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Researchers from COMSATS University in Lahore, Pakistan have developed a cellulose paper-based aptasensing protocol for the detection of the cancer biomarker mucin 1 (MUC1). The paper surface was modified using polydopamine modified carbon nanotubes (PDA@CNTS) to create a strong adhesion and binding interface. The researchers used dynamic laser speckle (DLS) analysis to analyze the speckle patterns generated from the cellulose-based paper surface, providing sensitive and accurate analysis of the target biomarker. The paper-based aptasensor demonstrated sensitive and selective detection of MUC1, making it a promising tool for low-cost and portable biological applications. [Extracted from the article]

Researchers from Northeast Forestry University in Harbin, China have developed antibacterial food-preservative paper incorporating ceramic pigments. The paper was created by coating silver onto red ceramic powder using the electroless plating method. The ceramic pigments have a porous crystalline structure, and the silver particles were successfully loaded onto the surface and into the pores of the ceramic. The paper was tested using spinach as an example, and it was found that while the ceramic preservative paper did not have antibacterial properties, it reduced weight loss from the spinach and increased retention of vitamin C and chlorophyll. The antibacterial preservative papers inhibited the growth of bacteria by over 99% and preserved the spinach more effectively. The researchers concluded that the antibacterial food-preservative paper has great potential in food packaging applications. [Extracted from the article]

A report from investigators at Peking Union Medical College in Beijing, China compares two urine tests, the Congo-red dot paper test (CRD) and dipstick urinalysis, for screening preeclampsia in pregnant women. The study found that the agreement between the two tests was modest, with the CRD test having higher specificity but lower sensitivity compared to urinalysis. The researchers concluded that urinalysis is a better diagnostic test for preeclampsia, but CRD could aid in the diagnosis and combining the two tests may improve performance. Further research is needed for potential clinical practice. [Extracted from the article]

A study conducted by researchers at Chulalongkorn University in Bangkok, Thailand, has explored the use of molecularly imprinted polymer paper-based analytical devices (MIP-PADs) for biomarker detection. MIP-PADs have the potential to improve the selectivity and specificity of paper-based analytical devices, making them more effective in complex analysis conditions and samples. The study highlights the fabrication and characterization processes of MIP-PADs, discusses their applications in biological samples, and evaluates their potential for commercialization. This research is the first of its kind to assess MIP-PADs for biomarker analysis. [Extracted from the article]

A recent study conducted by researchers at Shanghai University in China has developed a simple and affordable paper analytical device for on-site detection of lead (Pb). The device utilizes a visual distance-based method to detect Pb by inhibiting the catalytic activity of G-quadruplex/hemin DNAzyme induced by potassium (K+). The device has been optimized to detect Pb concentrations ranging from 0.02 μM to 50 μM, with a lowest detection limit of 1 nM. The researchers believe that this device could be particularly useful for detecting heavy metal ions in resource-limited areas. [Extracted from the article]

Researchers from Yangzhou University in China have developed a new method for detecting tumor-derived extracellular vesicles (T-EVs) using a paper-based lipid bilayer magnetic interface. T-EVs are important biomarkers for predicting immunotherapy response, but traditional bioassays have limited detection specificity. The new biosensor combines the use of magnetic beads covered with liposome bilayers and aptamers to isolate and amplify the signals of T-EVs. The biosensor demonstrated high sensitivity, with a detection limit as low as 5.0 EVs/μL, and has potential applications in predicting immunotherapy response and point-of-care disease diagnosis. [Extracted from the article]

A recent study conducted by researchers at the Harbin Institute of Technology in Shenzhen, China, has developed a paper-based microfluidic sensor array for the discrimination of tetracycline antibiotics. The sensor array utilizes lanthanide metal-carbon quantum dots composite ink and inkjet printing technology to create a portable and cost-effective device. The platform successfully differentiated six different tetracycline antibiotics and demonstrated its practicality in real samples. This research has potential applications in disease diagnosis, food safety, and environmental contamination. [Extracted from the article]

A recent study conducted by researchers at South China Agricultural University in Guangzhou, China, has developed a new method for detecting nitrofuran metabolite residues in food-producing animals. These residues pose a threat to human health and public safety, and accurate measurement is necessary. The researchers used an original structure-based hapten design strategy to produce a monoclonal antibody that could directly recognize the metabolite of furaltadone without the need for derivatization. They also established a gold-based paper lateral flow immunoassay for detection, which was sensitive, accurate, and completed within 10 minutes. This research provides a theoretical basis for antibody production of other ultrasmall molecules. [Extracted from the article]