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1,030 results on '"Massie, Barry M."'

1. International differences in clinical characteristics, management, and outcomes in acute heart failure patients: better short‐term outcomes in patients enrolled in Eastern Europe and Russia in the PROTECT trial

Author

Mentz, Robert J, Cotter, Gad, Cleland, John GF, Stevens, Susanna R, Chiswell, Karen, Davison, Beth A, Teerlink, John R, Metra, Marco, Voors, Adriaan A, Grinfeld, Liliana, Ruda, Mikhail, Mareev, Viacheslav, Lotan, Chaim, Bloomfield, Daniel M, Fiuzat, Mona, Givertz, Michael M, Ponikowski, Piotr, Massie, Barry M, and O'Connor, Christopher M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Cardiovascular, Patient Safety, Clinical Trials and Supportive Activities, Heart Disease, Good Health and Well Being, Acute Disease, Adenosine A1 Receptor Antagonists, Aged, Aged, 80 and over, Diuretics, Europe, Eastern, Female, Geography, Heart Failure, Hospitalization, Humans, Internationality, Length of Stay, Male, Middle Aged, Quality of Life, Russia, Xanthines, Acute heart failure, Length of stay, Trial, Regional differences, Global variation, Outcomes, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

AimsThe implications of geographical variation are unknown following adjustment for hospital length of stay (LOS) in heart failure (HF) trials that included patients whether or not they had systolic dysfunction. We investigated regional differences in an international acute HF trial.Methods and resultsThe PROTECT trial investigated 2033 patients with acute HF and renal dysfunction hospitalized at 173 sites in 17 countries with randomization to rolofylline or placebo. We grouped enrolling countries into six regions. Baseline characteristics, in-hospital management, and outcomes were explored by region. The primary study outcome was 60-day mortality or cardiovascular/renal hospitalization. Secondary outcomes included 180-day mortality. Of 2033 patients, 33% were from Eastern Europe, 19% from Western Europe, 16% from Israel, 15% from North America, 14% from Russia, and 3% from Argentina. Marked differences in baseline characteristics, HF phenotype, in-hospital diuretic and vasodilator strategies, and LOS were observed by region. LOS was shortest in North America and Israel (median 5 days) and longest in Russia (median 15 days). Regional event rates varied significantly. Following multivariable adjustment, region was an independent predictor of the risk of mortality/hospitalization at 60 days, with the lowest risk in Russia (hazard ratio 0.39, 95% confidence interval 0.23-0.64 vs. Western Europe) due to lower rehospitalization; mortality differences were attenuated by 180 days.ConclusionsIn an international HF trial, there were differences in baseline characteristics, treatments, LOS, and rehospitalization amongst regions, but little difference in longer term mortality. Rehospitalization differences exist independent of LOS. This analysis may help inform future trial design and should be externally validated.

Published
2014

2. Benefit of Warfarin Compared With Aspirin in Patients With Heart Failure in Sinus Rhythm

Author

Homma, Shunichi, Thompson, John LP, Sanford, Alexandra R, Mann, Douglas L, Sacco, Ralph L, Levin, Bruce, Pullicino, Patrick M, Freudenberger, Ronald S, Teerlink, John R, Graham, Susan, Mohr, JP, Massie, Barry M, Labovitz, Arthur J, Di Tullio, Marco R, Gabriel, André P, Lip, Gregory YH, Estol, Conrado J, Lok, Dirk J, Ponikowski, Piotr, and Anker, Stefan D

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Research, Cardiovascular, Stroke, Brain Disorders, Adult, Age Factors, Aged, Anticoagulants, Aspirin, Brain Ischemia, Cerebral Hemorrhage, Double-Blind Method, Female, Heart Failure, Heart Rate, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Stroke Volume, Time Factors, Treatment Outcome, Ventricular Function, Left, Warfarin, aspirin, heart failure, sinus rhythm, stroke, warfarin, WARCEF Investigators, Biochemistry and Cell Biology, Cardiorespiratory Medicine and Haematology, Medical Physiology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Medical physiology
Abstract

BackgroundThe Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) trial found no difference in the primary outcome between warfarin and aspirin in 2305 patients with reduced left ventricular ejection fraction in sinus rhythm. However, it is unknown whether any subgroups benefit from warfarin or aspirin.Methods and resultsWe used a Cox model stepwise selection procedure to identify subgroups that may benefit from warfarin or aspirin on the WARCEF primary outcome. A secondary analysis added major hemorrhage to the outcome. The primary efficacy outcome was time to the first to occur of ischemic stroke, intracerebral hemorrhage, or death. Only age group was a significant treatment effect modifier (P for interaction, 0.003). Younger patients benefited from warfarin over aspirin on the primary outcome (4.81 versus 6.76 events per 100 patient-years: hazard ratio, 0.63; 95% confidence interval, 0.48-0.84; P=0.001). In older patients, therapies did not differ (9.91 versus 9.01 events per 100 patient-years: hazard ratio, 1.09; 95% confidence interval, 0.88-1.35; P=0.44). With major hemorrhage added, in younger patients the event rate remained lower for warfarin than aspirin (5.41 versus 7.25 per 100 patient-years: hazard ratio, 0.68; 95% confidence interval, 0.52-0.89; P=0.005), but in older patients it became significantly higher for warfarin (11.80 versus 9.35 per 100 patient-years: hazard ratio, 1.25; 95% confidence interval, 1.02-1.53; P=0.03).ConclusionsIn patients

Published
2013

3. Predictors of early dyspnoea relief in acute heart failure and the association with 30‐day outcomes: findings from ASCEND‐HF

Author

Mentz, Robert J, Hernandez, Adrian F, Stebbins, Amanda, Ezekowitz, Justin A, Felker, G Michael, Heizer, Gretchen M, Atar, Dan, Teerlink, John R, Califf, Robert M, Massie, Barry M, Hasselblad, Vic, Starling, Randall C, O'Connor, Christopher M, and Ponikowski, Piotr

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Cardiovascular, Clinical Trials and Supportive Activities, Aging, Good Health and Well Being, Acute Disease, Age Factors, Aged, Blood Pressure, Blood Urea Nitrogen, Dyspnea, Edema, Female, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Natriuretic Agents, Natriuretic Peptide, Brain, Natriuretic Peptides, Respiratory Rate, Risk Assessment, Treatment Outcome, Acute heart failure, Dyspnoea relief, Prognosis, Outcomes, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

AimsTo examine the characteristics associated with early dyspnoea relief during acute heart failure (HF) hospitalization, and its association with 30-day outcomes.Methods and resultsASCEND-HF was a randomized trial of nesiritide vs. placebo in 7141 patients hospitalized with acute HF in which dyspnoea relief at 6 h was measured on a 7-point Likert scale. Patients were classified as having early dyspnoea relief if they experienced moderate or marked dyspnoea improvement at 6 h. We analysed the clinical characteristics, geographical variation, and outcomes (mortality, mortality/HF hospitalization, and mortality/hospitalization at 30 days) associated with early dyspnoea relief. Early dyspnoea relief occurred in 2984 patients (43%). In multivariable analyses, predictors of dyspnoea relief included older age and oedema on chest radiograph; higher systolic blood pressure, respiratory rate, and natriuretic peptide level; and lower serum blood urea nitrogen (BUN), sodium, and haemoglobin (model mean C index = 0.590). Dyspnoea relief varied markedly across countries, with patients enrolled from Central Europe having the lowest risk-adjusted likelihood of improvement. Early dyspnoea relief was associated with lower risk-adjusted 30-day mortality/HF hospitalization [hazard ratio (HR) 0.81; 95% confidence interval (CI) 0.68-0.96] and mortality/hospitalization (HR 0.85; 95% CI 0.74-0.99), but similar mortality.ConclusionClinical characteristics such as respiratory rate, pulmonary oedema, renal function, and natriuretic peptide levels are associated with early dyspnoea relief, and moderate or marked improvement in dyspnoea was associated with a lower risk for 30-day outcomes.

Published
2013

4. Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the ENABLE Trials

Author

Packer, Milton, Caspi, Avi, Kiowski, Wolfgang, Krum, Henry, Pratt, Craig, Swedberg, Karl, Massie, Barry, McMurray, John, Connally, Eugene, Petrie, Mark, DeMets, David, Anderson, Susan, Barnet, Jody, Cody, Robert, Dargie, Henry, Francis, Gary, Greenberg, Barry, Reichen, Juerg, Karrasch, J., Krum, H., Horowitz, J., Amerena, J., Sindone, A., MacDonald, P., Jeffrey, I., Button, I., DeAngelis, E., Pacher, R., Davies, R., McAlister, F., Tanser, P., Sussex, B., Baumann, G., Fleck, E., Olbrich, H.-G., Werdan, K., Klein, H., Staffeld, F., Zeiher, A.M., Roediger, C., Caspi, A., Marmor, A., Reisin, L., Vered, Z., Klainman, E., Roguin, N., Tzivoni, D., David, D., Lewis, B., Abinader, E., Omary, M., Rosenman, Y., Kaluski, E., Breedveld, R.W., van der Burgh, P.H., Dunselman, P.H.J.M., Schaafsma, H.J., Hertzberger, D.P., Holwerda, N.J., Kragten, J.A., van Wijngaarden, J., Posma, J.L., Said, S.A.M., Slegers, L.C., Tjon Joe Gin, R.M., Wempe, F.N., Wesdorp, J.C.L., Willems, A.R., Withagen, A.J.A.M., Cornel, J.M., van Kempen, L.H.J., Kiowski, W., Bertel, O., Moccetti, T., McMurray, J.J.V., Greenbaum, R.A., Bennett, P., Swan, J., Davies, G., Findlay, I., Gould, B., Ball, S., Hubner, P., Lahiri, A., McLay, J., Northcote, R., Saltissi, S., Squire, I., Stephens, J., Stewart, M., Bridgen, G., Walsh, J., Webb, D.J., Ansari, Z., Baron, S., Bellinger, R., Bennet, W., Benvenuti, D., Dawley, D., Egbujiobi, L.C., Eisenstein, I., Little, T., Hertsberg, A., Greenspan, M., Grossman, R.J., Hanley, P., Jesrani, M., Kashou, H., Levites, R., Malik, R., Marmorstein, B., Schwartz, M., Nisar, A., Perelman, R., Schwarz, M.L., Sedlis, S., Srebro, J., Taveras, M., Weiss, R., Weitzman, P., Wetherley, G.K., El Shahawy, M., Kereiakes, D., Campos, L., Peterson, G., Small, R.S., Davis, W.R., Olivari, M.-T., Meengs, W., Koren, M., Slagona, P., Jennison, S., Hershberger, R., Browne, K.F., Farnham, D.J., Zelenkofske, S., Lawless, C., Nathan, M., Meyer, T., Kukin, M., Parekh, H., Berkowitz, R., Boehmer, J., Brozena, S., Dandona, P., Dec, G.W., DeQuattro, V., Fenster, P., Fowler, M., Ellaham, S., Geller, M., Gheorgiade, M., Ghali, J., Murali, S., Katz, S., Bott-Silverman, C., Singh, B., Thadani, U., Torre, G., Teerlink, J., Chandraratna, T., Kesselbrenner, M., Mukherjee, A., Che-Pin Tsai, C., Abbo, K., Goldberg, M., Smith, T., Martin, R.T., McMurray, John J.V., Massie, Barry M., Pratt, Craig M., Petrie, Mark C., Kobrin, Isaac, and Roux, Sebastien

Published
2017
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10. The Heart Failure Society of America in 2020: A Vision for the Future

Author

Greenberg, Barry H., Anand, Inder S., Burnett, John C., Jr., Chin, John, Dracup, Kathleen A., Feldman, Arthur M., Force, Thomas, Francis, Gary S., Houser, Steven R., Hunt, Sharon A., Konstam, Marvin A., Lindenfeld, JoAnn, Mann, Douglas L., Mehra, Mandeep R., Paul, Sara C., Piano, Mariann R., Ross, Heather J., Sabbah, Hani N., Starling, Randall C., Udelson, James E., Yancy, Clyde W., Zile, Michael R., and Massie, Barry M.

Published
2012
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11. ACCF/AHA/HFSA 2011 Survey Results: Current Staffing Profile of Heart Failure Programs, Including Programs That Perform Heart Transplant and Mechanical Circulatory Support Device Implantation: A Report of the ACCF Heart Failure and Transplant Committee, AHA Heart Failure and Transplantation Committee, and Heart Failure Society of America

Author

Jessup, Mariell, Albert, Nancy M., Lanfear, David E., Lindenfeld, JoAnn, Massie, Barry M., Walsh, Mary Norine, and Zucker, Mark J.

Published
2011
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12. Effects of the Adenosine A1 Receptor Antagonist Rolofylline on Renal Function in Patients With Acute Heart Failure and Renal Dysfunction: Results From PROTECT (Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function)

Author

Voors, Adriaan A., Dittrich, Howard C., Massie, Barry M., DeLucca, Paul, Mansoor, George A., Metra, Marco, Cotter, Gad, Weatherley, Beth D., Ponikowski, Piotr, Teerlink, John R., Cleland, John G.F., O'Connor, Christopher M., and Givertz, Michael M.

Published
2011
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21. Acute heart failure in elderly patients: worse outcomes and differential utility of standard prognostic variables. Insights from the PROTECT trial

Author

Metra, Marco, Mentz, Robert J., Chiswell, Karen, Bloomfield, Daniel M., Cleland, John G.F., Cotter, Gad, Davison, Beth A., Dittrich, Howard C., Fiuzat, Mona, Givertz, Michael M., Lazzarini, Valentina, Mansoor, George A., Massie, Barry M., Ponikowski, Piotr, Teerlink, John R., Voors, Adriaan A., and OʼConnor, Christopher M.

Published
2015
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23. Phase III clinical trial end points in acute heart failure syndromes: A virtual roundtable with the acute heart failure syndromes international working group

Author

Gheorghiade, Mihai, Adams, Kirkwood F., Cleland, John G.F., Cotter, Gad, Felker, G. Michael, Filippatos, Gerasimos S., Fonarow, Gregg C., Greenberg, Barry H., Hernandez, Adrian F., Khan, Sadiya, Komajda, Michel, Konstam, Marvin A., Liu, Peter P., Maggioni, Aldo P., Massie, Barry M., McMurray, John J., Mehra, Mandeep, Metra, Marco, O'Connell, John, O'Connor, Christopher M., Pang, Peter S., Piña, Ileana L., Sabbah, Hani N., Teerlink, John R., Udelson, James E., Yancy, Clyde W., Zannad, Faiez, and Stockbridge, Norman

Published
2009
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25. The Safety of an Adenosine A1-Receptor Antagonist, Rolofylline, in Patients with Acute Heart Failure and Renal Impairment: Findings from PROTECT

Author

Teerlink, John R., Iragui, Vicente J., Mohr, Jay P., Carson, Peter E., Hauptman, Paul J., Lovett, David H., Miller, Alan B., Piña, Ileana L., Thomson, Scott, Varosy, Paul D., Zile, Michael R., Cleland, John G. F., Givertz, Michael M., Metra, Marco, Ponikowski, Piotr, Voors, Adriaan A., Davison, Beth A., Cotter, Gad, Wolko, Denise, DeLucca, Paul, Salerno, Christina M., Mansoor, George A., Dittrich, Howard, O’Connor, Christopher M., and Massie, Barry M.

Published
2012
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28. Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure

Author

Massie, Barry M., O'Connor, Christopher M., Metra, Marco, Ponikowski, Piotr, Teerlink, John R., Cotter, Gad, Weatherley, Beth Davison, Cleland, John G.F., Givertz, Michael M., Voors, Adriaan, DeLucca, Paul, Mansoor, George A., Salemo, Christina M., Bloomfield, Daniel M., and Dittrich, Howard C.

Subjects
Adenosine -- Health aspects, Antagonists (Biochemistry) -- Health aspects, Antagonists (Biochemistry) -- Usage, Cardiac patients -- Health aspects, Cardiac patients -- Care and treatment, Kidney failure -- Drug therapy, Kidney failure -- Prevention, Outcome and process assessment (Health Care)
Abstract

A study was conducted to evaluate the effect and benefits of the use of rolofylline, an adenosine A1-receptor antagonist in improving dyspnea and reducing the risk of renal failure in the case of patients with acute heart failure. Results indicated that rolofylline did not have any kind of favorable outcome in the case of such patients.

Published
2010

33. Irbesartan in patients with heart failure and preserved ejection fraction

Author

Massie, Barry M., Carson, Peter E., McMurray, John J., Komajda, Michel, McKelvie, Robert, Zile, Michael R., Anderson, Susan, Donovan, Mark, Iverson, Erik, Staiger, Christoph, and Ptaszynska, Agata

Subjects
Irbesartan -- Usage, Irbesartan -- Health aspects, Heart failure -- Care and treatment, Heart failure -- Risk factors, Cardiac output -- Care and treatment
Abstract

A study was carried out to assess the benefits of irbesartan in patients with a left ventricular ejection fraction following heart failure. Results showed that no significant benefits were noticed following therapy with irbesartan.

Published
2008

36. The Antihypertensive and Lipid Lowering reatment to prevent Heart Attack Trial (ALLHAT) heart failure validation study: diagnosis and prognosis

Author

Einhorn, Paula T., Davis, Barry R., Massie, Barry M., Cushman, William C., Piller, Linda B., Simpson, Lara M., Levy, Daniel, Nwachuku, Chuke E., and Black, Henry R.

Subjects
Heart failure -- Diagnosis, Heart failure -- Risk factors, Heart failure -- Patient outcomes, Heart failure -- Research, Antihypertensive drugs -- Research, Cardiac patients -- Prognosis, Health
Published
2007

42. Contributors

Author

Abrams, Charles S., primary, Accurso, Frank J., additional, Afdhal, Nezam H., additional, Akin, Cem, additional, Aksamit, Allen J., additional, Al-Awqati, Qais, additional, Allos, Ban Mishu, additional, Altshuler, David, additional, Aminoff, Michael J., additional, Anderson, Jeffrey L., additional, Anderson, Karl E., additional, Anderson, Larry J., additional, Antman, Karen H., additional, Antony, Aśok C., additional, Appel, Gerald B., additional, Appelbaum, Frederick R., additional, Arend, William P., additional, Arguin, Paul, additional, Armitage, James O., additional, Armstrong, Cheryl A., additional, Arnaout, M. Amin, additional, Arnold, Robert, additional, Atkins, David, additional, Atkinson, William L., additional, Ausiello, Dennis, additional, Bacon, Bruce R., additional, Bagby, Grover C., additional, Bain, Barbara J., additional, Bajorin, Dean F., additional, Ballow, Mark, additional, Baloh, Robert W., additional, Barasch, Jonathan, additional, Barbano, Richard L., additional, Baron, Murray G., additional, Barrett-Connor, Elizabeth, additional, Barry, Michael J., additional, Barshop, Bruce A., additional, Bartlett, John G., additional, Barton, Mary, additional, Basner, Robert C., additional, Baum, Stephen G., additional, Bausch, Daniel G., additional, Bayer, Arnold S., additional, Bazari, Hasan, additional, Beigel, John H., additional, Beller, George A., additional, Bennett, Robert M., additional, Berger, Joseph R., additional, Berk, Paul, additional, Berliner, Nancy, additional, Bernat, James L., additional, Bierman, Philip J., additional, Bistrian, Bruce R., additional, Biundo, Joseph J., additional, Blanke, Charles D., additional, Blankson, Joel N., additional, Blaser, Martin J., additional, Blattner, William A., additional, Bleck, Thomas P., additional, Boden, William E., additional, Boland, C. Richard, additional, Bolognia, Jean, additional, Bonomo, Robert, additional, Borish, Larry, additional, Bosque, Patrick J., additional, Brand, Randall, additional, Brook, Itzhak, additional, Brunetti, Enrico, additional, Buchner, David M., additional, Buffet, Pierre A., additional, Bunn, H. Franklin, additional, Calabresi, Peter A., additional, Calfee, David P., additional, Calkins, Hugh, additional, Cameron, Douglas, additional, Camilleri, Michael, additional, Cannon, Grant W., additional, Cappellini, Maria Domenica, additional, Carabello, Blase A., additional, Carvalho, Edgar M., additional, Castellanos, Agustin, additional, Chalasani, Naga P., additional, Chambers, Henry, additional, Charlson, Mary, additional, Cheshire, William P., additional, Chinnery, Patrick F., additional, Christiani, David C., additional, Clemmons, David R., additional, Cohen, Jeffrey, additional, Cohen, Myron S., additional, Cohen, Steven P., additional, Cohn, Steven L., additional, Colebunders, Robert, additional, Connors, Joseph M., additional, Cook, Deborah J., additional, Corey, C. Ralph, additional, Cowan, Kenneth H., additional, Craig, William A., additional, Croft, Simon L., additional, Crow, Mary K., additional, Crump, John A., additional, Cullen, Mark R., additional, Curhan, Gary C., additional, Damon, Inger K., additional, Daniels, Troy E., additional, Davidson, Nancy, additional, DeAngelis, Lisa M., additional, DeCamp, Malcolm M., additional, Del Rio, Carlos, additional, Demetri, George D., additional, Demling, Robert H., additional, Deuster, Patricia A., additional, Diasio, Robert B., additional, Diemert, David J., additional, Digre, Kathleen B., additional, Douglas, John M., additional, Drazen, Jeffrey M., additional, Dreskin, Stephen C., additional, Drew, W. Lawrence, additional, Drusano, George L., additional, DuBose, Thomas D., additional, Duffy, F. Daniel, additional, DuPont, Herbert L., additional, Duvic, Madeleine, additional, Edwards, Kathryn M., additional, Edwards, N. Lawrence, additional, Einhorn, Lawrence H., additional, Elin, Ronald J., additional, Eliopoulos, George M., additional, Elliott, Perry, additional, Ellner, Jerrold J., additional, Elsas, Louis J., additional, Elston, Dirk M., additional, Emanuel, Ezekiel J., additional, Erickson, Gregory F., additional, Ernst, Armin, additional, Ernst, Joel D., additional, Ettinger, David S., additional, Evoli, Amelia, additional, Faigel, Douglas O., additional, Falk, Gary W., additional, Favus, Murray J., additional, Feder, Gene, additional, Fihn, Stephan D., additional, Firestein, Gary S., additional, Fishman, Neil, additional, Fleisher, Lee A., additional, Ford, Marsha D., additional, Forsmark, Chris E., additional, Fowler, Vance G., additional, Fox, Jay W., additional, Franco, Manuel A., additional, French, Martyn A., additional, Freund, Karen, additional, Fried, Linda P., additional, Gabay, Cem, additional, Gage, Kenneth L., additional, Gagel, Robert F., additional, Galgiani, John N., additional, Gallagher, Patrick G., additional, Galun, Eithan, additional, Ganz, Leonard, additional, Garcia-Tsao, Guadalupe, additional, Gates, Jonathan D., additional, Geisler, William M., additional, George, Tony P., additional, Gerding, Dale N., additional, Gershwin, M. Eric, additional, Gertz, Morie A., additional, Ginder, Gordon D., additional, Ginsberg, Jeffrey, additional, Ginsburg, Geoffrey S., additional, Glogauer, Michael, additional, Gnann, John W., additional, Golden, Matthew R., additional, Goldman, Lee, additional, Goldstein, Ellie J., additional, Goodnough, Lawrence T., additional, Goronzy, Jörg J., additional, Gotuzzo, Eduardo, additional, Grady, Deborah, additional, Grammer, Leslie C., additional, Greco, F. Anthony, additional, Greenberg, Harry B., additional, Gregersen, Peter K., additional, Griggs, Robert C., additional, Guay-Woodford, Lisa M., additional, Guerrant, Richard L., additional, Hadigan, Colleen, additional, Hainsworth, John D., additional, Hamsten, Anders, additional, Hande, Kenneth R., additional, Handsfield, H. Hunter, additional, Hansson, Göran K., additional, Haque, Rashidul, additional, Harris, Raymond C., additional, Hauser, Stephen Crane, additional, Hayden, Frederick G., additional, Healey, Letha, additional, Heimburger, Douglas C., additional, Hewlett, Erik L., additional, Hill, David R., additional, Hill, Nicholas S., additional, Hillis, L. David, additional, Hirsh, Jack, additional, Holers, V. Michael, additional, Holland, Steven M., additional, Hollenberg, Steven, additional, Hook, Edward W., additional, Huang, Laurence, additional, Hudson, Leonard D., additional, Hyman, Steven E., additional, Iannuzzi, Michael, additional, Inman, Robert D., additional, Inouye, Sharon K., additional, Insogna, Karl L., additional, Inzucchi, Silvio E., additional, Isselbacher, Eric M., additional, Jemal, Ahmedin, additional, Jen, Joanna, additional, Jensen, Dennis M., additional, Jensen, Michael D., additional, Jensen, Robert T., additional, Jessup, Mariell, additional, Johnson, Stuart, additional, Józefowicz, Ralph F., additional, Kaler, Stephen G., additional, Kamya, Moses R., additional, Kantarjian, Hagop, additional, Karp, David R., additional, Kastner, Daniel L., additional, Katzka, David A., additional, Katzman, Debra K., additional, Kauffman, Carol A., additional, Kaushansky, Kenneth, additional, Keeffe, Emmet B., additional, Kern, Morton, additional, Keusch, Gerald T., additional, Kim, David H., additional, Kim, Matthew, additional, Kirchhoff, Louis V., additional, Klag, Michael J., additional, Klein, Samuel, additional, Knopman, David S., additional, Knox, Tamsin A., additional, Ko, Albert I., additional, Komrokji, Rami S., additional, Kontoyiannis, Dimitrios P., additional, Koppel, Barbara S., additional, Korenblat, Kevin, additional, Korf, Bruce R., additional, Korman, Neil J., additional, Kovacs, Joseph A., additional, Kraft, Monica, additional, Kramer, Christopher M., additional, Krasnewich, Donna M., additional, Krause, Peter J., additional, Kronenberg, Henry M., additional, Kuipers, Ernst J., additional, Ladenson, Paul, additional, Landry, Donald W., additional, Lane, Nancy E., additional, Lang, Anthony E., additional, Lange, Richard A., additional, Lawry, George V., additional, Lee, Thomas H., additional, Lee, William M., additional, Leggett, James, additional, Lerner, Adam, additional, Levin, Stuart, additional, Levine, Stephanie M., additional, Lichtenstein, Gary R., additional, Lim, Henry W., additional, Lima, Aldo A.M., additional, Limper, Andrew H., additional, Ling, Geoffrey S.F., additional, List, Alan F., additional, Little, William C., additional, Loeser, Richard F., additional, Lorber, Bennett, additional, Low, Donald E., additional, Lucey, Daniel R., additional, Lupski, James R., additional, Lynch, Henry T., additional, Lyness, Jeffrey M., additional, Lytle, Bruce W., additional, MacKenzie, C. Ronald, additional, MacMillan, Harriet, additional, Madoff, Robert D., additional, Mahowald, Mark W., additional, Malhotra, Atul, additional, Mandell, Lionel A., additional, Manu, Peter, additional, Marcus, Marsha D., additional, Marelli, Ariane J., additional, Markman, Maurie, additional, Marks, Andrew R., additional, Marr, Kieren A., additional, Marrie, Thomas J., additional, Martin, Paul, additional, Mason, Joel B., additional, Massie, Barry M., additional, Masur, Henry, additional, Matteson, Eric L., additional, Maurer, Toby, additional, Mayer, Emeran A., additional, McClave, Stephen A., additional, McCool, F. Dennis, additional, McCulloch, Charles E., additional, McGuigan, Michael A., additional, McHutchison, John, additional, McKenna, William, additional, McLaughlin, Vallerie, additional, McMurray, John J.V., additional, McNaughton-Collins, Mary, additional, McQuaid, Kenneth, additional, Miller, Frederick W., additional, Minaker, Kenneth L., additional, Mink, Jonathan W., additional, Mishell, Daniel R., additional, Mitch, William E., additional, Molitch, Mark E., additional, Molitoris, Bruce A., additional, Montoya, José G., additional, Morady, Fred, additional, Moscow, Jeffrey A., additional, Murr, Andrew H., additional, Myerburg, Robert J., additional, Naguwa, Stanley, additional, Naides, Stanley J., additional, Nash, Theodore E., additional, Nath, Avindra, additional, Neilson, Eric G., additional, Neinstein, Lawrence S., additional, Newman, Thomas B., additional, Nichols, William L., additional, Nieman, Lynnette K., additional, Niewoehner, Dennis E., additional, Norrby, S. Ragnar, additional, Norris, David A., additional, O’Brien, Susan, additional, O’Connor, Francis G., additional, O’Connor, Patrick G., additional, O'Dell, James R., additional, O'Donnell, Anne E., additional, Oh, Jae K., additional, Olgin, Jeffrey E., additional, Olin, Jeffrey W., additional, Orenstein, Walter A., additional, Osmon, Douglas R., additional, Otto, Catherine M., additional, Paget, Stephen A., additional, Papania, Mark, additional, Pappas, Peter G., additional, Pasricha, Pankaj Jay, additional, Paterson, David L., additional, Patrono, Carlo, additional, Pawlotsky, Jean-Michel, additional, Pearson, Richard D., additional, Perencevich, Eli N., additional, Perl, Trish M., additional, Perry, Michael C., additional, Petri, William A., additional, Pfeffer, Marc A., additional, Pickhardt, Perry J., additional, Pier, Gerald B., additional, Pisetsky, David S., additional, Posner, Marshall R., additional, Prather, Charlene, additional, Pruitt, Basil A., additional, Pyeritz, Reed E., additional, Quinn, Thomas C., additional, Radhakrishnan, Jai, additional, Raghu, Ganesh, additional, Ragni, Margaret V., additional, Raja, Srinivasa N., additional, Rajkumar, S. Vincent, additional, Raoult, Didier, additional, Rebar, Robert W., additional, Reboli, Annette C., additional, Reddy, K. Rajender, additional, Redelmeier, Donald A., additional, Reef, Susan E., additional, Resnick, Neil M., additional, Reuben, David B., additional, Reynolds, Herbert Y., additional, Rivers, Emanuel P., additional, Rizza, Robert A., additional, Roberts, Lewis R., additional, Rolain, Jean-Marc, additional, Romero, José R., additional, Roodman, G. David, additional, Rosen, Clifford, additional, Rosene-Montella, Karen, additional, Rosenthal, Philip J., additional, Rothenberg, Marc E., additional, Rugo, Hope S., additional, Russell, James A., additional, Rustgi, Anil K., additional, Salata, Robert A., additional, Salmon, Jane E., additional, Santos, Renato M., additional, Sawka, Michael N., additional, Schafer, Andrew I., additional, Schaffner, William, additional, Scheld, W. Michael, additional, Schneider, Eileen, additional, Schnitzer, Thomas J., additional, Schooley, Robert T., additional, Schriger, David L., additional, Schroeder, Steven A., additional, Schuchter, Lynn M., additional, Schulman, Sam, additional, Schwartz, Lawrence B., additional, Schwartz, Robert S., additional, Seas, Carlos, additional, Seifert, Steven A., additional, Seifter, Julian L., additional, Semenkovich, Clay F., additional, Semrad, Carol E., additional, Service, F. John, additional, Shaw, George M., additional, Shaw, Pamela J., additional, Sherwin, Robert S., additional, Shy, Michael E., additional, Sibbitt, Wilmer L., additional, Sidransky, Ellen, additional, Siliciano, Robert F., additional, Simberkoff, Michael S., additional, Simel, David L., additional, Skorecki, Karl, additional, Slutsky, Arthur S., additional, Small, Eric J., additional, Smetana, Gerald W., additional, Southwick, Frederick S., additional, Spiera, Robert F., additional, Spinola, Stanley M., additional, Stankiewicz, Pawel, additional, Stark, Paul, additional, Steinbach, Lynne S., additional, Steinberg, Martin H., additional, Steiner, Theodore S., additional, Stephens, David S., additional, Stevens, David A., additional, Stevenson, William G., additional, Stillman, Arthur E., additional, Stoller, James K., additional, Stone, John H., additional, Su, Edwin P., additional, Sutter, Roland W., additional, Swartz, Morton N., additional, Swerdloff, Ronald S., additional, Sykes, Megan, additional, Tami, Thomas A., additional, Tarlo, Susan M., additional, Taylor, Victoria M., additional, Tefferi, Ayalew, additional, Teirstein, Paul S., additional, Telford, Sam R., additional, Tempero, Margaret, additional, Thun, Michael J., additional, Tolkoff-Rubin, Nina, additional, Tosti, Antonella, additional, Treanor, John J., additional, Turner, Ronald B., additional, Upton, Arthur C., additional, Van den Berghe, Greet, additional, Varga, John, additional, Vella, Adrian, additional, Verbalis, Joseph G., additional, Victor, Ronald G., additional, Vincent, Angela, additional, Volberding, Paul A., additional, Vose, Julie M., additional, Wachter, Robert M., additional, Wagner, Edward H., additional, Walsh, Edward E., additional, Walsh, Thomas J., additional, Wang, Christina, additional, Wanke, Christine, additional, Wasserman, Stephen I., additional, Wedemeyer, Heiner, additional, Weinberg, Geoffrey A., additional, Weinstein, David A., additional, Weinstein, Robert S., additional, Weiss, Roger D., additional, Weisse, Martin, additional, Weitz, Jeffrey I., additional, Wells, Samuel A., additional, Wenzel, Richard P., additional, Werth, Victoria P., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, A. Clinton, additional, White, Christopher J., additional, White, Perrin C., additional, Whitley, Richard J., additional, Whyte, Michael P., additional, Wiebe, Samuel, additional, Wiener-Kronish, Jeanine P., additional, Wildes, Jennifer E., additional, Wilmer, Alexander, additional, Winkenwerder, William, additional, Wolfsdorf, Joseph I., additional, Wormser, Gary P., additional, Wysolmerski, John J., additional, Yanoff, Myron, additional, Young, Neal S., additional, Young, William F., additional, Yu, Alan S.L., additional, Zeidel, Mark L., additional, Zimetbaum, Peter, additional, and Zivin, Justin A., additional

Published
2012
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44. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients

Author

Butler, Jeved, Forman, Daniel E., Abraham, William T., Gottlieb, Stephen S., Loh, Evan, Massie, Barry M., O'Connor, Christopher M., Rich, Michael W., Stevenson, Lynne Warner, Wang, Yonfei, Young, James B., and Krumholz, Harlan M.

Subjects
Diuretics -- Dosage and administration, Kidney failure -- Risk factors, Hospital care -- Complications and side effects, Heart failure -- Complications and side effects, Health
Published
2004

48. Utility of Impedance Cardiography for the Identification of Short-Term Risk of Clinical Decompensation in Stable Patients With Chronic Heart Failure

Author

Packer, Milton, Abraham, William T., Mehra, Mandeep R., Yancy, Clyde W., Lawless, Christine E., Mitchell, Judith E., Smart, Frank W., Bijou, Rachel, O’Connor, Christopher M., Massie, Barry M., Pina, Ileana L., Greenberg, Barry H., Young, James B., Fishbein, Daniel P., Hauptman, Paul J., Bourge, Robert C., Strobeck, John E., Murali, Srinvivas, Schocken, Douglas, Teerlink, John R., Levy, Wayne C., Trupp, Robin J., and Silver, Marc A.

Published
2006
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50. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: A randomized controlled trial. (Original Contribution)

Author

Cuffe, Michael S., Califf, Robert M., Adams, Kirkwood F., Benza, Raymond, Bourge, Robert, Colucci, Wilson S., Massie, Barry M., O'Conner, Christopher M., Pina, Ileana, Quigg, Rebecca, Silver, Marc A., and Gheorghiade, Mihai

Subjects
Congestive heart failure -- Drug therapy, Milrinone -- Evaluation
Abstract

The drug milrinone does not appear to be effective for treating congestive heart failure, according to a study of 951 patients. In fact, patients who took the drug were more likely to develop low blood pressure or a heart arrhythmia than patients who took a placebo, or inactive substance. Mortality rates were the same in both groups., Context: Little randomized evidence is available to guide the in-hospital management of patients with an acute exacerbation of chronic heart failure. Although intravenous inotropic therapy usually produces beneficial hemodynamic effects and is labeled for use in the care of such patients, the effect of such therapy on intermediate-term clinical outcomes is uncertain. Objective: To prospectively test whether a strategy that includes short-term use of milrinone in addition to standard therapy can improve clinical outcomes of patients hospitalized with an exacerbation of chronic heart failure. Design: Prospective, randomized, double-blind, placebo-controlled trial conducted from July 1997 through November 1999. Setting: Seventy-eight community and tertiary care hospitals in the United States. Participants: A total of 951 patients admitted with an exacerbation of systolic heart failure not requiring intravenous inotropic support (mean age, 65 years; 92% with baseline New York Heart Association class Ill or IV; mean left ventricular ejection fraction, 23%). Intervention: Patients were randomly assigned to receive a 48-hour infusion of either milrinone, 0.5 [micro]g/kg per minute initially (n=477), or saline placebo (n=472). Main Outcome Measure: Cumulative days of hospitalization for cardiovascular cause within 60 days following randomization. Results: The median number of days hospitalized for cardiovascular causes within 60 days after randomization did not differ significantly between patients given milrinone (6 days) compared with placebo (7 days; P=.71). Sustained hypotension requiring intervention (10.7% vs 3.2%; P Conclusion: These results do not support the routine use of intravenous milrinone as an adjunct to standard therapy in the treatment of patients hospitalized for an exacerbation of chronic heart failure.

Published
2002

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