1. Depression and Plasma pTau181 Levels Are Associated with Frailty Status in Hispanic Community-Dwelling Older Women.
- Author
-
Rangel, Giselle A., Tratner, Adam E., Oviedo, Diana C., Villarreal, Alcibiades E., Carreira, Maria B., Rodriguez-Araña, Sofia, Flores Millender, Eugenia, Xavier Hall, Casey, Wong, Frank Y., O'Bryant, Sid, and Britton, Gabrielle B.
- Subjects
HISPANIC American women ,GERIATRIC Depression Scale ,OLDER people ,OLDER women ,NEUROPSYCHOLOGICAL tests - Abstract
The population of Hispanic older adults is growing along with the burden of chronic diseases. This cross-sectional study aims to assess the factors associated with frailty among community-dwelling Hispanic women aged ≥60 years (n = 357) enrolled in the Panama Aging Research Initiative—Health Disparities study of cognitive-functional health of older persons in Panama. Cognitive function was assessed with a neuropsychological test battery. Depression was measured with the Geriatric Depression Scale. Frailty was defined using the Fried criteria and participants were classified as non-frail, pre-frail or frail. A subsample (n = 281) provided fasting blood samples for quantification of protein biomarkers. Associations were examined using hierarchical multiple linear regressions. 59.4% and 9.0% of participants (M = 69.2 years, SD = 6.3) were pre-frail and frail, respectively. Having more depression (β =.28, p <.001) was significantly associated with frailty, even after covariate adjustment. Cognitive function was not associated with frailty. Higher pTau181 levels were associated with increased frailty (β =.13, p =.039), whereas higher α2M levels were associated with decreased frailty (β = −.16, p =.004). These findings advance the search for health indicators and biomarkers of frailty and warrant further studies to decrease the burden of frailty among older Hispanic women. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF