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This paper discusses three case studies of early science museum-related websites in the 1990s and early 2000s, when web technology was still relatively new and evolving. The Virtual Museum of Computing (VMoC) was a completely virtual museum, originally produced in 1995 as part of the Virtual Library museums pages (VLmp), an international online museum directory within the WWW Virtual Library, adopted by the International Council of Museums (ICOM). The Science Museum in London was one of the first museums in the United Kingdom to have its own web server. The museum hosted an early meeting on web service provision by and for museums, concurrently with an exhibition on the Information Superhighway at the museum in 1995. Exhiblets were launched online in 1998. Ingenious was a multi-site digital collections transformation project, launched as a website in 2003. Virtual Leonardo and Leonardo's Ideal City were two experiments conducted by the digital team of the Science and Technology Museum of Milan, between 1999 and 2001. The experiment consisted of the creation of a shared online 3D world, namely a reconstruction of the real museum in the first case and a completely imaginary world in the second case. This paper describes the above three case studies from the early World Wide Web and then draws some conclusions, from first-hand experience of developments at the time. We cover both the advantages and the challenges encountered by the various projects and illustrate why they did not necessarily become established, despite promising early results. [ABSTRACT FROM AUTHOR]

Analytical performance specifications (APS) based on outcomes refer to how 'good' the analytical performance of a test needs to be to do more good than harm to the patient. Analytical performance of a measurand affects its clinical performance. Without first setting clinical performance requirements, it is difficult to define how good analytically the test needs to be to meet medical needs. As testing is indirectly linked to health outcomes through clinical decisions on patient management, often simulation-based studies are used to assess the impact of analytical performance on the probability of clinical outcomes which is then translated to Model 1b APS according to the Milan consensus. This paper discusses the related key definitions, concepts and considerations that should assist in finding the most appropriate methods for deriving Model 1b APS. We review the advantages and limitations of published methods and discuss the criteria for transferability of Model 1b APS to different settings. We consider that the definition of the clinically acceptable misclassification rate is central to Model 1b APS. We provide some examples and guidance on a more systematic approach for first defining the clinical performance requirements for tests and we also highlight a few ideas to tackle the future challenges associated with providing outcome-based APS for laboratory testing. [ABSTRACT FROM AUTHOR]

The increasing use of electromedical equipment in hospital care services necessitates effective management of complex devices often unsupported by existing control systems. This paper focuses on developing a pool of evaluation indices for the Clinical Engineering Department (CED) of the ASST Grande Ospedale Metropolitano Niguarda in Milano (Italy), aiming to enhance awareness of the economic value, assess operational units, and optimize maintenance processes. Leveraging business intelligence, this study identifies 18 key performance indicators (KPIs) across logistics, technical, and equipment management categories. An interactive dashboard, implemented using Power BI, facilitates dynamic analysis and visualization of these KPIs, providing insights into the maintenance efficiency and obsolescence of medical devices. It offers a comprehensive framework for ongoing monitoring and decision-making. The results showcase the potential of the developed KPIs and dashboard to enhance operational insights and guide improvements in the healthcare facility's maintenance processes. [ABSTRACT FROM AUTHOR]

The increases in both the elderly population and urbanization present new problems for planning new cities and managing old cities. To solve this challenge, innovative ideas/proposals that encourage walkability and reduce fossil energy motor transport are needed, in line with the actions advocated by Sustainable Development Goal #11 (SDG11), Sustainable Cities and Communities. Opening passages that cross blocks, creating connections between the streets, is the proposal discussed in this paper, as seen in cities like Paris, Prague, Milan, and Juíz de Fora, which have passages in their urban fabric. These can be implemented in a building's rehabilitation or when a new building replaces it. New architectural project designs should have several characteristics that promote walkability in the city, including passages and galleries. Although previous research has obtained promising results, extending the research to different urban fabrics and block sizes is needed. Using space syntax and data analysis, we simulated and quantitatively assessed the walkability of three neighborhoods in Lisbon, Portugal. The comparison of all simulations and the discussion of the results show that the passages improve walkability. It is also noticeable that there is higher walkability in orthogonal urban fabrics than in non-orthogonal fabrics. The results for block size are inconclusive. [ABSTRACT FROM AUTHOR]

The sedimentary cycle of Fengcheng Formation in Junggar Basin changes rapidly and is difficult to identify. The low classification accuracy of high-frequency fine-grained sedimentary cycles restricts the exploration of unconventional shale oil and gas. Full-interval coring of well Maye 1 provides a solid foundation for small-layer research. In this paper, the high-frequency sedimentary cycle of Milan kovitch in Fengcheng Formation is studied by means of spectral analysis and wavelet transform, and the shale sweet spot is identified. The long period of eccentricity of 405ka, short period of eccentricity of 100ka and long period of axis slope of 42736a can be used as semi-quantitative basis for the classification of the fourth, fifth and sixth sequences. The Fengcheng Formation can be divided into 2 quaternary sequence cycles, 9 quaternary sequence cycles and 16 quaternary sequence cycles. A long period of eccentricity of 405ka can identify large-scale lake recessional and recessional, and there is a maximum lake flooding surface in the middle of the second Fengcheng Formation, which corresponds to high abundance of organic matter and high hydrocarbon generation potential. The 100ka short period eccentricity can identify the sweet spot layer, and there are 8 sweet spots in the well Maye 1, which is consistent with the results of nuclear magnetic interpretation. The research results provide a semi-quantitative basis for the classification of high-frequency sedimentary cycles and the identification of sweet spots of Fengcheng Formation in Mahu Sag, Junggar Basin. [ABSTRACT FROM AUTHOR]

This paper suggests a "neoclassical" reading of Ernan McMullin's thought on science and theology. McMullin's Augustinian convictions on God and the God–world relation coincide with those of some prominent scholars from two renowned schools of neo-scholastic philosophy of the twentieth century in Louvain and Milan. The school of Milan, thanks to the work of some disciples of its leading figure, Amato Masnovo, developed a neoclassical version of neo-scholasticism, articulating a fundamental theory of knowledge, as well as an essential, rigorous path to God. We recall the main tenets of a neoclassical path to God, and we interpret this path as a possible contribution to the science–theology dialogue, in line with McMullin's Augustinism. A neoclassical approach to science and theology, with its rediscovery and reactualization of some ideas of classic philosophy in an interdisciplinary context, grounds the intelligibility of the universe and safeguards its mystery. [ABSTRACT FROM AUTHOR]

The emergence of antibiotic resistance poses a significant threat to public health worldwide, affecting various medical fields, including ophthalmology. Eye infections, ranging from conjunctivitis to more severe conditions like keratitis, are commonly treated with antibiotics. However, the misuse and overuse of these drugs have led to the development of resistant strains of bacteria, allowing traditional treatments ineffective. This paper aims to examine the current situation of antibiotic resistance in eye infections globally, with a specific focus on a large group of hospitals located in Milan (Italy) with considerable experience in cataract and cornea surgery as well as in retinopathy. The results of the study show the prevalence of Gram-positives in the tested samples and a low resistance of fluoroquinolones and glycopeptides. The results also highlight the need to implement sample collection methods for ocular infections, as the quantity of positive samples is rather low compared to the total number of samples. In conclusion, the study, although with limited data, shows that resistance to aminoglycosides and cephalosporins is a situation to be monitored. These data also show the critical need to improve and guide the biological sample collection modalities in order to make the diagnosis more reliable. [ABSTRACT FROM AUTHOR]

This study conducted an extensive literature review spanning from 1950 to 2023, exploring the methodologies in urban geomorphology and urban geoheritage assessment, and the possibility of applying Nature-Based Solutions (NbSs) in order to enhance geomorphological maps. The methodology proposed here is based on a two-step approach: (i) a bibliographic review and methodological investigation and (ii) methodological proposal in order to enhance the traditional geomorphological and geoheritage maps with NbS to reduce the geomorphological risk in urban areas. This paper aims to introduce a methodological framework and illustrated its practical application to provide researchers and practitioners with a clear understanding of its implementation in real-world scenarios. The proposed methodology was applied in the north and northeastern parts of Milan, Italy. The implementation of the proposed methodology demonstrated its effectiveness in urban contexts and its potential for further modification and extension to various urban environments in the future. [ABSTRACT FROM AUTHOR]

Migrant community-based organizations (MCBOs) are key mediating structures between immigrants and host societies. However, when implementing this role in host societies, MCBOs often face a number of challenges that reduce their chances to be effective in promoting social justice. This paper aims to analyze the challenges that MCBOs settled in Milan (Northern Italy) experience and the coping strategies that they use in order to provide some guidelines on how to support them. In-depth interviews, observations and document analysis with 15 MCBOs were conducted. Based on a situational analysis, we present the main challenges perceived by MCBOs at three levels: internal (i.e., surviving), inter-organizational (i.e., collaborating) and community (i.e., being recognized as mediating actors). We provide specific guidelines for action on how to address such challenges and thus foster the role of MCBOs as mediating structures in receiving societies. [ABSTRACT FROM AUTHOR]

The genetic causes of epilepsies and developmental and epileptic encephalopathies (DEE) with onset in early childhood are increasingly recognized. Their outcomes vary from benign to severe disability. In this paper, we wished to retrospectively review the clinical, genetic, EEG, neuroimaging, and outcome data of patients experiencing the onset of epilepsy in the first three years of life, diagnosed and followed up in four Italian epilepsy centres (Epilepsy Centre of San Paolo University Hospital in Milan, Child Neurology and Psychiatry Unit of AUSL-IRCCS di Reggio Emilia, Pediatric Neurology Unit of Vittore Buzzi Children's Hospital, Milan, and Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia). We included 168 patients (104 with monogenic conditions, 45 with copy number variations (CNVs) or chromosomal abnormalities, and 19 with variants of unknown significance), who had been followed up for a mean of 14.75 years. We found a high occurrence of generalized seizures at onset, drug resistance, abnormal neurological examination, global developmental delay and intellectual disability, and behavioural and psychiatric comorbidities. We also documented differing presentations between monogenic issues versus CNVs and chromosomal conditions, as well as atypical/rare phenotypes. Genetic early-childhood-onset epilepsies and DEE show a very wide phenotypic and genotypic spectrum, with a high risk of complex neurological and neuropsychiatric phenotypes. [ABSTRACT FROM AUTHOR]

The application of artificial intelligence (AI) techniques may lead to significant improvements in different aspects of rail sector. Considering asset management and maintenance, AI can improve data analysis and asset status forecasting and decision-making processes, fostering predictive and prescriptive maintenance strategies. A prescriptive approach should be able to predict future scenarios as well as to suggest a course of actions. Nevertheless, the decision-making in rail asset management is often based on the classical asset-oriented approach, concentrating on the function of the asset itself as a main key performance indicator (KPI), whereas a user-oriented approach could lead to improved performance in terms of level of service. This paper is aimed at integrating the passengers' perspective in the decision-making process for asset management to mitigate the impact that service interruptions may have on the final users. A data-driven prioritisation framework is developed to prioritise maintenance interventions taking into account asset status and criticality. In particular, a three-step approach is proposed, which focuses on the analysis of passenger data to evaluate the failure impact on the service, the analysis of alarms and anomalies to evaluate the asset status, and the suggestion of maintenance interventions. The proposed approach is applied to the maintenance of the metro line M5 in the Italian city of Milan. Results show the usefulness of the proposed approach to support infrastructure managers and maintenance operators in making decisions regarding the priority of maintenance activities, reducing the risk of critical failures and service interruptions. [ABSTRACT FROM AUTHOR]

Most victims of physical violence sooner or later will access a hospital or medical cabinet because of that violence, and in particular emergency departments (EDs). This paper aims to analyze the performance of emergency ward clinicians in the forensic management of such victims by examining the activities carried out and the data reported. A total of 991 medical records were extrapolated from the database of the ED of the Policlinico of Milan in an average pre-pandemic 1-year activity. For each medical record, 16 parameters were analyzed in-depth including epidemiological data, information on the type of violent actions, injuries, and time between the infliction of the lesion and access to the ED. In the vast majority of cases, all the actions with medicolegal implications had been neglected by health professionals causing loss of data not only for the justice system but especially for correctly interpreting what happened and taking appropriate measures to protect the patient/victim. Hence, given that clinicians in EDs are busy with non-forensic clinical tasks (and rightly so), it should be ensured that there be specific forensic clinical personnel. However, it is crucial that when unfortunately there can be no forensic staff, at least the clinicians who work in the ED are properly trained to correctly apply essential medicolegal measures. Overall, timely and informed medical and forensic intervention is possible and necessary for the improvement and maintenance of the mental and physical health of victims of violence. [ABSTRACT FROM AUTHOR]

Broadband Coherent Anti-Stokes Raman Scattering (BCARS) is a valuable spectroscopic imaging tool for visualizing cellular structures and lipid distributions in biomedical applications. However, the inevitable biological changes in the samples (cells/tissues/lipids) introduce spectral variations in BCARS data and make analysis challenging. In this work, we conducted a systematic study to estimate the biological variance in BCARS data of two commonly used cell lines (HEK293 and HepG2) in biomedical research. The BCARS data were acquired from two different experimental setups (Leibniz Institute of Photonics Technology (IPHT) in Jena and Politecnico di Milano (POLIMI) in Milano) to evaluate the reproducibility of results. Also, spontaneous Raman data were independently acquired at POLIMI to validate those results. First, Kramers–Kronig (KK) algorithm was utilized to retrieve Raman-like signals from the BCARS data, and a pre-processing pipeline was subsequently used to standardize the data. Principal component analysis – Linear discriminant analysis (PCA-LDA) was performed using two cross-validation (CV) methods: batch-out CV and 10-fold CV. Additionally, the analysis was repeated, considering different spectral regions of the data as input to the PCA-LDA. Finally, the classification accuracies of the two BCARS datasets were compared with the results of spontaneous Raman data. The results demonstrated that the CH band region (2770–3070 cm−1) and spectral data in the 1500–1800 cm−1 region have significantly contributed to the classification. A maximum of 100% balanced accuracies were obtained for the 10-fold CV for both BCARS setups. However, in the case of batch-out CV, it is 92.4% for the IPHT dataset and 98.8% for the POLIMI dataset. This study offers a comprehensive overview for estimating biological variance in biomedical applications. The insights gained from this analysis hold promise for improving the reliability of BCARS measurements in biomedical applications, paving the way for more accurate and meaningful spectroscopic analyses in the study of biological systems. [ABSTRACT FROM AUTHOR]

This paper reflects ethnographically on law enforcement against squatting in Milan. To this end, it examines labor practices, moral economies, and everyday narratives of those who work with the institutional mandate of tackling squatting in public housing. I propose to grasp these processes considering two specific political and legal configurations that traverse the arena under investigation: the entrenched presence, in the Italian context, of what has been defined as penal populism; additionally, the increasingly pronounced prominence of an infra‐legal dimension of law. Squatting—and the way in which it is publicly managed and punished—represents a privileged lens for examining the specific forms of normative and political governance in contemporary cities. [ABSTRACT FROM AUTHOR]

In the last years, Urban Air Mobility (UAM) has been receiving increasing attention and even if the first services are expected to be launched shortly, there is still uncertainty about which type of commercial services (e.g., airport shuttles or city-taxis) will be implemented at an early stage, as well as which price point will be perceived as affordable by travelers. Based on data collected through a large-scale survey campaign in the Milan metropolitan area (Italy), in this paper passengers' value of travel time savings for different UAM services are estimated using advanced discrete choice modeling. Estimated mixed logit models allowed to comparatively analyze the differences between the two potential use cases, i.e., airport shuttle and city-taxi services. Results show a willingness to pay for UAM services from/to airports that is greater (in a range of 44%–57%) than for travelling within the metropolitan area, and greater (in a range of 31%–44%) for business travels than for other purposes, indicating that the most financially sustainable UAM services will potentially be available for airport-shuttle connections from/to central business districts. • Willingness to pay for UAM airport shuttles (48–69 €/h) is greater than that for UAM city-taxis (34–44 €/h). • Business travelers are willing to pay 31%–44% more than non-business ones for UAM services. • In the early stages, UAM services connecting airports and central business districts will be the most financially sustainable. [ABSTRACT FROM AUTHOR]

The existing literature shows that social contacts and resources available through social networks are particularly important for migrant entrepreneurs. This seems to apply also to transnational migrant entrepreneurs, who are migrants involved in entrepreneurial activities crossing national borders. It is still not entirely clear which kind of social contacts they use, nor the differences with migrant entrepreneurs conducting a domestic (namely, non-transnational) business. The paper focuses on the use of social networks by transnational and domestic entrepreneurs, by illustrating the case of Moroccan migrant entrepreneurs in Amsterdam and Milan. The research reveals that transnational entrepreneurs have more heterogenous, geographically dispersed and territorially articulated support networks, which are both more extensive and less dense than those of domestic entrepreneurs. Transnational entrepreneurs exploit their capacity to have contacts with different people in different places. In contrast, domestic entrepreneurs tend to mobilize resources within their dense, homogeneous, and locally based networks. [ABSTRACT FROM AUTHOR]

Purpose: The tracheoesophageal puncture for the voice prosthesis (VP) placement is the recognized gold standard in post-laryngectomy voice rehabilitation. Despite the development of specific intraoperative techniques, a subset of patients will suffer from poor functional outcomes due to pharyngoesophageal spasms (PES). This paper evaluates the functional outcomes after transcutaneous botulinum toxin type A (BTX-A) infiltration for PES with a videofluoroscopy-guided technique. Methods: Since 2022, eight consecutive patients with VP and affected by PES were treated with BTX-A injection by a standard videofluoroscopic guided technique at the European Institute of Oncology, IRCCS (IEO) in Milan. A lidocaine test was performed pre-operatively to evaluate the potential effect of chemical neurectomy. All patients with positive lidocaine tests were injected with 50 IU of BTX-A (Allergan, Irvine, CA) according to the sites marked during the videofluoroscopy. Reported symptoms (VHI, SECEL), perceptual (INFVo), aerodynamic (MPT) and manometric parameters were collected before and after treatment. Results: In all cases, BTX-A was performed as an outpatient procedure without complications. For seven patients, only one BTX-A injection was needed, while one patient required a re-injection. Subjective and perceptive improvement after BTX-A was significant for VHI, SECEL and INFVo. MPT showed significant improvement after a chemical neurectomy. After a mean follow-up of 6 months, all patients maintained a good TES quality. Conclusion: The videofluoroscopic guided BTX-A injection of the pharyngoesophageal tract showed to be a feasible and reproducible technique in all cases. The pharyngoesophageal videofluoroscopy allows defining of patients' anatomical landmarks that help the surgeon to perform a homogeneous injection, empowered by post-injection massage. [ABSTRACT FROM AUTHOR]

Severe deficiency of growth hormone (GHD) of the newborn is a rare but potentially life-threatening disease. GH measured during the first week of life, using dried blood spots (DBS), may offer several advantages. Aim of the study was to estimate the reference values for GH in newborns by a new analytical method using DBS. Using a new developed analytical method, GH was estimated from DBS of 1,036 healthy newborns attending the Neonatology Unit of Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan in the period July–October 2021. Reference values for GH deficiency were estimated by the Harrell–Davis bootstrap method, with 90 %CI calculated by the bias-corrected and accelerated bootstrap method. All GH measurements required 33 analytical sessions (8 months) with a CV% for calibration curve slopes equal to 6.9 %. Intermediate precision evaluated by measurement of low (3 μg/L) and high (10 μg/L) quality controls was, respectively, 14 and 6.5 %. GH reference values, estimated at percentiles 1.0st, 2.5th and 5.0th, and their 90 %CI, were, respectively, 4.5 μg/L (90 %CI 3.8–5.1), 5.9 μg/L (90 %CI 5.4–6.4) and 7.0 μg/L (90 %CI 6.7–7.3). GH levels were not associated with sex, standard deviation scores, birth weight, gestational age, type of delivery or mother's variables (age, smoking habit, gestational diabetes). Validation data suggest that this method can be used to measured GH in newborns using DBS. The reference values estimated in this study are in accordance with previous published works using ELISA and may help confirming the clinical suspicion of neonatal GHD. [ABSTRACT FROM AUTHOR]

The urban heat island effect exacerbates the vulnerability of cities to climate change, emphasizing the need for sustainable urban planning driven by data evidence. In the last decade, the Local Climate Zone (LCZ) model emerged as a key tool for categorizing urban landscapes, aiding in the development of urban temperature mitigation strategies. In this work, the contribution of hyperspectral satellite imagery to LCZ mapping, leveraging the Italian Space Agency (ASI)'s PRISMA satellite, is investigated. Mapping performances are compared with traditional multispectral-based LCZ mapping using Sentinel-2 satellite imagery. The Random Forest algorithm is utilized for LCZ classification, with evaluation conducted through spectral separability analysis and accuracy assessment between PRISMA and Sentinel-2 derived LCZ maps as well as with the benchmark LCZ Generator mapping tool. An initial experiment on the effect of PRISMA image pan-sharpening on LCZ spectral separability is also presented. Results obtained for Milan (Northern Italy) demonstrate the potential of hyperspectral imagery in enhancing LCZ identification compared to multispectral data, with promising improvements in LCZ maps overall accuracy. Finally, air temperature patterns within each LCZ class are explored, qualitatively confirming the influence of urban morphology on thermal comfort. [ABSTRACT FROM AUTHOR]

Urbanisation is a main driver of land-use change, leading to rising in temperatures and fragmentation and reduction of green areas. Bees and wasps, which are important insect groups due to the ecosystem services they provide, may respond to this disturbance via changes in morphological traits which are functionally relevant. To date, studies focusing on this aspect only investigated few social bee species, and often gave contrasting results even at intra-generic level. Here, we studied how body size, wing loading, wing aspect ratio and wing fluctuating asymmetry vary in a social ground-nesting bee (Halictus scabiosae), a solitary hole-nesting bee (Osmia cornuta) and a social paper wasp (Polistes dominula) along an urbanisation gradient within Milan (Italy). By assessing the effects of temperature, green areas fragmentation and vegetation productivity on the above-listed functional traits, we found the three species to variably respond to increasing urbanisation, albeit the driving environmental parameters differed among species. More specifically, smaller individuals were sampled in warmer (for bees) and in less productive (for wasps) areas along the urbanisation gradient. Furthermore, greater wing aspect ratio values were recorded at warmer locations for H. scabiosae , lower wing loading was recorded at more fragmented sites for O. cornuta , and greater wing loading was recorded at locations with greater productivity for P. dominula. H. scabiosae and P. dominula showed greater wing fluctuating asymmetry at more fragmented sites. Although distinct species seemed sensitive to different driving factors, our results point toward a consistent response: smaller body but potentially improved flight performance in more urbanised environments. [ABSTRACT FROM AUTHOR]

Since pedestrians are impacted by solar radiation differently, urban designers must evaluate solar radiation exposure of pedestrian paths adopting an inclusive approach. This paper proposes a maximum threshold of direct solar radiation exposure for pedestrians based on activity, user profile and environmental conditions, defined as the difference between the energy consumption before feeling exhausted and the energy cost of walking. Two users of diverse walking abilities, a young adult and an elderly person with mobility impairment, were characterised by metabolic activity, walking speed and maximum energy capacity. Based on the theoretical framework, the energy budget of young adults to cope with thermal stress was set as three times higher than for the elderly. This framework was used to quantify the contribution of direct solar radiation to energy balance and then classify walkability during clear-sky summer hours; the term 'walkable' referred to environmental conditions allowing users to walk without feeling exhausted. The methodology was tested on an open area and an urban canyon in Milan; applicability by urban designers was key in developing a simplified way to evaluate shading needs. This approach could be applied to evaluate solar radiation exposure of pedestrian paths adopting diverse user experiences as an evaluation criterion. [ABSTRACT FROM AUTHOR]

This study challenges historical paradigms using a large-scale integrated bioarchaeological approach, focusing on the female experience over the last 2,000 years in Milan, Italy. Specifically, 492 skeletons from the osteological collection of Milan were used to elucidate female survivorship and mortality by integrating bioarchaeological and paleopathological data, paleoepidemiological analyses, and historical contextualization. Findings revealed changes in female longevity, with a notable increase from Roman to contemporary eras, albeit plateauing in the Middle Ages/modern period. Significant sex-specific differences in mortality risk and survivorship were observed: females had higher mortality risk and lower survivorship in the Roman (first-fifth century AD) and Modern (16th-18th century AD) eras, but this trend reversed in the contemporary period (19th-20th century AD). Cultural and social factors negatively impacted female mortality in Roman and modern Milan, while others buffered it during the Middle Ages (sixth-15th century AD). This study underscored the importance of bioarchaeological inquiries in reconstructing the past, providing answers that may challenge historical assumptions and shedding light on how the interplay of cultural, social, and biological factors shaped the female experience across millennia. [ABSTRACT FROM AUTHOR]

How do privileged young people engage in artistic fields? Are the arts classified and classifying for educational paths? To examine these questions, I propose observations and reflections from a study of secondary art schools in Italy. Artistic education has received focused but limited attention from sociology, as part of an increasing interest towards cultural labour. However, Italian artistic schools remain a neglected research theme. The proposed study on secondary art schools aims to examine certain early dynamics of creative fields in Milan. This article interrogates the educational experiences of privileged students at art schools. The research is based on discursive interviews and focus groups with these students. Students' class culture is investigated focusing on diverse scholastic dispositions and different outlooks on the future. The Bourdieusian notions of cultural capital and habitus allow certain dynamics of the aspiring young creatives' process of self-formation to be examined. The analysis reveals privileged individuals who are ambitious, self-confident and with great forward-thinking skills, but who are also academically negligent. The trust in individual enterprise and success is deeply interiorised by interviewees. These neoliberal and entrepreneurial ideas are infused with moral, and often tacit, considerations on class boundaries. The analysis reveals some aspects of the symbolic boundary-making; dynamics in which a meritocratic ethos plays a key role in legitimating social divisions. [ABSTRACT FROM AUTHOR]

Cellular contractility, migration, and extracellular matrix (ECM) mechanics are critical for a wide range of biological processes including embryonic development, wound healing, tissue morphogenesis, and regeneration. Even though the distinct response of cells near the tissue periphery has been previously observed in cell-laden microtissues, including faster kinetics and more prominent cell-ECM interactions, there are currently no models that can fully combine coupled surface and bulk mechanics and kinetics to recapitulate the morphogenic response of these constructs. Mailand et al. (Biophys J 117(5):975–986, 2019) had shown the importance of active elastocapillarity in cell-laden microtissues, but modeling the distinct mechanosensitive migration of cells on the periphery and the interior of highly deforming tissues has not been possible thus far, especially in the presence of active elastocapillary effects. This paper presents a framework for understanding the interplay between cellular contractility, migration, and ECM mechanics in dynamically morphing soft tissues accounting for distinct cellular responses in the bulk and the surface of tissues. The major novelty of this approach is that it enables modeling the distinct migratory and contractile response of cells residing on the tissue surface and the bulk, where concurrently the morphing soft tissues undergo large deformations driven by cell contractility. Additionally, the simulation results capture the changes in shape and cell concentration for wounded and intact microtissues, enabling the interpretation of experimental data. The numerical procedure that accounts for mechanosensitive stress generation, large deformations, diffusive migration in the bulk and a distinct mechanism for diffusive migration on deforming surfaces is inspired from recent work on bulk and surface poroelasticity of hydrogels involving elastocapillary effects, but in this work, a two-field weak form is proposed and is able to alleviate numerical instabilities that were observed in the original method that utilized a three-field mixed finite element formulation. [ABSTRACT FROM AUTHOR]

The article discusses the International Thermal Spray Conference and Exposition (ITSC) that was held at the Allianz MiCo Milano Convention Centre in Milan, Italy from April 29 to May 1, 2024. Topics discussed include the increasing demand for coating solutions driven by climate protection, energy transition, and sustainability requirements. Attendees included Mohamed Amer from Coventry University and Laurène Youssef from IRCER CNRS in France.

• Green infrastructure networks enhance green access and distribution in cities. • Pluvial flood risks can be reduced by means of urban green infrastructure networks. • In Milan, increasing green cover by 25 % can potentially halve pluvial flood damage to buildings. • Population exposure can be reduced by up to one-third extending green areas in Milan. • Priority areas for green interventions can support urban climate strategies. Rethinking cities in a more sustainable and integrated way is a key opportunity for successful climate change adaptation and disaster risk management. Nature-based solutions and green infrastructures can help to safeguard urban nature and biodiversity while providing multiple benefits to reduce climate risks and improve human well-being. Nature-based solutions help to mitigate flood risk by regulating storm-water runoff and peak-flow. This paper investigates the effects of nature-based solutions and green infrastructure networks on pluvial flood risk in the Milan metropolitan area in terms of direct economic damage to buildings and population exposed. Results show that extending the urban green networks by 25 % can potentially halve the pluvial flood damages and reduce the population exposed by 40 %. For all analysed rainfall intensities, damages to buildings and share of population exposed decrease (up to 60 % and 50 % respectively) as green area coverage increases, with slightly higher flood risk reduction for lower-intensity events. The applied methodological framework makes it possible to identify priority-action urban areas and hence inform decision-making processes as for where green solutions are most efficient. [ABSTRACT FROM AUTHOR]

Background: The systemic inflammatory syndrome called "cytokine storm" has been described in COVID-19 pathogenesis, contributing to disease severity. The analysis of cytokine and chemokine levels in the blood of 21 SARS-CoV-2 positive patients throughout the phases of the pandemic has been studied to understand immune response dysregulation and identify potential disease biomarkers for new treatments. The present work reports the cytokine and chemokine levels in sera from a small cohort of individuals primarily infected with SARS-CoV-2 during the first wave of the COVID-19 pandemic in Milan (Italy). Results: Among the 27 cytokines and chemokines investigated, a significant higher expression of Interleukin-9 (IL-9), IP-10 (CXCL10), MCP-1 (CCL2) and RANTES (CCL-5) in infected patients compared to uninfected subjects was observed. When the change in cytokine/chemokine levels was monitored over time, from the hospitalization day to discharge, only IL-6 and IP-10 showed a significant decrease. Consistent with these findings, a significant negative correlation was observed between IP-10 and anti-Spike IgG antibodies in infected individuals. In contrast, IL-17 was positively correlated with the production of IgG against SARS-CoV-2. Conclusions: The cytokine storm and the modulation of cytokine levels by SARS-CoV-2 infection are hallmarks of COVID-19. The current global immunity profile largely stems from widespread vaccination campaigns and previous infection exposures. Consequently, the immunological features and dynamic cytokine profiles of non-vaccinated and primarily-infected subjects reported here provide novel insights into the inflammatory immune landscape in the context of SARS-CoV-2 infection, and offer valuable knowledge for addressing future viral infections and the development of novel treatments. [ABSTRACT FROM AUTHOR]

Analytical performance specifications (APS) represent the criteria that specify the quality required for laboratory test information to satisfy clinical needs. In 2014 the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) considered timely to update the topic of APS by organizing a conference in Milan in which some strategic concepts were proposed. Here I summarize the essential points representing the EFLM Strategic Conference heritage and discuss the approaches that will permit us to become more concrete, including roles and main actions expected from each of involved stakeholders for contributing a quantum leap forward in the way of practicality of Milan consensus about APS. [ABSTRACT FROM AUTHOR]

To be accurate and equivalent among assays, laboratory results should be traceable to higher-order references and their quality should fulfill maximum allowable measurement uncertainty (MU) as defined to fit the intended clinical use. Accordingly, laboratory professionals should estimate and validate MU of performed tests using appropriate analytical performance specifications (APS). Current consensus supports the derivation of APS by using one of the three models established by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Strategic Conference held in Milan in 2014. It is recognized that some models are better suited for certain measurands than for others and the attention should be primarily directed towards their biological and clinical characteristics. Among others, model 3 should reflect the state of the art of the measurements that can be defined as the best analytical performance that is technically achievable. Taking serum C-reactive protein and ferritin as examples, here we describe the theoretical premises and the experimental protocol to be used to derive APS for MU when a measurand is allocated to this model. Although the model lacks a direct relationship with clinical outcomes, useful information about the in vitro diagnostic medical device performance and the average quality of provided results may be obtained. [ABSTRACT FROM AUTHOR]

Urban heat island (UHI) mitigation and adaptation are urgent needs in a built environment, which requires us to search for sustainable solutions to limit the urban heat island effect and improve the energy efficiency of building envelopes. Among these solutions, vertical green structures (VGSs) have recently attracted significant attention for their potential to mitigate adverse effects, especially in densely built areas. This study presents a comprehensive data analysis of the microclimate of a living wall in Milan, Italy. Our aim was to evaluate this VGS's performance in mitigating temperature increases caused by the UHI effect. In the literature, similar studies are limited to shorter monitoring periods (mostly in cooling seasons) and specific orientations (mostly facing south). However, the VGS presented in this case study here faces northwest and was continuously monitored for one calendar year. During this continuous in situ monitoring campaign, air temperature data from sensors either embedded in vegetation or exposed on a bare wall were collected and analysed over a whole calendar year, which is a novelty compared to the existing literature focused on VGSs due to the long duration. The findings indicate that the studied VGS has the ability to influence the outdoor microclimate depending on the season, the precipitation events, the wall exposure, the type of vegetation, and the vegetation's phenological attributes. The analysis showed that the VGS consistently maintained cooler temperatures than the bare wall, with mean temperature differences ranging from 2.8 °C in autumn to 0.8 °C in spring through the winter. The vegetation acted as a natural insulator by reducing the air temperature during the hot summer and in early autumn, corresponding to the growing period of the vegetation. Thus, VGSs show potential to mitigate the global warming effect. These findings provide valuable insights on vegetation's capability to act as a thermal regulator for sustainable urban planning and energy-efficient building design and retrofitting. [ABSTRACT FROM AUTHOR]

Using the dispersive method we perform a two-loop analysis of the leading non-perturbative power correction to the change in jet transverse momentum pT, in the small R limit of a Cambridge-Aachen jet clustering algorithm. We frame the calculation in such a way so as to maintain connection with the universal "Milan factor" that corrects for the naive inclusive treatment of the leading hadronization corrections. We derive an enhancement factor that differs from the universal Milan factor computed for event-shape variables as well as the corresponding enhancement factor previously derived for the kt algorithm. Our calculation directly exploits the soft and triple-collinear limit of the QCD matrix element and phase space, which is relevant for capturing the coefficient of the leading 1/R power correction. As an additional check on our approach, we also independently confirm the known result for the kt algorithm. [ABSTRACT FROM AUTHOR]

This research has investigated Italian consumers' preferences for and purchasing behaviors of strawberries utilizing the Best–Worst Scaling methodology (BWS). This approach enables the key factors that influence strawberry purchasing decisions to be identified and different choice groups to be characterized. To achieve this goal, a survey was conducted on a sample of 496 respondents living in the metropolitan area of Milan (North Italy). The declared preferences of the individuals for 12 strawberry characteristics, divided into intrinsic, extrinsic, and credence attributes, were first measured. A Latent Class Analysis (LCA) was then performed to identify different clusters of consumers according to the individuals' preferences. Subsequently, the heterogeneity of the clusters was tested, using the Chi-square test, and sociodemographic characteristics and purchasing habits were considered. The results suggest that the most important attribute in the choice of strawberries was appearance, highlighting the importance of preserving it throughout the supply chain, followed by one of the increasingly important aspects of diets, which is health benefits. The attribute considered the least important was the brand. This study demonstrates, from a holistic point of view, that sociodemographic characteristics, food habits, and perceptions of different strawberry attributes influence consumers' preferences and behaviors. Practical implications suggest a new prospective for communication marketing strategies for producers, creating a better brand identity and highlighting in their marketing all of the aspects that consumers would like to know about the fruits they choose as quality certifications. [ABSTRACT FROM AUTHOR]

Introduction: Recent studies have highlighted the prognostic value of easily accessible inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for predicting severe outcomes in patients affected by Coronavirus disease 2019 (COVID-19). Our study validates NLR and PLR cut-off values from a prior cohort at IRCCS Policlinico San Matteo (OSM) of Pavia, Italy, across two new cohorts from different hospitals. This aims to enhance the generalizability of these prognostic indicators. Methods: In this retrospective cohort study, conducted at Milan's Ospedale Luigi Sacco (OLS) and IRCCS Ospedale Maggiore Policlinico (OMP) hospitals, we assess the predictive capacity of NLR and PLR for three main outcomes—non-invasive ventilation (NIV) or continuous positive airway pressure (CPAP) usage, invasive ventilation (IV), and death—in patients with COVID-19 at admission. For each outcome, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were computed separately for male and female cohorts. Distinct NLR and PLR cut-off values were used for men (7.00, 7.29, 7.00 for NLR; 239.22, 248.00, 250.39 for PLR) and women (6.36, 7.00, 6.28 for NLR; 233.00, 246.45, 241.54 for PLR), retrieved from the first cohort at OSM. Results: A total of 3599 patients were included in our study, 1842 from OLS and 1757 from OMP. OLS and OMP sensitivity values for both NLR and PLR (NLR: 24–67%, PLR: 40–64%) were inferior to specificity values (NLR: 64–76%, PLR: 55–72%). Additionally, PPVs generally remained lower (< 63%), while NPVs consistently surpassed 68% for PLR and 72% for NLR. Finally, both PLR and NLR exhibited consistently higher NPVs for more severe outcomes (> 82%) compared to NPVs for CPAP/NIV. Conclusions: Consistent findings across diverse patient populations validate the reliability and applicability of NLR and PLR cut-off values. High NPVs emphasize their role in identifying individuals less likely to experience severe outcomes. These markers not only aid in risk stratification but also guide resource allocation in emergencies or limited-resource situations. [ABSTRACT FROM AUTHOR]

Background: The current literature lacks studies which evaluate the failure of short stems in total hip arthroplasty (THA). Therefore, the present clinical investigation reported our experience with the failure of short stems in THA, evaluating the causes of failure, survivorship, and the clinical outcomes of revision arthroplasty. Methods: The present study was performed according to the STROBE guidelines. This study was conducted at the Department of Orthopaedic Surgery of the Humanitas Clinical Institute, Milan, Italy, between 2017 and 2022. All patients who underwent revision surgery of a previously implanted THA using a short stem were prospectively included in the present study. Surgeries were performed with patients in lateral position, using a minimally invasive posterolateral approach. The outcomes of interest were to report information on the type and survivorship of implants used for the revision surgery and evaluate the clinical outcomes and the rate of complications. The following patient-reported outcome measures (PROMs) used for the clinical assessment were the Western Ontario McMaster Osteo-Arthritis Index (WOMAC) and related subscales of pain, stiffness, and function, and the visual analogue scale (VAS). Results: Data from 45 patients were retrieved. Of them, 31% (14 of 45 patients) were women. The mean age was 63.7 ± 13.9 years. The mean length of the implant survivorship was 6.2 ± 5.7 years. In total, 58% (26 of 45 patients) underwent revision of all components, 36% (16 of 45 patients) revised only the stem, and 1% (3 of 45 patients) received a two-stage revision. The mean length of the follow-up was 4.4 ± 1.5 years. The cup was revised in 58% (26 of 45) of patients. At 4.4 ± 1.5 years of follow-up, the WOMAC score was 3.5 ± 1.3 and the VAS was 1.2 ± 1.3. In total, 9% (4 of 45) of patients experienced minor complications. One patient used a walking aid because of reduced function. One patient evidenced muscular hypotrophy. Two patients experienced hip dislocations. All two dislocations were managed conservatively with repositioning in the emergency room under fluoroscopy. No patient needed additional revision surgery or experienced further dislocations. Conclusions: Revision surgery is effective and safe when a short stem THA fails. At approximately four years of follow-up, all patients were highly satisfied with their clinical outcomes. Despite the relatively high number (9%), complications were of a minor entity and were successfully managed conservatively. [ABSTRACT FROM AUTHOR]

The most frequent cause of periprosthetic infections (PJIs) is intraoperative contamination; hence, antibiotic prophylaxis plays a crucial role in prevention. Modifications to standard prophylaxis can be considered if there is a high incidence of microorganisms resistant to current protocols. To date, very few studies regarding microbial etiology have been published in Italy. In this single-center, retrospective study conducted at IRCCS Ospedale Galeazzi-Sant'Ambrogio in Milan, we analyzed hip, knee, and shoulder PJIs in patients undergoing first implantation between 1 January 17 and 31 December 2021. The primary aim was to derive a local microbiological case history. The secondary aim was to evaluate the adequacy of preoperative antibiotic prophylaxis in relation to the identified bacteria. A total of 57 PJIs and 65 pathogens were identified: 16 S. aureus, 15 S. epidermidis, and 10 other coagulase-negative staphylococci (CoNS), which accounted for 63% of the isolations. A total of 86.7% of S. epidermidis were methicillin-resistant (MRSE). In line with other case reports, we found a predominance of staphylococcal infections, with a lower percentage of MRSA than the Italian average, while we found a high percentage of MRSE. We estimated that 44.6% of the bacteria isolated were resistant to cefazolin, our standard prophylaxis. These PJIs could be prevented by using glycopeptide alone or in combination with cefazolin, but the literature reports conflicting results regarding the adequacy of such prophylaxis. In conclusion, our study showed that in our local hospital, our standard antibiotic prophylaxis is ineffective for almost half of the cases, highlighting the importance of defining specific antibiotic guidelines based on the local bacterial prevalence of each institution. [ABSTRACT FROM AUTHOR]

Simple Summary: In this study, we studied the potential health benefits of probiotic supplements in individuals with chronic diarrhea. Dysbiosis, resulting from factors like poor diet or stress, can lead to various systemic diseases. Probiotics are known for stabilizing gut microbiota and alleviating gastrointestinal issues, such as irritable bowel syndrome (IBS). We focused on the tryptophan pathway's role in regulating serotonin levels and its impact on host physiology and behavior. Nanovesicles isolated from subjects' plasma before and after 60 days of probiotics consumption showed enhanced levels of Tryptophan 2,3-dioxygenase 2 (TDO 2), suggesting a potential role in the gut–brain axis. In vitro experiments demonstrated the probiotics' cytoprotective effect against H2O2-induced stress, reducing heat shock protein 60 kDa levels and preserving intestinal integrity. Moreover, the probiotics increased TDO 2 and serotonin receptor expression. These results provide evidence for the role of nanovesicles in mediating the gut–brain axis and offer insights into potential therapeutic avenues for neurological disorders. Background: Dysbiosis, influenced by poor diet or stress, is associated with various systemic diseases. Probiotic supplements are recognized for stabilizing gut microbiota and alleviating gastrointestinal issues, like irritable bowel syndrome (IBS). This study focused on the tryptophan pathways, which are important for the regulation of serotonin levels, and on host physiology and behavior regulation. Methods: Nanovesicles were isolated from the plasma of subjects with chronic diarrhea, both before and after 60 days of consuming a probiotic mix (Acronelle®, Bromatech S.r.l., Milan, Italy). These nanovesicles were assessed for the presence of Tryptophan 2,3-dioxygenase 2 (TDO 2). Furthermore, the probiotics mix, in combination with H2O2, was used to treat HT29 cells to explore its cytoprotective and anti-stress effect. Results: In vivo, levels of TDO 2 in nanovesicles were enhanced in the blood after probiotic treatment, suggesting a role in the gut–brain axis. In the in vitro model, a typical H2O2-induced stress effect occurred, which the probiotics mix was able to recover, showing a cytoprotective effect. The probiotics mix treatment significantly reduced the heat shock protein 60 kDa levels and was able to preserve intestinal integrity and barrier function by restoring the expression and redistribution of tight junction proteins. Moreover, the probiotics mix increased the expression of TDO 2 and serotonin receptors. Conclusions: This study provides evidence for the gut–brain axis mediation by nanovesicles, influencing central nervous system function. [ABSTRACT FROM AUTHOR]

In recent years remote working (RW) arrangements have increased in many countries, mainly because of the COVID-19 pandemic, which has also intensified the need for humans to live closer to nature. Within this context, the paper aims to discuss three possible future scenarios for the spread of RW by 2050, and how this could affect residential choices, people's relationship with the natural environment, and thus the renewed role of large cities, small towns, and areas close to nature. A specific focus is placed on the city of Milan in northwest Italy. To give empirical foundations to our scenarios, we analyzed data for the year 2021. The first scenario we consider (the Gentrified City) implies the risk that Milan will become a gentrified city, thus pushing social and economic inequality. However, on the contrary, our data suggest that in Italy a potential pool of workers would leave the city and move to a small town or closer to nature if allowed to work remotely. This trend could lead to the second scenario (the Doughnut City), but data for Milan show that the share of those willing to leave Milan is lower than the national average, which can be explained by the good quality of offered services; thus, the city center is unlikely to empty due to RW. The desirable option would be represented by the third scenario: some remote workers move to intermediary cities (the Intermediary Cities scenario), reducing territorial disparities. • We discuss possible future scenarios for the spread of remote working (RW) by 2050 in Italy. • We highlight how RW could affect residential choices and people's relationship with the natural environment. • A potential pool of remote workers in Italy would leave the city and move to a small town or closer to nature. • Based on these challenges, we provide some policy recommendations. [ABSTRACT FROM AUTHOR]

Budhathoki S, Diergaarde B, Liu G, et al. A risk prediction model for head and neck cancers incorporating lifestyle factors, HPV serology and genetic markers. Int J Cancer 2023;152(10):2069‐2080. doi:10.1002/ijc.34444In the article by Budhathoki et al, the author "Jerry Polesel" was incorrectly affiliated to affiliation 19: National Cancer Institute, IRCCS, Milan, Italy. To correct this, we have added as new affiliation (No. 26: Centro di Riferimento Oncologico di Aviano [CRO] IRCCS, Aviano, Italy). The affiliations 26 to 28 in the original paper has been renumbered as 27 to 29 to reflect this change.We apologize for this error. [Extracted from the article]

Increased temperature and fragmentation of green spaces in urban areas could drive variations in functional traits of insects. Such morphological shifts may occur for sensory systems, which were previously reported to be prone to change with habitat characteristics in non-urban contexts. Here, we measured traits related to the visual and antennal sensory systems in the bees Halictus scabiosae and Osmia cornuta and the wasp Polistes dominula along an urbanisation gradient within Milan (Italy). We hypothesised that fragmentation could filter for better visual properties, and that higher temperature could filter for fewer thermoreceptors and more olfactory hairs. While controlling for body size, results show subtle but appreciable responses to urbanisation in one or more traits in all species, though not always supporting our hypotheses. O. cornuta shows marginally higher ommatidia density and smaller ommatidia diameter (associated with better visual resolution) in more fragmented sites, as well as marginally fewer thermoreceptors in hotter sites, in agreement with our two predictions. On the other hand, H. scabiosae has marginally smaller antennae and P. dominula has smaller eyes at warmer locations, and the wasp also has smaller antennae and 9th flagellomeres in more fragmented areas. Perhaps higher temperatures accelerate development of sensory system at higher speed than the rest of body in these two species. Our results represent the first evidence of urbanisation effects on the visual and antennal sensory systems of bees and wasps and underline how such effects may involve a much broader bouquet of traits then previously observed. [ABSTRACT FROM AUTHOR]

Background: Non-surgical rhinoplasty is one of the best choices in mild cases of the saddle nose, and it represents a solution for the aesthetical amelioration of facial deformity; nevertheless, in most critical cases, surgical intervention is still required. This study reports the experience and results of a single facial plastic surgeon (M.G.) using a non-surgical technique for the correction of saddle noses in a large cohort of patients. Methods: This retrospective study assesses all patients injected from January 2017 through October 2023 in private clinics in Milan (Italy), London (UK), and Dubai (UAE). All patients were followed up for 12 months. The harvested adipose tissues were processed with different systems and with or without acoustic wave therapy (AWT). The extracted products have been characterized in terms of cellular yield and cell growth. Ninety-seven patients were injected with adipose-derived products or hyaluronic acid (HA). Patients were followed up for 12 months, and satisfaction data were analyzed. Results: The stem cells obtained from the patients who previously received AWT displayed a statistically higher cell growth ability in comparison with those of the cells derived from patients who did not receive AWT. The evolution of patient satisfaction during the time for each group of treatment was investigated, and cellular treatments show the best maintenance of patient satisfaction over time. Conclusions: Dermgraft and AWT approaches resulted in the highest patient satisfaction for the non-surgical correction of the saddle nose deformity. [ABSTRACT FROM AUTHOR]

Introduction: Differential diagnosis among subjects with Primary Progressive Aphasia (PPA) can be challenging. Structural MRI can support the clinical profile. Visual rating scales are a simple and reliable tool to assess brain atrophy in the clinical setting. The aims of the study were to establish to what extent the visual rating scales could be useful in the differential diagnosis of PPA, to compare the clinical diagnostic impressions derived from routine MRI interpretations with those obtained using the visual rating scale and to correlate results of the scales in a voxel-based morphometry (VBM) analysis. Method: Patients diagnosed with primary progressive aphasia (PPA) according to current criteria from two centers—Ospedale Maggiore Policlinico of Milan and Hospital Clínic de Barcelona—were included in the study. Two blinded clinicians evaluated the subjects MRIs for cortical atrophy and white matter hyperintensities using two protocols: routine readings and the visual rating scale. The diagnostic accuracy between patients and controls and within PPA subgroups were compared between the two protocols. Results: One hundred fifty Subjects were studied. All the scales showed a good to excellent intra and inter-rater agreement. The left anterior temporal scale could differentiate between semantic PPA and all other variants. The rater impression after the protocol can increase the accuracy just for the logopenic PPA. In the VBM analysis, the scores of visual rating scales correlate with the corresponding area of brain atrophy. Conclusion: The Left anterior temporal rating scale can distinguish semantic PPA from other variants. The rater impression after structured view improved the diagnostic accuracy of logopenic PPA compared to normal readings. The unstructured view of the MRI was reliable for identifying semantic PPA and controls. Neither the structured nor the unstructured view could identify the nonfluent and undetermined variants. [ABSTRACT FROM AUTHOR]

Background and Objective: The dynamic assessment of disease activity during the follow-up of patients with Crohn's disease (CD) remains a significant challenge. In this study, we aimed to identify the role of dynamic contrast-enhanced ultrasound (DCE-US) in the evaluation of activity of CD. Methods: In the retrospective study, patients diagnosed with CD in our hospital were included. All the diagnoses were confirmed by clinical symptoms and ileocolonoscopical results. All patients underwent intestinal ultrasound and contrast-enhanced ultrasound (CEUS) examinations within 1 week of the ileocolonoscopy examinations. Acuson Sequoia (Siemens Healthineers, Mountain View, CA, USA) and Resona R9 Elite (Mindray Medical Systems, China) with curved array and Line array transducers were used. The CEUS examination was performed with SonoVue (Bracco SpA, Milan, Italy). DCE-US analysis was performed by UltraOffice (version: 0.3-2010, Mindray Medical Systems, China) software. Two regions of interest (ROIs) were set in the anterior section of the infected bowel wall and its surrounding normal bowel wall 2 cm distant from the inflamed area. Time–intensity curves (TICs) were generated and quantitative perfusion parameters were obtained after curve fittings. The Simple Endoscopic Score for Crohn's disease (SES-CD) was regarded as the reference standard to evaluate the activity of CD. The receiver operating characteristic curve (ROC) analyses were used to determine the diagnostic efficiency of DCE-US quantitative parameters. Results: From March 2023 to November 2023, 52 CD patients were included. According to SES-CD score, all patients were divided into active group with the SES-CD score > 5 (n = 39) and inactive group SES-CD score < 5 (n = 13). Most of the active CD patients showed bowel wall thickness (BWT) > 4.2 mm (97.4%, 38/39) or mesenteric fat hypertrophy (MFH) on intestinal ultrasound (US) scan (69.2%, 27/39). Color Doppler signal of the bowel wall mostly showed spotty or short striped blood flow signal in active CD patients (56.4%, 22/39). According to CEUS enhancement patterns, most active CD patients showed a complete hyperenhancement of the entire intestinal wall (61.5%, 24/39). The TICs of active CD showed an earlier enhancement, higher peak intensity, and faster decline. Among all CEUS quantitative parameters, amplitude-derived parameters peak enhancement (PE), wash-in area under the curve (WiAUC), wash-in rate (WiR), wash-in perfusion index (WiPI), and wash-out rate (WoR) were significantly higher in active CD than in inactive CD (p < 0.05). The combined AUROC of intestinal ultrasound features and DCE-US quantitative perfusion parameters in the diagnosis of active CD was 0.987, with 97.4% sensitivity, 100% specificity, and 98.1% accuracy. Conclusions: DCE-US with quantitative perfusion parameters is a potential useful noninvasive imaging method to evaluate the activity of Crohn's disease. [ABSTRACT FROM AUTHOR]

Purpose: Besides the well-established efficacy in preventing severe COVID-19, the impact of early treatments, namely antivirals and monoclonal antibodies (mAbs), on the time length to negativization of SARS-CoV-2 nasal swabs is still unclear. The aim of this study was to compare the efficacy of different early treatments in reducing the SARS-CoV-2 viral shedding, identifying a single drug that might potentially lead to a more rapid negativization of SARS-CoV-2 nasal swab. Methods: This was a single-centre, retrospective, observational study conducted at Ospedale Luigi Sacco in Milan. Data of high-risk COVID-19 patients who received early treatments between 23 December 2021 and March 2023 were extracted. The comparison across treatments was conducted using the Kruskall-Wallis test for continuous variables. Dunn's test with Bonferroni adjustment was performed for post-hoc comparisons of days to negativization. Secondly, a negative binomial regression adjusted for age, sex, number of comorbidities, immunosuppression, and SARS-CoV-2 vaccination status was implemented. Results: Data from 428 patients receiving early treatments were collected. The majority were treated with Nirmatrelvir/Ritonavir and were affected by SARS-CoV-2 Omicron infection with BA.2 sublineage. The median length time to SARS-CoV-2 nasal swab negativization was 9 days [IQR 7–13 days]. We found that Nirmatrelvir/Ritonavir determined a significant decrease of the length time to SARS-CoV-2 nasal swab negativization compared to mAbs (p = 0.003), but not compared to Remdesivir (p = 0.147) and Molnupiravir (p = 0.156). Conclusion: Our findings highlight the importance of promptly treating high-risk COVID-19 patients with Nirmatrelvir/Ritonavir, as it also contributes to achieving a faster time to negative SARS-CoV-2 nasal swabs. [ABSTRACT FROM AUTHOR]

The geopolitical conflict between Russia and Ukraine has disrupted Europe's natural gas supplies, driving up gas prices and leading to a shift towards biomass for residential heating during colder months. This study assessed the consequent air quality and toxicological impacts in Milan, Italy, focusing on fine particulate matter (PM2.5, dp < 2.5 μm) emissions. PM2.5 samples were analyzed for their chemical composition and assessed for their oxidative potential using the dithiothreitol (DTT) assay across three periods reflecting residential heating deployment (RHD): pre-RHD, intra-RHD, and post-RHD periods. During the intra-RHD period, PM2.5 levels were significantly higher than those in other periods, with concentrations reaching 57.94 ± 7.57 μg/m3, indicating a deterioration in air quality. Moreover, levoglucosan was 9.2 times higher during the intra-RHD period compared to the pre-RHD period, correlating with elevated levels of elemental carbon (EC) and polycyclic aromatic hydrocarbons (PAHs). These findings were compared with previous local studies before the conflict, underscoring a significant rise in biomass-related emissions. DTT assay levels during the intra-RHD were 2.1 times higher than those observed during the same period in 2022, strongly correlating with biomass burning emissions. Our findings highlight the necessity for policies to mitigate the indirect health effects of increased biomass burning emissions due to the energy crisis triggered by the geopolitical conflict. [ABSTRACT FROM AUTHOR]

To meet the United Nations and European Union goals of reducing road crash fatalities and injuries, it is also relevant to address the negative externalities due to mega-events on the road network and the local communities, to assess the safety of the road network involved, and to implement appropriate measures for different road environments. Despite their relevance, the literature often overlooks social costs and risks associated with mega-events. This study presents an operating framework for rapidly assessing the safety of the Milano–Cortina 2026—"Via Olimpica" road—which will host a significant proportion of the traffic during the Winter Olympic Games in 2026. The framework proposes a simplified Road Infrastructure Safety Management (RISM) to address the unique challenges posed by the limited time available for screening and implementation by local authorities. The framework integrates four data sources and follows a seven-step procedure. It provides recommendations for improving road safety by identifying critical road sections and blackspots. Road authorities, practitioners, and public administrations may all benefit from the framework, as it makes it easier to prioritise safety improvements within time constraints. [ABSTRACT FROM AUTHOR]