Search

Copyright of Journal of Vibration, Measurement & Diagnosis is the property of Nanjing Hangkong Daxue and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the changes of bone mass, gut microbiota and neuropeptides in ovariectomized mice treated with Loganin. Methods 28 female C57BL/6J mice were randomly divided into sham operation group (SHAM), ovariectomized group (OVX), Loganin low-dose group (Loganin-L) and Loganin high-dose group (Loganin-H), with 7 mice in each group. Loganin-L and Loganin-H groups received Loganin 5mg / (kgd) and 20 mg/(kg.d) via oral gavage, respectively, while SHAM and OVX groups received the same dose of distilled water via oral gavage. After 12 weeks of intervention, BMD, BV/TV, Tb. N and Tb. Sp of the left femur were detected by Micro-CT. CTX, TRAP, PINP, TNF-α, IL-6, IL-10, CGRP, SP, VIP, NPY and LPS were detected by ELISA. 16 S rRNA high-throughput sequencing was used to detect the gut microbiota. Results BMD, BV/TV, Tb. N, P1NP, IL-10, CGRP, SP, VIP and NPY were significantly decreased in OVX group compared with SHAM group ( P < 0.05, P < 0, 1 ) ; Tb. Sp, CTX, TRAP, TNF-α, IL-6 and LPS were significantly increased in OVX group (P< 0.05, P < 0.01 . BMD, BV/TV, Tb. N, PINP, IL-10, CGRP, SP, VIP, and NPY of Loganin-L group tended to increase compared with OVX group (P > 0.05), while Tb. Sp CTX, TRAP, TNF-α, IL-6 and LPS tended to decrease (P > 0.05) . BMD, BV/TV, Tb. N, PINP, IL-10, CGRP, SP, VIP and NPY were significantly increased in Loganin-H group compared with OVX group (P<0.05); Tb. Sp, CTX, TRAP, TNF-α, IL-6 and LPS were significantly decreased (P < 0.05) At the phylum level, F/ B ratio was significantly decreased in OVX group ( P < 0.05 ) compared with SHAM group. However the F/B ratio in Loganin-L group has an increasing trend compared with OVX group (P > 0.05), and it was significantly increased in Loganin-H group (P< 0.05). At the genus level, norank f_Muribaculaceae exhibited a significant increase ( P < 0 ) while Lactobacillus demonstrated a significant decrease ( P < 0.05 ) in OVX group compared with SHAM group. Compared with OVX group, norank_f_Muribaculaceae tended to decrease in Loganin-L group ( P > 0.05, and Lactobacillustended to increase (P > 0.05) . Norank f_Muribaculaceae ( p < 0.01 showed a significant decrease (P < 0.05) whereas Lactobacillus exhibited a significant increase in Loganin-H group. Conclusion Loganin can inhibit bone loss in OVX mice in a dose-dependent manner, which may be achieved by reducing inflammatory response, increasing the level of neuropeptides and regulating the abundance of norank f_ Muribaculaceae and Lactobacillus. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agro-Environment Science is the property of Journal of Agro-Environment Science Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)