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Your search keyword '"Glycolipids therapeutic use"' showing total 5 results
Start Over Descriptor "Glycolipids therapeutic use" Publication Year Range More than 50 years ago
5 results on '"Glycolipids therapeutic use"'

1. Biologically active components from mycobacterial cell walls. II. Suppression and regression of strain-2 guinea pig hepatoma.

Author

Meyer TJ, Ribi EE, Azuma I, and Zbar B

Subjects
Animals, Carcinoma, Hepatocellular immunology, Disaccharides analysis, Glycolipids analysis, Guinea Pigs, Immunity, Liver Neoplasms immunology, Male, Mycolic Acids analysis, Neoplasms, Experimental immunology, Neoplasms, Experimental therapy, Peptides analysis, Polysaccharides analysis, Skin Tests, Trehalose analysis, Trehalose therapeutic use, Carcinoma, Hepatocellular therapy, Cell Wall analysis, Disaccharides therapeutic use, Glycolipids therapeutic use, Immunotherapy, Liver Neoplasms therapy, Mycobacterium bovis analysis, Mycolic Acids therapeutic use, Peptides therapeutic use, Polysaccharides therapeutic use
Published
1974
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2. Suppression of growth of Ehrlich ascites tumor cells in mice by trehalose-6,6'-dimycolate (cord factor) and BCG.

Author

Yarkoni E, Wang L, and Bekierkunst A

Subjects
Animals, Carcinoma, Ehrlich Tumor drug therapy, Injections, Intraperitoneal, Injections, Intravenous, Mice, Time Factors, Trehalose therapeutic use, Carcinoma, Ehrlich Tumor therapy, Disaccharides therapeutic use, Glycolipids therapeutic use, Mycobacterium tuberculosis
Abstract

Growth of Ehrlich ascites tumor cells in mice pretreated with cord factor was compared to growth of the tumor cells after pretreatment with Calmette-Guérin bacilli. Growth of Ehrlich ascites cells was strongly inhibited in the peritoneal cavities of mice pretreated with 80 mug of cord factor. The median survival time of the animals was prolonged (70 versus 17 days), and 40% of the mice survived more than 90 days. Tumor suppression was still detectable 36 days after administration of cord factor. The effect of cord factor was local. Comparable results were obtained with living or killed Calmette-Guérin bacilli. The results are discussed.

Published
1974
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3. Enhancement of resistance of mice to tuberculosis by purified components of mycobacterial lipid fractions.

Author

Anacker RL, Matsumoto J, Ribi E, Smith RF, and Yamamoto K

Subjects
Air Microbiology, Animals, BCG Vaccine therapeutic use, Cell Fractionation, Cell Wall analysis, Chloroform, Chromatography, Chromatography, Gel, Female, Glycolipids therapeutic use, Lung, Methanol, Mice, Organ Size, Solvents, Waxes analysis, Waxes therapeutic use, Glycolipids isolation & purification, Mycobacterium bovis analysis, Mycobacterium tuberculosis analysis, Tuberculosis immunology
Published
1973
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4. Biological characterization of diumycin, a phosphorus-containing glycolipid antibiotic.

Author

Meyers E, Slusarchyk DS, Pansy FE, Basch HI, and Trejo WH

Subjects
Animals, Male, Mice, Microbial Sensitivity Tests, Neisseria drug effects, Phosphorus analysis, Pneumococcal Infections drug therapy, Protein Binding, Staphylococcal Infections drug therapy, Staphylococcus drug effects, Streptococcus drug effects, Streptomyces analysis, Anti-Bacterial Agents analysis, Anti-Bacterial Agents blood, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents toxicity, Anti-Bacterial Agents urine, Glycolipids blood, Glycolipids pharmacology, Glycolipids therapeutic use, Glycolipids toxicity, Glycolipids urine
Published
1972
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5. Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.

Author

Bekierkunst A, Levij IS, and Yarkoni E

Subjects
Adenoma chemically induced, Adenoma drug therapy, Adenoma pathology, Animals, Glycolipids isolation & purification, Granuloma etiology, Injections, Intraperitoneal, Injections, Intravenous, Lung pathology, Lung Neoplasms chemically induced, Lung Neoplasms drug therapy, Lung Neoplasms pathology, Mice, Neoplasms, Experimental drug therapy, Urethane, Adenoma therapy, BCG Vaccine administration & dosage, Glycolipids therapeutic use, Lung Neoplasms therapy, Mycobacterium tuberculosis analysis
Abstract

Trehalose-6,6-dimycolate (cord factor), a glycolipid from mycobacteria, suppressed the development of urethan-induced tumors in the lungs of mice to a similar degree as living Mycobacterium bovis (strain BCG) bacilli. The inhibition was apparently due to the host cellular reaction caused locally by cord factor.

Published
1971
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