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Copyright of BE N'ius - Beiträge aus der Berner Justiz Contributions de la Justice Bernoise is the property of University Library of Bern and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Internationales Handelsrecht is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article explores a mural painting cycle at the Federal Polytechnic in Zurich that celebrates Switzerland's industrial accomplishments in the early 1900s. The paintings showcase various aspects of Swiss industry, such as commerce, textiles, agriculture, metalwork, and railway stations. Although these artworks were initially overlooked, they have recently gained recognition and popularity thanks to the ETH. The article also highlights the artists responsible for creating the paintings and the sponsors who generously donated them to the ETH. Overall, the text sheds light on the artwork of Swiss painters during this period, which praised the industrial achievements of Switzerland and emphasized the integration of industry into the landscape, the role of machines in the workplace, and the connection between labor and leisure. These artworks were often displayed in educational and government institutions, underscoring their educational and cultural significance. [Extracted from the article]

Copyright of Journal of Immersion & Content-Based Language Education is the property of John Benjamins Publishing Co. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nachhaltigkeitsrecht is the property of Verlag Oesterreich GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of BE N'ius - Beiträge aus der Berner Justiz Contributions de la Justice Bernoise is the property of University Library of Bern and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With an area almost 5 times smaller than that of Romania and a population of almost 9 million inhabitants, Switzerland is one of the richest and safest countries in the world. However, this stability is not seen in the legislative field, where each of the 26 cantons has its own laws and regulations. Nevertheless, there is a situation where the national law, applicable at federal level, imposes the one of the cantons to adopt a certain conduct. We will also analyze one of these situations in the following study, referring here to wills and succession pacts which, considering their importance in the civil circuit, must comply with a series of conditions in order to be considered valid. The study invites to a comparative reflection with the Romanian legislation, with the aim of analyzing, as all juristss do involuntarily, if others are better or if we can borrow something from the way the Swiss have chosen to regulate this matter. For the drafting of the study, both Swiss legal literature and the relevant legislation from the country of the cantons were used. [ABSTRACT FROM AUTHOR]

Copyright of Zeitschrift für Stiftungswesen is the property of Verlag Oesterreich GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The burden of herpes zoster (shingles) virus and associated complications, such as post-herpetic neuralgia, is higher in older adults and has a significant impact on quality of life. The incidence of herpes zoster and post-herpetic neuralgia is increased in people living with HIV (PLWH) compared to an age-matched general population, including PLWH on long-term antiretroviral therapy (ART) with no detectable viremia and normal CD4 counts. PLWH – even on effective ART may- exhibit sustained immune dysfunction, as well as defects in cells involved in the response to vaccines. In the context of herpes zoster, it is therefore important to assess the immune response to varicella zoster virus vaccination in older PLWH and to determine whether it significantly differs to that of HIV-uninfected healthy adults or younger PLWH. We aim at bridging these knowledge gaps by conducting a multicentric, international, non-randomised clinical study (SHINGR'HIV) with prospective data collection after vaccination with an adjuvant recombinant zoster vaccine (RZV) in two distinct populations: in PLWH on long-term ART (> 10 years) over 50 years of and age/gender matched controls. Methods: We will recruit participants from two large established HIV cohorts in Switzerland and in France in addition to age-/gender-matched HIV-uninfected controls. Participants will receive two doses of RZV two months apart. In depth-evaluation of the humoral, cellular, and innate immune responses and safety profile of the RZV will be performed to address the combined effect of aging and potential immune deficiencies due to chronic HIV infection. The primary study outcome will compare the geometric mean titer (GMT) of gE-specific total IgG measured 1 month after the second dose of RZV between different age groups of PLWH and between PLWH and age-/gender-matched HIV-uninfected controls. Discussion: The SHINGR'HIV trial will provide robust data on the immunogenicity and safety profile of RZV in older PLWH to support vaccination guidelines in this population. Trial registration: ClinicalTrials.gov NCT05575830. Registered on 12 October 2022. Eu Clinical Trial Register (EUCT number 2023-504482-23-00). [ABSTRACT FROM AUTHOR]

Copyright of Zeitschrift für Abgaben-, Finanz- und Steuerrecht is the property of Verlag Oesterreich GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background Advancements in access to antiretroviral therapy (ART) and human immunodeficiency virus (HIV) care have led to a decline in AIDS-related deaths among people with HIV (PWH) in Switzerland. However, data on the ongoing changes in causes of death among PWH over the past 15 years are scarce. Methods We investigated all reported deaths in the Swiss HIV Cohort Study between 2005 and 2022. Causes of death were categorized using the Coding Causes of Death in HIV protocol. The statistical analysis included demographic stratification to identify time trends and logistic regression models to determine associated factors for the underlying cause of death. Results In total, 1630 deaths were reported, with 23.7% of individuals assigned female sex at birth. These deaths included 147 (9.0%) HIV/AIDS-related deaths, 373 (22.9%) due to non-AIDS, non-hepatic cancers, 166 (10.2%) liver-related deaths, and 158 (9.7%) cardiovascular-related deaths. The median age at death (interquartile range) increased from 45.0 (40.0–53.0) years in 2005–2007 to 61.0 (56.0–69.5) years in 2020–2022. HIV/AIDS- and liver-related deaths decreased, whereas deaths from non-AIDS, non-hepatic cancers increased and cardiovascular-related deaths remained relatively stable. Conclusions The proportionally decreasing HIV/AIDS and liver-related deaths showcase the effectiveness of ART, comprehensive HIV patient care, and interventions targeting hepatitis C virus coinfection. Future research should focus on managing cancer and cardiovascular-related conditions as the new leading causes of death among PWH. Comprehensive healthcare strategies focusing on non–AIDS-related comorbid conditions, cancer management, and sustaining liver and cardiovascular health are needed to bridge the ongoing health disparities between PWH and the general population. [ABSTRACT FROM AUTHOR]

Solar has confirmed its dominance among all power generation technologies, and along with the demand for zero-emission buildings, Photovoltaics (PV) is contributing to transforming the building skin. More than 200 products for Building Integrated Photovoltaics (BIPV) are commercialized nowadays in the EU market. However, only 1–3% of all PV installations are BIPV due to the weak penetration in the construction sector. At the state of the art, the sector lacks a specific analysis from a construction technology perspective, describing the dynamics and the traits that BIPV innovation articulates on construction and architectural processes. The authors, elaborating a new model from the building technology sector to explore the relationship between PV technology and architectural innovation, aim to identify the main principles, forms, and approaches that describe the structural organization of the "integrability" concept of PV in buildings. This study applies the method to a database of 233 real buildings located in Switzerland, a unique country leading with a 10% BIPV rate on PV installations documented between the years 1997 and 2023. The novel findings of the research suggest the definition of the levels of innovation and the reference traits of the innovative process of BIPV in the Swiss construction sector, which can also be used in other practical applications and contexts. The results of the paper are expected to impact both the scientific academy and the key players from the construction sector, encouraging the adoption of an integrated research and design approach to revolutionize the energy role of building skins with PV. [ABSTRACT FROM AUTHOR]

Hail is a major threat associated with severe thunderstorms, and estimating the hail size is important for issuing warnings to the public. For the validation of existing operational, radar-derived hail estimates, ground-based observations are necessary. Automatic hail sensors, for example within the Swiss Hail Network, record the kinetic energy of hailstones to estimate the hail sizes. Due to the small size of the observational area of these sensors (0.2 m2), the full hail size distribution (HSD) cannot be retrieved. To address this issue, we apply a state-of-the-art custom trained deep learning object detection model to drone-based aerial photogrammetric data to identify hailstones and estimate the HSD. Photogrammetric data of hail on the ground were collected for one supercell thunderstorm crossing central Switzerland from southwest to northeast in the afternoon of 20 June 2021. The hail swath of this intense right-moving supercell was intercepted a few minutes after the passage at a soccer field near Entlebuch (canton of Lucerne, Switzerland) and aerial images were taken by a commercial DJI drone, equipped with a 45 -megapixel full-frame camera system. The resulting images have a ground sampling distance (GSD) of 1.5 mm per pixel, defined by the focal length of 35 mm of the camera and a flight altitude of 12 m above the ground. A 2-dimensional orthomosaic model of the survey area (750.4 m2) is created based on 116 captured images during the first drone mapping flight. Hail is then detected using a region-based convolutional neural network (Mask R-CNN). We first characterize the hail sizes based on the individual hail segmentation masks resulting from the model detections and investigate the performance using manual hail annotations by experts to generate validation and test data sets. The final HSD, composed of 18 207 hailstones, is compared with nearby automatic hail sensor observations, the operational weather-radar-based hail product MESHS (Maximum Expected Severe Hail Size) and crowdsourced hail reports. Based on the retrieved data set, a statistical assessment of sampling errors of hail sensors is carried out. Furthermore, five repetitions of the drone-based photogrammetry mission within 18.65 min facilitate investigations into the hail-melting process on the ground. [ABSTRACT FROM AUTHOR]

Background: Surgical training curricula have changed little over the past decades. Current advances in surgical techniques, especially in minimally invasive surgery, as well as the rapidly changing socioeconomic environment pose a major challenge for the training of young surgeons. The aim of this survey was to provide a representative overview of the surgical training landscape in Switzerland focusing on laparoscopic surgical training: How do department chairs of teaching hospitals deal with the above challenges, and what should a future training curriculum look like? Methods: This is a prospective, questionnaire-based, cross-sectional study among the heads of departments of all certified surgical teaching hospitals in Switzerland. Results: The overall response rate was 56% (48/86) and 86% (19/22) for tertiary centers. Two-thirds of the centers (32) organize themselves in training networks. Laparoscopic training courses are offered in 25 (52%) hospitals, mainly in tertiary centers. Self-training opportunities exist in 40 (83%) hospitals. In addition to commercial (27) and self-built (7) box trainers, high-fidelity trainers are available in 16 (33%) hospitals. A mandatory training curriculum exists in 7 (15%) facilities, and a training assessment is performed in 15 (31%) institutions. Thirty-two (65%) heads of departments indicated that residents have sufficient practical exposure in the operating room, but the ability to work independently with obtaining the specialist title is seen critically (71%). They state that the surgical catalog does not adequately reflect the manual skills of the resident (64%). The desire is for training to be restructured from a numbers-based to a performance-based curriculum (53%) and for tools to assess residents' manual skills (56%) to be introduced. Conclusions: Department chairs stated that the existing curriculum in Switzerland does not meet the requirements of a modern training curriculum. This study highlights the need to create an improved, competency-based curriculum that ensures the training of a new generation of surgeons, taking into account the growing evidence of the effectiveness of state-of-the-art training modalities such as simulation or proficiency-based training. [ABSTRACT FROM AUTHOR]

Heart Diseases have the highest mortality worldwide, necessitating precise predictive models for early risk assessment. Much existing research has focused on improving model accuracy with single datasets, often neglecting the need for comprehensive evaluation metrics and utilization of different datasets in the same domain (heart disease). This research introduces a heart disease risk prediction approach by harnessing the whale optimization algorithm (WOA) for feature selection and implementing a comprehensive evaluation framework. The study leverages five distinct datasets, including the combined dataset comprising the Cleveland, Long Beach VA, Switzerland, and Hungarian heart disease datasets. The others are the Z-AlizadehSani, Framingham, South African, and Cleveland heart datasets. The WOA-guided feature selection identifies optimal features, subsequently integrated into ten classification models. Comprehensive model evaluation reveals significant improvements across critical performance metrics, including accuracy, precision, recall, F1 score, and the area under the receiver operating characteristic curve. These enhancements consistently outperform state-of-the-art methods using the same dataset, validating the effectiveness of our methodology. The comprehensive evaluation framework provides a robust assessment of the model's adaptability, underscoring the WOA's effectiveness in identifying optimal features in multiple datasets in the same domain. [ABSTRACT FROM AUTHOR]

Background: A substantial fraction of dizzy patients are assessed by neurologists and ear--nose--throat (ENT) physicians. With the differential diagnosis being broad and often different specialties involved, we aimed to assess the interaction with generalists from the specialists' perspective to identify limitations and needs and to define strategies for improvement in patient care and education by the specialist. Methods: One hundred eleven board-certified neurologists (n = 62) and ENT physicians (n = 49) working in Switzerland participated in an online survey. Here, we focused on limitations faced in the diagnostic workup and treatment of the dizzy patient and potential strategies to improve the standard of care and the interaction between generalists and specialists. Descriptive statistical analyses were performed. We hypothesized that those specialists applying modern concepts in history-taking and bedside examination techniques reach a specific diagnosis more often and request fewer referrals. Results: Specialists indicated higher confidence in reaching a specific diagnosis for patients presenting with acute dizziness than episodic/chronic dizziness (80% vs. 60%) at the first consultation. Knowledge of the timing-and-trigger concept [odds ratio (OR) = 0.81 (0.67-0.98), p = 0.034], as well as of subtle oculomotor/ vestibular signs [OR = 0.80 (0.68-0.94), p = 0.007] was predictive of the selfreported probability of reaching a specific diagnosis in patients with episodic/chronic dizziness, while no such differences were observed in the care of acutely dizzy patients. Further referrals of acutely dizzy patients were significantly higher in neurologists than in ENT physicians (17% vs. 10%, p < 0.001) and in specialists located in the Latin part of Switzerland [OR = 2.84 (1.63-4.93), p < 0.001], while this was not the case for patients with episodic/chronic dizziness. Identified unmet needs included regular communication between physicians (27%/53%; always/often true) and sufficiently detailed information on the previous workup from the referrals (27%/53%). Specialists expressed most interest in hands-on courses/workshops, webinars, and practical guidelines for education. Conclusion: In our survey, bedside state-of-the-art assessments were key in reducing the fraction of unclear dizzy cases. Several gaps were identified that should be addressed. Specifically, referring physicians should provide more comprehensive details regarding urgency, prior diagnostics, and treatment. Specifically, when promoting the knowledge of neurologists and ENT physicians, this should be preferentially done by offering a combination of hands-on courses and webinars. [ABSTRACT FROM AUTHOR]

Copyright of Perspektive Mediation is the property of Verlag Oesterreich GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Informationswissenschaft: Theorie, Methode & Praxis / Sciences de l’information: Théorie, Méthode & Pratique is the property of University Library of Bern and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Praxis (16618157) is the property of Aerzteverlag medinfo AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Switzerland is an ichthyosaur country: it has a rich record of marine reptile fossils, particularly the fish-shaped ichthyosaurs, and the according research. Here, we provide an overview over the 12 or more genera and at least 13 species plus numerous fragmentary remains of ichthyosaurs from the Triassic to the Cretaceous that have been discovered in twelve cantons thus far, of which four species are based on Swiss holotypes. This wealth of ichthyosaur species can be explained by their abundance in the Middle Triassic conservation deposits (Konservat Lagerstätte) of Monte San Giorgio, as well as occasional discoveries in strata of Middle Triassic to Early Cretaceous age. The moderate abundance of outcrops in reasonable conditions in combination with the long history of palaeontological research in Switzerland explains this good fossil record. In addition to this unique overview, we provide more data for further studies and update the knowledge of these taxa. [ABSTRACT FROM AUTHOR]

The global transition to decentralized energy systems signifies a fundamental transformation toward sustainable energy paradigms. This study specifically focuses on the Swiss energy system, analyzing how dynamic pricing influences the strategic decisions of different actors. The main contributions include 1) a detailed examination of pricing models tailored to the Swiss context, 2) an exploration of strategic financial burden shifts among end-users, TSOs, and DSOs, and 3) a comparison of decentralized versus centralized energy models, highlighting their respective efficiencies and resilience. This research differentiates from existing literature by providing an in-depth actor-based analysis within a Swiss context, offering valuable insights into decentralized energy system optimization. This study tackles the problem of how pricing influences strategic decisions across different actors in Switzerland's evolving decentralized energy landscape. Here we show that a carefully tailored pricing model, designed for the Swiss context, enables optimized strategies that balance local efficiencies with systemic equity and resilience. The analysis reveals that decentralized approaches, in contrast to centralized models, not only accommodate diverse stakeholder preferences but also enhance system robustness against market and operational disruptions. Moreover, the study illustrates the strategic financial burden shifting where end-users compensate for cost shifts, with observed additional costs up to 5200 CHF/year cap when service providers are prioritized as objective actors. Notably, the most frequently selected system configuration in the primal problem, which optimizes the total system costs, aligns with the preferences of TSO and DSO for a 47.1 GW PV deployment. However, end-users demonstrate a preference for increased PV installations, constrained by urban grid capacities. Additionally, the study highlights significant regional disparities across Switzerland, necessitating tailored pricing approaches that reflect varied urban forms. The emergence of prosumers catalyzes new business models, redistributing investments across TSOs (256-261 CHF/cap/year), DSOs (244-413 CHF/cap/year), and prosumers (556-764 CHF/cap/year), showcasing the evolving dynamics of energy system economics. [ABSTRACT FROM AUTHOR]

Objectives: To identify official sources that routinely collect data on functioning in Switzerland, to provide an overview of the existing data and its comparability, and to assess the extent to which the data is suitable for developing a functioning metric and indicator. Methods: Data sources were identified through an iterative search. Standardized rules were applied to map the functioning information assessed by the sources using a current WHO functioning and disability survey as a reference framework for the content comparison. Results: Four sources were identified: the Swiss Survey of Health, Ageing and Retirement in Europe (SHARE), the Swiss Health Survey (SHS), the Lausanne cohort 65+ (Lc65+), and the Swiss Household Panel (SHP). All tools addressed sleep functions, energy level, emotional functions, and sensation of pain. Additionally, nine functioning categories were common across three sources. Conclusion: Population data sources in Switzerland routinely collect comparable functioning data, which can serve as the basis for creating a functioning indicator. Among others, this indicator is relevant to complement mortality and morbidity data and to support both the estimation of rehabilitation and long-term care needs. [ABSTRACT FROM AUTHOR]

The judiciary is a foundation of democracy, upholding the rule of law and protecting rights. Efficient court administration is vital for public trust, justice, and timely proceedings. Currently, courts face challenges such as inconsistencies, adjournments, and absence of transparency, undermining the justice system. Traditional manual processes and paper-based documentation cause significant backlogs, slow resolutions, and limited public access. As case volumes and complexities rise, modernizing court administration through digital transformation is progressively critical. Currently, many countries are integrating technologies in the courts for its administration and other activities. In recent years, courts and judges have been subjected to pressure to improve performance, uplifting judicial effectiveness to a top priority. Subsequently, several countries have integrated simplification and digitization strategies in judicial initiatives to enhance court efficiency. Switzerland's Justitia 4.0 and Brazil's PJE are notable initiatives that focused to strengthen court administration through digitalization. These aspects motivated this study to examine the detailed integration of industry 4.0 technologies such as the Internet of things, cloud computing, blockchain, big data analytics, robotics, drones, Metaverse, digital twins, and artificial intelligence for court administration with digitalized infrastructure. According to the study, integrating these technologies in less complex cases helps minimize expenditures and save time, making to resolve cases conveniently, efficiently, and superiorly. The study also identified the challenges and issues associated with industry 4.0 technologies such as evidence gathering, evidence preservation, robot judges for pre-judgment analysis, and judgment delivery, which future studies need to be explored. [ABSTRACT FROM AUTHOR]

Background: The ethnobotanical analysis of two bordering areas allows for the in-depth understanding of the dynamics of Local Ecological Knowledge, which mirrors the naturalistic, historical, and sociopolitical features of each area. As part of the Interreg Italy-Switzerland B-ICE&Heritage and GEMME projects, this work is an ethnobotanical comparative study of two neighboring Alpine territories: Valmalenco (Italy) and Valposchiavo (Switzerland). Methods: A total of 471 informants were interviewed on different fields of use (medicinal, food, veterinary, etc.). All data were organized in Excel™ spreadsheets. Informant Consensus Factor was calculated for the pathologies reported. Jaccard's similarity indices were calculated to compare the Valmalenco and Valposchiavo areas. Subsequently, another comparison between Valmalenco/Valposchiavo and Italian/Swiss Alpine neighboring areas was carried out. Results: The number of taxa for Valmalenco was 227 (77 families) and 226 in Valposchiavo (65). Out of the 10 most cited species, 7 were mentioned in both. Arnica montana L. was the most cited in Valmalenco, and Sambucus nigra L. in Valposchiavo. The 5 most cited families were the same. Regarding the medicinal and food fields, the similarity indices were fairly low (0.31 and 0.34 for the species; 0.22 and 0.31 for the uses). Concerning the comparison with Italian and Swiss Alps, similarity values were slightly higher with Italy (Valmalenco food species: 0.38 with Italy and 0.26 with Switzerland, medicinal: 0.26 IT and 0.14 SW; Valposchiavo food species: 0.36 with IT and 0.26 with SW, medicinal: 0.21 IT and 0.14 SW). Conclusion: Although Valmalenco and Valposchiavo partly share natural environment, language, history, and culture, they had low similarity indices. They both seemed to have more similarities with Italy than Switzerland, maintaining low values with the surrounding territories too. They showed a common core of Local Ecological Knowledge with several divergent branches possibly due to pivotal historical happenings, as well as more modern external influences. [ABSTRACT FROM AUTHOR]

A method directly using rainfall records to predict a slope's potential instability is devised. The method consists of three sequential steps: identifying the critical suction stress (pore water pressure when soil is saturated) profile of a given slope, developing a rainfall intensity–duration threshold curve for the slope, and using rainfall record to determine if the threshold is reached (failure occurs) or not (no failure). It innovatively uses a slope's strength parameters and slope angle to develop the critical suction stress (tensile) or compressive pore water pressure profile where, at each depth within the slope, the effective stress reaches the failure state. Hydromechanical numerical modeling is then conducted under various rainfall intensities to identify their corresponding duration for slope failure, thus, the rainfall intensity–duration threshold curve of the slope. Two previously well-documented and studied rainfall-induced slope instability cases; one near the town of Edmonds, Washington State, and the other near the village of Rüdlingen in northern Switzerland are used to validate the method. Excellent predictions of the slope failure depth and timing are demonstrated, indicating the effectiveness of the proposed method. Because the suction stress–based rainfall intensity–duration curve is characteristic of a given slope and it can be determined a priori, the method provides a practical way to conduct real-time rainfall monitoring and predict instability for a specific slope, and a pathway to forecast instability of natural slopes in a region. [ABSTRACT FROM AUTHOR]

Religious adult education, characterized as non-formal religious education (RE) that has often been established over many decades, is frequently marked by patterns of institutional separation, local conditions and denominational divisions. This is also the case in Switzerland, where in each canton various church academies and RE organizations generally offer their respective programs along both denominational and cantonal lines. The increasing digitalization of society, and consequently of education, alters the original situation for these actors, both on an individual and organizational level. This article discusses the challenges of religious adult education in navigating the post-digital pivot. It addresses the issues of changing forms of teaching and learning, dealing with shifts in authority, and the growing need for collaboration and shared strategies among RE organizations in post-digital society. A participatory research project involving nearly 60 Swiss RE organizations investigated how these organizations are dealing with digitalization, analyzing the perspectives of the organizational leaders, the teachers, and learners through mixed methods. The findings provide insights into factors influencing the intent to offer or use digital RE courses, as well as factors contributing to the readiness to cooperate in the digital educational field. [ABSTRACT FROM AUTHOR]

This study presents the structural damage classification of a large-scale bridge, considering several damage scenarios using One dimensional convolutional neural network (1D-CNN). Measurements obtained from the Z24 bridge in Switzerland during the short-term progressive damage tests are used for this study. Acceleration responses at 291 sensor locations are measured under forced and ambient excitations. This study considers only the measurements under ambient excitations, which has the advantage over forced excitation of not required to measure the excitations. Furthermore, to reduce the overall cost of monitoring the structure, this study aims to use fewer sensor measurements. Out of 291 sensors, only three measurements are used in this study. Each measurement contains 65,536 samples collected at a sampling frequency of 100 Hz. The measurements from three sensors are processed into shorter lengths of 150 data points, each with a 50% overlap. The processed data are inputted to the proposed 1D-CNN model. The proposed 1D-CNN consists of two 1D-CNN networks with different kernel sizes to perform better with different abstract features. The flattened outputs from these two networks using the same input are concatenated and fed into a fully connected dense network for damage classification. The labelled outputs are the different damage scenarios introduced in the progressive damage tests. The performance of the proposed approach is measured in terms of accuracy supported by a confusion matrix. The performance is measured for three cases. The result indicates that better performance is obtained compared to a previous study with the fused features as input to the deep learning models, although fewer sensors are used. Practical Applications: The findings from this study demonstrated that a good damage classification could be achieved using fewer sensor measurements from a large-scale bridge. The Z24 bridge benchmark data are used as an example in this study. Several damage scenarios were considered during the progressive damage test, and all tests were performed under ambient and forced excitation conditions. A multi-headed, one-dimensional convolutional neural network is proposed to classify the damages using the ambient condition data set. The performance is compared with an existing study using the same data set, but the data pre-processing techniques and model are improved. Three cases are defined by varying the size and length of the available time-series data. The proposed model has obtained better damage classification results for all the cases than an existing study. The advantage of the study is that the damage classification is performed using data obtained from a real large-scale structure under ambient conditions, eliminating the need for external force excitation. The proposed method could also be used for condition monitoring and safety evaluation of aerospace and mechanical structures. [ABSTRACT FROM AUTHOR]

Introduction: Bovine paratuberculosis (PTB) is a chronic enteric disease caused by Mycobacterium avium subsp. paratuberculosis (MAP). Control of PTB is important given its negative economic consequences and the potential zoonotic role of MAP in Crohn's disease in humans. Methods: To determine the seroprevalence of MAP in Swiss dairy herds and to identify risk factors associated with seropositive herd status and high within-herd seroprevalence, 10,063 serum samples collected from cattle over 12 months of age in 171 Swiss dairy farms were analyzed using a commercial ELISA test. Eight herds were excluded due to non-interpretable ELISA results. Risk factors associated with seropositive herd status and high within-herd seroprevalence were investigated with regression models using results from a questionnaire on management practices possibly associated with the introduction or spread of MAP in the remaining 163 herds. Univariable logistic regression was performed, carrying forward for multivariable regression analysis when p < 0.2. Results: The calculated between-herd true seroprevalence was 3.6% (95% CI, 0.96-8.4%). Due to the low within-herd seroprevalence, it was not possible to calculate the true seroprevalence at animal level; the apparent within-herd seroprevalence ranged from 2.3 to 5.5% with a median of 3.6% in nine positive farms. Herd size (p = 0.037) and the common grazing of lactating cows with cows from other herds (p = 0.014) were associated with seropositive herd status, while heifers sharing alpine pasture with dairy cattle from other herds were associated with a decreased probability of the herd to test seropositive (p = 0.042). Reliable identification of significant risk factors associated with MAP spread and high seroprevalence of PTB within seropositive herds was not possible due to low observed seroprevalence within herds and low sensitivity of the ELISA test. Discussion: These results highlight the limitation of serology for MAP diagnosis in small herds with low infection prevalence. [ABSTRACT FROM AUTHOR]

Digital Elevation Models (DEMs) are a necessity for modelling many large-scale environmental processes. In this study, we investigate the potential of data from two spaceborne lidar altimetry missions, ICESat-2 and GEDI—with respect to their vertical accuracies and planimetric data collection patterns—as sources for rasterisation towards creating global DEMs. We validate the terrain measurements of both missions against airborne lidar datasets over three areas in the Netherlands, Switzerland, and New Zealand and differentiate them using land-cover classes. For our experiments, we use five years of ICESat-2 ATL03 data and four years of GEDI L2A data for a total of 252 million measurements. The datasets are filtered using parameter flags provided by the higher-level products ICESat-2 ATL08 and GEDI L3A. For all areas and land-cover classes combined, ICESat-2 achieves a bias of −0.11 m, an MAE of 0.43 m, and an RMSE of 0.93 m. From our experiments, we find that GEDI is less accurate, with a bias of 0.09 m, an MAE of 0.98 m, and an RMSE of 2.96 m. Measurements in open land-cover classes, such as "Cropland" and "Grassland", result in the best accuracy for both missions. We also find that the slope of the terrain has a major influence on vertical accuracy, more so for GEDI than ICESat-2 because of its larger horizontal geolocation error. In contrast, we find little effect of either beam power or background solar radiation, nor do we find noticeable seasonal effects on accuracy. Furthermore, we investigate the spatial coverage of ICESat-2 and GEDI by deriving a DEM at different horizontal resolutions and latitudes. GEDI has higher spatial coverage than ICESat-2 at lower latitudes due to its beam pattern and lower inclination angle, and a derived DEM can achieve a resolution of 500 m. ICESat-2 only reaches a DEM resolution of 700 m at the equator, but it increases to almost 200 m at higher latitudes. When combined, a 500 m resolution lidar-based DEM can be achieved globally. Our results indicate that both ICESat-2 and GEDI enable accurate terrain measurements anywhere in the world. Especially in data-poor areas—such as the tropics—this has potential for new applications and insights. [ABSTRACT FROM AUTHOR]

Background: An array of evidence shows how the presence of implicit bias in clinical encounters can negatively impact provider-patient communication, quality of care and ultimately contribute to health inequities. Reflexive practice has been explored as an approach to identify and address implicit bias in healthcare providers, including medical students. At the Lausanne School of Medicine, a clinically integrated module was introduced in 2019 to raise students' awareness of gender bias in medical practice using a reflexivity and positionality approach. The purpose of this study is to describe the gender bias that were identified by medical students, analysing their types, places and modes of emergence during a clinical encounter. It further explores how positionality supported students' reflection on the way in which social position modulates their relationship to patients. Methods: As part of the teaching activity, medical students individually reflected on gender bias in a specific clinical encounter by answering questions in their electronic portfolio. The questionnaire included a section on positionality. We qualitatively analysed the students' assignments (n=76), applying a thematic analysis framework. Results: Medical students identified and described gender biases occurring at different moments of the clinical encounter (anamnesis (i.e. patient history), physical exam, differential diagnosis, final management). They causally associated these biases with wider social phenomena such as the gendered division of labour or stereotypes around sexuality and gender. Analysing students' reflections on how their position influenced their relationship with patients, we found that the suggested exercise revealed a major contradiction in the process of medical enculturation: the injunction to be neutral and objective erases the social and cultural context of patients and impedes an understanding of gender bias. Conclusion: Gender biases are present in the different steps of a clinical consultation and are rooted in broader gendered social representations. We further conclude that the tension between a quest for objectivity and the reality of social encounters should be made explicit to students, because it is constitutive of medical practice. [ABSTRACT FROM AUTHOR]

The management of existing civil infrastructure is becoming more crucial as a large share of bridges is approaching their theoretical end of service duration. Structural performance monitoring aims to verify bridge safety at a given time, and it should be differentiated from structural health monitoring, which aims at detecting structural damage. Possible monitoring techniques include bridge load testing, non-destructive testing, and continuous monitoring of structural behaviour, environmental conditions, and load levels. Nonetheless, selecting the optimal combination of monitoring techniques is challenging as each method provides unique but also redundant information. This study proposes a framework to assess the value of information from multiple bridge monitoring techniques. This framework enables defining the appropriate set of monitoring techniques to ensure that the collected information will potentially correct engineering decisions regarding structural safety. A full-scale bridge in Switzerland is used for validating the framework predictions. Combining four monitoring techniques, the expected average increase of degrees of compliance of structural verification is estimated to 19%, which is consistent with the 36% obtained after performing these monitoring techniques. The methodology supports decision-makers in selecting an optimal combination of monitoring techniques for structural performance monitoring by maximizing the value of information. [ABSTRACT FROM AUTHOR]

Purpose: In public management research, the focus in the public value debate has been on public administration organizations' broader societal outcomes. Public value describes how public administrations form a vital part of the social context in which people develop and grow. However, there has not yet been an analysis of how public administration contributes to happiness in society. Design/methodology/approach: In this study, we empirically analyze the relationship between people's happiness and the public value of public administration. Our approach is based on a unique Swiss survey dataset comprising 870 individuals. Findings: We find a positive relationship between public administration's public value and happiness. We also find preliminary evidence with a moderation analysis that the relationship between a value-creating public administration sector and self-reported happiness is stronger for public administration employees. Research limitations/implications: While correlation studies cannot claim causal explanations and common method bias may additionally limit any research in social science, we took a number of measures to mitigate related problem. We tested our model in two samples and took both several procedural techniques and a survey design minimizing common method bias. Practical implications: The paper discusses implications for public sector performance measurement for public management and practitioners. Social implications: This study calls for a more positive view on the multiple functions public administration performs for society. After an era of critical voices, our study helps reclaim public administration as a positive force for society at large in times of grand challenges, such as climate crisis, demographics and digitization. Originality/value: This study has highlighted the importance between public administration's public value and happiness in Swiss public service organizations. The study also showed that an employment in the public administration contributes to the happiness of individuals and beyond to society. [ABSTRACT FROM AUTHOR]

Background: In Northwestern Switzerland, recent legislation tackles the needs of community-dwelling older adults by creating Information and Advice Centers (IACs). IACs are a new service in the community that aims to assess the needs and provide information on age-related issues to community-dwelling older adults and their families. Previous studies reported difficulties in reaching community-dwelling older adults for community-based programs. We aimed to: 1) systematically identify implementation strategies to promote the IAC among community care providers, older adults and informal caregivers; 2) monitor the delivery of these strategies by the IAC management; and 3) describe the impact of those strategies on reach of community-dwelling older adults. This study was conducted as part of the TRANS-SENIOR project. Methods: As part of the INSPIRE feasibility assessment, we conducted a pre-test post-test study between March and September 2022. The sample included 8,840 older adults aged 65 + visiting/calling or being referred to the IAC for the first time. Implementation strategies were selected using implementation mapping and organized in bundles for each group of community care providers and older adults/caregivers. Our evaluation included: estimation of fidelity to the delivery of implementation strategies and bundles by the IAC management and their coverage; referral source of older adults to the IAC; and impact of the strategies on reach of the IAC on the 65 + population living in the care region. Adaptations to the strategies were documented using the FRAME-IS. Descriptive statistics were calculated and reported. Results: Seven implementation strategies were selected and organized in bundles for each community care provider and older adults and their caregivers. The lowest fidelity score was found in implementation strategies selected for nursing homes whereas the highest score corresponded to strategies targeting older adults and caregivers. "Informational visits" was the strategy with the lowest coverage (2.5% for nursing homes and 10.5% for hospitals and specialized clinics). The main referral sources were self-referrals and referrals by caregivers, followed by nursing homes. The IAC reach among the 65 + population was 5.4%. Conclusion: We demonstrated the use of implementation mapping to select implementation strategies to reach community-dwelling older adults. The reach was low suggesting that higher fidelity to the delivery of the strategies, and reflection on the causal pathway of the implementation strategies might be needed. [ABSTRACT FROM AUTHOR]

Cosmic radiation on Earth responds to heliospheric, geomagnetic, atmospheric, and lithospheric changes. In order to use its signal for soil hydrological monitoring, the signal of thermal and epithermal neutron detectors needs to be corrected for external influencing factors. However, theories about the neutron response to soil water, air pressure, air humidity, and incoming cosmic radiation are still under debate. To challenge these theories, we isolated the neutron response from almost any terrestrial changes by operating a bare and a moderated neutron detector in a buoy on a lake in Germany from July 15 to 02 December 2014. We found that the count rate over water has been better predicted by a theory from Köhli et al. (2021, https://doi.org/10.3389/frwa.2020.544847) compared to the traditional approach from Desilets et al. (2010, https://doi.org/10.1029/2009wr008726). We further found strong linear correlation parameters to air pressure (β = 0.0077 mb−1) and air humidity (α = 0.0054 m3/g) for epithermal neutrons, while thermal neutrons responded with α = 0.0023 m3/g. Both approaches, from Rosolem et al. (2013, https://doi.org/10.1175/jhm‐d‐12‐0120.1) and from Köhli et al. (2021, https://doi.org/10.3389/frwa.2020.544847), were similarly able to remove correlations of epithermal neutrons to air humidity. Correction for incoming radiation proved to be necessary for both thermal and epithermal neutrons, for which we tested different neutron monitor stations and correction methods. Here, the approach from Zreda et al. (2012, https://doi.org/10.5194/hess‐16‐4079‐2012) worked best with the Jungfraujoch monitor in Switzerland, while the approach from McJannet and Desilets (2023, https://doi.org/10.1029/2022wr033889) was able to adequately rescale data from more remote neutron monitors. However, no approach was able to sufficiently remove the signal from a major Forbush decrease event on 13 September, to which thermal and epithermal neutrons showed a comparatively strong response. The buoy detector experiment provided a unique data set for empirical testing of traditional and new theories on Cosmic‐Ray Neutron Sensing. It could serve as a local alternative to reference data from remote neutron monitors. Plain Language Summary: Cosmic radiation near the Earth's surface is influenced by solar activity, atmospheric conditions, and changes of nearby soil moisture or snow. To better understand how cosmic‐ray neutron measurements should be corrected for meteorological effects, we operated a detector for low‐energy neutrons in a buoy on a lake in Germany for 5 months in 2014. Since the water content in the surroundings is constant, we were able to isolate the signal from almost any ground‐related disturbances. With this instrument, we challenged traditional and recent theories on the neutron response to water, air humidity, and to reference data from high‐energy neutron monitors around the world. We found that in some cases, recent theories showed superior performance over traditional approaches. We also found a stronger response of the neutrons detected by the buoy to a major solar event than was observed by traditional neutron monitors. The concept of a neutron detector on a lake could be useful as a reference station for similar land‐side detectors and help provide more reliable soil moisture products. Key Points: Neutron detectors on a buoy were deployed in the center of a lake for 5 monthsThermal and epithermal signals correlated with air pressure, air humidity, and secondary cosmic rays from neutron monitorsData was used to challenge traditional correction approaches and to serve as an alternative neutron monitor [ABSTRACT FROM AUTHOR]

The article provides an overview of the village of Helvetia in West Virginia, which was established by Swiss immigrants 150 years ago. Despite its rich Swiss heritage and the celebration of Swiss festivals, the village is currently grappling with issues such as a dwindling population, aging residents, and limited economic prospects. The article emphasizes the village's distinctive features, including its Swiss-style direct democracy and commitment to preserving traditions. Additionally, it mentions an individual who pursued studies in ethnology, psychology, and linguistics at the University of Zurich and Jerusalem, ultimately earning a PhD from the University of Zurich in 1994. [Extracted from the article]

INTRODUCTION Prior research has linked media tobacco promotion to increased tobacco use and favorable perceptions of tobacco products. Switzerland's tobacco lobby employs advertisements to sway policy decisions in its favor, yet no recent research has assessed this in detail. Our study aims to provide detailed estimates of tobacco industry (TI) advertisement costs, focusing on Philip Morris International (PMI) in Switzerland, and examine potential chronological links between TI advertisement campaigns and parliamentary discussions on tobacco bills. By spreading knowledge on this issue, we aim to support the development of future tobacco advertisement regulations. METHODS We conducted an expenditure analysis of tobacco-related press advertisements in Swiss print media published between August 2020 and August 2021, accessed through the media intelligence firm Argus Data Insights. Advertisement costs were estimated using publicly available data. We plotted expenditure sums of PMI against key parliamentary session dates featuring discussions on proposed tobacco control measures, such as tighter restrictions on advertising. RESULTS Over 12 months, 501 advertisements with tobacco-specific headlines were published in Swiss press media. Of these, 437 advertisements (87.22%) were linked to PMI. PMI accounted for 88.21% (CHF 6486969) of total advertisement expenditure. Notably, PMI advertisements coincided with key political sessions discussing tobacco legislation in parliament, with a limited presence outside these periods. CONCLUSIONS PMI advertisements were published parallel to key moments of parliamentary discussions, suggesting an attempt by TI to potentially influence discussions. Applying such an advertisement monitoring methodology helps understand the contextual conditions of public health in Switzerland. By analyzing TI advertisements in print media, we sought to highlight regulatory gaps and support the creation of stricter advertising regulations. We recommend continuing such research to strengthen tobacco control policymaking. Key public health efforts should include raising awareness of TI tactics, implementing a comprehensive ban on tobacco advertising, and strategically engaging with the media in tobacco control campaigns. [ABSTRACT FROM AUTHOR]

Copyright of Migraciones is the property of Universidad Pontificia Comillas, Instituto Universitario de Estudios sobre Migraciones and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper aims to find an answer to the questions of "whether chief executive officers (CEOs) are compensated for market risk", and "how the combined interaction of board size and CEO duality moderates this relationship" from the tenets of agency theory and managerial power theory. Even though the contracting view of agency theory posits that agents are neither to be punished nor rewarded for events that go beyond their direct control (market risk), the research findings in the corporate governance domain are contradictory. It was found that Chinese and American executives were paid for market risk, including oil prices and exchange rates, which was explained by retention risk and weaker corporate governance systems. To shed light on previous inconclusive research, this paper investigates the topic further in a new country setting, that of Switzerland, because the previous results were mostly related to Anglo-Saxon countries. Switzerland is also one of the exemplary countries for executive compensation. Furthermore, it investigates the combined (cascaded) interaction effects of the board size and CEO duality on CEO compensation and market risk from the perspective of managerial power theory, which has not been previously analyzed in the literature to date. For the direct effect, in contrast to previous findings in Anglo-Saxon countries, it has been found that CEOs were not paid for market risk in Switzerland, which confirms agency theory's contracting prediction. This finding outlines the future comparative research area in this domain. For the combined interaction effect, it has been found that board size incorporated with CEO duality is the significant cascaded moderator, and large boards with CEO duality are significantly more effective in controlling asymmetric compensation, which confirms the efficacy of large boards with CEO duality in coping with asymmetric compensation and managerial entrenchment (managerial power theory). These results have both practical and academic implications for boards of directors, Human Resources and corporate governance literature, agency theory, and managerial power theory, by providing further evidence on previous inconclusive findings on board size, CEO duality, and the role of market risk in the CEO pay structure. [ABSTRACT FROM AUTHOR]

Copyright of SEMS-Journal is the property of Schwiez Zschr Sportmed Sporttraumatologie and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The COVID-19 pandemic has challenged the provision of maternal care. The IMAgiNE EURO study investigates the Quality of Maternal and Newborn Care during the pandemic in over 20 countries, including Switzerland. Aim: This study aims to understand women's experiences of disrespect and abuse in Swiss health facilities during the COVID-19 pandemic. Methods: Data were collected via an anonymous online survey on REDCap®. Women who gave birth between March 2020 and March 2022 and answered an open-ended question in the IMAgiNE EURO questionnaire were included in the study. A qualitative thematic analysis of the women's comments was conducted using the International Confederation of Midwives' RESPECT toolkit as a framework for analysis. Findings: The data source for this study consisted of 199 comments provided by women in response to the open-ended question in the IMAgiNE EURO questionnaire. Analysis of these comments revealed clear patterns of disrespect and abuse in health facilities during the COVID-19 pandemic. These patterns include non-consensual care, with disregard for women's choices and birth preferences; undignified care, characterised by disrespectful attitudes and a lack of empathy from healthcare professionals; and feelings of abandonment and neglect, including denial of companionship during childbirth and separation from newborns. Insufficient organisational and human resources in health facilities were identified as contributing factors to disrespectful care. Empathic relationships with healthcare professionals were reported to be the cornerstone of positive experiences. Discussion: Swiss healthcare facilities showed shortcomings related to disrespect and abuse in maternal care. The pandemic context may have brought new challenges that compromised certain aspects of respectful care. The COVID-19 crisis also acted as a magnifying glass, potentially revealing and exacerbating pre-existing gaps and structural weaknesses within the healthcare system, including understaffing. Conclusions: These findings should guide advocacy efforts, urging policy makers and health facilities to allocate adequate resources to ensure respectful and high-quality maternal care during pandemics and beyond. [ABSTRACT FROM AUTHOR]

Working fluids that incorporate solid microencapsulated phase change materials (MPCMs) can benefit from properties such as density and viscosity, which are crucial for improving heat capacity and transfer. However, limited data are available on these parameters for specific slurry and mass ratios. In this study, we present a comparative analysis of the experimental results on the viscosity of three different MPCM aqueous dispersions, namely MPCM 31-S50, MPCM 25-S50, and Micronal 5428X. Varying MPCM mass ratios of distilled water were used to obtain different mass concentrations of the phase change material (PCM), and the resulting slurries were analysed at temperatures ranging from 15 to 40 °C. Our findings showed that all slurries exhibited non-Newtonian characteristics at low shear rates, with viscosity stabilising at higher shear rates, resulting in the characteristics of a Newtonian fluid. The viscosity results were highly dependent on the type of MPCM base dispersion, particularly at high mass ratios, with the slurries having viscosities higher than those of water. Furthermore, we conducted density experiments as a function of temperature, using a flow test setup and a Coriolis flowmeter (Endress+Hauser, Reinach, Switzerland) to determine the density of two MPCMs, namely MPCM 25-S50 and Micronal 5428X. The test samples were prepared at mass concentrations of 10%, 15%, and 20% of the phase change material. We found significant differences in density and viscosity for different MPCM slurries as a result of both the PCM concentration and the material studied. Our results also revealed an apparent PCM phase change process, in which the slurry density significantly decreased in the temperature range of the phase transition from solid to liquid. [ABSTRACT FROM AUTHOR]

Simple Summary: Treosulfan and melphalan (TreoMel)-based high-dose chemotherapy (HDCT) has been successfully used as a conditioning regimen in acute myeloid leukemia (AML) patients undergoing autologous stem cell transplantation (ASCT). However, despite intensive first-line induction treatment and upfront consolidation with HDCT and ASCT, AML relapse rates are still high, and further efforts are needed to improve patient outcomes. In this study, we investigated how increased doses of melphalan impact the safety of HDCT with TreoMel and patient outcomes. A total of 51 AML patients were included in the analysis: 31 (60.8%) received standard-dose treosulfan combined with melphalan 140 mg/m2 (TreoMel 140) and 20 (39.2%) received melphalan 200 mg/m2 (TreoMel 200). There were no statistically significant differences in relapse (0.45 vs. 0.30, p = 0.381) and mortality rates (0.42 vs. 0.15, p = 0.064) between the melphalan 140 mg/m2 and 200 mg/m2 cohorts, nor for PFS (HR: 0.81, 95% CI: 0.29–2.28, p = 0.70) or OS (HR: 0.70, 95% CI: 0.19–2.57, p = 0.59) for the TreoMel 140 vs. TreoMel 200 cohorts. The side effect profile was comparable between both patient groups. Our results show that a higher melphalan dose is well tolerated. No significant differences for patient outcomes could be observed, possibly due to the relatively small patient cohort and short follow-up. Longer follow-up and prospective randomized studies would be required to confirm the safety profile and clinical benefit. (1) Background: Treosulfan and melphalan (TreoMel)-based high-dose chemotherapy (HDCT) has shown promising safety and efficacy as a conditioning regimen for acute myeloid leukemia (AML) patients undergoing autologous stem cell transplantation (ASCT). However, despite intensive first-line induction treatment and upfront consolidation with HDCT and ASCT, AML relapse rates are still high, and further efforts are needed to improve patient outcomes. The aim of this study was to compare two melphalan dose schedules in regard to the safety of TreoMel HDCT and patient outcomes. (2) Methods: We retrospectively analyzed the safety and efficacy of two melphalan dose schedules combined with standard-dose treosulfan in AML patients undergoing HDCT and ASCT at the University Hospital of Bern, Switzerland, between August 2019 and August 2023. Patients received treosulfan 42 g/m2 combined with either melphalan 140 mg/m2 (TreoMel 140) or melphalan 200 mg/m2 (TreoMel 200). Co-primary endpoints were progression-free survival (PFS), overall survival (OS), as well as safety profile. (3) Results: We included a total of 51 AML patients: 31 (60.8%) received TreoMel 140 and 20 (39.2%) TreoMel 200. The patients' basal characteristics were comparable between both cohorts. No significant differences in the duration of hospitalization or the adverse event profile were identified. There were no statistically significant differences in relapse (0.45 vs. 0.30, p = 0.381) and mortality rates (0.42 vs. 0.15, p = 0.064) between the melphalan 140 mg/m2 and 200 mg/m2 cohorts, nor for PFS (HR: 0.81, 95% CI: 0.29–2.28, p = 0.70) or OS (HR: 0.70, 95% CI: 0.19–2.57, p = 0.59) for the TreoMel 140 vs. TreoMel 200 cohort. (4) Conclusions: A higher dose of melphalan (TreoMel 200) was well tolerated overall. No statistically significant differences for patient outcomes could be observed, possibly due to the relatively small patient cohort and the short follow-up. A longer follow-up and prospective randomized studies would be required to confirm the safety profile and clinical benefit. [ABSTRACT FROM AUTHOR]

Objectives: This study sought to understand how people living with HIV experience, perceive, and navigate stigma in their everyday life and in care settings in an urban Frenchspeaking area in Switzerland. Methods: Semi-structured interviews were carried out with 19 people living with HIV in Lausanne concerning their experience of HIV-related stigma in both everyday life and in healthcare settings. Content analysis was performed to identify main and sub-themes. Results: "Living with HIV" posed little or no difficulty for participants. However, the burden of anticipated and internalized HIV-related stigma played a disproportionately large role in their lives. Participants considered the general population's low level of knowledge about HIV as problematic in this regard. While participants reported few examples of enacted stigma generally, healthcare environments were sometimes experienced as sites of prejudice and discrimination. However, some healthcare professionals were also sources of information and knowledge, contributing to participants' "journeys of self-acceptance." Conclusion: Even in an urban environment in a country with ready access to healthcare and education, HIV-related stigma remains a concern for people living with HIV. [ABSTRACT FROM AUTHOR]

The purpose of this article is to investigate the common facilitators and barriers associated with the implementation of hospital-based health technology assessment (HB-HTA) across diverse hospital settings in seven countries. Through a two-round Delphi study, insights were gathered from a panel of 15 HTA specialists from France, Hungary, Italy, Kazakhstan, Poland, Switzerland, and Ukraine. Experts initially conducted a comprehensive review of the HB-HTA implementation in their respective countries, identifying the barriers and facilitators through descriptive analysis. Subsequently, panel experts ranked these identified barriers and facilitators on a seven-point Likert scale. A median agreement score ≥ 6 and interquartile range (IQR) ≤ 1 was accepted as reaching a consensus. Out of the 12 statements categorized as external and internal barriers and facilitators, the expert panel reached consensus on six statements (two barriers and four facilitators). The external barrier, which achieved consensus, was the lack of the formal recognition of the role of HB-HTA in national or regional legislations. The internal barrier reaching consensus was the limited availability of human resources dedicated to HB-HTA. This qualitative study indicates that HB-HTA still has progress to make before being formally accepted and integrated across most countries, although by building on the facilitating factors we identified there may be an opportunity for the implementation of internationally developed strategies to strengthen HB-HTA practices. [ABSTRACT FROM AUTHOR]

Copyright of GMS Journal for Medical Education is the property of German Medical Science Publishing House gGmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The application of calcium coacervates (CCs) may hold promise for dental hard tissue remineralization. The aim of this study was to evaluate the effect of the infiltration of artificial enamel lesions with a CC and its single components including polyacrylic acid (PAA) compared to that of the self-assembling peptide P11-4 in a pH-cycling (pHC) model. Enamel specimens were prepared from bovine incisors, partly varnished, and stored in demineralizing solution (DS; pH 4.95; 17 d) to create two enamel lesions per sample. The specimens were randomly allocated to six groups (n = 15). While one lesion per specimen served as the no-treatment control (NTC), another lesion (treatment, T) was etched (H3PO4, 5 s), air-dried and subsequently infiltrated for 10 min with either a CC (10 mg/mL PAA, 50 mM CaCl2 (Ca) and 1 M K2HPO4 (PO4)) (groups CC and CC + DS) or its components PAA, Ca or PO4. As a commercial control, the self-assembling peptide P11-4 (CurodontTM Repair, Credentis, Switzerland) was tested. The specimens were cut perpendicularly to the lesions, with half serving as the baseline (BL) while the other half was exposed to either a demineralization solution for 20 d (pH 4.95; group CC + DS) or pHC for 28 d (pH 4.95, 3 h; pH 7, 21 h; all five of the other groups). The difference in integrated mineral loss between the lesions at BL and after the DS or pHC, respectively, was analyzed using transversal microradiography (ΔΔZ = ΔZpHC − ΔZbaseline). Compared to the NTC, the mineral gain in the T group was significantly higher in the CC + DS, CC and PAA (p < 0.05, Wilcoxon). In all of the other groups, no significant differences between treated and untreated lesions were detected (p > 0.05). Infiltration with the CC and PAA resulted in a consistent mineral gain throughout the lesion body. The CC as well as its component PAA alone promoted the remineralization of artificial caries lesions in the tested pHC model. Infiltration with PAA further resulted in mineral gain in deeper areas of the lesion body. [ABSTRACT FROM AUTHOR]

This study aims to examine the complex relationship between leadership styles, organizational performance, and employee retention across different economic systems. Furthermore, it seeks to illustrate how different leadership approaches impact organizational dynamics within different economic contexts. Employing a mix of case study and qualitative methodologies, the research investigates the multiple organizations in Germany, Switzerland and Austria, utilizing a structured analysis on the collected data. The methodology is designed to capture the nuanced ways in which leadership influences key organizational outcomes, including employee loyalty and organizational efficacy. The findings suggest that transformational leadership universally enhances organizational performance and employee retention, yet the effectiveness of leadership styles is significantly shaped by cultural and economic factors. In conclusion, this research paper indicates that adaptable, context-aware leadership is crucial for navigating the complexities of global economic systems, highlighting the need for leaders to tailor their approaches according to the environment in which it operates. [ABSTRACT FROM AUTHOR]

Background: Biosimilars are biologic drugs that have the potential to increase the efficiency of healthcare spending and curb drug-related cost increases. However, their introduction into hospital formularies through initiatives such as non-medical switching must be carefully orchestrated so as not to cause treatment discontinuation or result in increased health resource utilization, such as additional visits or laboratory tests, among others. This retrospective cohort study aims to assess the impact of the introduction of CT-P13 on the healthcare expenditures of patients who were treated with originator infliximab or CT-P13. Methods: Gastroenterology, immunoallergology and rheumatology patients treated between September 2017 and December 2020 at a university hospital in Western Switzerland were included and divided into seven cohorts, based on their treatment pathway (i.e., use and discontinuation of CT-P13 and/or originator infliximab). Costs in Swiss francs were obtained from the hospital's cost accounting department and length of stay was extracted from inpatient records. Comparisons of costs and length of stay between cohorts were calculated by bootstrapping. Results: Sixty immunoallergology, 84 rheumatology and 114 gastroenterology patients were included. Inpatient and outpatient costs averaged (sd) CHF 1,611 (1,020) per hospital day and CHF 4,991 (6,931) per infusion, respectively. The mean (sd) length of stay was 20 (28) days. Although immunoallergology and rheumatology patients had higher average costs than gastroenterology patients, differences in costs and length of stay were not formally explained by treatment pathway. Differences in health resource utilization were marginal. Conclusions: The introduction of CT-P13 and the disruption of patient treatment management were not associated with differences in average outpatient and inpatient costs and length of stay, in contrast to the results reported in the rest of the literature. Future research should focus on the cost-effectiveness of non-medical switching policies and the potential benefits for patients. [ABSTRACT FROM AUTHOR]