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266 results on '"Wang, Kun‐Hua"'

2. AIWW: a new nutrition-screening tool for the oncologic population

Author

Ge, Yi-Zhong, Fu, Zhen-Ming, Zhang, Qi, Song, Meng-Meng, Ruan, Guo-Tian, Zhang, Xi, Zhang, Xiao-Wei, Li, Xiang-Rui, Zhang, Kang-Ping, Tang, Meng, Liu, Xiao-Yue, Yang, Ming, Liu, Tong, Xie, Hai-Lun, Zhang, He-Yang, Wang, Zi-Wen, Hu, Chun-Lei, Lin, Shi-Qi, Zhang, Rui, Xu, Hong-Xia, Li, Wei, Song, Chun-Hua, Liu, Ming, Chen, Jun-Qiang, Wang, Kun-Hua, Bo, Li, Cong, Ming-Hua, Li, Zeng-Ning, Guo, Zeng-Qin, Wang, Xiao-Bin, Wang, Bin-Yan, Xu, Benjamin, Qin, Xian-Hui, Xu, Xi-Ping, Barazzoni, Rocco, Yao, Qing-Hua, Weng, Min, Shen, Xian, and Shi, Han-Ping

Published
2023
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4. Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: a prospective multicenter cohort

Author

Ruan, Guo-Tian, Xie, Hai-Lun, Hu, Chun-Lei, Liu, Chen-An, Zhang, He-Yang, Zhang, Qi, Wang, Zi-Wen, Zhang, Xi, Ge, Yi-Zhong, Lin, Shi-Qi, Tang, Meng, Song, Meng-Meng, Zhang, Xiao-Wei, Liu, Xiao-Yue, Zhang, Kang-Ping, Yang, Ming, Yu, Kai-Ying, Wang, Kun-Hua, Hu, Wen, Deng, Li, Cong, Ming-Hua, and Shi, Han-Ping

Published
2023
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7. Association of systemic inflammation and low performance status with reduced survival outcome in older adults with cancer

Author

Ruan, Guo-Tian, Xie, Hai-Lun, Zhang, He-Yang, Zhang, Qi, Deng, Li, Wang, Zi-Wen, Zhang, Xi, Ge, Yi-Zhong, Hu, Chun-Lei, Tang, Meng, Song, Meng-Meng, Zhang, Xiao-Wei, Liu, Tong, Li, Xiang-Rui, Zhang, Kang-Ping, Yang, Ming, Gong, Yi-Zhen, Chen, Yong-Bing, Yu, Kai-Ying, Cong, Ming-Hua, Pan, Lei, Tang, Wei-Zhong, Wang, Kun-Hua, and Shi, Han-Ping

Published
2022
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13. Long noncoding RNA XIST regulates the EGF receptor to promote TGF-[beta]1-induced epithelial-mesenchymal transition in pancreatic cancer

Author

Zou, Lei, Chen, Feng-Rong, Xia, Ren-Pin, Wang, Hua-Wei, Xie, Zhen-Rong, Xu, Yu, Yu, Jue-Hua, and Wang, Kun-Hua

Subjects
Immunohistochemistry -- Analysis, Stem cells -- Analysis, Apoptosis -- Analysis, Antisense RNA -- Analysis, Pancreatic cancer -- Analysis, Growth factors -- Analysis, Biological sciences
Abstract

Background: This study focuses on the lncRNA XIST (X inactive-specific transcript), an lncRNA involved in multiple human cancers, and investigates the functional significance of XIST and the molecular mechanisms underlying the epithelial--mesenchymal transition (EMT) in pancreatic cancer (PC). Methods: Clinical specimens from 25 patients as well as 5 human PC cell lines were analyzed for XIST, YAP, and microRNA(miR)-34a by quantitative real-time PCR (qRT-PCR) and immunohistochemistry. To investigate how XIST influences cell proliferation, invasiveness, and apoptosis in PC, we performed the CCK-8 assays, Transwell assays, and flow cytometry. Luciferase reporter assays, qRT-PCR, and Western blot were applied to prove that miR-34a directly binds to XIST. Results: Up-regulation of XIST and Yes associated protein (YAP) and down-regulation of miR-34a were consistently observed in the clinical specimens and PC cell lines. Silencing XIST reduced the expression of YAP and suppressed transforming growth factor (TGF)-[beta]1-induced EMT, while over-expression of XIST increased the expression of YAP and promoted EMT. In addition, inhibition of epidermal growth factor receptor (EGFR) hampered the XIST-promoted EMT. The results from the luciferase reporter assays confirmed that miR-34a directly targets XIST and suggested that XIST regulates cell proliferation, invasiveness, and apoptosis in PC by sponging miR-34a. Conclusions: XIST promotes TGF-[beta]1-induced EMT by regulating the miR-34a-YAP-EGFR axis in PC. Key words: lncRNA XIST, miR-34a, pancreatic cancer, YAP, EGFR. Contexte : Cette étude se concentre sur l'ARNnm long XIST (X inactive-specific transcript), un ARNnm long impliqué dans plusieurs types de cancer chez l'humain, et vise à examiner l'importance fonctionnelle de XIST et les mécanismes moléculaires qui sous-tendent la TEM dans le cancer pancréatique (CP). Méthodes: Des spécimens cliniques prélevés de 25 patients et 5 lignées cellulaires humaines de cancer du pancréas ont été analysées quant à la présence de XIST, YAP, et du micro ARN (miR)-34a par qRT-PCR et immunohistochimie. Afin d'examiner comment XIST influence la prolifération, l'invasion et l'apoptose des cellules de CP, les auteurs ont réalisé un dosage avec le CCK-8, un test sur supports de culture Transwell, et de la cytométrie en flux. Le dosage du rapporteur luciférase, la qRT-PCR et le buvardage de Western ont été réalisés pour confirmer que le miR-34a se lie directement à XIST. Résultats : La régulation à la hausse de XIST et YAP, et la régulation à la baisse du miR-34a étaient systématiquement observées dans les spécimens cliniques et les lignées de CP. Le silençage de XIST réduisait l'expression de YAP et réprimait la TEM induite par le TGF-[beta]1 (Transforming Growth Factor Beta 1), alors que la surexpression de XIST accroissait l'expression de YAP et favorisait la TEM. De plus, l'inhibition du récepteur de l'EGF (EGFR) ralentissait la TEM favorisée par XIST. Le dosage du rapporteur luciférase confirmait que le miR-34a ciblait directement XIST et suggérait que XIST pourrait réguler la prolifération, l'invasion et l'apoptose des cellules de CP en captant le miR-34a. Conclusions: XIST favorise la TEM induite par le TGF-[beta]1 en régulant l'axe miR-34a-YAP-EGFR dans le CP. [Traduit par la Rédaction] Mots-clés: ARNnm long XIST, miR-34a, cancer pancréatique, YAP, EGFR., Introduction As one of the most fatal human malignancies, pancreatic cancer (PC) ranks as the 4th leading cause of cancer-related deaths in the USA (Michaud 2004). Because there is still [...]

Published
2020
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17. Prognostic value of systemic inflammation and for patients with colorectal cancer cachexia

Author

Ruan, Guo‐Tian, primary, Xie, Hai‐Lun, additional, Yuan, Kai‐Tao, additional, Lin, Shi‐Qi, additional, Zhang, He‐Yang, additional, Liu, Chen‐An, additional, Shi, Jin‐Yu, additional, Ge, Yi‐Zhong, additional, Song, Meng‐Meng, additional, Hu, Chun‐Lei, additional, Zhang, Xiao‐Wei, additional, Liu, Xiao‐Yue, additional, Yang, Ming, additional, Wang, Kun‐Hua, additional, Zheng, Xin, additional, Chen, Yue, additional, Hu, Wen, additional, Cong, Ming‐Hua, additional, Zhu, Li‐Chen, additional, Deng, Li, additional, and Shi, Han‐Ping, additional

Published
2023
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21. Whole-protein enteral nutrition formula supplementation reduces Escherichia and improves intestinal barrier function in HIV-infected immunological nonresponders.

Author

Lu, Danfeng, Wang, Yue-Xin, Geng, Shi-Tao, Zhang, Zunyue, Xu, Yu, Peng, Qing-Yan, Li, Shao-You, Zhang, Jian-Bo, Wang, Kun-Hua, and Kuang, Yi-Qun

Subjects
HIV infections, INTESTINAL barrier function, HIV-positive persons, PILOT projects, GUT microbiome, IMMUNE system, ANTIRETROVIRAL agents, NUTRITIONAL requirements, DIETARY supplements, IMMUNITY, CD4 lymphocyte count, RESEARCH funding, ENTERAL feeding, T cells, DIETARY proteins, ELEMENTAL diet, ESCHERICHIA, NUTRITIONAL status
Abstract

People living with human immunodeficiency virus (PLWH) have persistent malnutrition, intestinal barrier dysfunction, and gut microbial imbalance. The interplay between gut microbiota and nutrients is involved in the immune reconstitution of PLWH. To evaluate the effects of whole-protein enteral nutrition formula supplementation on T-cell levels, intestinal barrier function, nutritional status, and gut microbiota composition in human immunodeficiency virus (HIV)-infected immunological nonresponders (INRs) who failed to normalize CD4+ T-cell counts, with a number <350 cells/µL, a pilot study was carried out in 13 HIV-infected INRs undergoing antiretroviral therapy who received a 3-month phase supplementation of 200 mL/200 kcal/45 g whole-protein enteral nutrition formula once daily. Our primary endpoint was increased CD4+ T-cell counts. Secondary outcome parameters were changes in intestinal barrier function, nutritional status, and gut microbiota composition. We showed that CD4+ T-cell counts of HIV-infected INRs increased significantly after the 3-month supplementation. Dietary supplementation for 3 months improved the intestinal barrier function and nutritional status of HIV-infected INRs. Furthermore, the enteral nutrition formula significantly decreased the relative abundance of Escherichia at the genus level and increased the alpha diversity of gut microbiota in HIV-infected INRs. The findings demonstrated that the whole-protein enteral nutrition formula aids in reducing Escherichia and improving intestinal barrier function in HIV-infected INRs. This study provides insight into the role of nutrients in the improvement of immune reconstitution in HIV-infected INRs. This study is registered in the Chinese Clinical Trial Registry (Document No. ChiCTR2000037839; http://www.chictr.org.cn/index.aspx). [ABSTRACT FROM AUTHOR]

Published
2024
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25. The prognostic value of the combination of body composition and systemic inflammation in patients with cancer cachexia

Author

Xie, Hai‐Lun, primary, Ruan, Guo‐Tian, additional, Wei, Lishuang, additional, Zhang, Qi, additional, Ge, Yi‐Zhong, additional, Song, Meng‐Meng, additional, Zhang, Xi, additional, Lin, Shi‐qi, additional, Liu, Xiao‐yue, additional, Zhang, Xiao‐Wei, additional, Li, Xiang‐Rui, additional, Zhang, Kang‐Ping, additional, Hu, Chun‐Lei, additional, Yang, Ming, additional, Tang, Meng, additional, Song, Chun‐Hua, additional, Cong, Ming‐Hua, additional, Weng, Min, additional, Li, Zeng‐Ning, additional, Li, Wei, additional, Wang, Kun‐Hua, additional, and Shi, Han‐Ping, additional

Published
2023
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28. Planar defect–free pure red perovskite light-emitting diodes via metastable phase crystallization

Author

Song, Yong-Hui, primary, Ge, Jing, additional, Mao, Li-Bo, additional, Wang, Kun-Hua, additional, Tai, Xiao-Lin, additional, Zhang, Qian, additional, Tang, Le, additional, Hao, Jing-Ming, additional, Yao, Ji-Song, additional, Wang, Jing-Jing, additional, Ma, Tao, additional, Yang, Jun-Nan, additional, Lan, Yi-Feng, additional, Ru, Xue-Chen, additional, Feng, Li-Zhe, additional, Zhang, Guozhen, additional, Lin, Yue, additional, Zhang, Qun, additional, and Yao, Hong-Bin, additional

Published
2022
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32. A Novel Systemic Inflammation Prognostic Score to Stratify Survival in Elderly Patients With Cancer

Author

Ruan, Guo-Tian, primary, Xie, Hai-Lun, additional, Deng, Li, additional, Ge, Yi-Zhong, additional, Zhang, Qi, additional, Wang, Zi-Wen, additional, Zhang, Xi, additional, Zhang, He-Yang, additional, Tang, Meng, additional, Song, Meng-Meng, additional, Zhang, Xiao-Wei, additional, Yang, Ming, additional, Pan, Lei, additional, Wang, Kun-Hua, additional, Cong, Ming-Hua, additional, Gong, Yi-Zhen, additional, Wang, Meng-Yan, additional, and Shi, Han-Ping, additional

Published
2022
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33. A Novel Inflammation and Insulin Resistance Related Indicator to Predict the Survival of Patients With Cancer

Author

Ruan, Guo-Tian, primary, Xie, Hai-Lun, additional, Zhang, He-Yang, additional, Liu, Chen-An, additional, Ge, Yi-Zhong, additional, Zhang, Qi, additional, Wang, Zi-Wen, additional, Zhang, Xi, additional, Tang, Meng, additional, Song, Meng-Meng, additional, Zhang, Xiao-Wei, additional, Yang, Ming, additional, Chen, Yong-Bing, additional, Yu, Kai-Ying, additional, Deng, Li, additional, Gong, Yi-Zhen, additional, Hu, Wen, additional, Wang, Kun-Hua, additional, Cong, Ming-Hua, additional, and Shi, Han-Ping, additional

Published
2022
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35. Transcriptomic Profiling Reveals Underlying Immunoregulation Mechanisms of Resistant Hypertension in Injection Drug Users

Author

Jia,Jie, Yang,Ji-Qun, Du,Ying-Rong, Xu,Yu, Kong,Deshenyue, Zhang,Xiu-Ling, Mao,Jun-Hong, Hu,Gui-Fang, Wang,Kun-Hua, Kuang,Yi-Qun, Jia,Jie, Yang,Ji-Qun, Du,Ying-Rong, Xu,Yu, Kong,Deshenyue, Zhang,Xiu-Ling, Mao,Jun-Hong, Hu,Gui-Fang, Wang,Kun-Hua, and Kuang,Yi-Qun

Abstract

Jie Jia,1,2 Ji-Qun Yang,3 Ying-Rong Du,3 Yu Xu,2 Deshenyue Kong,1,2 Xiu-Ling Zhang,3 Jun-Hong Mao,1,2 Gui-Fang Hu,3 Kun-Hua Wang,1,2,4 Yi-Qun Kuang1,2 1NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 3Third People’s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City, Kunming, 650041, People’s Republic of China; 4School of Medicine, Yunnan University, Kunming, 650500, People’s Republic of ChinaCorrespondence: Yi-Qun Kuang; Kun-Hua Wang, NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, 650032, People’s Republic of China, Email yq610433@hotmail.com; wangkunhua1964@126.comBackground: Hypertension is a common complication in injection drug users (IDU), especially a high proportion of resistant hypertension occurs among them. However, the involving mechanisms remain largely unknown.Methods: We here investigated the key signaling moieties in resistant hypertension in drug users. Analyses were performed with high-throughput transcriptomic sequencing data of peripheral blood from individuals with drug-sensitive hypertension (Ctrl-DS), IDU with resistant hypertension (IDU-DR), and IDU with sensitive hypertension (IDU-DS).Results: We showed that 17 and 1 genes in IDU-DS, 48 and 4 genes in IDU-DR were upregulated and downregulated compared Ctrl-DS, and 2 and 4 genes were upregulated and downregulated in IDU-DR compared with IDU-DS, respectively (p ≤ 0.01 and |log2(FC)| ≥ 1). Differentially expressed genes (DEGs) between Ctrl-DS and IDU-DS were mainly involved in Gene ontology terms of immunoglobulin complex and blood microparticle. DEGs between IDU-DS and IDU-DR were mainly involved in i

Published
2022

36. Association Between Systemic Inflammation and Malnutrition With Survival in Patients With Cancer Sarcopenia—A Prospective Multicenter Study

Author

Ruan, Guo-Tian, primary, Ge, Yi-Zhong, additional, Xie, Hai-Lun, additional, Hu, Chun-Lei, additional, Zhang, Qi, additional, Zhang, Xi, additional, Tang, Meng, additional, Song, Meng-Meng, additional, Zhang, Xiao-Wei, additional, Liu, Tong, additional, Li, Xiang-Rui, additional, Zhang, Kang-Ping, additional, Yang, Ming, additional, Li, Qin-Qin, additional, Chen, Yong-Bing, additional, Yu, Kai-Ying, additional, Braga, Marco, additional, Cong, Ming-Hua, additional, Wang, Kun-Hua, additional, Barazzoni, Rocco, additional, and Shi, Han-Ping, additional

Published
2022
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37. Additional file 6 of Effects and associated transcriptomic landscape changes of methamphetamine on immune cells

Author

Kong, Deshenyue, Mao, Jun-Hong, Li, Hong, Wang, Jian-Yu, Li, Yu-Yang, Wu, Xiao-Cong, Re, Guo-Fen, Luo, Hua-You, Kuang, Yi-Qun, and Wang, Kun-Hua

Subjects
fungi, hemic and immune systems, natural sciences
Abstract

Additional file 6. Table S1. GO and KEGG pathways of interest in Jurkat cells. Table S2. GO and KEGG pathways of interest in NK-92 cells. Table S3. GO and KEGG pathways of interest in THP-1 cells.

Published
2022
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38. Coupled Analysis of Single-Cell Transcriptome and TCR Sequencing Uncovers the Role of TRAV1-2 +/J33 + MAIT Cells in Immune Reconstitution of Hiv-Infected Patients Under Antiretroviral Therapy

Author

Jia, Jie, primary, Zhao, Yu, additional, Kong, Deshenyue, additional, Lu, Danfeng, additional, Yang, Ji-Qun, additional, Mao, Jun-Hong, additional, Zhang, Xiu-Ling, additional, Wang, Xiu-wen, additional, Su, Bin, additional, Wang, Kun-Hua, additional, Wang, Jian-Hua, additional, and Kuang, Yi-Qun, additional

Published
2022
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43. Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study

Author

Ruan, Guo-Tian, primary, Yang, Ming, additional, Zhang, Xiao-Wei, additional, Song, Meng-Meng, additional, Hu, Chun-Lei, additional, Ge, Yi-Zhong, additional, Xie, Hai-Lun, additional, Liu, Tong, additional, Tang, Meng, additional, Zhang, Qi, additional, Zhang, Xi, additional, Zhang, Kang-Ping, additional, Li, Xiang-Rui, additional, Li, Qin-Qin, additional, Chen, Yong-Bing, additional, Yu, Kai-Ying, additional, Cong, Ming-Hua, additional, Wang, Kun-Hua, additional, and Shi, Han-Ping, additional

Published
2021
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44. Geriatric Nutrition Risk Index: Prognostic factor related to inflammation in elderly patients with cancer cachexia

Author

Ruan, Guo‐Tian, primary, Zhang, Qi, additional, Zhang, Xi, additional, Tang, Meng, additional, Song, Meng‐Meng, additional, Zhang, Xiao‐Wei, additional, Li, Xiang‐Rui, additional, Zhang, Kang‐Ping, additional, Ge, Yi‐Zhong, additional, Yang, Ming, additional, Li, Qin‐Qin, additional, Chen, Yong‐Bing, additional, Yu, Kai‐Ying, additional, Cong, Ming‐Hua, additional, Li, Wei, additional, Wang, Kun‐Hua, additional, and Shi, Han‐Ping, additional

Published
2021
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46. Additional file 1 of PG-SGA SF in nutrition assessment and survival prediction for elderly patients with cancer

Author

Zhang, Qi, Li, Xiang-Rui, Zhang, Xi, Ding, Jia-Shan, Liu, Tong, Qian, Liang, Song, Meng-Meng, Song, Chun-Hua, Barazzoni, Rocco, Tang, Meng, Wang, Kun-Hua, Xu, Hong-Xia, and Shi, Han-Ping

Abstract

Additional file 1: Supplementary Figure 1. A flow chart of the patients inclusion. Supplementary Figure 2. Estimation of the cut-off value for the PG-SGA SF. Supplementary Figure 3. Correlation analysis of clinical parameters. The blue and red edges represent negative and positive correlations, respectively, and the stronger is in correlation, the darker in color. Supplementary Figure 4. Kaplan-Meier curves for all-cause mortality by the PG-SGA and GLIM in elderly patients with cancer. Supplementary Figure 5. (A)Time-dependent area under the curve (AUC) by the three nutritional assessment tools. (B) Time-dependent ROC curves for survival prediction in 12 months by TNM stage model and TNM stage model combined with PG-SGA SF. Supplementary Figure 6. Kaplan-Meier curves for all-cause mortality by the PG-SGA SF in different tumor types. Supplementary Figure 7. Kaplan-Meier curves for all-cause mortality by the PG-SGA SF in each TNM stages. Supplementary Figure 8. Kaplan-Meier curves for all-cause mortality by the PG-SGA SF in elderly patients with cancer treatment with immunotherapy.

Published
2021
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47. Additional file 1 of Association between CD4+ T cell counts and gut microbiota and serum cytokines levels in HIV-infected immunological non-responders

Author

Lu, Danfeng, Zhang, Jian-Bo, Wang, Yue-Xin, Geng, Shi-Tao, Zhang, Zunyue, Xu, Yu, Li, Shao-You, Wang, Kun-Hua, and Kuang, Yi-Qun

Abstract

Additional file 1. Fig. S1. Beta diversity of gut microbiota in INRs. (A, B) Ordination of unweighted UniFrac distance between samples by PCoA (A) or NMDS (B). R andP values were derived from ANOSIM analyses of distance metrics. Fig. S2. Rectal microbial community composition of study participants. (A–C) A slight decrease in Bacteroidaceae (P = 0.3223) (A) and increase in Prevotellaceae (P = 0.7339) (B) and Prevotellaceae/Bacteroidaceae ratio (P = 0.4023) (C) were observed in the CD4 count < 200 cells/μL group compared to the CD4 count > 200 cells/μL group. The differences were statistically significant at a cut-off value of P < 0.05 (Mann-Whitney test).

Published
2021
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49. Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study

Author

Ruan,Guo-Tian, Yang,Ming, Zhang,Xiao-Wei, Song,Meng-Meng, Hu,Chun-Lei, Ge,Yi-Zhong, Xie,Hai-Lun, Liu,Tong, Tang,Meng, Zhang,Qi, Zhang,Xi, Zhang,Kang-Ping, Li,Xiang-Rui, Li,Qin-Qin, Chen,Yong-Bing, Yu,Kai-Ying, Cong,Ming-Hua, Wang,Kun-Hua, Shi,Han-Ping, Ruan,Guo-Tian, Yang,Ming, Zhang,Xiao-Wei, Song,Meng-Meng, Hu,Chun-Lei, Ge,Yi-Zhong, Xie,Hai-Lun, Liu,Tong, Tang,Meng, Zhang,Qi, Zhang,Xi, Zhang,Kang-Ping, Li,Xiang-Rui, Li,Qin-Qin, Chen,Yong-Bing, Yu,Kai-Ying, Cong,Ming-Hua, Wang,Kun-Hua, and Shi,Han-Ping

Abstract

Guo-Tian Ruan,1– 3,&ast; Ming Yang,1– 3,&ast; Xiao-Wei Zhang,1– 3,&ast; Meng-Meng Song,1– 3 Chun-Lei Hu,1– 3 Yi-Zhong Ge,1– 3 Hai-Lun Xie,1– 3 Tong Liu,1– 3 Meng Tang,1– 3 Qi Zhang,1– 3 Xi Zhang,1– 3 Kang-Ping Zhang,1– 3 Xiang-Rui Li,1– 3 Qin-Qin Li,1– 3 Yong-Bing Chen,1– 3 Kai-Ying Yu,1– 3 Ming-Hua Cong,4 Kun-Hua Wang,5 Han-Ping Shi1– 3 1Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 2Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 3Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, 100038, People’s Republic of China; 4Comprehensive Oncology Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100038, People’s Republic of China; 5Department of Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, 650000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Han-Ping ShiDepartment of Gastrointestinal Surgery and Beijing Shijitan Hospital, Capital Medical University, 10 Tie Yi Road, Beijing, 100038, People’s Republic of ChinaTel +86-10- 6392 6985Fax +86-10 -6392 6325Email shihp@ccmu.edu.cnBackground: Systemic inflammation and cachexia are associated with adverse clinical outcomes in elderly patients with cancer. The survival outcomes of elderly patients with cancer cachexia (EPCC) with high inflammation and a high risk of mortality are unknown. This study aimed to investigate the impact of high inflammation on the prognosis of EPCC patients with high mortality.Patients and Methods: This multicenter cohort study included 746 EPCC (age > 65 years) with a mean age of 72.00 ± 5.24 years, of whom 489 (65.5%) were male. The cut-off value

Published
2021

50. Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer: Results from 24 hospitals in China

Author

Ren, Tai, primary, Li, Yong-Sheng, additional, Dang, Xue-Yi, additional, Li, Yang, additional, Shao, Zi-Yu, additional, Bao, Run-Fa, additional, Shu, Yi-Jun, additional, Wang, Xu-An, additional, Wu, Wen-Guang, additional, Wu, Xiang-Song, additional, Li, Mao-Lan, additional, Cao, Hong, additional, Wang, Kun-Hua, additional, Cai, Hong-Yu, additional, Jin, Chong, additional, Jin, Hui-Han, additional, Yang, Bo, additional, Jiang, Xiao-Qing, additional, Gu, Jian-Feng, additional, Cui, Yun-Fu, additional, Zhang, Zai-Yang, additional, Zhu, Chun-Fu, additional, Sun, Bei, additional, Dai, Chao-Liu, additional, Zheng, Lin-Hui, additional, Cao, Jing-Yu, additional, Fei, Zhe-Wei, additional, Liu, Chang-Jun, additional, Li, Bing, additional, Liu, Jun, additional, Qian, Ye-Ben, additional, Wang, Yi, additional, Hua, Ya-Wei, additional, Zhang, Xi, additional, Liu, Chang, additional, Lau, Wan-Yee, additional, and Liu, Ying-Bin, additional

Published
2021
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