8 results on '"Huitao Zhang"'
Search Results
2. Associations of the circulating levels of cytokines with the risk of myeloproliferative neoplasms: a bidirectional mendelian-randomization study
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Hao Xiong, Huitao Zhang, Jun Bai, Yanhong Li, Lijuan Li, and Liansheng Zhang
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Myeloproliferative neoplasms ,Mendelian randomization ,Inflammatory ,Cytokines ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Objective In the pathogenesis of myeloproliferative neoplasms (MPN), inflammation plays an important role. However, it is unclear whether there is a causal link between inflammation and MPNs. We used a bidirectional, two-sample Mendelian randomization (MR) approach to investigate the causal relationship between systemic inflammatory cytokines and myeloproliferative neoplasms. Methods A genome-wide association study (GWAS) of 8293 European participants identified genetic instrumental variables for circulating cytokines and growth factors. Summary statistics of MPN were obtained from a GWAS including 1086 cases and 407,155 controls of European ancestry. The inverse-variance-weighted method was mainly used to compute odds ratios (OR) and 95% confidence intervals (Cl). Results Our results showed that higher Interleukin-2 receptor, alpha subunit (IL-2rα) levels, and higher Interferon gamma-induced protein 10 (IP-10) levels were associated with an increased risk of MPN (OR = 1.36,95%CI = 1.03–1.81, P = 0.032; OR = 1.55,95%CI = 1.09–2.22, P = 0.015; respectively).In addition, Genetically predicted MPN promotes expression of the inflammatory cytokines interleukin-10 (IL-10) (BETA = 0.033, 95% CI = 0.003 ~ 0.064, P = 0.032) and monokine induced by interferon-gamma (MIG) (BETA = 0.052, 95% CI = 0.002–0.102, P = 0.043) and, on activation, normal T cells express and secrete RANTES (BETA = 0.055, 95% CI = 0.0090.1, P = 0.018). Conclusion Our findings suggest that cytokines are essential to the pathophysiology of MPN. More research is required if these biomarkers can be used to prevent and treat MPN.
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- 2024
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3. Grating-based x-ray dark-field CT for lung cancer diagnosis in mice
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Peiyuan Guo, Li Zhang, Jincheng Lu, Huitao Zhang, Xiaohua Zhu, Chengpeng Wu, Xiangwen Zhan, Hongxia Yin, Zhenchang Wang, Yan Xu, and Zhentian Wang
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Disease progression ,Early detection of cancer ,Lung diseases ,Tomography (x-ray computed) ,X-rays ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background The low absorption of x-rays in lung tissue and the poor resolution of conventional computed tomography (CT) limits its use to detect lung disease. However, x-ray dark-field imaging can sense the scattered x-rays deflected by the structures being imaged. This technique can facilitate the detection of small alveolar lesions that would be difficult to detect with conventional CT. Therefore, it may provide an alternative imaging modality to diagnose lung disease at an early stage. Methods Eight mice were inoculated with lung cancers simultaneously. Each time two mice were scanned using a grating-based dark-field CT on days 4, 8, 12, and 16 after the introduction of the cancer cells. The detectability index was calculated between nodules and healthy parenchyma for both attenuation and dark-field modalities. High-resolution micro-CT and pathological examinations were used to crosscheck and validate our results. Paired t-test was used for comparing the ability of dark-field and attenuation modalities in pulmonary nodule detection. Results The nodules were shown as a signal decrease in the dark-field modality and a signal increase in the attenuation modality. The number of nodules increased from day 8 to day 16, indicating disease progression. The detectability indices of dark-field modality were higher than those of attenuation modality (p = 0.025). Conclusions Compared with the standard attenuation CT, the dark-field CT improved the detection of lung nodules. Relevance statement Dark-field CT has a higher detectability index than conventional attenuation CT in lung nodule detection. This technique could improve the early diagnosis of lung cancer. Key points • Lung cancer progression was observed using x-ray dark-field CT. • Dark-field modality complements with attenuation modality in lung nodule detection. • Dark-field modality showed a detectability index higher than that attenuation in nodule detection. Graphical Abstract
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- 2024
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4. A spider mating plug functions to protect sperm.
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He Jiang, Yongjia Zhan, Qingqing Wu, Huitao Zhang, Matjaž Kuntner, and Lihong Tu
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Medicine ,Science - Abstract
Mating plugs in animals are ubiquitous and are commonly interpreted to be products of mating strategies. In spiders, however, mating plugs may also take on functions beyond female remating prevention. Due to the vagaries of female genital (spermathecal) anatomy, most spiders face the problem of having to secure additional, non-anatomical, protection for transferred sperm. Here, we test the hypothesis that mating plugs, rather than (or in addition to) being adaptations for mating strategies, may serve as sperm protection mechanism. Based on a comparative study on 411 epigyna sampled from 36 families, 187 genera, 330 species of entelegyne spiders, our results confirm the necessity of a sperm protection mechanism. We divided the entelegyne spermathecae into four types: SEG, SED, SCG and SCD. We also studied detailed morphology of epigynal tracts in the spider Diphya wulingensis having the SEG type spermathecae, using 3D-reconstruction based on semi thin histological series section. In this species, we hypothesize that two distinct types of mating plug, the sperm plug and the secretion plug, serve different functions. Morphological details support this: sperm plugs are formed on a modified spermathecal wall by the spilled sperm, and function as a temporary protection mechanism to prevent sperm from leaking and desiccating, while secretion plugs function in postcopulation both as a permanent protection mechanism, and to prevent additional mating. Furthermore, with the modified spermathecal wall of S2 stalk, the problem of shunt of sperm input and output, and the possibility of female multiple mating have been resolved. Variation in spermathecal morphology also suggests that the problem of sperm protection might be resolved in different ways in spiders. Considering mating plugs of varying shapes and origins in the vast morphospace of spiders, we conclude that mating plugs might serve different purposes that relate both to mating strategies, as well as to sperm protection.
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- 2024
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5. Fracture-vuggy carbonate reservoir characterization based on multiple geological information fusion
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Yan Wang, Pengfei Xie, Huitao Zhang, Yuming Liu, and Aiying Yang
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carbonate reservoir ,Fractured-vuggy reservoir ,geological modeling ,probability fusion ,fracture ,Science - Abstract
The complexity and strong heterogeneity of carbonate reservoirs with fracture-vuggy structures present significant challenges in reservoir characterization. To address these challenges, we propose a novel multi-element information fusion modeling approach. This approach is designed to integrate multiple methods and incorporate multi-probability fusion at various facies and scales, thereby bridging the gap between geological information and reservoir modeling. Our methodology involves four key steps. First, the statistics between frequency of karst and geological information are acquired, and we quantify the statistics to regression equations. Second, these regression equations are transferred to probability bodies. The probability bodies can be applied in modeling as a soft control. But just one single body can be input in modeling process. Third, multiple probability bodies are fused into a fusion probability body by a probability fusion algorithm, which can keep the potential information of probability bodies. Finally, we apply the probability body in modeling workflow. By this way, the fusion method bridges the gap between geological information and modeling. The model established through our proposed method showed a significant level of consistency with reservoir re-evaluation, achieving an impressive 90% degree of alignment. Furthermore, the history match analysis revealed a high correlation, indicating the model's reliability. The method effectively integrates various scales and types of geological information, offering an accurate approach to complex carbonate reservoir modeling.
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- 2024
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6. Generation of Stable Cell Lines of APP695 (K595N, M596L) Gene Over-Expression via Lentiviral Over-Expression System
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Huitao Zhang, Hao, Rui, Yu, Zitong, Hu, Shi, Ren, Jingyi, Hong, Yanhang, Wang, Shifan, Sun, Huihui, Zhang, Pengcheng, Zhang, Yi, Yang, Hui, and Ding, Juan
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- 2024
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7. Available energy routing algorithm considering QoS requirements for LEO satellite network.
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Li Yang, Huitao Zhang, Yaowen Qi, and Qilong Huang
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- 2024
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8. Think of Several Issues on Precision Guided Weapons Intelligentizing
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Fan Huitao, Zhang Xinchao
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precision guided weapons ,artificial intelligence ,transfer learning ,the combination of intuition and rationality ,Motor vehicles. Aeronautics. Astronautics ,TL1-4050 - Abstract
This article introduces the role of artificial intelligence technology in advancing the intlelligence of precision Guided weapons, outlines the current status of intelligence in it’s detection and recognizing, guidance and control. It discusses the problems faced during the intelligentization process, such as the construction of large samples, transferring simulation performance to real-world capabilities, issues with interptetability and reliability, and the assessment of intelligent weapon performance. Targeted solutions are pesented, including hardware-in-the-loop simulation training, transfer learning, combining human intuition with rationality, and reconstructiong evaluation methods. Three impacts of intelligent precision guided weapons on equipment development and operational use were proposed: increasing importance of simulation technology, significant changed in training patterns, and existing conmbat modes will be overturned.
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- 2024
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