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2. Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial

Author

Paton, Nicholas, Hayden, Fred, Darbyshire, Janet, Lucas, Amy, Lorch, Ulrika, Freedman, Andrew, Knight, Richard, Julious, Stevan, Byrne, Rachel, Cubas Atienzar, Ana, Jones, Jayne, Williams, Chris, Song, Anna, Dixon, Jan, Alexandersson, Anja, Hatchard, Parys, Tilt, Emma, Titman, Andrew, Doce Carracedo, Ale, Chandran Gorner, Vatsi, Davies, Andrea, Woodhouse, Louis, Carlucci, Nicola, Okenyi, Emmanuel, Bula, Marcin, Dodd, Kate, Gibney, Jennifer, Dry, Lesley, Rashid Gardner, Zalina, Sammour, Amin, Cole, Christine, Rowland, Tim, Tsakiroglu, Maria, Yip, Vincent, Osanlou, Rostam, Stewart, Anna, Parker, Ben, Turgut, Tolga, Ahmed, Afshan, Starkey, Kay, Subin, Sujamole, Stockdale, Jennifer, Herring, Lisa, Baker, Jonathon, Oliver, Abigail, Pacurar, Mihaela, Owens, Dan, Munro, Alistair, Babbage, Gavin, Faust, Saul, Harvey, Matthew, Pratt, Danny, Nagra, Deepak, Vyas, Aashish, Khoo, Saye H, FitzGerald, Richard, Saunders, Geoffrey, Middleton, Calley, Ahmad, Shazaad, Edwards, Christopher J, Hadjiyiannakis, Dennis, Walker, Lauren, Lyon, Rebecca, Shaw, Victoria, Mozgunov, Pavel, Periselneris, Jimstan, Woods, Christie, Bullock, Katie, Hale, Colin, Reynolds, Helen, Downs, Nichola, Ewings, Sean, Buadi, Amanda, Cameron, David, Edwards, Thomas, Knox, Emma, Donovan-Banfield, I'ah, Greenhalf, William, Chiong, Justin, Lavelle-Langham, Lara, Jacobs, Michael, Northey, Josh, Painter, Wendy, Holman, Wayne, Lalloo, David G, Tetlow, Michelle, Hiscox, Julian A, Jaki, Thomas, Fletcher, Thomas, and Griffiths, Gareth

Published
2023
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4. Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial

Author

Donovan-Banfield, I’ah, Penrice-Randal, Rebekah, Goldswain, Hannah, Rzeszutek, Aleksandra M., Pilgrim, Jack, Bullock, Katie, Saunders, Geoffrey, Northey, Josh, Dong, Xiaofeng, Ryan, Yan, Reynolds, Helen, Tetlow, Michelle, Walker, Lauren E., FitzGerald, Richard, Hale, Colin, Lyon, Rebecca, Woods, Christie, Ahmad, Shazaad, Hadjiyiannakis, Dennis, Periselneris, Jimstan, Knox, Emma, Middleton, Calley, Lavelle-Langham, Lara, Shaw, Victoria, Greenhalf, William, Edwards, Thomas, Lalloo, David G., Edwards, Christopher J., Darby, Alistair C., Carroll, Miles W., Griffiths, Gareth, Khoo, Saye H., Hiscox, Julian A., and Fletcher, Thomas

Published
2022
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5. Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial

Author

Munro, Alasdair P S, Feng, Shuo, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Qureshi, Ehsaan, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kanji, Nasir, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Holliday, Kyra, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Bawa, Tanveer, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Maallah, Mina, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Lambe, Teresa, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, Faust, Saul N, Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris, Katechia, Kashyap, Cooper, Alison, Freedman, Andrew, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Harrison, Elizabeth, Snashall, Emma, Mallon, Lewis, Burton, Katharine, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Murira, Jennifer, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Sturdy, Ann, Barcella, Lara, Soussi, Najwa, Mpelembue, Mushiya, Raj, Sreena, Sharma, Rajni, Corrah, Tumena, John, Laurence, Whittington, Ashley, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Abeywickrama, Movin, Spence, Niamh, Packham, Alice, Serafimova, Teona, Aslam, Suahil, McGreevy, Caitlin, Borca, Alessandro, DeLosSantosDominguez, Pamela, Palmer, Emily, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Gokani, Karishma, Trinham, Charlotte, Sabine, Charlette, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Stone, Megan, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Turnbull, Iain, Morshead, Gertraud, Drake-Brockman, Rachael, Smith, Catherine, Li, Grace, Kasanyinga, Mwila, Clutterbuck, Elizabeth A, Bibi, Sagida, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicia, Nabunjo, Martha, Osuji, Carol, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Grierson, Jacques, Males, Samantha, Askoolam, Krishna, Barry, Joshua, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karen, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Hamal, Shama, Ricamara, Marivic, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalvescordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Appleby, Kim, Dineen, Emily, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Denny, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Habash-Bailey, Haniah, Magan, Javier, and Hardy, Anna

Published
2022
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6. Are the Kids Alright? Exploring Students' Experiences of Support Mechanisms to Enhance Wellbeing on an Engineering Programme in the UK

Author

Chadha, Deesha, Kogelbauer, Andreas, Campbell, James, Hellgardt, Klaus, Maraj, Marsha, Shah, Umang, Brechtelsbauer, Clemens, and Hale, Colin

Abstract

In this paper, we aim to explore students' experiences of support mechanisms that support their wellbeing on an engineering degree programme at a research-intensive higher education institution and understand how theory relates to practice. This study was conducted using a mixed-methods approach involving student survey responses (N = 173), interviews with 16 students and focus groups. Kahu and Nelson's conceptual framework was used as a lens through which to explore student support mechanisms. Preliminary data analysis indicates that the intense workload adversely affects students as do some of the interactions they have with personal tutors and their peers. Our findings suggest that workload needs to be reduced, personal tutors need to fill gaps in their skills set, especially associated with student support, and institutional and departmental protocols be continually updated to support student wellbeing. Additionally, student wellbeing officers and professional, dedicated wellbeing advisors could be part of a long-term solution.

Published
2021
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8. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Author

Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris A, Hughes, Stephen, Longshaw, Laura, Stockport, Jane, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Guha, Arpan, Snashall, Emma, Eadsforth, Tom, Reeder, Sally, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Holliday, Kyra, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Makia, Fiona, Hopkins, NinaSimone, Barcella, Lara, Mpelembue, Mushiya, dabagh, Maja, lang, Matilda, khan, Farida, Adebambo, Olumide, Chita, Sunder, Corrah, Tumena, Whittington, Ashley, John, Laurence, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Serafimova, Teona, Nanino, Elisa, Cooney, Enya, Wilson-Goldsmith, Jaimie, Nguyen, Hanna, Mazzella, Andrea, Jackson, Beth, Aslam, Suahil, Bawa, Tanveer, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Qureshi, Ehsaan, Trinham, Charlotte, Sabine, Charlotte, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Smith, David, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Cifuentes, Liliana, Morshead, Gertraud, Drake-Brockman, Rachael, Kinch, Patrick, Kasanyinga, Mwila, Clutterbuck, Elizabeth A., Bibi, Sagida, Stuart, Arabella SV, Shaw, Robert H, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicja, Nabunjo, Martha, Osuji, Carool, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karren, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Freedman, Andrew, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Ricamara, Marivic, Hamal, Shama, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalves cordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross-Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Habash-Bailey, Haniah, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Dennyl, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Magan, Javier, Hardy, Anna, Appleby, Kim, Munro, Alasdair P S, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Gokani, Karishma, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kwok, Jonathan, Lambe, Teresa, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Murira, Jennifer, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Salkeld, Jo, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Sturdy, Ann, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, and Faust, Saul N

Published
2021
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13. Quantum Ghost Imaging through Turbulence

Author

Dixon, P. Ben, Howland, Gregory, Chan, Kam Wai Clifford, O'Sullivan-Hale, Colin, Rodenburg, Brandon, Hardy, Nicholas D., Shapiro, Jeffrey H., Simon, D. S., Sergienko, A. V., Boyd, R. W., and Howell, John C.

Subjects
Quantum Physics, Physics - Optics
Abstract

We investigate the effect of turbulence on quantum ghost imaging. We use entangled photons and demonstrate that for a novel experimental configuration the effect of turbulence can be greatly diminished. By decoupling the entangled photon source from the ghost imaging central image plane, we are able to dramatically increase the ghost image quality. When imaging a test pattern through turbulence, this method increased the imaged pattern visibility from V = 0.14 +/- 0.04 to V = 0.29 +/- 0.04.

Published
2011

15. Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial

Author

Khoo, Saye H, primary, FitzGerald, Richard, additional, Saunders, Geoffrey, additional, Middleton, Calley, additional, Ahmad, Shazaad, additional, Edwards, Christopher J, additional, Hadjiyiannakis, Dennis, additional, Walker, Lauren, additional, Lyon, Rebecca, additional, Shaw, Victoria, additional, Mozgunov, Pavel, additional, Periselneris, Jimstan, additional, Woods, Christie, additional, Bullock, Katie, additional, Hale, Colin, additional, Reynolds, Helen, additional, Downs, Nichola, additional, Ewings, Sean, additional, Buadi, Amanda, additional, Cameron, David, additional, Edwards, Thomas, additional, Knox, Emma, additional, Donovan-Banfield, I'ah, additional, Greenhalf, William, additional, Chiong, Justin, additional, Lavelle-Langham, Lara, additional, Jacobs, Michael, additional, Northey, Josh, additional, Painter, Wendy, additional, Holman, Wayne, additional, Lalloo, David G, additional, Tetlow, Michelle, additional, Hiscox, Julian A, additional, Jaki, Thomas, additional, Fletcher, Thomas, additional, Griffiths, Gareth, additional, Paton, Nicholas, additional, Hayden, Fred, additional, Darbyshire, Janet, additional, Lucas, Amy, additional, Lorch, Ulrika, additional, Freedman, Andrew, additional, Knight, Richard, additional, Julious, Stevan, additional, Byrne, Rachel, additional, Cubas Atienzar, Ana, additional, Jones, Jayne, additional, Williams, Chris, additional, Song, Anna, additional, Dixon, Jan, additional, Alexandersson, Anja, additional, Hatchard, Parys, additional, Tilt, Emma, additional, Titman, Andrew, additional, Doce Carracedo, Ale, additional, Chandran Gorner, Vatsi, additional, Davies, Andrea, additional, Woodhouse, Louis, additional, Carlucci, Nicola, additional, Okenyi, Emmanuel, additional, Bula, Marcin, additional, Dodd, Kate, additional, Gibney, Jennifer, additional, Dry, Lesley, additional, Rashid Gardner, Zalina, additional, Sammour, Amin, additional, Cole, Christine, additional, Rowland, Tim, additional, Tsakiroglu, Maria, additional, Yip, Vincent, additional, Osanlou, Rostam, additional, Stewart, Anna, additional, Parker, Ben, additional, Turgut, Tolga, additional, Ahmed, Afshan, additional, Starkey, Kay, additional, Subin, Sujamole, additional, Stockdale, Jennifer, additional, Herring, Lisa, additional, Baker, Jonathon, additional, Oliver, Abigail, additional, Pacurar, Mihaela, additional, Owens, Dan, additional, Munro, Alistair, additional, Babbage, Gavin, additional, Faust, Saul, additional, Harvey, Matthew, additional, Pratt, Danny, additional, Nagra, Deepak, additional, and Vyas, Aashish, additional

Published
2023
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20. A Randomised -Controlled Phase 2 trial of Molnupiravir in Unvaccinated and Vaccinated Individuals with Early SARS-CoV-2

Author

Khoo, Saye H, primary, FitzGerald, Richard, additional, Saunders, Geoffrey, additional, Middleton, Calley, additional, Ahmad, Shazaad, additional, Edwards, Christopher J, additional, Hadjiyiannakis, Dennis, additional, Walker, Lauren, additional, Lyon, Rebecca, additional, Shaw, Victoria, additional, Mozgunov, Pavel, additional, Periselneris, Jimstan, additional, Woods, Christie, additional, Bullock, Katie, additional, Hale, Colin, additional, Reynolds, Helen, additional, Downs, Nichola, additional, Ewings, Sean, additional, Buadi, Amanda, additional, Cameron, David, additional, Edwards, Thomas, additional, Knox, Emma, additional, Donovan-Banfield, I’ah, additional, Greenhalf, William, additional, Chiong, Justin, additional, Lavelle-Langham, Lara, additional, Jacobs, Michael, additional, Painter, Wendy, additional, Holman, Wayne, additional, Lalloo, David G, additional, Tetlow, Michelle, additional, Hiscox, Julian A, additional, Jaki, Thomas, additional, Fletcher, Thomas, additional, and Griffiths, Gareth, additional

Published
2022
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21. Characterisation of SARS-CoV-2 genomic variations in response to molnupiravir treatment in the AGILE Phase IIa clinical trial.

Author

Fletcher, Thomas, primary, Donovan-Banfield, I'ah, additional, Penrice-Randal, Rebekah, additional, Goldswain, Hannah, additional, Rzeszutek, Aleksandra, additional, Pilgrim, Jack, additional, Bullock, Katie, additional, Saunders, Geoffrey, additional, Northey, Josh, additional, Dong, Xiaofeng, additional, Ryan, Yan, additional, Reynolds, Helen, additional, Tetlow, Michelle, additional, Walker, Lauren, additional, FitzGerald, Richard, additional, Hale, Colin, additional, Lyon, Rebecca, additional, Woods, Christie, additional, Ahmad, Shazaad, additional, Hadjiyiannakis, Dennis, additional, Periselneris, Jimstan, additional, Knox, Emma, additional, Middleton, Calley, additional, Lavelle-Langham, Lara, additional, Shaw, Victoria, additional, Greenhalf, William, additional, Edwards, Thomas, additional, Lalloo, David, additional, Edwards, Christopher, additional, Darby, Alistair, additional, Carroll, Miles, additional, Griffiths, Gareth, additional, Khoo, Saye, additional, and Hiscox, Julian, additional

Published
2022
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23. Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Author

FitzGerald, Richard, primary, Dickinson, Laura, additional, Else, Laura, additional, Fletcher, Thomas, additional, Hale, Colin, additional, Amara, Alieu, additional, Walker, Lauren, additional, Penchala, Sujan Dilly, additional, Lyon, Rebecca, additional, Shaw, Victoria, additional, Greenhalf, William, additional, Bullock, Katie, additional, Lavelle-Langham, Lara, additional, Reynolds, Helen, additional, Painter, Wendy, additional, Holman, Wayne, additional, Ewings, Sean, additional, Griffiths, Gareth, additional, and Khoo, Saye, additional

Published
2022
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26. Pharmacokinetics of β-d-N4-hydroxycytidine, the active metabolite of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

Author

FitzGerald, Richard, primary, Dickinson, Laura, additional, Else, Laura, additional, Fletcher, Thomas, additional, Hale, Colin, additional, Amara, Alieu, additional, Walker, Lauren, additional, Dilly Penchala, Sujan, additional, Lyon, Rebecca, additional, Shaw, Victoria, additional, Greenhalf, William, additional, Lavelle-Langham, Lara, additional, Reynolds, Helen, additional, Painter, Wendy, additional, Holman, Wayne, additional, Ewings, Sean, additional, Griffiths, Gareth, additional, and Khoo, Saye, additional

Published
2021
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27. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Author

Munro, Alasdair P S, primary, Janani, Leila, additional, Cornelius, Victoria, additional, Aley, Parvinder K, additional, Babbage, Gavin, additional, Baxter, David, additional, Bula, Marcin, additional, Cathie, Katrina, additional, Chatterjee, Krishna, additional, Dodd, Kate, additional, Enever, Yvanne, additional, Gokani, Karishma, additional, Goodman, Anna L, additional, Green, Christopher A, additional, Harndahl, Linda, additional, Haughney, John, additional, Hicks, Alexander, additional, van der Klaauw, Agatha A, additional, Kwok, Jonathan, additional, Lambe, Teresa, additional, Libri, Vincenzo, additional, Llewelyn, Martin J, additional, McGregor, Alastair C, additional, Minassian, Angela M, additional, Moore, Patrick, additional, Mughal, Mehmood, additional, Mujadidi, Yama F, additional, Murira, Jennifer, additional, Osanlou, Orod, additional, Osanlou, Rostam, additional, Owens, Daniel R, additional, Pacurar, Mihaela, additional, Palfreeman, Adrian, additional, Pan, Daniel, additional, Rampling, Tommy, additional, Regan, Karen, additional, Saich, Stephen, additional, Salkeld, Jo, additional, Saralaya, Dinesh, additional, Sharma, Sunil, additional, Sheridan, Ray, additional, Sturdy, Ann, additional, Thomson, Emma C, additional, Todd, Shirley, additional, Twelves, Chris, additional, Read, Robert C, additional, Charlton, Sue, additional, Hallis, Bassam, additional, Ramsay, Mary, additional, Andrews, Nick, additional, Nguyen-Van-Tam, Jonathan S, additional, Snape, Matthew D, additional, Liu, Xinxue, additional, Faust, Saul N, additional, Riordan, Andrew, additional, Ustianowski, Andrew, additional, Rogers, Chris A, additional, Hughes, Stephen, additional, Longshaw, Laura, additional, Stockport, Jane, additional, Hughes, Rachel, additional, Grundy, Lynne, additional, Tudor Jones, Lona, additional, Guha, Arpan, additional, Snashall, Emma, additional, Eadsforth, Tom, additional, Reeder, Sally, additional, Storton, Kim, additional, Munusamy, Malathi, additional, Tandy, Bridget, additional, Egbo, Akamino, additional, Cox, Stephen, additional, Ahmed, Nabeela Nazir, additional, Shenoy, Anil, additional, Bousfield, Rachel, additional, Wixted, Donna, additional, Gutteridge, Helen, additional, Mansfield, Becky, additional, Herbert, Christopher, additional, Holliday, Kyra, additional, Calderwood, James, additional, Barker, Dominique, additional, Brandon, Jacqueline, additional, Tulloch, Hayley, additional, Colquhoun, Suzie, additional, Thorp, Helen, additional, Radford, Helen, additional, Evans, Julie, additional, Baker, Helena, additional, Thorpe, Jeanette, additional, Batham, Sally, additional, Hailstone, Jessica, additional, Phillips, Rachael, additional, Kumar, Dileep, additional, Westwell, Fran, additional, Makia, Fiona, additional, Hopkins, NinaSimone, additional, Barcella, Lara, additional, Mpelembue, Mushiya, additional, dabagh, Maja, additional, lang, Matilda, additional, khan, Farida, additional, Adebambo, Olumide, additional, Chita, Sunder, additional, Corrah, Tumena, additional, Whittington, Ashley, additional, John, Laurence, additional, Roche, Siobhan, additional, Wagstaff, Lynda, additional, Farrier, Adam, additional, Bisnauthsing, Karen, additional, Serafimova, Teona, additional, Nanino, Elisa, additional, Cooney, Enya, additional, Wilson-Goldsmith, Jaimie, additional, Nguyen, Hanna, additional, Mazzella, Andrea, additional, Jackson, Beth, additional, Aslam, Suahil, additional, Bawa, Tanveer, additional, Broadhead, Samantha, additional, Farooqi, Sadaf, additional, Piper, Jo, additional, Weighell, Rowena, additional, Pickup, Lorinda, additional, Shamtally, Djamila, additional, Domingo, Jason, additional, Kourampa, Evgenia, additional, Hale, Colin, additional, Gibney, Jennifer, additional, Stackpoole, Michael, additional, Rashid-Gardner, Zalina, additional, Lyon, Rebecca, additional, McDonnell, Chloe, additional, Cole, Christine, additional, Stewart, Anna, additional, McMillan, Gillian, additional, Savage, Mary, additional, Beckett, Helen, additional, Moorbey, Chantelle, additional, Desai, Amisha, additional, Brown, Claire, additional, Naker, Kush, additional, Qureshi, Ehsaan, additional, Trinham, Charlotte, additional, Sabine, Charlotte, additional, Moore, Sophie, additional, Hurdover, Steve, additional, Justice, Edwin, additional, Smith, David, additional, Plested, Emma, additional, Ferreira Da Silva, Carla, additional, White, Rachel, additional, Robinson, Hannah, additional, Cifuentes, Liliana, additional, Morshead, Gertraud, additional, Drake-Brockman, Rachael, additional, Kinch, Patrick, additional, Kasanyinga, Mwila, additional, Clutterbuck, Elizabeth A., additional, Bibi, Sagida, additional, Stuart, Arabella SV, additional, Shaw, Robert H, additional, Singh, Michael, additional, Champaneri, Trishna, additional, Irwin, Margaret, additional, Khan, Mohammed, additional, Kownacka, Alicja, additional, Nabunjo, Martha, additional, Osuji, Carool, additional, Hladkiwskyj, John, additional, Galvin, Dominic, additional, Patel, Gita, additional, Mouland, Johanna, additional, Longhurst, Beverley, additional, Moon, Maria, additional, Giddins, Beth, additional, Pereira Dias Alves, Carlota, additional, Richmond, Leah, additional, Minnis, Christine, additional, Baryschpolec, Sonia, additional, Elliott, Scott, additional, Fox, Lauren, additional, Graham, Victoria, additional, Baker, Natalie, additional, Godwin, Kerry, additional, Buttigieg, Karren, additional, Knight, Chanice, additional, Brown, Phillip, additional, Lall, Paminder, additional, Shaik, Imam, additional, Chiplin, Emily, additional, Brunt, Emily, additional, Leung, Stephanie, additional, Allen, Lauren, additional, Thomas, Steve, additional, Fraser, Sara, additional, Choi, Bea, additional, Gouriet, Jade, additional, Freedman, Andrew, additional, Perkins, Jonathan, additional, Gowland, Andrew, additional, Macdonald, Jonathan, additional, Seenan, John Paul, additional, Starinskij, Igor, additional, Seaton, Andrew, additional, Peters, Erica, additional, Singh, Stephen, additional, Gardside, Ben, additional, Bonnaud, Avril, additional, Davies, Ceri, additional, Gordon, Elizabeth, additional, Keenan, Samantha, additional, Hall, Jane, additional, Wilkins, Suzanne, additional, Tasker, Suzanne, additional, James, Rob, additional, Seath, Ingrid, additional, Littlewood, Kelly, additional, Newman, Joseph, additional, Boubriak, Iryna, additional, Suggitt, Debbie, additional, Haydock, Helen, additional, Bennett, Sara, additional, Woodyatt, Wiesia, additional, Hughes, Kerry, additional, Bell, Judith, additional, Coughlan, Tricia, additional, van Welsenes, Donald, additional, Kamal, Mohammed, additional, Cooper, Chris, additional, Tunstall, Simon, additional, Ronan, Nicholas, additional, Cutts, Rebecca, additional, Dare, Tracey, additional, Yim, Yee Ting Nicole, additional, Whittley, Sarah, additional, Ricamara, Marivic, additional, Hamal, Shama, additional, Adams, Kirsty, additional, Baker, Holly, additional, Driver, Kimberley, additional, Turner, Nicola, additional, Rawlins, Todd, additional, Roy, Subarna, additional, Merida-Morillas, Marta, additional, Sakagami, Yukari, additional, Andrews, Antonette, additional, Goncalves cordeiro, Lillian, additional, Stokes, Matthew, additional, Ambihapathy, Wythehi, additional, Spencer, Joanne, additional, Parungao, Nina, additional, Berry, Lisa, additional, Cullinane, James, additional, Presland, Laura, additional, Ross-Russell, Amy, additional, Warren, Sarah, additional, Baker, Jonathan, additional, Oliver, Abigail, additional, Buadi, Amanda, additional, Lee, Kim, additional, Haskell, Louise, additional, Romani, Rossana, additional, Bentley, Ian, additional, Whitbred, Tim, additional, Fowler, Simon, additional, Gavin, John, additional, Magee, Alan, additional, Watson, Tara, additional, Nightingale, Kari, additional, Marius, Phedra, additional, Summerton, Eloise, additional, Locke, Emily, additional, Honey, Thomas, additional, Lingwood, Aidan, additional, de la Haye, Anastasia, additional, Elliott, Ryan Stephen, additional, Underwood, Karen, additional, King, Mikayala, additional, Davies-Dear, Sharon, additional, Horsfall, Emily, additional, Chalwin, Olivia, additional, Burton, Holly, additional, Edwards, Christopher J, additional, Welham, Benjamin, additional, Garrahy, Sarah, additional, Hall, Fran, additional, Ladikou, Eleni, additional, Mullan, Dee, additional, Hansen, Daniel, additional, Campbell, Marion, additional, Dos Santos, Filipa, additional, Habash-Bailey, Haniah, additional, Lakeman, Nicki, additional, Branney, Debbie, additional, Vamplew, Luke, additional, Hogan, Alison, additional, Frankham, Jorden, additional, Wiselka, Martin, additional, Vail, Dennyl, additional, Wenn, Victoria, additional, Renals, Valerie, additional, Ellis, Kate, additional, Lewis-Taylor, Jessica, additional, Magan, Javier, additional, Hardy, Anna, additional, and Appleby, Kim, additional

Published
2021
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30. An open label, adaptive, phase 1 trial of high-dose oral nitazoxanide in healthy volunteers: an antiviral candidate for SARS-CoV-2

Author

Walker, Lauren E, primary, FitzGerald, Richard, additional, Saunders, Geoffrey, additional, Lyon, Rebecca, additional, Fisher, Michael, additional, Martin, Karen, additional, Eberhart, Izabela, additional, Woods, Christie, additional, Ewings, Sean, additional, Hale, Colin, additional, Rajoli, Rajith KR, additional, Else, Laura, additional, Dilly-Penchala, Sujan, additional, Amara, Alieu, additional, Lalloo, David G, additional, Jacobs, Michael, additional, Pertinez, Henry, additional, Hatchard, Parys, additional, Waugh, Robert, additional, Lawrence, Megan, additional, Johnson, Lucy, additional, Fines, Keira, additional, Reynolds, Helen, additional, Rowland, Timothy, additional, Crook, Rebecca, additional, Byrne, Kelly, additional, Mozgunov, Pavel, additional, Jaki, Thomas, additional, Khoo, Saye, additional, Owen, Andrew, additional, Griffiths, Gareth, additional, and Fletcher, Thomas E, additional

Published
2021
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31. Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

Author

Khoo, Saye H, primary, Fitzgerald, Richard, additional, Fletcher, Thomas, additional, Ewings, Sean, additional, Jaki, Thomas, additional, Lyon, Rebecca, additional, Downs, Nichola, additional, Walker, Lauren, additional, Tansley-Hancock, Olana, additional, Greenhalf, William, additional, Woods, Christie, additional, Reynolds, Helen, additional, Marwood, Ellice, additional, Mozgunov, Pavel, additional, Adams, Emily, additional, Bullock, Katie, additional, Holman, Wayne, additional, Bula, Marcin D, additional, Gibney, Jennifer L, additional, Saunders, Geoffrey, additional, Corkhill, Andrea, additional, Hale, Colin, additional, Thorne, Kerensa, additional, Chiong, Justin, additional, Condie, Susannah, additional, Pertinez, Henry, additional, Painter, Wendy, additional, Wrixon, Emma, additional, Johnson, Lucy, additional, Yeats, Sara, additional, Mallard, Kim, additional, Radford, Mike, additional, Fines, Keira, additional, Shaw, Victoria, additional, Owen, Andrew, additional, Lalloo, David G, additional, Jacobs, Michael, additional, and Griffiths, Gareth, additional

Published
2021
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32. Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a phase 1, dose-escalating, randomised controlled study

Author

Khoo, Saye H, primary, FitzGerald, Richard, additional, Fletcher, Thomas, additional, Ewings, Sean, additional, Jaki, Thomas, additional, Lyon, Rebecca, additional, Downs, Nichola, additional, Walker, Lauren, additional, Tansley-Hancock, Olana, additional, Greenhalf, William, additional, Woods, Christie, additional, Reynolds, Helen, additional, Marwood, Ellice, additional, Mozgunov, Pavel, additional, Adams, Emily, additional, Bullock, Katie, additional, Holman, Wayne, additional, Bula, Marcin D, additional, Gibney, Jennifer L, additional, Saunders, Geoffrey, additional, Corkhill, Andrea, additional, Hale, Colin, additional, Thorne, Kerensa, additional, Chiong, Justin, additional, Condie, Susannah, additional, Pertinez, Henry, additional, Painter, Wendy, additional, Wrixon, Emma, additional, Johnson, Lucy, additional, Yeats, Sara, additional, Mallard, Kim, additional, Radford, Mike, additional, Fines, Keira, additional, Shaw, Victoria, additional, Owen, Andrew, additional, Lalloo, David G, additional, Jacobs, Michael, additional, and Griffiths, Gareth, additional

Published
2021
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34. An Open Label, Adaptive, Phase 1 Trial of High‐Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS‐CoV‐2.

Author

Walker, Lauren E., FitzGerald, Richard, Saunders, Geoffrey, Lyon, Rebecca, Fisher, Michael, Martin, Karen, Eberhart, Izabela, Woods, Christie, Ewings, Sean, Hale, Colin, Rajoli, Rajith K. R., Else, Laura, Dilly‐Penchala, Sujan, Amara, Alieu, Lalloo, David G., Jacobs, Michael, Pertinez, Henry, Hatchard, Parys, Waugh, Robert, and Lawrence, Megan

Subjects
CORONAVIRUS disease treatment, COVID-19, SARS-CoV-2, VOLUNTEERS, VOLUNTEER service, ANTIPARASITIC agents
Abstract

Repurposing approved drugs may rapidly establish effective interventions during a public health crisis. This has yielded immunomodulatory treatments for severe coronavirus disease 2019 (COVID‐19), but repurposed antivirals have not been successful to date because of redundancy of the target in vivo or suboptimal exposures at studied doses. Nitazoxanide is a US Food and Drug Administration (FDA) approved antiparasitic medicine, that physiologically‐based pharmacokinetic (PBPK) modeling has indicated may provide antiviral concentrations across the dosing interval, when repurposed at higher than approved doses. Within the AGILE trial platform (NCT04746183) an open label, adaptive, phase I trial in healthy adult participants was undertaken with high‐dose nitazoxanide. Participants received 1,500 mg nitazoxanide orally twice‐daily with food for 7 days. Primary outcomes were safety, tolerability, optimum dose, and schedule. Intensive pharmacokinetic (PK) sampling was undertaken day 1 and 5 with minimum concentration (Cmin) sampling on days 3 and 7. Fourteen healthy participants were enrolled between February 18 and May 11, 2021. All 14 doses were completed by 10 of 14 participants. Nitazoxanide was safe and with no significant adverse events. Moderate gastrointestinal disturbance (loose stools or diarrhea) occurred in 8 participants (57.1%), with urine and sclera discoloration in 12 (85.7%) and 9 (64.3%) participants, respectively, without clinically significant bilirubin elevation. This was self‐limiting and resolved upon drug discontinuation. PBPK predictions were confirmed on day 1 but with underprediction at day 5. Median Cmin was above the in vitro target concentration on the first dose and maintained throughout. Nitazoxanide administered at 1,500 mg b.i.d. with food was safe with acceptable tolerability a phase Ib/IIa study is now being initiated in patients with COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Trace Element Export From the Critical Zone Triggered by Snowmelt Runoff in a Montane Watershed, Provo River, Utah, USA

Author

Checketts, Hannah N., primary, Carling, Gregory T., additional, Fernandez, Diego P., additional, Nelson, Stephen T., additional, Rey, Kevin A., additional, Tingey, David G., additional, Hale, Colin A., additional, Packer, Brian N., additional, Cordner, Cameron P., additional, Dastrup, Dylan B., additional, and Aanderud, Zachary T., additional

Published
2020
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40. Are the kids alright? Exploring students' experiences of support mechanisms to enhance wellbeing on an engineering programme in the UK.

Author

Chadha, Deesha, Kogelbauer, Andreas, Campbell, James, Hellgardt, Klaus, Maraj, Marsha, Shah, Umang, Brechtelsbauer, Clemens, and Hale, Colin

Subjects
WELL-being, ENGINEERING students, TUTORS & tutoring, STUDENT well-being
Abstract

In this paper, we aim to explore students' experiences of support mechanisms that support their wellbeing on an engineering degree programme at a research-intensive higher education institution and understand how theory relates to practice. This study was conducted using a mixed-methods approach involving student survey responses (N = 173), interviews with 16 students and focus groups. Kahu and Nelson's conceptual framework was used as a lens through which to explore student support mechanisms. Preliminary data analysis indicates that the intense workload adversely affects students as do some of the interactions they have with personal tutors and their peers. Our findings suggest that workload needs to be reduced, personal tutors need to fill gaps in their skills set, especially associated with student support, and institutional and departmental protocols be continually updated to support student wellbeing. Additionally, student wellbeing officers and professional, dedicated wellbeing advisors could be part of a long-term solution. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Teaming with Confidence: How Peer Connections in Problem-based Learning Impact the Team and Academic Self-efficacy of Engineering Students.

Author

Maraj, Marsha, Hale, Colin Paul, Kogelbauer, Andreas, and Hellgardt, Klaus

Abstract

Engineers will routinely work in teams to solve complex problems. Team-working and collaboration are therefore an integral part of engineering education as they offer enhanced opportunities of acquiring both transferable and subject-specific skills. This paper examines the experiences of third-year engineering students studying a designbased module which uses problem-based learning (PBL) as the main pedagogical approach where students work in teams of 5 or 6 to achieve the associated learning outcomes. PBL allows students to not only play an active role in their own learning but also affords the added opportunity of learning with and from each other (peer learning). The success of this experience can however, be impacted by the team efficacy which exists or ensues as part of the process. These interactions can influence academic self-efficacy and a key aim of this paper is to use the students' perceptions of their experiences with PBL to examine the relationships which exist among academic self-efficacy, peer learning and team efficacy within the module. Findings show that a large percentage of students (85%) felt they learned from each other and that this collaborative experience strongly improved their understanding of mechanical design principles. Self-efficacy scales ranging from 0 (cannot do at all) to 100 (highly certain can do) showed that 65% of students rated their average academic self-efficacy across all learning outcomes as high (above 75). This efficacy was positively related to the support received from peers. Only 6% of respondents indicated that they would be confident undertaking the module by themselves and that while peer-to-peer interactions helped with sharing the workload and producing deliverables, they would have been able to successfully tackle the module alone had the time allotted been increased proportionally. This information is valuable as it can inform and direct future module design within our programme in which many modules are team-based. This could involve and lead to the introduction of new- and the strengthening of existing peer learning opportunities which could transform the way we teach and learn in our department. [ABSTRACT FROM AUTHOR]

Published
2019

45. Quantum ghost imaging through turbulence

Author

Dixon, P. Ben, primary, Howland, Gregory A., additional, Chan, Kam Wai Clifford, additional, O’Sullivan-Hale, Colin, additional, Rodenburg, Brandon, additional, Hardy, Nicholas D., additional, Shapiro, Jeffrey H., additional, Simon, D. S., additional, Sergienko, A. V., additional, Boyd, R. W., additional, and Howell, John C., additional

Published
2011
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