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Background: Several COVID-19 vaccines were developed and approved in China. Of these, the BIBB-CorV and CoronaVac inactivated whole-virion vaccines were widely distributed in China and developing countries. However, the performance of the two vaccines in the real world has not been summarized. Methods: A living systematic review based on findings from ongoing post-licensure studies was conducted, applying standardized algorithms. Articles published between 1 May 2020 and 31 May 2022 in English and Chinese were searched for in Medline, Embase, WanFang Data, medRxiv, bioRxiv, arXiv, SSRN, and Research Square, using SARS-CoV-2, COVID-19, and vaccine as the MeSH terms. Studies with estimates of safety, immunogenicity, and effectiveness from receiving the BIBB-CorV or CoronaVac vaccine that met the predefined screening criteria underwent a full-text review. The Joanna Briggs Institute's Critical Appraisal Checklist and the Cochrane risk of bias were used for assessment of the quality. A random-effects meta-regression model was applied to identify the potential impact factors on the vaccines' effectiveness. Results: In total, 32578 articles were identified, of these, 770 studies underwent a full-text review. Eventually, 213 studies were included. The pooled occurrence of solicited and unsolicited adverse events after any dose of either vaccine varied between 10% and 40%. The top five commonly reported rare adverse events were immunization stress-related responses (211 cases, 50.0%), cutaneous responses (43 cases, 10.2%), acute neurological syndrome (39 cases, 9.2%), anaphylaxis (17 cases, 4.0%), and acute stroke (16 cases, 3.8%). The majority (83.3%) recovered or were relieved within several days. The peak neutralization titers against the ancestral strain was found within 1 month after the completion of the primary series of either vaccine, with a GMT (geometric mean titer) of 43.7 (95% CI: 23.2–82.4), followed by a dramatic decrease within 3 months. At Month 12, the GMT was 4.1 (95% CI: 3.8–4.4). Homologous boosting could restore humoral immunity, while heterologous boosting elicited around sixfold higher neutralization titers in comparison with homologous boosting. The effectiveness of receiving either vaccine against death and severe disease was around 85% for both shortly after the primary series. At Month 12, the protection against death did not decline, while the protection against severe disease decreased to ~75%. Conclusions: Both the BIBP-CorV and CoronaVac inactivated vaccines are safe. Sustained vaccine effectiveness against death was determined 12 months after the primary series, although protection against severe disease decreased slightly over time. A booster dose could strengthen the waning effectiveness; however, the duration of the incremental effectiveness and the additional benefit provided by a heterologous booster need to be studied. [ABSTRACT FROM AUTHOR]

The land use change (LUC) and urbanization caused by human activities have markedly increased the occurrence of landslides, presenting significant challenges in accurately predicting landslide susceptibility despite decades of model advancements. This study, focusing on the Li River Valley (LRV) within the Yongding District, China, employs two common models, namely an analytic hierarchy process–comprehensive index (AHP-CI) model and a logistic regression (LR) model to assess landslide susceptibility (LS). The AHP-CI model is empirically based, with the advantage of being constructible and applicable at various scales without a dataset, though it remains highly subjective. The LR model is a statistical model that requires a training set. The two models represent heuristic and statistical approaches, respectively, to assessing LS. Meanwhile, the basic geological and environmental conditions are considered in the AHP-CI model, while the LR model accounts for the conditions of LUC and urbanization. The results of the multicollinearity diagnostics reflect the rationality of the predisposing factor selection (1.131 < VIF < 4.441). The findings reveal that the AHP-CI model underperforms in LUC and urbanization conditions (AUROC = 0.645, 0.628, and 0.667 for different validation datasets). However, when all the time-varying human activity predisposing factors are considered, the LR model (AUROC = 0.852) performs significantly better under the conditions of solely considering 2010 (AUROC = 0.744) and 2020 (AUROC = 0.810). The CA–Markov model was employed to project the future land use for the short-term (2025), mid-term (2030), and long-term (2040) planning periods. Based on these projections, maps of future LS were created. Importantly, this paper discussed the relationships between landslide management and regional sustainable development under the framework of the UN SDGs, which are relevant to Goal 1, Goal 11, Goal 13, and Goal 15. Finally, this study highlights the importance of integrating strategic land planning, reforestation efforts, and a thorough assessment of human impact predisposing factors with SDG-aligned LS predictions, advocating for a comprehensive, multi-stakeholder strategy to promote sustainable landslide mitigation. [ABSTRACT FROM AUTHOR]

In gas cap reservoirs underlain by bottom water, the connection between the reservoir and the aquifer leads to an increasing invasion of bottom water as reservoir development progresses. The average formation pressure of the reservoir will change, and the separated phase recovery of the gas cap reservoir with bottom water will be affected by the change in the average formation pressure. The traditional average formation pressure calculation formulas do not consider the water influx, so the accurate calculation of separated recovery cannot be obtained by those calculation methods. The development of gas cap reservoirs with bottom water presents several challenges, including the simultaneous production of oil and gas, undetermined rates of bottom water influx, and uncertain formation pressure and gas-to-oil ratios. These factors contribute to substantial discrepancies between theoretical calculations and actual observations. A more accurate and comprehensive approach is required to address these issues and enable a precise determination of the phase separated recovery in gas cap reservoirs with bottom water. The volume-deficit method is integrated with the Fetkovich quasi-steady state method for water influx. The water-influx prediction is incorporated into the material balance equation, which is further refined by introducing the Fetkovich model to enhance the estimation of the average formation pressure. The average formation pressure, once determined, is utilized in conjunction with the established relationships among this pressure, surface oil production, gas production, and the dissolved gas–oil ratio. Through the application of mass conservation principles, the varying degree of phase recovery, as influenced by fluctuations in the average formation pressure, is calculated. The precision of this refined method has been validated by a comparison with outcomes generated by simulation software. The results reveal a commendable accuracy: an error in the average formation pressure calculation is found to be merely 2.61%, while the errors in recovery degrees for gas cap gas, dissolved gas, and oil-rim oil are recorded at 2.73%, 2.94%, and 1.28%, respectively. These minor discrepancies indicate a good level of consistency and affirm the reliability of this advanced methodology, as demonstrated by passive assessments. This paper provides a method to accurately calculate the phase recovery without some oil- and gas-production data, which provides accurate data support for the actual production evaluation and subsequent development measures. [ABSTRACT FROM AUTHOR]

Bacterial antimicrobial resistance (AMR) poses a significant global public health challenge. The escalation of AMR is primarily attributed to the horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs), often facilitated by plasmids. This underscores the critical need for a comprehensive understanding of the resistance mechanisms and transmission dynamics of these plasmids. In this study, we utilized in vitro drug sensitivity testing, conjugation transfer assays, and whole-genome sequencing to investigate the resistance mechanism of an extensively drug-resistant (XDR) Pseudomonas aeruginosa clinical isolate, MAS152. We specifically focused on analyzing the drug-resistant plasmid pMAS152 it harbors and its potential for widespread dissemination. Bioinformatics analysis revealed that MAS152 carries a distinct IncpP-2A plasmid, pMAS152, characterized by a 44.8 kb multidrug resistance (MDR) region. This region houses a 16S rRNA methyltransferase (16S-RMTase) gene, rmtB, conferring high-level resistance to aminoglycoside antibiotics. Notably, this region also contains an extended-spectrum β-Lactamase (ESBL) gene, blaPER-1, and an efflux pump operon, tmexCD-oprJ, which mediate resistance to β-Lactams and quinolone antibiotics, respectively. Such a combination of ARGs, unprecedented in reported plasmids, could significantly undermine the effectiveness of first-line antibiotics in treating P. aeruginosa infections. Investigation into the genetic environment of the MDR region suggests that Tn2 and IS91 elements may be instrumental in the horizontal transfer of rmtB. Additionally, a complex Class I integron with an ISCR1 structure, along with TnAs1, seems to facilitate the horizontal transfer of blaPER-1. The conjugation transfer assay, coupled with the annotation of conjugation-related genes and phylogenetic analysis, indicates that the plasmid pMAS152 functions as a conjugative plasmid, with other genus Pseudomonas species as potential hosts. Our findings provide vital insights into the resistance mechanisms and transmission potential of the XDR P. aeruginosa isolate MAS152, underlining the urgent need for novel strategies to combat the spread of AMR. This study highlights the complex interplay of genetic elements contributing to antibiotic resistance and underscores the importance of continuous surveillance of emerging ARGs in clinical isolates. [ABSTRACT FROM AUTHOR]

Astragali Radix, derived from the roots of Astragalus mongholicus, is a traditional Chinese medicine containing flavonoids and saponins as its key ingredients. With a shortage in the wild sources of the herbal plant, it is especially important to explore a cultivation mode for A. mongholicus for medicinal purposes. Cutting, a physical environmental stress method, was used in this study with the objective of improving the quality of this herbal legume. We found that cutting of the top 1/3 of the aboveground part of A. mongholicus during the fruiting period resulted in a significant increase in the content of flavonoids and saponins, as well as in root growth, including length, diameter, and dry weight. Furthermore, the leaves were sampled and analyzed using a combined transcriptome and metabolome analysis approach at five different time points after the treatment. Sixteen differentially expressed unigenes (DEGs) involved in the biosynthesis of flavonoids were identified; these were found to stimulate the synthesis of flavonoids such as formononetin and calycosin–7–O–β–D–glucoside. Moreover, we identified 10 DEGs that were associated with the biosynthesis of saponins, including astragaloside IV and soyasaponin I, and found that they only regulated the mevalonic acid (MVA) pathway. These findings provide new insights into cultivating high-quality A. mongholicus, which could potentially alleviate the scarcity of this valuable medicinal plant. [ABSTRACT FROM AUTHOR]

In this study, the barrier properties and diffusion behavior of carbon-doped Cu(Ni) alloy film were investigated. The films were fabricated using magnetron sputtering on a barrierless silicon substrate. X-ray diffraction patterns and electric resistivity results demonstrated that the barrierless Cu(NiC) alloy films remained thermally stable up to 650 °C. Transmission electron microscopy images provided the presence of a self-formed diffusion layer between the Cu(NiC) alloy and Si substrate. The effect of carbon-doped atoms on the diffusion behavior of the Cu(NiC) films was analyzed by X-ray photoemission spectroscopy depth profile. Results revealed that carbon doping can improve the barrier properties of barrierless Cu(Ni) film. Moreover, X-ray photoemission spectroscopy was performed to examine the chemical states of the self-formed layer at the Cu(NiC)/Si interface. The self-formed diffusion layer was found to consist of Cu metal, Ni metal, Si, Cu2O, NiO, and SiO2. [ABSTRACT FROM AUTHOR]

In this paper, the sol-gel method was used to synthesize powders of LaMnO3 (LMO), La0.85Ca0.15MnO3 (LCM), and La0.85Sr0.15MnO3 (LSM). The effect of substituting Ca and Sr at the A-site on the perovskite crystal structure and electrochemical capabilities of LMO was investigated. LCM retained its orthogonal structure in comparison to the parent LMO components, whereas LSM transitioned to a rhombic structure. At 0.5 A/g, the specific capacitance of LCM and LSM electrodes is 185.5 F/g and 248 F/g, respectively. The specific capacitance of LCM was three times greater than that of the LMO electrode. Among the three samples (LMO, 22.25 m2 g−1; LSM, 31.56 m2 g−1), the LCM sample exhibited the highest specific surface area of 38.79 m2 g−1. The charge transfer resistances of the LMO, LCM, and LSM are 0.48 Ω, 0.36 Ω, and 0.38 Ω, respectively. The LCM electrode exhibits the greatest capacitance performance due to its more refined morphology, increased concentration of oxygen vacancy, and more complete utilization of the perovskite bulk structure. The above results demonstrate that Ca or Sr substitution of A-site compounds has great potential for supercapacitor applications. [ABSTRACT FROM AUTHOR]