88 results on '"Sauvaire, Y"'
Search Results
2. Nouvelle méthode pour mesurer in situ l'activité nitrogénase par réduction de l'acétylène / New method for in situ measuring of nitrogenase activity by acetylene reduction
- Author
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DESPERRIER, N., BACCOU, J. C., SAUVAIRE, Y., and PARIS-PIREYRE, N.
- Published
- 1984
3. Fixation de l'azote atmosphérique et assimilation du nitrate chez le fenugrec (Trigonella foenum graecum L.) cultivé au champ / Nitrogen fixation and nitrate assimilation in field-grown fenugreek (Trigonella foenum graecum L.)
- Author
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DESPERRIER, N., BACCOU, J. C., and SAUVAIRE, Y.
- Published
- 1986
4. Sterol composition and biosynthesis in sorghum: Importance to developmental regulation
- Author
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Heupel, Rick C., Sauvaire, Y., Le, Phu H., Parish, Edward J., and Nes, W. David
- Published
- 1986
- Full Text
- View/download PDF
5. Nouvelle méthode pour mesurerin situ l'activité nitrogénase par réduction de l'acétylène
- Author
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Desperrier, N., Baccou, J. C., Sauvaire, Y., and Paris-Pireyre, N.
- Published
- 1984
- Full Text
- View/download PDF
6. 4-Hydroxyisoleucine improves glucose tolerance in normal and NIDDM animals
- Author
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Broca, C, Gross, R, Petit, P, Sauvaire, Y, Manteghetti, M, Masiello, Pellegrino, Gomis, R, and Ribes, G.
- Published
- 1998
7. ChemInform Abstract: An Epoxidized Iridal from Iris germanica var. “Rococo”.
- Author
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BONFILS, J.-P., primary, MARNER, F.-J., additional, and SAUVAIRE, Y., additional
- Published
- 2010
- Full Text
- View/download PDF
8. Relation entre la composition en acides aminés libres des graines de fenugrec et la qualité aromatique
- Author
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Sauvaire, Y., Brenac, P., Guichard, E., Fournier, N., FLAveur, VIsion et Comportement du consommateur (FLAVIC), Etablissement National d'Enseignement Supérieur Agronomique de Dijon (ENESAD)-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), and ProdInra, Migration
- Subjects
[SDV] Life Sciences [q-bio] ,FENUGREC ,[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 1992
9. Occurrence of amino acids and proteins in miocene fossil leaves
- Author
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Roiron, P., Sauvaire, Y., Chardard, I., and Risterucci, Ange-Marie
- Subjects
Analyse de tissus ,Feuille ,Protéine ,Paléontologie ,F60 - Physiologie et biochimie végétales ,Anatomie végétale ,Acide aminé - Published
- 1991
10. Volatile Components ofNigella damascenaL. andNigella sativaL. Seeds
- Author
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Rchid, H., primary, Nmila, R., additional, Bessière, J. M., additional, Sauvaire, Y., additional, and Chokaïri, M., additional
- Published
- 2004
- Full Text
- View/download PDF
11. Insulinotropic Effect of Citrullus colocynthis Fruit Extracts
- Author
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Nmila, R., primary, Gross, R., additional, Rchid, H., additional, Roye, M., additional, Manteghetti, M., additional, Petit, P., additional, Tijane, M., additional, Ribes, G., additional, and Sauvaire, Y., additional
- Published
- 2000
- Full Text
- View/download PDF
12. Isolation and structure determination of three epoxidized iridals from Iris cristata
- Author
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Taillet, L., primary, Bonfils, J-P., additional, Marner, F-J., additional, and Sauvaire, Y., additional
- Published
- 1999
- Full Text
- View/download PDF
13. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion
- Author
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Sauvaire, Y., primary, Petit, P., additional, Broca, C., additional, Manteghetti, M., additional, Baissac, Y., additional, Fernandez-Alvarez, J., additional, Gross, R., additional, Roye, M., additional, Leconte, A., additional, Gomis, R., additional, and Ribes, G., additional
- Published
- 1998
- Full Text
- View/download PDF
14. Effects of a fenugreek seed extract on feeding behaviour in the rat: Metabolic-endocrine correlates
- Author
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Petit, P., primary, Sauvaire, Y., additional, Ponsin, G., additional, Manteghetti, M., additional, Fave, A., additional, and Ribes, G., additional
- Published
- 1993
- Full Text
- View/download PDF
15. EFFECTS OF A FENUGREEK SEED EXTRACT ON FEEDING BEHAVIOUR IN THE RAT
- Author
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PETIT, P, primary, SAUVAIRE, Y, additional, FAVE, A, additional, and RIBES, G, additional
- Published
- 1992
- Full Text
- View/download PDF
16. Fagaronine, a novel antileukaemic alkaloid
- Author
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Barret, Y., primary and Sauvaire, Y., additional
- Published
- 1992
- Full Text
- View/download PDF
17. Effet des saponines stéroïdiques de fenugrec sur l'hypercholestérolémie du chien diabétique
- Author
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Sauvaire, Y., primary, Ribes, G., additional, Baccou, JC, additional, and Loubatières-Mariani, MM, additional
- Published
- 1990
- Full Text
- View/download PDF
18. Hypocholesterolaemic and hypotriglyceridaemic effects of subfractions from fenugreek seeds in alloxan diabetic dogs.
- Author
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Ribes, G., Da Costa, C., Loubatières-Mariani, M. M., Sauvaire, Y., and Baccou, J. C.
- Published
- 1987
- Full Text
- View/download PDF
19. Composition of pulp, skin and seeds of prickly pears fruit (Opuntia ficus indica sp.).
- Author
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El Kossori, Radia, Villaume, Christian, El Boustani, Essadiq, Sauvaire, Yves, Méjean, Luc, El Kossori, R L, Villaume, C, El Boustani, E, Sauvaire, Y, and Méjean, L
- Abstract
The proximate composition of pulp, skin and seeds of prickly pear cactus (Opuntia ficus indica) was investigated and is reported on a dry weight basis. The most abundant component of the pulp and skin was ethanol-soluble carbohydrates. Pulp contained glucose (35%) and fructose (29%) while the skin contained essentially glucose (21%). Protein content was 5.1% (pulp), 8.3% (skin) and 11.8% (seeds). Starch was found in each of the three parts of the fruit. Pulp fibers were rich in pectin (14.4%), skin and seeds were rich in cellulose (29.1 and 45.1%, respectively). Skin was remarkable for its content of calcium (2.09%) and potassium (3.4%). Prickly pear is a neglected nutritional source which should be more widely used because of its potential nutrient contribution. [ABSTRACT FROM AUTHOR]
- Published
- 1998
- Full Text
- View/download PDF
20. Spectrophotometric method for the determination of total steroidal sapogenin.
- Author
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Baccou, J. C., Lambert, F., and Sauvaire, Y.
- Published
- 1977
- Full Text
- View/download PDF
21. Antidiabetic Effects of Subtractions from Fenugreek Seeds in Diabetic Dogs.
- Author
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Ribes, G., Sauvaire, Y., Costa, C. Da, Baccou, J. C., and Loubatieres-Mariani, M. M.
- Published
- 1986
- Full Text
- View/download PDF
22. 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion
- Author
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Broca, C., Manteghetti, M., Gross, R., Baissac, Y., Jacob, M., Petit, P., Sauvaire, Y., and Ribes, G.
- Published
- 2000
- Full Text
- View/download PDF
23. 35th Annual Meeting of the European Association for the Study of Diabetes
- Author
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Juhl, C., Pørksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th., Müller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Björn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H.-M., Oksanen, L., Tuomainen, T.-P., Kontula, K., Salonen, J. T., Dekker, J. M., de Boks, P., de Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D’Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., MacAlpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M., Kozáková, H., Kaas, A., Kofronová, O., Tlaskalová-Hogenová, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sørensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Haskó, G., Szabó, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Van Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H.-H., Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabák, Á. Gy., Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Cantón, A., Burgos, R., Hernández, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simó, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., McDermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y.-S., Sternesjö, J., Sandler, S., Chen, M.-C., Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Bréant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., van der Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, De Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessières-Lacombe, S., Tauber, J.-P., Home, P. D., Lindholm, A., Riis, A., Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Steiner, G., Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Vergès, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph., Benko, B., Ljubić, S., Turk, Z., Granić, M., März, W., Wollschläger, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O’Rahilly, S., Hattersley, A. T., McCarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., de Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Van Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Simán, C., Wisse, Bert, Gittenberger-de Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ożegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rość, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Škrha, J., Kvasnička, J., Kalvodová, B., Hilgertová, J., Schatteman, K., Goossens, F., Scharpé, S., De Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th. D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Häring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., McKinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnæs, A. M., Andersen, N. Aa., Osterhoff, M., Möhlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Fürnsinn, C., Nowotny, P., Waldhäusl, W., Roden, M., Neeft, M., Meijer, A. J., Båvenholm, P., Pigon, J., Efendic, S., Kästenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Van Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovská, A., Kasalicky, P., Hosová, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefèbvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valéro, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., de Galan, B., Netea, M. G., Hancu, N., Smits, P., Van der Meer, J. W. M., Osterbye, T., Jørgensen, K. H., Tranum-Jensen, J., Fredman, P., Høy, M., Bokvist, K., Olsen, H. L., Horn, T., Gromada, J., Laub, R., Lohmann, T., Hahn, H. J., Adler, T., Emmrich, F., Rabuazzo, A. M., Lupi, R., Dotta, F., Patanè, G., Marselli, L., Realacci, M., Piro, S., Del Guerra, S., Santangelo, C., Navalesi, R., Purrello, F., Marchetti, P., de Vos, P., Visser, L., de Haan, B. J., Klok, P., van Schilfgaarde, R., Poppema, S., Juang, J.-H., Kuo, C.-H., Hsu, B. R.-S., Nacher, V., Pérez, M., Biarnés, M., Raurell, M., Soler, J., Montanya, E., Ritzel, R., Maubach, J., Büsing, M., Becker, T., Klempnauer, J., Hücking, K., Schmiegel, W. H., Nauck, M. A., Bouček, P., Saudek, F., Adamec, M., Kožitarová, R., Jedináková, T., Vlasáková, Z., Skibová, J., Bartoš, V., Maffi, P., Bertuzzi, F., Aldrighetti, L., Taglietti, M. V., Castelnuovo, A., Pozza, G., Di Carlo, V., Secchi, A., Renier, G., Mamputu, J.-C., Gillespie, J. S., McMaster, D., Mercer, C., Trimble, E. R., Lecomte, M., Véricel, E., Paget, C., Ruggiero, D., Lagarde, M., Wiernsperger, N., Pricci, F., Leto, G., Amadio, L., Cordone, S., Iacobini, C., Catalano, S., Violi, F., Rotella, C. M., Pugliese, G., Zicari, A., Gradini, R., Sale, P., Pala, L., Cresci, B., Giannini, S., Manuelli, C., Dahlfors, G., Arnqvist, H. J., Gonelle-Gispert, C., Halnan, P. A., Sadoul, K., Wolter, S., Lang, J., Niwa, T., Yu, W., Hidaka, H., Senda, T., Niki, I., Fukasawa, T., Renstrom, E., Barg, S., Seward, E., Rorsman, P., Rutter, G. A., Molinete, M., Lilla, V., Ravazzola, M., Halban, P. A., Efanov, A. M., Bertorello, A. M., Zaitsev, S. V., Zwiller, J., Berggren, P.-O., MŞengül, A., Salman, F., Sargrn, M., Özer, E., Karşidaǧ, K., Salman, S., Gedik, S., Satman, İ., Dinççaǧ, N., Yılmaz, M. T., Lloyd, A., Hopkinson, P. K., Testa, M. A., Blonde, L., Turner, R. R., Hayes, J., Simonson, D. C., van der Ven, N. C. W., Lubach, C. H. C., Snoek, F. J., Mollema, E. D., van der Ploeg, H. M., Danne, T., Hoey, H., McGee, H., Fitzgerald, H., Lernmark, B., Thernlund, G., Fredin, K., Hägglöf, B., Lugari, R., Dell’Anna, C., Ugolotti, D., Dei Cas, A., Barilli, A. L., Sard, L., Marani, B., Iotti, M., Zandomeneghi, R., Gnudi, A., Kjems, L. L., Volund, Aa., Toft-Nielsen, M., Damholt, M. B., Hilsted, L., Hughes, T. E., Krarup, T., Holst, J. J., Young, A., Gottlieb, A., Fineman, M., Kolterman, O., Cancelas, J., García-Martínez, J. A., Villanueva-Peñacarrillo, M. L., Valverde, I., Malaisse, W. J., Filipsson, K., Ahrén, B., Balkan, B., Kwasnik, L., Battle, B., Li, X., Egan, J. M., Clocquet, A. R., Elahi, D., Petrella, E., Pricket, K., Petersen, K. F., Sullivan, J. T., Amatruda, J. M., Livingston, J. N., Shulman, G. I., Freyse, E.-J., Knospe, S., Glund, K., Demuth, H.-U., Walker, D., Malik, R. A., Reljanovic, M., Barada, A., Milicevic, Z., Tack, Cees J., Goldstein, David S., Van Huysen, C., Stevens, M. J., Cao, X., Sundkvist, G., Dahlin, L.-B., Eriksson, K.-F., Rosén, I., Lattimer, S. A., Sima, A. A. F., Sullivan, K., Shaw, J. E., de Courten, M. P., Zimmet, P. Z., Gourdy, P., Ruidavets, J. B., Arveiler, D., Amouyel, Ph., Bingham, A., Tauber, J. P., Lam, K. S. L., Wat, N. M. S., Lam, T. H., Janus, E. D., de Pablos, P., Rodriguez, F., Martínez, J., Sánchez, V., Santana, C., García, I., Macías, A., Levin, K., Hother-Nielsen, O., Henriksen, J. E., Beck-Nielsen, H., Brechtel, K., Machann, J., Koch, M., Nielsen, M., Löblein, K., Becker, R., Denignger, M., Renn, W., Machicao, F., Claussen, C. D., Schick, F., Diraison, F., Moulin, P., Beylot, M., Thams, P., Capito, K., Eliasson, Lena, Barg, Sebastian, Göpel, Sven, Kanno, Takahiro, Renström, Erik, Meda, P., Charollais, A., Gjnovci, A., Calabrese, A., Wonkam, A., Caton, D., Wisznievski, L., Serre, V., Cogne, F., Bauquis, J., Bosco, D., Huarte, J., Herrera, P., Gotfredsen, C. F., Vessby, B., Manuel y Keenoy, B., Engelen, W., Vertommen, J., Schrans, S., Louheranta, A., Lindström, J., Tuomilehto, J., Segal, K. R., Heymsfield, S., Hauptman, J., Boldrin, M., Lucas, C., Pandolfi, A., Cetrullo, D., Polishchuck, R., Alberta, M., Pellegrini, G., Calafiore, A., Vitacolonna, E., Capani, F., Consoli, A., Halleux, C. M., Gillot, E. F., Brichard, S. M., Van der Planken, M., Corthouts, B., Peiffer, F., Scholten, D., Walke, M., Assert, R., Pirags, V., Pedula, K. L., Hillier, T. A., Brown, J. B., Santini, S. A., Marra, G., Cotroneo, P., Manto, A., Di Leo, M. A. S., Di Gregorio, S., Tordi, A., Pitocco, D., Ruotolo, V., Ghirlanda, G., Temelkova-Kurktschiev, T., Schaper, F., Koehler, C., Henkel, E., Hanefeld, M., Mancini, L., Citterio, F., Cotroneo, A., Ceroone, S., Castagneto, M., Rajbhandari, S. M., Dent, M. T., Plater, M. E., Harris, N. D., Tesfaye, S., Ward, J. 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E., Ramu, Y., Vidyullatha, Y., Strojek, K., Gorska, J., Morawin, E., Ritz, E., Ciavarella, A., Malini, P. L., Strocchi, E., Fiumi, N., Ambrosioni, E., Idzior-Waluś, B., Stevens, L., McEneny, J., O’Kane, M. J., Moles, K. W., McMaster, C., Young, I. S., Leonhardt, W., Konstadelou, E., Gürlek, Alper, Soedamah-Muthu, S., Taskinen, M. R., Ehnholm, C., Wägner, A., Bayen, Laia, Rigla, M., Ortega, E., Caixàs, A., Mestrón, A., Ordóñez, J., Pérez, A., Sotiropoulou, G., Servais, P. L., Bertolotto, A., Pilo, M., Suchánková, G., Andratschke, S., Tschöp, M., Strasburger, C.-J., Rizzo, L., Aerts, P., Vinckx, M., Ansquer, J. C., Ryan, M., Buter, H., Navis, G. J., de Jong, P. E., de Zeeuw, D., Carreras, G., Giménez, G., Pou, J. M., Howorka, K., Gabriel, M., Pumprla, J., Köves, A., Bhowmik, N. B., Haque, A., Rahman, A., Paleari, F., Gamba, P., Mauri, G., Rovaris, G., Giannattasio, C., Piatti, M. L., Zincone, A., Cavaletti, G., Mancia, G., Lan, S., Arezzo, J., Gerber, R. A., Klioze, S. S., Saponara, C., Tartaglione, T., Cercone, S., Caputo, S., Meloni, T., Brunetti, D., Di Lazzaro, V., Xu, G., Jiang, H. Y., Shy, M. E., Sugimoto, K., Zhang, W.-X., Kuchmerovskaya, T., Donchenko, G., Shymansky, I., Kuchmerovsky, N., Pakyrbaeva, L., Cameron, N. E., Keegan, A., Cotter, M. A., Mirrlees, D., Smale, S. E., Biessels, G. J., Duis, S. E. J., Kamal, A., Gispen, W. H., Carrington, A., Carman, S., Smiarowski, H., Lavoie, D., Sawicki, D., Sabetta, A., Litchfield, J., Van Zandt, M., Sredy, J., Smirnova, V., Strokov, I., Ivanova, L., Ichunina, A., Nakamura, J., Nakayama, M., Hamada, Y., Chaya, S., Kato, K., Kasuya, Y., Mizubayashi, R., Miwa, K., Yasuda, Y., Kamiya, H., Hotta, N., Bíró, K., Kukorelli, T., Szilágyi, N., Kürthy, M., Komáromy, A., Mogyorosi, T., Nagy, K., Çakir, M., Baskal, N., Güllü, S., Elhan, A. H., Erdogan, G., Ziegler, D., Piolot, R., Neubauer, J., Senesi, B., Bonetti, R., Napolitano, A., Canepa, F., Ottonello, P., Schabmann, A., Giménez-Pérez, G., Arroyo, J. A., López, T., Ponz, E., Mauricio, D., Diem, P., Zanchin, L., Suter, S. L., Lefrandt, J. D., Smit, A., van Roon, A. M., Dullaart, R., Voita, D., Mackevics, V., Vitols, A., Lengyel, Cs., Farkas, Gy., Török, T., Légrády, P., Várkonyi, T. T., Kardos, A., Gingl, Z., Kempler, P., Rudas, L., Lonovics, J., Marchand, M., Stevens, L. K., Tarnás, Gy., Estrella, F., Christensen, N. J., Keresztes, K., Barna, I., Hermányi, Zs., Vargha, P., Bonnevie, L., Chanudet, X., Larroque, P., Tutuncu, N. Bascil, Deger, A., Batur, M. K., Yildirir, A., Onalan, O., Aksöyek, S., Kabakçι, G., Erbaş, T., Galicka-Latała, D., Surdacki, A., Gerritsen, J., TenVoorde, B. J., Heethaar, R. M., Tagawa, T. S., Kodama, M., Yoshioka, R., Yamasaki, Y., Didangelos, T., Athyros, V., Kontopoulos, A., Papageorgiou, A., Karamitsos, D., Lacigová, S., Rušavý, Z., Kárová, R., Perrild, H., Kay, L., Jørgensen, T., Bień, A. I., Witek, P., Geraldes, Elizabete, Rodrigues, D., Pereira, L., Doménech, A., Leitão, P., Anagnostopoulos, D., Foster, A. V. M., Nag, S., Barsoum, M., Lewis, G., Dunlop, N., Connolly, V., Bilous, R., Kelly, W., Chantelau, E., Gede, A., Sharman, D., O’Halloran, D., Best, C., Abbas, Z. G., Lutale, J., Gill, G. V., Jarvis, W. R., Archibald, L. K., Corcoran, S., Mansell, J., Pibworth, L., Terada, H., Shiba, T., Utugi, N., Utugi, T., Blum, M., Strobel, J., Höffken, K., Razvi, F. M., Kritzinger, E. E., Taylor, K., Jones, S., Illahi, W., Grüβer, M., Hartmann, P., Hoffstadt, K., van Leiden, H. A., Moll, A. C., Polak, B. C. P., Pietragalla, G. B., Maurino, M., Montanaro, M., Karadeniz, Ş., Tommasini, P., Quadrini, C., Demiraj, V., Rispoli, E., Ota, A., Takama, H., Saito, N., Hemández, C., Lepore, D., Antico, L., Giardina, B., Franconi, F., Michoud, E., Chamot, S., Riva, Ch., Hammes, H.-P., Renner, O., Breier, G., Lin, J., Alt, A., Betzholtz, C., Bretzel, R. G., Manti, R., Gallo, M., Molinar Hin, A., Brignardello, E., Boccuzzi, G., Li, Shanfang, Xiang, Kunsan, Zhang, Rugeng, Shangguan, Xinhong, Wu, Jianrong, Donnan, P. T., Broomhall, J., Hunter, K., Morris, A. D., Ioannidis, G., Peppa, M., Rontogianni, E., Kallifronas, M., Lekatsas, I., Chrysanthopoulou, G., Anthopoulos, L., Kesse, M., Thalassinos, N., Neves, C., Medina, J. L., Lopes, F., Yılmaz, M., Güvener, N., Güvener, M., Kocagöz, T., Böke, E., Paşaoglu, I., Bascil Tutuncu, N., Oto, A., Karvonen, M. K., Koulu, M., Pesonen, U., Mercuri, M., Rauramaa, R., Rutter, M. K., Kestevan, P., McComb, J. M., Marshall, S. M., Sobieska, M., Wiktorowicz, K., Kanters, S. D. J. M., Banga, J. D., Algra, A., Frijns, C. J. M., Beutler, J. J., Fijnheer, R., Nicoloff, G., Baydanoff, S., Stanimirova, N., Petrova, Ch., Lario, S., Campistol, J. M., Cases, A., Clària, J., Iñigo, P., Esmatjcs, E., Sármán, B., Tóth, M., Kocsis, I., Somogyi, A., Bumbure, A., Jachimowicz, K., Samson, J., Tomasiak, M., Sobol, A., Stańczyk, L., Watala, C., Stradina, P., Wiśniewska-Jarosińska, M., Marciniak, D., Więcławska, B., Watała, C., Golański, J., Zinnat, R., Mahmud, I., Büyükasik, Yahya, Demiroğlu, H., Szczepanik, A., Skowroński, M., Murawska, A., Meeking, D. R., Allard, S., Munday, J., Chowienczyk, P., Shaw, K. M., Cummings, M. H., Šimková, R., Jirsa, M., Hadoke, P. W. F., McIntyre, C. A., Jones, G. C., Williams, B. C., Elliott, A. I., McKnight, J. A., Pernow, J., Bombonato, G. C., Finucci, G. F., Zotta, L., Senses, V., Ozyazgan, S., Ince, E., Tunçdemir, M., Oztürk, M., Sultuybek, G., Akkan, A. G., Özyazgan, S., Unlücerci, Y., Bekpınar, S., Meyer, M. F., Lee, B. C., Shore, A. C., Humphreys, J. M., Tooke, J. E., Dell’Omo, G., Giovannitti, G., Caricato, F., Mariani, M., Pedrinelli, R., Kiviet-Boehm, C., Schwelling, V., Matthäei, S., Pfohl, M., McInerney, D., Itoh, H., Ohno, T., Katoh, N., Baumgartner-Parzer, S., Artwohl, M., Graier, W., Ludwig, C., Tachi, Y., Bannai, C., Shinohara, M., Shimpuku, H., Ohura, K., Bertacca, A., Sasvári, M., Szaleczki, E., Pusztai, P., Boes, U., Klaus, E., Dittrich, P., Wagner, Z., Wittmann, I., Pótó, L., Wagner, L., Mazák, I., Nagy, J., Feletto, F., Taboga, C., Tonutti, L., Lizzio, S., Russo, A., Selmo, V., Ceriello, A., Lekakis, J., Papamichael, C. M., Stamatelopoulos, K., Stamatelopoulos, S., Yillar, D. O., Gay, M., Lillaz, E., Passaro, A., Vanini, A., Calzoni, F., D’Elia, K., Carantoni, M., Zuliani, G., Fellin, R., Solini, A., Chwatko, G., Bald, E., Dramais, A.-S., Wallemacq, P. E., Vandeleene, B., Ciaria, M. V., Ariano, M., Strom, R., Gibney, J., Weiss, U., Turner, B., O’Gorman, P., Watts, G., Powrie, J., Crook, M., Shaw, K., and Cummings, M.
- Published
- 1999
- Full Text
- View/download PDF
24. Volatile Components of Nigella damascena L. and Nigella sativa L. Seeds.
- Author
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Rchid, H., Nmila, R., Bessière, J. M., Sauvaire, Y., and Chokaïri, M.
- Subjects
ESSENTIAL oils ,LOVE-in-a-mist ,BLACK cumin ,CHLOROFORM ,PLANT extracts ,ANTHRANIL ,SEEDS - Abstract
The volatile components in chloroform extracts and essential oils from the seeds of Nigella damascena and Nigella sativa were analyzed by GC and GC/MS. The volatile compositions differed in the two species: N. damascena contained sesquiterpenes, including a large proportion of β-elemene (27.7% extract, 54.7% oil) and methyl 3-methoxy-N-methyl anthranilate (30.7% extract, 12.7% oil), which account for the characteristic aroma of this species, whereas only monoterpenes, including p-cymene (49.0% extract, 47.4% oil) and thymoquinone (20.6% extract, 20.8% oil), were detected in N. sativa. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
25. Characterization of a dioxygenase from Trigonella foenum-graecum involved in 4-hydroxyisoleucine biosynthesis
- Author
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Haefele, C., Bonfils, C., and Sauvaire, Y.
- Published
- 1997
- Full Text
- View/download PDF
26. Protective effect of iridals from saponin injury in Candida albicans cells
- Author
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Leconte, O., Bonfils, J.-P., and Sauvaire, Y.
- Published
- 1997
- Full Text
- View/download PDF
27. Effect of tridemorph and fenpropimorph on sterol composition in fenugreek
- Author
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Cerdon, C., Rahier, A., Taton, M., and Sauvaire, Y.
- Published
- 1996
- Full Text
- View/download PDF
28. Accumulation of sterols and steroidal sapogenins in developing fenugreek pods: possible biosynthesis in situ
- Author
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Brenac, P. and Sauvaire, Y.
- Published
- 1996
- Full Text
- View/download PDF
29. Chemotaxonomic value of sterols and steroidal sapogenins in the genusTrigonella
- Author
-
Brenac, P. and Sauvaire, Y.
- Abstract
The composition in sterols and steroidal sapogenins was investigated in seven species of the genusTrigonella. Fenugreek (Trigonella foenum-graecum L.), considered as representative of this genus, was used as a reference species. Its sterolic composition is characterized by a quasi absence of stigmasterol and by the presence of @D7-sterols and of pollinastanol (14@a-methyl-9@b,19-cyclo-5@a-cholestan-3@b-ol), an unusual sterol. The composition in steroidal sapogenins (11 different compounds representing 1.5% DW) is also taken into consideration. The results of the analysis of these substances in the seven species studied are presented and their taxonomic contribution is discussed. First, our results support the unchanged assignment ofT. corniculata (L.) L.,T. caerulea (L.) Ser. andT. melilotus caeruleus (L.) Ascherson et Graebner to the genusTrigonella. They confirm the regroup of the two last species under the name ofT. caerulea (L.) Ser. The transfer ofT. monspeliaca L. to the genusMedicago is also confirmed, this species presenting a sterolic composition different from the other species but similar to that ofMedicago sativa L. However, our results do not support completely the unchanged assignment ofT. calliceras Fisch. in M. Bieb. to the genusTrigonella, nor the reassignment ofT. cretica (L.) Boiss. toMelitotus cretica (L.) Desr., the composition of this species being close to that ofTrigonella foenumgraecum L. for the compounds investigated. In conclusion, we propose the use of pollinastanol and steroidal sapogenins as chemotaxonomic markers to investigate the generic separation betweenTrigonella, Medicago andMelilotus.
- Published
- 1996
- Full Text
- View/download PDF
30. Volatile Components of Nigella damascenaL. and Nigella sativaL. Seeds
- Author
-
Rchid, H., Nmila, R., Bessière, J.M., Sauvaire, Y., and Chokaïri, M.
- Abstract
AbstractThe volatile components in chloroform extracts and essential oils from the seeds of Nigella damascenaand Nigella sativawere analyzed by GC and GC/MS. The volatile compositions differed in the two species: N. damascenacontained sesquiterpenes, including a large proportion of β-elemene (27.7% extract, 54.7% oil) and methyl 3-methoxy-N-methyl anthranilate (30.7% extract, 12.7% oil), which account for the characteristic aroma of this species, whereas only monoterpenes, including p-cymene (49.0% extract, 47.4% oil) and thymoquinone (20.6% extract, 20.8% oil), were detected in N. sativa.
- Published
- 2004
- Full Text
- View/download PDF
31. Volatile Constituents of Fenugreek Seeds
- Author
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Girardon, P., primary, Bessiere, J., additional, Baccou, J., additional, and Sauvaire, Y., additional
- Published
- 1985
- Full Text
- View/download PDF
32. Antidiabetic Effects of Subtractions from Fenugreek Seeds in Diabetic Dogs
- Author
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Ribes, G., primary, Sauvaire, Y., additional, Costa, C. D., additional, Baccou, J. C., additional, and Loubatieres-Mariani, M. M., additional
- Published
- 1986
- Full Text
- View/download PDF
33. Hypocholesterolaemic effect of Fenugreek seeds in dogs
- Author
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VALETTE, G, primary, SAUVAIRE, Y, additional, BACCOU, J, additional, and RIBES, G, additional
- Published
- 1984
- Full Text
- View/download PDF
34. Screening for Diosgenin in Rhizomes from 3CostusSpecies(C. deistellii, C. igneus, C. lucanusianus)
- Author
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Lambert, N., primary, Baccou, J.-C., additional, and Sauvaire, Y., additional
- Published
- 1988
- Full Text
- View/download PDF
35. Changes in growth, proteins and free amino acids of developing seed and pod of fenugreek
- Author
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Sauvaire, Y., primary, Girardon, P., additional, Baccou, J.C., additional, and Ristérucci, A.M., additional
- Published
- 1984
- Full Text
- View/download PDF
36. An epoxidized iridal from Iris germanica var Rococo
- Author
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Bonfils, J.-P., Marner, F.-J., and Sauvaire, Y.
- Published
- 1998
- Full Text
- View/download PDF
37. Screening for Diosgenin in Rhizomes from 3 Costus Species (C. deistellii, C. igneus, C. lucanusianus)
- Author
-
Lambert, N., Baccou, J.-C., and Sauvaire, Y.
- Published
- 1988
- Full Text
- View/download PDF
38. ChemInform Abstract: An Epoxidized Iridal from Iris germanica var. 'Rococo'.
- Author
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BONFILS, J.-P., MARNER, F.-J., and SAUVAIRE, Y.
- Published
- 1998
- Full Text
- View/download PDF
39. Nitrogen fixation and nitrate assimilation in field-grown fenugreek (Trigonella foenum graecum L.)
- Author
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Baccou, J. C., Desperrier, N., and Sauvaire, Y.
- Subjects
NITROGEN fixation ,PLANT physiology - Published
- 1986
40. New method for in situ measuring of nitrogenase activity by acetylene reduction
- Author
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Paris-Pireyre, N., Desperrier, N., Baccou, J. C., and Sauvaire, Y.
- Subjects
BOTANY ,NITROGEN fixation - Published
- 1984
41. Effect of diniconazole on sterol composition of roots and cell suspension cultures of fenugreek
- Author
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Cerdon, C., Rahier, A., Taton, M., and Sauvaire, Y.
- Published
- 1995
- Full Text
- View/download PDF
42. The protective function of the xanthophyll cycle in photosynthesis
- Author
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Sarry, J.-E., Montiller, J.-L., Sauvaire, Y., and Havaux, M.
- Published
- 1994
- Full Text
- View/download PDF
43. Occurrence of Diosgenin in Borderea pyrenaica, an Endemic Dioscoreaceae from the Pyrenees
- Author
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Cerdon, C., Brenac, P., and Sauvaire, Y.
- Published
- 1995
- Full Text
- View/download PDF
44. Nutritional Value of the Proteins of a Leguminous Seed: Fenugreek (Trigonella foenum-graecum L.)
- Author
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Baccou, J. C., Sauvaire, Y., and Besancon, P.
- Published
- 1976
45. Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets.
- Author
-
Rchid H, Chevassus H, Nmila R, Guiral C, Petit P, Chokaïri M, and Sauvaire Y
- Subjects
- Animals, Dose-Response Relationship, Drug, Hypoglycemic Agents chemistry, In Vitro Techniques, Insulin Secretion, Islets of Langerhans metabolism, Male, Plant Extracts chemistry, Plant Extracts pharmacology, Rats, Rats, Wistar, Seeds chemistry, Glucose pharmacology, Hypoglycemic Agents pharmacology, Insulin metabolism, Islets of Langerhans drug effects, Nigella sativa chemistry
- Abstract
Nigella sativa L. 'Black cumin' (Ranunculaceae) is one of the plants commonly used in Moroccan folk medicine for treatment of various ailments including diabetes mellitus. The present study was undertaken to investigate the effect of different N. sativa seed extracts on insulin secretion. Different fractions of the seed were prepared: the defatted fraction (HR II), which was divided into two subfractions: the first (HR III) containing acidic and neutral compounds and the second (HR IV) containing basic compounds. The insulin secretory effects of these extracts were evaluated individually at different concentrations (0.01, 0.1, 1 and 5 mg/mL), in vitro in isolated rat pancreatic islets in the presence of 8.3 mmol/L glucose. The results show that addition of the defatted whole extract or of the basic subfraction of the seed in the incubation medium significantly increased glucose-induced insulin release from the islets. In the case of the acidic and neutral subfraction, the stimulatory effect was observed only for the higher concentration (5 mg/mL). However, a clear concentration-dependent increase in insulin release from isolated pancreatic islets was observed for the basic subfraction. Our data show that the antidiabetic properties of N. sativa seeds may be, at least partly, mediated by stimulated insulin release, and that the basic subfraction largely contributes to this stimulatory effect. Further phytochemical studies are underway in order to isolate the pharmacological compound(s) responsible for the insulinotropic effect of N. sativa seeds.
- Published
- 2004
- Full Text
- View/download PDF
46. Antiplasmodial and antifungal activities of iridal, a plant triterpenoid.
- Author
-
Benoit-Vical F, Imbert C, Bonfils JP, and Sauvaire Y
- Subjects
- Animals, Azadirachta chemistry, Candida classification, Candida drug effects, Candida albicans drug effects, Cell Line, Chloroquine pharmacology, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Drug Resistance, Female, Humans, Inhibitory Concentration 50, Injections, Intraperitoneal, Mice, Microbial Sensitivity Tests, Plants, Medicinal chemistry, Plasmodium falciparum drug effects, Triterpenes chemistry, Antifungal Agents pharmacology, Antimalarials pharmacology, Iridaceae chemistry, Triterpenes pharmacology
- Abstract
Iridal, a triterpenoidic compound extracted from Iris germanica L., was previously shown to have an interesting activity on two cultured human tumor cell lines (A2780 and K562). In the present work, this same product was tested in vitro on Plasmodium falciparum chloroquine-resistant and -sensitive strains, in vivo on P. vinckei, and on some Candida albicans and C. parapsilosis strains too. The IC(50) obtained in vitro on human malaria strain ranged from 1.8 to 26.0 microg/ml and the ED(50) in vivo is about 85 mg/kg/day by intraperitoneal route. The minimal inhibitory concentrations were higher than to 50 microg/ml, whatever the strain of yeast tested. This product presents an antiplasmodial activity similar to that obtained with extracts from the plant Azadirachta indica classically taken as reference in malaria phytomedicine. Conversely iridal shows no important antifungal activity. The specific activity of iridal on human malaria parasite and on tumor cell lines is discussed.
- Published
- 2003
- Full Text
- View/download PDF
47. Cytotoxicity of iridals, triterpenoids from Iris, on human tumor cell lines A2780 and K562.
- Author
-
Bonfils JP, Pinguet F, Culine S, and Sauvaire Y
- Subjects
- Drug Screening Assays, Antitumor, Humans, K562 Cells, Molecular Structure, Triterpenes chemistry, Tumor Cells, Cultured, Antineoplastic Agents, Phytogenic pharmacology, Magnoliopsida chemistry, Triterpenes pharmacology
- Abstract
Six different triterpenoids (known iridals) extracted from Iris germanica L. were purified and bioassayed on two cultured human tumor cell lines: A2780 and K562 (and for each one a drug-sensitive and a drug-resistant cell line). All of the tested iridals had an IC50 in the 0.1 to 5.3 microg/ml range. Some of them were shown to be more effective than doxorubicine. Toxicity of iridals on multi-drug resistance (MDR) expressing cell lines seemed to indicate that the effects of these triterpenoids are less affected by MDR than those of doxorubicine or taxol.
- Published
- 2001
- Full Text
- View/download PDF
48. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties.
- Author
-
Broca C, Gross R, Petit P, Sauvaire Y, Manteghetti M, Tournier M, Masiello P, Gomis R, and Ribes G
- Subjects
- Acids pharmacology, Animals, Diabetes Mellitus, Type 2 chemically induced, Diabetes Mellitus, Type 2 metabolism, Diabetes Mellitus, Type 2 physiopathology, Glucose Tolerance Test, Insulin Secretion, Islets of Langerhans drug effects, Islets of Langerhans metabolism, Isoleucine chemistry, Isoleucine drug effects, Isoleucine therapeutic use, Male, Niacinamide, Rats, Rats, Wistar, Reference Values, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents therapeutic use, Insulin metabolism, Isoleucine analogs & derivatives
- Abstract
We have recently shown in vitro that 4-hydroxyisoleucine (4-OH-Ile), an amino acid extracted from fenugreek seeds, potentiates insulin secretion in a glucose-dependent manner. The present study was designed to investigate whether 4-OH-Ile could exert in vivo insulinotropic and antidiabetic properties. For this purpose, intravenous or oral glucose tolerance tests (IVGTTs and OGTTs, respectively) were performed not only in normal animals but also in a type II diabetes rat model. During IVGTT in normal rats or OGTT in normal dogs, 4-OH-Ile (18 mg/kg) improved glucose tolerance. The lactonic form of 4-OH-Ile was ineffective in normal rats. In non-insulin-dependent diabetic (NIDD) rats, a single intravenous administration of 4-OH-Ile (50 mg/kg) partially restored glucose-induced insulin response without affecting glucose tolerance; a 6-day subchronic administration of 4-OH-Ile (50 mg/kg, daily) reduced basal hyperglycemia, decreased basal insulinemia, and slightly, but significantly, improved glucose tolerance. In vitro, 4-OH-Ile (200 microM) potentiated glucose (16.7 mM)-induced insulin release from NIDD rat-isolated islets. So, the antidiabetic effects of 4-OH-Ile on NIDD rats result, at least in part, from a direct pancreatic B cell stimulation.
- Published
- 1999
- Full Text
- View/download PDF
49. Steroid saponins from fenugreek and some of their biological properties.
- Author
-
Sauvaire Y, Baissac Y, Leconte O, Petit P, and Ribes G
- Subjects
- Animals, Anticholesteremic Agents, Seeds chemistry, Trigonella, Plant Extracts chemistry, Saponins chemistry, Saponins isolation & purification, Saponins pharmacology, Steroids chemistry, Steroids isolation & purification, Steroids pharmacology
- Published
- 1996
- Full Text
- View/download PDF
50. Steroid saponins from fenugreek seeds: extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol.
- Author
-
Petit PR, Sauvaire YD, Hillaire-Buys DM, Leconte OM, Baissac YG, Ponsin GR, and Ribes GR
- Subjects
- Animals, Body Weight, Chromatography, High Pressure Liquid, Diabetes Mellitus, Experimental, Gas Chromatography-Mass Spectrometry, Kinetics, Male, Rats, Rats, Wistar, Saponins pharmacology, Steroids pharmacology, Cholesterol blood, Eating drug effects, Saponins isolation & purification, Seeds chemistry, Steroids isolation & purification
- Abstract
The seeds of fenugreek (Trigonella foenum graecum L.) are traditionally assumed to have restorative properties. We have recently shown that a fenugreek seed extract containing steroid saponins increased food consumption and induced hypocholesterolemia in rats. This study aims to investigate the specific role of purified steroid saponins in these properties. For this purpose, an original technique for extraction and purification of steroid saponins was carried out. Thereafter, the effects of these steroid saponins were investigated on feeding behavior and metabolic endocrine changes in normal and diabetic rats. All the steroid saponins (furostanol type) were extracted from the seeds and separated from all other constituents of the entire extract by using several purification procedures to give an extract containing at least 90% of steroid saponins. Pharmcological experiments were performed in vivo in normal and streptozotocin diabetic rats: steroid saponins were administered chronically mixed with food (12.5 mg/day per 300 g body weight). Our data show that the treatment with steroid saponins significantly increased food intake and the motivation to eat in normal rats, while modifying the circadian rhythm of feeding behavior; it also stabilized the food consumption in diabetic rats, which resulted in a progressive weight gain in these animals, in contrast to untreated diabetic controls. Both in normal and diabetic rats, steroid saponins decreased total plasma cholesterol without any change in triglycerides. In conclusion, the present work reports a clear methodology to obtain all the steroid saponins and demonstrates that these saponins enhance food consumption and motivation to eat, and reduce plasma cholesterol levels in rats.
- Published
- 1995
- Full Text
- View/download PDF
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