1. Prenatal iron containing supplements provided to Chinese women with no or mild anemia had no effect on hemoglobin concentration in post-partum women or their infants at 6 and 12 months of age
- Author
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Serdula, Mary K., Zhou, Yubo, Li, Hongtian, Liu, Jian-meng, and Mei, Zuguo
- Subjects
Anemia -- Research -- Comparative analysis ,Pregnancy -- Comparative analysis ,Folic acid -- Comparative analysis ,Anemia in pregnancy -- Research -- Comparative analysis ,Glycosylated hemoglobin -- Comparative analysis ,Infants -- Comparative analysis ,Pregnant women -- Comparative analysis ,Food/cooking/nutrition ,Health - Abstract
Background Although prenatal iron-containing supplements have been associated with lower anemia prevalence in later pregnancy, few trials have examined the effect of supplements on the anemia status of post-partum women and their infants. Objective We compared the effects of folic acid alone (FA), iron-folic acid (IFA) and multiple micronutrients (MMN) when provided to pregnant women with no or mild anemia on the hemoglobin levels of post-partum women and their infants at 6 and 12 months of age. We also examined the potential modifying effect of maternal hemoglobin concentration at enrollment. Methods A double-blind randomized controlled trial was conducted in China; 18,775 nulliparous women with a hemoglobin concentration > 100 g/L were randomly assigned to receive daily FA (400 [mu]g); IFA (FA, Fe 30 mg), or MMN (FA, Fe and 13 micronutrients) from before 20 gestational weeks until delivery. Results Compared with daily prenatal FA, supplementation with IFA or MMN did not affect the prevalence of anemia at 4-6 weeks post-partum (27.2%, 26.8%, and 26.3%, respectively). At 6 months of age, the anemia prevalence in infants was 6.9%, 6.7%, and 6.7%, respectively. Findings were similar at 12 months of age. Among both post-partum women and infants, findings were similar across all levels of hemoglobin at enrollment. Conclusions Compared to FA alone, prenatal IFA and MMN provided to women with no or mild anemia did not affect anemia in women post-partum or their infants regardless of baseline maternal hemoglobin concentration at enrollment., Author(s): Mary K. Serdula [sup.1], Yubo Zhou [sup.2] [sup.3], Hongtian Li [sup.2] [sup.3], Jian-meng Liu [sup.2] [sup.3], Zuguo Mei [sup.1] Author Affiliations: (1) Division of Nutrition, Physical Activity and Obesity, [...]
- Published
- 2019
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