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A new report presents research on the incidence of eosinophilic esophagitis (EoE) in patients with inflammatory bowel disease (IBD). The study aimed to differentiate true EoE from esophageal eosinophilia in IBD patients by evaluating the expression of major basic protein (MBP) and interleukin-13 (IL-13) in esophageal biopsies. The results showed that MBP may be an excellent marker in distinguishing true EoE from eosinophilia caused by IBD. The researchers concluded that MBP, along with endoscopic and histologic changes, can assist in the diagnosis of EoE in IBD patients. [Extracted from the article]

A recent study conducted at Brigham and Women's Hospital in Boston, Massachusetts, explored the predictive value of baseline peripheral eosinophil counts (AECs) for proton pump inhibitor (PPI) response in eosinophilic esophagitis (EoE). The study found that baseline peripheral eosinophilia independently predicts PPI nonresponse and food impaction in EoE patients. This information may help guide therapy selection and prevent delays in achieving histologic remission. The study was published in the Journal of Clinical Gastroenterology and has been peer-reviewed. [Extracted from the article]

A recent study conducted at the Department of Pediatrics focused on eosinophilic esophagitis (EoE), a condition characterized by inflammation of the esophagus. The researchers aimed to determine the extent to which specific foods trigger inflammation in EoE patients. They found that mast cells, a type of immune cell, were reduced with a 4-food elimination diet (4FED) and increased with the reintroduction of certain foods. Specifically, wheat led to increased mast cells in the upper esophagus, while milk was associated with increased mast cells throughout the esophagus and various symptoms. This suggests that milk may have unique effects on mast cells in EoE patients. [Extracted from the article]

A recent study conducted at Orlando Health in Florida has found that measuring eosinophil-derived neurotoxin (EDN) from esophageal epithelial brushings can be a useful tool in diagnosing eosinophilic esophagitis (EoE) and assessing disease activity. The study analyzed patient records and found that EDN values correlated with endoscopic reference scores and peak eosinophil counts. The research concluded that measuring EDN in esophageal brushing samples provides an objective and accurate reflection of disease activity, particularly in cases of exclusive distal esophageal eosinophilia and when there are discrepancies between endoscopy and histology. [Extracted from the article]

A recent study conducted at Yamagata University Hospital in Japan aimed to understand the long-term course of untreated asymptomatic esophageal eosinophilia (aEE) and minimally symptomatic eosinophilic esophagitis (mEoE). The study followed 36 patients with EE for over 5 years and divided them into two groups: a no treatment group (NT group) and a proton pump inhibitor/potassium competitive acid blocker group (Tx group). The results showed that untreated aEE and mEoE are unlikely to worsen even without treatment for a median follow-up of 7 years. Additionally, the localized type of the condition may spontaneously improve, suggesting a different pathogenesis compared to the diffuse type. Further research is needed to clarify the long-term prognosis. [Extracted from the article]