abnormal IARs of motor nerves in lower limbs were more detected in the EGPA than the MPA group ( P <0.01). Logistic regression analysis suggested that higher Birmingham vasculitis activity score-version 3 (BVAS-V3) ( OR =6.85, 95% CI 1.33-35.30) was associated with better treatment outcomes of VN. However, central nervous system involvement was a risk factor for poor treatment outcomes ( OR =0.13, 95% CI 0.02-0.89). Conclusions: The clinical and electrophysiological characteristics of VN were slightly different among subsets of AAV. Patients with GPA often presented with polyneuropathy and had fewer nerves affected; mononeuritis multiplex was more common in EGPA than GPA and MPA. Higher BVAS-V3 and central nervous system involvement might predict the treatment outcome of VN.

Published
2024
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19. Effects of manganese glycine on eggshell quality, eggshell ultrastructure, and elemental deposition in aged laying hens.

Author

Lu J, Jiang DC, Ma M, Wang Q, Guo J, Wang XG, Dou TC, Li YF, Hu YP, Wang KH, and Qu L

Subjects
Animals, Female, Egg Shell, Chickens, Ovum, Dietary Supplements, Diet veterinary, Animal Feed analysis, Manganese pharmacology, Fabaceae
Abstract

Poor eggshell quality of eggs laid by aged laying hens is the major problem affecting the length of the rearing period in the laying hen industry. Trace elements are required and play vital roles in the eggshell quality of laying hens. Appropriate dose of organic microelements is environmentally friendly and sufficient to satisfy the needs of hens because of their greater bioavailability and lower excretion than inorganic forms. The aim of this experiment was to investigate the effects of manganese (Mn) glycine (MG) on eggshell quality, elemental deposition, and eggshell ultrastructure in aged laying hens. A total of 720 Hy-Line Brown hens 70 weeks old were assigned equally to four groups with six replicates of 30 birds each. The hens were fed basal diets (without Mn supplementation) supplemented with 120 mg/kg of Mn from manganese sulfate monohydrate (MSM), or 40, 80, or 120 mg/kg Mn from MG for 12 weeks. Dietary supplementation with 80 mg/kg Mn from MG resulted in the greatest eggshell strength after 6 weeks of treatment (P = 0.047), and in greater eggshell strength than observed in the MSM control after 12 weeks of treatment (P = 0.025). After 12 weeks of treatment, the eggs of hens in the MG groups showed lower mammillary layer thickness in the blunt end, equator, and acute end than observed in the MSM control group (P < 0.001). With the exception of the blunt ends of eggs from hens in the 120 mg/kg MG group, the eggs of hens in the MG groups, compared with the MSM control group, exhibited a lower mammillary layer ratio, and greater palisade layer ratio and effective layer ratio in the blunt end, equator, and acute end (P < 0.001). Dietary supplementation with 80 mg/kg Mn from MG, compared with the MSM control and 40 and 120 mg/kg MG, resulted in the greatest palisade layer thickness and effective layer thickness, and the lowest mammillary layer thickness in the equator (P < 0.001, P = 0.001, P < 0.001, respectively). Furthermore, supplementation with 80 mg/kg Mn from MG exhibited the greatest ratio of the palisade layer and effective layer, and the lowest mammillary layer ratio in the blunt end and equator (all P < 0.001). The Mn content of eggshells in hens-fed diets supplemented with 80 and 120 mg/kg Mn from MG was greater than that in the MSM control and 40 mg/kg MG groups (P = 0.035). Dietary supplementation with 80 or 120 mg/kg Mn from MG resulted in greater tibia Mn content than observed in the 40 mg/kg MG group (P = 0.019), and greater yolk Mn content than observed in the 40 mg/kg MG and MSM control groups (P = 0.018). In conclusion, dietary supplementation with 80 mg/kg Mn from MG, compared with the MSM control (120 mg/kg Mn), may increase the deposition efficiency of Mn, alter eggshell elemental composition, improve eggshell ultrastructure, and enhance eggshell strength in aged laying hens., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)

Published
2024
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20. A longitudinal and cross-sectional study of placental circulation between normal and placental insufficiency pregnancies.

Author

Chen JY, Yu BL, Wu XJ, Li YF, Zhong LY, and Chen M

Subjects
Pregnancy, Female, Humans, Placenta diagnostic imaging, Placenta blood supply, Placental Circulation, Cross-Sectional Studies, Longitudinal Studies, Gestational Age, Pregnancy Outcome, Fetal Growth Retardation, Ultrasonography, Prenatal, Placental Insufficiency, Pre-Eclampsia diagnosis
Abstract

Introduction: To longitudinally and cross-sectionally study the differences in the uterine artery pulsatility index (UTPI), umbilical artery pulsatility index (UAPI) and placental vascularization indices (PVIs, derived from 3-dimensional power Doppler) between normal and placental insufficiency pregnancies throughout gestation., Methods: UTPI, UAPI and PVI were measured 6 times at 4- to 5- week intervals from 11 to 13 +6 weeks-36 weeks. Preeclampsia (PE) and fetal growth restriction (FGR) were defined as placental insufficiency. Comparisons of UTPI, UAPI and PVI between normal and insufficiency groups were performed by one-way repeated measures analysis of variance., Results: A total of 125 women were included: monitored regularly from the first trimester to 36 weeks of gestation: 109 with normal pregnancies and 16 with placental insufficiency. Longitudinal study of the normal pregnancy group showed that UTPI and UAPI decreased significantly every 4 weeks, while PVIs increased significantly every 8 weeks until term. In the placental insufficiency group however, this decrease occurred slower at 8 weeks intervals and UTPI stabilized after 24 weeks. No significant difference was noted in PVIs throughout pregnancy. Cross-sectional study from different stages of gestation showed that UTPI was higher in the insufficiency group from 15 weeks onward and PVIs were lower after 32 weeks., Discussion: Compared to high-risk pregnancies with normal outcome, UTPI and UAPI needed a longer time to reach a significant change in those with clinical confirmation of placental insufficiency pregnancies and no significant change was found in PVI throughout gestation. UTPI was the earliest factor in detecting adverse outcome pregnancies., Competing Interests: Declaration of competing interest The authors report no conflict of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Published
2024
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21. [Efficacy and safety of venetoclax combined with hypomethylating agents in the treatment of 83 patients with higher-risk myelodysplastic syndromes].

Author

Liu L, He F, Xu Y, Li T, Li YF, Tang P, and Sun L

Subjects
Humans, Middle Aged, Male, Female, Aged, Adult, Aged, 80 and over, Adolescent, Retrospective Studies, Young Adult, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, DNA Methylation, Myelodysplastic Syndromes drug therapy, Bridged Bicyclo Compounds, Heterocyclic administration & dosage, Sulfonamides administration & dosage
Abstract

Objective: This study aimed to evaluate the efficacy and safety of venetoclax (VEN) combined with hypomethylating agents (HMA) in the treatment of higher-risk myelodysplastic syndromes (HR-MDS) and analyze the factors influencing their therapeutic effect. Methods: The clinical data of 83 patients with HR-MDS who were diagnosed at the First Affiliated Hospital of Zhengzhou University between November 2019 and May 2023 were retrospectively analyzed. All patients were treated with VEN combined with HMA. The Kaplan-Meier method was used to depict the survival curves, and the log-rank test was used to compare survival between the groups. Results: The median age was 57 (15-82) years old, and 51 patients (61.4%) were male. Forty-five patients (54.2%) were initially treated with HMA, 23 (27.7%) received ≤4 cycles of HMA, and 15 (18.1%) demonstrated HMA failure. At the median follow-up of 10.3 (0.6-34.4) months, the overall response rate (ORR) was 62.7% (52/83), including 18 patients (21.7%) with a complete response (CR), 14 (16.9%) with a bone marrow CR (mCR) with hematological improvement, and 20 (24.1%) with a mCR. The ORR of patients with initial treatment, ≤4 HMA cycles, and HMA failure were 66.7%, 60.9%, and 53.3%, respectively ( P =0.641). The median overall survival time was 14.6 (95% CI 7.2-22.0) months, and the median progression-free survival time was 8.9 (95% CI 6.7-11.1) months. The multivariate analysis showed that serum alkaline phosphatase (ALP) ≥90 U/L (OR=14.574, 95% CI 3.036-69.951, P =0.001), TP53 mutation ( OR =13.052, 95% CI 1.982-85.932, P =0.008), and U2AF1 mutation ( OR =7.720, 95% CI 1.540-38.698, P =0.013) were independent risk factors for poor efficacy of VEN combined with HMA. Hematological toxicity occurred in all patients, and the incidence of treatment-induced grade 3-4 leukopenia was 48.2% (40/83). Infection was the most common non-hematological adverse event, mainly pulmonary infection (31.3%) . Conclusion: VEN combined with HMA had a high response rate in patients with HR-MDS, both at initial treatment and with HMA failure. ALP ≥ 90 U/L, TP53 mutation, and U2AF1 mutation were independent risk factors for non-response to treatment.

Published
2024
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23. Effects of exogenous energy on synthesis of steroid hormones and expression characteristics of the CREB/StAR signaling pathway in theca cells of laying hen.

Author

Lu J, Zhang X, Wang Q, Ma M, Li YF, Guo J, Wang XG, Dou TC, Hu YP, Wang KH, and Qu L

Subjects
Female, Animals, Chickens metabolism, Cyclic AMP Response Element-Binding Protein metabolism, Cyclic AMP Response Element-Binding Protein pharmacology, Steroids metabolism, Steroids pharmacology, Signal Transduction, Glucose metabolism, Granulosa Cells, Theca Cells metabolism, Progesterone metabolism, Phosphoproteins
Abstract

Energy and the cAMP-response element binding protein (CREB)/steroidogenic acute regulatory protein (StAR) signaling pathway play important roles in steroid hormone production and follicular development in hens. This present study aimed to investigate the effects of exogenous energy on the synthesis of steroid hormones and the expression characteristics of the CREB/StAR signaling pathway in theca cells of laying hen. The primary theca cells of small yellow follicles were randomly divided into 6 treatments and cultured in medium with glucose concentrations of 1, 1.5, 3, 4.5, 6, and 7.5 mg/mL for 48 h. It was found that growth was robust and cell outlines were clear when cells were cultured with 1, 1.5, 3, and 4.5 mg/mL glucose, but cell viability was diminished and cell density decreased after exposure to glucose at 6 and 7.5 mg/mL for 48 h. Cell viability showed an increasing and then decreasing quadratic response to increasing glucose concentration in culture (r 2 = 0.688, P < 0.001). The cell viability of theca cells cultured with 4.5 mg/mL glucose was greater than those cultured with 1, 1.5, 6, and 7.5 mg/mL glucose (P < 0.05). The concentration of estradiol in the medium containing 3 mg/mL glucose was higher than in medium containing 1, 1.5, and 6 mg/mL glucose (P < 0.05). There was an increasing and then decreasing quadratic correlation between progesterone concentrations and glucose concentrations (r 2 = 0.522, P = 0.002). The concentration of progesterone in medium with 4.5 mg/mL glucose was higher than in medium with 1 and 7.5 mg/mL glucose (P < 0.05). There was an increasing and then decreasing quadratic correlation between the relative expression of CREB1 (r 2 = 0.752, P < 0.001), StAR (r 2 = 0.456, P = 0.002), CYP1B1 (r 2 = 0.568, P < 0.001), and 3β-HSD (r 2 = 0.319, P = 0.018) in theca cells of laying hens and glucose concentrations after treatment with different glucose concentrations for 48 h. After treatment with 4.5 mg/mL glucose, the expression of StAR, CYP1B1, and 3β-HSD genes were increased compared to treatment with 1, 1.5, 3, 6, and 7.5 mg/mL glucose (P < 0.001). There was an increasing and then decreasing quadratic correlation between glucose concentrations and protein expression of CREB1 (r 2 = 0.819, P < 0.001), StAR (r 2 = 0.844, P < 0.001), 3β-HSD (r 2 = 0.801, P < 0.001), and CYP11A1 (r 2 = 0.800, P < 0.001) in theca cells of laying hens. The protein expression of CREB1, StAR, and 3β-HSD in theca cells cultured with 4.5 mg/mL glucose was higher than in other groups (P < 0.001). The results indicate that the appropriate glucose concentration (4.5 mg/mL) can improve the synthesis of steroid hormones in theca cells of laying hens through the upregulation of key genes and proteins in the CREB/StAR signaling pathway., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2024
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24. [Intermediate and long-term outcomes of transcatheter closure of congenital coronary cameral fistulas in 66 children].

Author

Li YF, Li YF, Li JJ, Xie YM, Wang SS, and Zhang ZW

Subjects
Male, Female, Child, Humans, Retrospective Studies, Case-Control Studies, Treatment Outcome, Coronary Vessel Anomalies surgery, Coronary Artery Disease surgery, Fistula etiology, Myocardial Infarction, Coronary Aneurysm
Abstract

Objective: To evaluate the intermediate and long-term outcomes and technical aspects of transcatheter closure (TCC) of coronary cameral fistulas (CCF) in pediatric patients. Methods: This was a case-control study. All pediatric patients with CCF who underwent TCC between January 2005 and December 2019 were retrospectively reviewed. Data was collected from medical records, including demographic characteristics, procedural details, intraoperative and postoperative serious adverse events, follow-up results and prognosis. Patients with serious adverse events and without serious adverse events were compared regarding their clinical features and CCF characteristics. Comparisons between groups were performed with independent sample t test, chi-square test or Fisher exact test. Results: A total of 66 CCF patients (34 boys, 32 girls, 3.9 (1.9, 6.2) years old, 15 (11, 20) kg) underwent attempted TCC. All of the CCF were all medium or large fistulas including 55 proximal fistulas (83%) and 11 distal fistulas (17%). The CCF originated more frequently from the right coronary artery (38 cases (58%)), followed by the left coronary artery (28 cases (42%)). The incidence of coronary artery aneurysms (CAA) was 61% (40/66).Procedural treatment was achieved in 64 patients and procedural success was achieved in 59 patients (92%). Six (9%) serious adverse events occurred in 5 patients during the perioperative period. Acute complications included procedure-related death in one patient and acute myocardial infarction in one patient. Periprocedural complications occurred in 3 patients at one day postoperatively including acute myocardial infarction (2 cases), occluder detachment (1 case), and tricuspid chordae tendinae rupture (1 case). Clinical follow-up data were available in 58 of the 62 patients who underwent initial successful TCC with a follow-up period of 9.3 (6.5, 13.4) years. Ten adverse events occurred in 9 patients including 5 complications consisted of aortic valve perforation (1 case), coronary thrombosis (1 case), progressive aneurysmal dilation after reintervention (1 case), and new-onset tricuspid valve prolapse with significant regurgitation (2 cases) and large residual shunts due to fistula recanalization (5 cases). Therefore, the incidence of intermediate and long-term adverse events was 17% (10/58). During the periprocedural and follow-up period, 16 adverse events occurred in 13 patients, whereas no adverse events occurred in 51 patients. Patients with seriovs adverse events presented with larger proportion of large CCF (11/13 vs. 39% (20/51), P =0.005), giant CAA (10/13 vs. 14% (7/51), P =0.030), and higher mean pulmonary artery pressure ((20±9) vs. (16±6) mmHg, 1 mmHg=0.133 kPa, t =2.02, P =0.048) compared to patients without serious adverse events. Conclusions: TCC in CCF children appears to be effective with favorable intermediate and long-term outcomes. Strict indication of TCC is mandatory.

Published
2024
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25. Effect of occlusal stabilisation splint with or without arthroscopic disc repositioning on condylar bone remodelling in adolescent patients.

Author

Ding WH, Li YF, Liu W, Li W, Wu N, Hu SY, and Shi JJ

Subjects
Humans, Adolescent, Child, Young Adult, Adult, Temporomandibular Joint Disc surgery, Mandibular Condyle diagnostic imaging, Mandibular Condyle pathology, Splints, Temporomandibular Joint pathology, Magnetic Resonance Imaging methods, Occlusal Splints, Bone Remodeling, Temporomandibular Joint Disorders diagnostic imaging, Temporomandibular Joint Disorders therapy, Temporomandibular Joint Disorders pathology, Joint Dislocations surgery
Abstract

The aim of this study was to investigate the treatment effects of a stabilisation splint (SS) with and without arthroscopic disc repositioning (ADR) on condylar bone remodelling in adolescent patients with anterior disc displacement without reduction (ADDwoR). Cone beam computed tomography and magnetic resonance imaging were used to analyse condylar bone remodelling, condyle position, and disc position. Twenty-two temporomandibular joints of 14 patients who underwent ADR (age range 12-20 years; mean follow-up 12.5 ± 7.8 months) and 21 temporomandibular joints of 14 patients who did not undergo ADR (age range 13-20 years; mean follow-up 11.1 ± 5.1 months) were included. The change in bone volume (P < 0.001), rate of bone volume change (P < 0.001), and change in condyle height (P = 0.031) were significantly greater in patients with ADR than in those without ADR. The changes in posterior joint space (P = 0.013), superior joint space (P = 0.020), and ratio of condyle sagittal position (P = 0.013) were significantly greater in patients with ADR than in those without ADR. All discs in patients who underwent ADR and one disc in those who did not undergo ADR were backward repositioned. In conclusion, in adolescent patients with ADDwoR, ADR with SS therapy achieved better condyle and disc position than SS therapy alone, and also induced bone generation., Competing Interests: Competing interests None., (Copyright © 2023 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)

Published
2024
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