1. Abnormal serum and urine proteins in thirty-five cases of multiple myeloma, as studied by filter paper electrophoresis
- Author
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Dolores P. Lawlor and Elliott F. Osserman
- Subjects
Electrophoresis ,Pathology ,medicine.medical_specialty ,Filter paper ,business.industry ,Blood Proteins ,General Medicine ,Urine ,Plasma cell ,Chronic lymphatic leukemia ,medicine.disease ,Blood proteins ,Proteinuria ,medicine.anatomical_structure ,Homogeneous ,medicine ,Electrophoresis, Paper ,Multiple Myeloma ,business ,Filtration ,Multiple myeloma - Abstract
1.1. Filter paper electrophoretic analysis of the serum and urine proteins in thirty-five cases of multiple myeloma has been carried out. In all thirty-five cases characteristic protein abnormalities were observed; seventeen cases showing homogeneous peaks in both the serum and urine, eleven cases in serum only, seven cases in urine only. 2.2. All urine samples showing a positive Bence-Jones protein reaction also displayed a characteristic electrophoretic abnormality. Eight of the twenty-four electrophoretically positive urine samples were Bence-Jones protein negative by the usual tests. Because of the relative simplicity of urine electrophoresis by the filter paper technic, this test is considered to be a practical clinical procedure. 3.3. Two cases are presented in detail because certain atypical clinicopathologic features of their disease patterns possibly assist in an understanding of the relationship of the plasma cell dyscrasias to chronic lymphatic leukemia and the lymphosarcomas. A third case, which demonstrates the value of serial electrophoretic studies in myeloma, is also presented. 4.4. Consideration is given to some of the physicochemical properties of the myeloma serum and urine proteins, and to the possible nature of their interrelationship.
- Published
- 1955