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Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.
- Source :
-
Science (New York, N.Y.) [Science] 1971 Dec 17; Vol. 174 (4015), pp. 1240-2. - Publication Year :
- 1971
-
Abstract
- Trehalose-6,6-dimycolate (cord factor), a glycolipid from mycobacteria, suppressed the development of urethan-induced tumors in the lungs of mice to a similar degree as living Mycobacterium bovis (strain BCG) bacilli. The inhibition was apparently due to the host cellular reaction caused locally by cord factor.
- Subjects :
- Adenoma chemically induced
Adenoma drug therapy
Adenoma pathology
Animals
Glycolipids isolation & purification
Granuloma etiology
Injections, Intraperitoneal
Injections, Intravenous
Lung pathology
Lung Neoplasms chemically induced
Lung Neoplasms drug therapy
Lung Neoplasms pathology
Mice
Neoplasms, Experimental drug therapy
Urethane
Adenoma therapy
BCG Vaccine administration & dosage
Glycolipids therapeutic use
Lung Neoplasms therapy
Mycobacterium tuberculosis analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 174
- Issue :
- 4015
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 5002466
- Full Text :
- https://doi.org/10.1126/science.174.4015.1240