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A recent study conducted by researchers at the Hospital of Chengdu University of Traditional Chinese Medicine in Chengdu, China, analyzed the research status and trends in the field of metformin and gut microbiota. The study used bibliometric tools to analyze publications from 2012 to 2022 and found that the number of research articles on this topic has been increasing annually. The study included 517 papers from 57 countries and identified China as the leading country in terms of publications. The most influential institution was the Chinese Academy of Sciences, and the most popular journal was PLOS ONE. The study also highlighted emerging topics such as "metabolites," "aging," and "intestinal barrier." The researchers concluded that their study provides new research topics and trends for studying the effects of metformin on gut microbiota in different diseases. [Extracted from the article]

CellOrigin Biotechnology has announced the treatment of the first patient in China with their CAR-macrophage therapy product (CAR-M) SY001. This marks the first investigator-initiated clinical study of CAR-M cell therapy in China. The treatment was well tolerated with no dose-limiting toxicity observed, and the company expects that this innovative product will prove its safety and effectiveness in clinical trials, offering new hope for the treatment of solid tumors. CellOrigin has also collaborated with Zhejiang University on research papers exploring the development of second-generation CAR-iMAC and targeted glycan degradation for solid tumors. They are conducting further pre-clinical and clinical studies to provide safe and effective treatment choices for patients. [Extracted from the article]

A recent study conducted at Hubei Maternal and Child Health Hospital in China explored the role of pyroptosis-related genes in chronic rhinosinusitis (CRS), a chronic inflammatory disease of the nose and upper respiratory tract. The researchers used a weighted co-expression network analysis (WGCNA) to identify gene modules related to CRS and intersected them with genes associated with pyroptosis. They found that hub genes CASP3, IL18, NAIP, NLRC4, and TP53 were directly or indirectly related to CRS and could serve as diagnostic biomarkers. The study provides valuable insights into the molecular mechanisms of CRS and offers a foundation for further research on biomarkers for diagnosis and treatment. [Extracted from the article]

Researchers from Shandong Jianzhu University in China have developed a region of interest-based electrophysiological source imaging (ESI) technology for analyzing motor imagery electroencephalogram (MI-EEG) signals. ESI technology maps scalp potentials to the cerebral cortex, addressing the limitations of low spatial resolution and volume conduction effects of EEG signals. The proposed method utilizes ESI technology to map scalp potential data to the cerebral cortex, determines regions of interest (ROI) based on sensor position information, and performs feature extraction and classification using filter bank CSP and support vector machine. Experimental results show that this method improves signal processing speed and accuracy, making it suitable for online brain-computer interface applications. [Extracted from the article]

A study conducted by researchers at Southern Medical University in China examined the impact of the New Rural Pension Scheme (NRPS) on the health status of elderly individuals with chronic diseases in rural areas. The study used data from the 2018 China Health and Retirement Longitudinal Study (CHARLS) and employed Bayesian networks and fuzzy regression discontinuity design for causal analysis. The results showed a positive effect of receiving NRPS on the health status of elderly individuals with chronic obstructive pulmonary disease (COPD) and asthma. The researchers concluded that the Chinese government should increase the uptake of NRPS to improve the health status of elderly individuals with chronic diseases in rural areas. [Extracted from the article]