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1. Myeloblasts can be discriminated in the supravital technique by the great numbers of tiny mitochondria in the cytoplasm and the absence of any other vitally stainable substance. 2. There are three stages in the maturation of myelocytes. 3. These three phases can be correlated with three types of the oxidase reaction. 4. One case of myeloblastic leucemia showed such an amount of an abnormal type of amitosis as to suggest the disordered cell division of neoplasms. 5. In this case transfusions were correlated with a maturation of myeloblasts into myelocytes, with an increase of the oxidase reaction, and with an increase in amitosis.

It has come to be the accepted opinion that the phagocytic cells of the tissues, which have been designated as clasmatocytes, macrophages or histiocytes, and the large mononuclear elements of the b...

The observations reported in the preceding communication1 led us to consider the possibility that the phagocytic cells occurring in peritoneal exudates might be separated into the same two groups that were found in the spleen. It has been possible to demonstrate that this is true. A normal rabbit was given intraperitoneally 25 cc. of whole blood, which had been removed by a sterile puncture from the heart of another rabbit, and, after 24 hours, samples of the exudate were removed and studied. Another injection was then given and the examination repeated at the end of the second 24 hours. This procedure was repeated at 24 hour intervals over as long a time as was desired. Some of the experiments were carried out on rabbits whose blood-cells had been carefully matched, while in other instances animals were selected in which the serum of one agglutinated the red blood-cells of the other and vice versa. The exudate was studied with neutral red and Janus green in vital-dye films. It has been shown2 that the fi...

The exhibition of purpura as a clinical sign of disease was first ascribed solely to the effects of pestilential fevers. With the demonstration, however, by Denys 1 in 1887 that the purpura of Werlhof is characterized by a lowered level of circulating blood platelets, the clinical purpuric states were definitely shown to consist of thrombocytopenic and nonthrombocytopenic groups. Further differentiation within the thrombocytopenic group has been accomplished slowly since Denys's observations and has depended largely on cumulative experience with known etiologic states in which both purpura and marked thrombocytopenia have been observed to occur. There has thus arisen the practical and important subclassification of thrombocytopenic purpura into two groups—the idiopathic and the symptomatic. This is justified because the successful management of the former often requires life-saving surgery, whereas the latter should be managed strictly by medical means. The reversal of these therapeutic principles may promote disaster to the patient. The

Progress in the solution of the problems of disease in man must depend to a considerable degree on fundamental progress in the recognition and interpretation of alterations in disturbed physiologic equilibriums. It may be true that physiology "has its own problems, great in number and enormous in complexity, and those of disease are not among them."1Nevertheless, experience has established that the origin and explanation of many abnormal states may be traced to deranged physiologic processes, and more particularly to disturbed physiologic equilibriums. Granted that this is beyond the scope of pure physiologic research, the recognition of states of physiologic imbalance and of pathologic alterations produced in the tissues by this imbalance then becomes an important concern of the clinical investigator. That this "borderline" territory between physiology and medicine has proved a very fruitful field for clinical investigation, in one direction at least, is quite apparent when one reviews