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Your search keyword '"Poon, Peter Yam-Kau"' showing total 16 results
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16 results on '"Poon, Peter Yam-Kau"'

2. Urinary Long Non-Coding RNA Levels as Biomarkers of Lupus Nephritis

Author

Szeto, Cheuk-Chun, primary, So, Ho, additional, Poon, Peter Yam-Kau, additional, Luk, Cathy Choi-Wan, additional, Ng, Jack Kit-Chung, additional, Fung, Winston Wing-Shing, additional, Chan, Gordon Chun-Kau, additional, Chow, Kai-Ming, additional, Lai, Fernand Mac-Moune, additional, and Tam, Lai-Shan, additional

Published
2023
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16. Relationship between beta1-adrenergic receptor polymorphisms and cardiovascular disease in patients with diabetic nephropathy.

Author

Poon PY, Szeto CC, Kwan BC, Chow KM, and Li PK

Subjects
Asian People genetics, Cardiovascular Diseases ethnology, Cardiovascular Diseases mortality, China, Diabetic Nephropathies complications, Diabetic Nephropathies ethnology, Diabetic Nephropathies mortality, Disease-Free Survival, Genetic Predisposition to Disease, Humans, Phenotype, Prognosis, Proportional Hazards Models, Risk Assessment, Risk Factors, Time Factors, Cardiovascular Diseases genetics, Diabetic Nephropathies genetics, Polymorphism, Genetic, Receptors, Adrenergic, beta-1 genetics
Abstract

Aim: Activation of beta1-adrenergic receptor (beta1AR) enhances contractility and heart rate. The polymorphism Arg389Gly in the beta1AR gene was found to be functionally important in determining receptor activity. The relationship between this polymorphism and the risk of cardiovascular disease was investigated in Chinese subjects with overt diabetic nephropathy., Methods: A total of 219 type 2 diabetic subjects with nephropathy were recruited. Genotyping of the beta1AR Arg389Gly polymorphism was determined. Patients were followed up to 96 months for the development of cardiovascular events., Results: There were 122, 86 and 11 patients with Arg/Arg, Arg/Gly and Gly/Gly genotype, respectively. At 96 months, the event-free survival of primary composite cardiovascular end-point was 33.0% and 44.3% for Gly(+) and Gly(-) groups, respectively (log-rank test, P = 0.105), while the event-free survival for first ischaemic heart disease was 62.4% and 75.9%, respectively (log-rank test, P = 0.038). However, with multivariate analysis by the Cox proportional hazard model to adjust for confounders, only low-density lipoprotein and baseline glomerular filtration rate were independent predictors of first ischaemic heart event., Conclusion: The beta1AR Arg389Gly polymorphism is not an independent predictor of cardiovascular events in subjects with overt diabetic nephropathy.

Published
2010
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