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408 results on '"Hoermann, Rudolf"'

8. Branched‐chain amino acid supplementation does not improve measures of sarcopenia in cirrhosis: results of a randomised controlled trial.

Author

Hey, Penelope, Hoermann, Rudolf, Sinclair, Marie, Chapman, Brooke, Testro, Adam, Apostolov, Ross, Angus, Peter, and Gow, Paul

Subjects
*SARCOPENIA, *RANDOMIZED controlled trials, *BODY composition, *PHYSICAL mobility, *AMINO acids, *CIRRHOSIS of the liver
Abstract

Summary: Background: Sarcopenia is associated with adverse outcomes in cirrhosis. Branched‐chain amino acids (BCAA) target several pathways that lead to muscle loss in this population. Aims: We aimed to evaluate the impact of BCAA supplementation on sarcopenia measures in patients with cirrhosis. Methods: We conducted a 12‐month double‐blinded, randomised, controlled trial of BCAA supplementation (30 g daily) compared to an equicaloric, equi‐nitrogenous whey protein in volunteers with cirrhosis and reduced muscle strength. The primary endpoint was an increase in grip strength and upper limb lean mass measured on DEXA. Mean‐adjusted differences (MAD, 95% CI) between groups at 6 and 12 months are reported as treatment effect using a linear mixed model for repeated measures. Results: A total of 150 volunteers entered the trial (74 BCAA, 76 control), with a median age of 58 years [IQR 48; 63] and MELD of 14 [12; 17]. At 12 months, 57% in the BCAA arm and 61% in the control arm met the primary endpoint (p = 0.80). No significant between‐group difference was found in grip strength (MAD ‐0.15 kg [−0.37; 0.06], p = 0.29) or upper limb lean mass (1.7 kg [−0.2; 3.6], p = 0.22) at 12 months. No significant differences in other body composition parameters, physical performance, frailty, rates of hospitalisation or mortality were found between the BCAA and the control group. Fatigue improved across the entire cohort, without significant between‐group differences. 15% of volunteers reported side effects, with distaste higher in the BCAA arm (p = 0.045). Conclusion: BCAA supplementation did not improve measures of muscle strength, mass or performance or physical frailty compared to a whey protein supplement in a randomised controlled setting. ACTRN12618000802202. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Effects of aromatase inhibitor therapy on adiposity and cardiometabolic health in postmenopausal women: a controlled cohort extension study

Author

Cheung, Yee-Ming M, primary, Hoermann, Rudolf, additional, Van, Karen, additional, Wu, Damian, additional, Healy, Jenny, additional, Halim, Bella, additional, Raval, Manjri, additional, McGill, Maria, additional, Al-Fiadh, Ali, additional, Chao, Michael, additional, White, Shane, additional, Yeo, Belinda, additional, Zajac, Jeffrey D, additional, and Grossmann, Mathis, additional

Published
2023
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14. sj-docx-1-tae-10.1177_20420188231158163 – Supplemental material for The role of supporting and disruptive mechanisms of FT3 homeostasis in regulating the hypothalamic–pituitary–thyroid axis

Author

Hoermann, Rudolf, Pekker, Mark J., Midgley, John E. M., and Dietrich, Johannes W.

Subjects
FOS: Clinical medicine, 111403 Paediatrics, 110306 Endocrinology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tae-10.1177_20420188231158163 for The role of supporting and disruptive mechanisms of FT3 homeostasis in regulating the hypothalamic–pituitary–thyroid axis by Rudolf Hoermann, Mark J. Pekker, John E. M. Midgley and Johannes W. Dietrich in Therapeutic Advances in Endocrinology and Metabolism

Published
2023
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16. Modeling Supportive and Disruptive Mechanisms of FT3 Homeostasis: Supplementary Information

Author

Hoermann, Rudolf, Pekker, Mark J, Midgley, John E M, and Dietrich, Johannes W

Subjects
hypothalamic pituitary thyroid axis, triiodothyronine, homeostasis, mathematical model
Abstract

Wepresent a mechanistic mathematicalmodelwhichextendsthe concept of HPT axis regulation beyond TSH and FT4 to integrate the biologically more active sister hormone FT3 and mechanisms of FT3 homeostasis. Disruption of homeostatic mechanisms leads to disease. The mathematical model consists of a system of four coupled first-order parametrized nonlinear ordinary differential equations (ODEs), which were developed to account for the interdependencies between the four hormones TRH, TSH, FT4 and FT3 in the network of the hypothalamic-pituitary-thyroid (HPT) axis regulation. While TRH and TSH feed forward to the pituitary and thyroid, respectively, FT4 and FT3 feed back to both the pituitary and hypothalamus.FT4 is converted to its biologically more active sister hormone FT3 through a partly TSH-dependent multi-enzyme process. Themodel evaluatesdisease-defining mechanisms, frequently conflated in population statistics, structural parameters and individualized homeostatic outcomes and targets..This is particularly important, given theadaptive expression of balancein thecomplex regulatory network ofthe HPT axis regulation, which tend to move in a non-linear way and are otherwise difficult to predict.

Published
2022
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17. Störungen des Kalzium- und Knochenstoffwechsels

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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18. Endokrinologische Anamnesebögen

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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19. Referenzbereiche endokrinologischer Laborparameter

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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20. Vorgehen bei ausgewählten Schilddrüsenerkrankungen

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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21. Diabetes mellitus

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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22. Störungen der Nebennierenfunktion

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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23. Störungen der Hypophysenfunktion

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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24. Primärer Hyperaldosteronismus

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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25. Phäochromozytom

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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26. Hypophysenhinterlappen

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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27. Gonadotrope Funktion

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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28. Somatotrope Funktion

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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29. Corticotrope Funktion

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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30. Schilddrüsenerkrankungen

Author

Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., Vogel, E., Fröhlich, Jürgen, Hörmann, Rudolf, Saller, Bernhard, Mann, Klaus, Fink, H., Reinhardt, W., Sauer, J., Schulte, C., and Vogel, E.

Published
1999
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36. Minimal HPT Axis Model: Supplementary Information

Author

Hoermann, Rudolf, Pekker, Mark J, Midgley, John E M, Larisch, Rolf, and W, Dietrich Johannes

Subjects
Quantitative Biology::Neurons and Cognition, triiodothyronine, homeostasis, allostasis, adaptation, endocrine regulation, mathematical model, hypothalamic-pituitary-thyroid axis
Abstract

A minimal mathematical model, in the form of a parametrized nonlinear dynamical system of 4 ODEs, is formulated as a proof-of-concept to elucidate principles of hypothalamic-pituitary-thyroid (HPT) axis regulation. The model allows uncovering mechanisms for the homeostasis of the key biologically active hormone free triiodothyronine (FT3)., {"references":["Hoermann et al. 2020 doi:10.1111/eci.13192"]}

Published
2022
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47. Effects of aromatase inhibitor therapy on visceral adipose tissue area and cardiometabolic health in postmenopausal women with early and locally advanced breast cancer.

Author

Cheung, Yee‐Ming M., Hoermann, Rudolf, Van, Karen, Wu, Damian, Healy, Jenny, Chao, Michael, White, Shane, Yeo, Belinda, Zajac, Jeffrey, and Grossmann, Mathis

Subjects
*METASTATIC breast cancer, *ADIPOSE tissues, *AROMATASE inhibitors, *POSTMENOPAUSE, *DUAL-energy X-ray absorptiometry
Abstract

Objective: Aromatase inhibitor (AI) therapy provides oncological benefits in postmenopausal women with oestrogen receptor‐positive breast cancer. However, AI treatment has been associated with increased cardiovascular risk. In nonbreast cancer populations, experimentally induced low oestrogen states and natural transition to menopause have been associated with increases in visceral adipose tissue (VAT), a known surrogate marker for cardiometabolic risk. Given that AI treatment blocks oestradiol production, we hypothesized that AI treatment would increase VAT. Methods: We conducted a prospective 12‐month cohort study of 52 postmenopausal women newly initiating AI treatment (median age: 64.5 years) and 52 women with breast pathology not requiring endocrine therapy (median age: 63.5 years). VAT area and other body composition parameters were measured at baseline, 6 months and 12 months using dual X‐ray absorptiometry. Other risk markers of cardiometabolic health were also assessed. Results: In women initiating AI treatment, there was no statistically significant difference in VAT area after 12 months when compared to controls, with a mean adjusted difference of −5.00 cm2 (−16.9, 6.91), p =.55. Moreover, changes in total fat mass, lean mass, subcutaneous adipose tissue area, hepatic steatosis and measures in endothelial function were also not statistically different between groups after 12 months. Findings were similar after adjustments for activity levels and coronavirus disease 2019 lockdown duration. Conclusions: These data provide reassurance that over the initial 12 months of AI therapy, AI treatment is not associated with metabolically adverse changes in body composition, hepatic steatosis or vascular reactivity. The impact of extended AI therapy on cardiometabolic health requires further study. [ABSTRACT FROM AUTHOR]

Published
2023
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