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Relationship between beta1-adrenergic receptor polymorphisms and cardiovascular disease in patients with diabetic nephropathy.
- Source :
-
Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2010 Mar; Vol. 15 (2), pp. 242-7. - Publication Year :
- 2010
-
Abstract
- Aim: Activation of beta1-adrenergic receptor (beta1AR) enhances contractility and heart rate. The polymorphism Arg389Gly in the beta1AR gene was found to be functionally important in determining receptor activity. The relationship between this polymorphism and the risk of cardiovascular disease was investigated in Chinese subjects with overt diabetic nephropathy.<br />Methods: A total of 219 type 2 diabetic subjects with nephropathy were recruited. Genotyping of the beta1AR Arg389Gly polymorphism was determined. Patients were followed up to 96 months for the development of cardiovascular events.<br />Results: There were 122, 86 and 11 patients with Arg/Arg, Arg/Gly and Gly/Gly genotype, respectively. At 96 months, the event-free survival of primary composite cardiovascular end-point was 33.0% and 44.3% for Gly(+) and Gly(-) groups, respectively (log-rank test, P = 0.105), while the event-free survival for first ischaemic heart disease was 62.4% and 75.9%, respectively (log-rank test, P = 0.038). However, with multivariate analysis by the Cox proportional hazard model to adjust for confounders, only low-density lipoprotein and baseline glomerular filtration rate were independent predictors of first ischaemic heart event.<br />Conclusion: The beta1AR Arg389Gly polymorphism is not an independent predictor of cardiovascular events in subjects with overt diabetic nephropathy.
- Subjects :
- Asian People genetics
Cardiovascular Diseases ethnology
Cardiovascular Diseases mortality
China
Diabetic Nephropathies complications
Diabetic Nephropathies ethnology
Diabetic Nephropathies mortality
Disease-Free Survival
Genetic Predisposition to Disease
Humans
Phenotype
Prognosis
Proportional Hazards Models
Risk Assessment
Risk Factors
Time Factors
Cardiovascular Diseases genetics
Diabetic Nephropathies genetics
Polymorphism, Genetic
Receptors, Adrenergic, beta-1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1797
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nephrology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 20470286
- Full Text :
- https://doi.org/10.1111/j.1440-1797.2009.01182.x