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1. Did we observe changes in obstetric interventions in SARS-CoV-2 infected pregnant women at the beginning of COVID-pandemic in Belgium? Results of a nationwide population-based study.

Author

Vercoutere, An, Racapé, Judith, Zina, Mbiton Joel, Alexander, Sophie, Benoit, Karolien, Boulvain, Michel, Goemaes, Régine, Leroy, Charlotte, Van Leeuw, Virginie, Costa, Elena, Derisbourg, Sara, Goffard, Jean-Christophe, Roelens, Kristien, Vandenberghe, Griet, and Daelemans, Caroline

Published
2024
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6. Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019

Author

D'Antonio, Francesco, Sen, Cihat, Mascio, Daniele Di, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Arisoy, Resul, Ovayolu, Ali, Eroğlu, Hasan, Canales, Manuel Guerra, Ladella, Subhashini, Cojocaru, Liviu, Turan, Ozhan, Turan, Sifa, Hadar, Eran, Brzezinski-Sinai, Noa A., Dollinger, Sarah, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, Druškovič, Mirjam, Ples, Liana, Gündüz, Reyhan, Ağaçayak, Elif, Schvartzman, Javier Alfonso, Malbran, Mercedes Negri, Liberati, Marco, Sebastiano, Francesca Di, Oronzi, Ludovica, Cerra, Chiara, Buca, Danilo, Cagnacci, Angelo, Ramone, Arianna, Barra, Fabio, Carosso, Andrea, Benedetto, Chiara, Cosma, Stefano, Pintiaux, Axelle, Daelemans, Caroline, Costa, Elena, Özel, Ayşegül, Muhçu, Murat, Lopez, Jesús S Jimenez, Alvarado, Clara, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Schera, Giovanni Battista Luca, Volpe, Nicola, Frusca, Tiziana, Samardjiski, Igor, Simeonova, Slagjana, Papestiev, Irena Aleksioska, Hojman, Javier, Turkcuoglu, Ilgin, Cromi, Antonella, Laganà, Antonio Simone, Ghezzi, Fabio, Sirico, Angelo, Familiari, Alessandra, Scambia, Giovanni, Sukhikh, Zulfiya Khodjaeva Gennady T., Gorina, Ksenia A., de Sa, Renato Augusto Moreira, Vaz, Mariana, Feuerschuette, Otto Henrique May, Gatta, Anna Nunzia Della, Youssef, Aly, Donna, Gaetana Di, Martinez-Varea, Alicia, Loscalzo, Gabriela, Morales Roselló, José, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Ayala, Rodrigo, Molpeceres, Rebeca Garrote, Vázquez, Asunción Pino, Sandri, Fabrizio, Cataneo, Ilaria, Lenzi, Marinella, Haberal, Esra Tustas, Huertas, Erasmo, Sanchez, Amadeo, Arango, Pedro, Bermejo, Amanda, Alcantara, María Monica Gonzalez, Göynümer, Gökhan, Okuyan, Erhan, Madalina, Ciuhodaru, Guisan, Ana Concheiro, Schulte, Alejandra Martínez, Esposito, Valentina, De Robertis, Valentina, Zdjelar, Snezana, Lackovic, Milan, Mihajlovic, Sladjana, Jekova, Nelly, Saccone, Gabriele, Aslan, Mehmet Musa, Dedda, Maria Carmela Di, Chalid, Maisuri, Canache, Jose Enrique Moros, Daskalakis, George, Antsaklis, Panos, Vega, Enrique Criado, Cueto, Elisa, Taccaliti, Chiara, Aykanat, Yeliz, Özlem Genç, Şerife, Froessler, Bernd, Radulova, Petya Angelova, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Meccariello, Gabriella, Rohatgi, Bindu, Schiattarella, Antonio, Morlando, Maddalena, Colacurci, Nicola, Villasco, Andrea, Biglia, Nicoletta, Marques, Ana Luiza Santos, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Pittaro, Alejandro, Lila, Albert, and Zlatohlávková, Blanka

Published
2021
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8. Implementation of Fetal Clinical Exome Sequencing: Comparing Prospective and Retrospective Cohorts

Author

Marangoni, Martina, Smits, Guillaume, Ceysens, Gilles, Costa, Elena, Coulon, Robert, Daelemans, Caroline, De Coninck, Caroline, Derisbourg, Sara, Gajewska, Kalina, Garofalo, Giulia, Gounongbe, Caroline, Guizani, Meriem, Holoye, Anne, Houba, Catherine, Makhoul, Jean, Norgaard, Christian, Regnard, Cecile, Romée, Stephanie, Soto, Jamil, Stagel-Trabbia, Aurore, Van Rysselberge, Michel, Vercoutere, An, Zaytouni, Siham, Bouri, Sarah, DʼHaene, Nicky, DʼOnle, Dominique, Dugauquier, Christian, Racu, Marie-Lucie, Rocq, Laureen, Segers, Valérie, Verocq, Camille, Avni, Ephraim Freddy, Cassart, Marie, Massez, Anne, Blaumeiser, Bettina, Brischoux-Boucher, Elise, Bulk, Saskia, De Ravel, Thomy, Debray, Guillaume, Dimitrov, Boyan, Janssens, Sandra, Keymolen, Kathelijn, Laterre, Marie, van Berkel, Kim, Van Maldergem, Lionel, Vandernoot, Isabelle, Vilain, Catheline, Donner, Catherine, Tecco, Laura, Thomas, Dominique, Désir, Julie, Abramowicz, Marc, and Migeotte, Isabelle

Published
2022
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9. Déficit sévère en thiamine récidivant suite à une chirurgie bariatrique chez la femme enceinte

Author

Safraoui, Sophia, Brenez, Camille, De Raedt, Sylvie, Vandemeulebroucke, Evy, Decochez, Katelijn, Lefèvre, G., Derisbourg, Sara, Daelemans, Caroline, Vercoutere, An, Safraoui, Sophia, Brenez, Camille, De Raedt, Sylvie, Vandemeulebroucke, Evy, Decochez, Katelijn, Lefèvre, G., Derisbourg, Sara, Daelemans, Caroline, and Vercoutere, An

Abstract

info:eu-repo/semantics/published

Published
2023

13. Implementation of fetal clinical exome sequencing: Comparing prospective and retrospective cohorts

Author

Marangoni, Martina, primary, Smits, Guillaume, additional, Ceysens, Gilles, additional, Costa, Elena, additional, Coulon, Robert, additional, Daelemans, Caroline, additional, De Coninck, Caroline, additional, Derisbourg, Sara, additional, Gajewska, Kalina, additional, Garofalo, Giulia, additional, Gounongbe, Caroline, additional, Guizani, Meriem, additional, Holoye, Anne, additional, Houba, Catherine, additional, Makhoul, Jean, additional, Norgaard, Christian, additional, Regnard, Cecile, additional, Romée, Stephanie, additional, Soto, Jamil, additional, Stagel-Trabbia, Aurore, additional, Van Rysselberge, Michel, additional, Vercoutere, An, additional, Zaytouni, Siham, additional, Bouri, Sarah, additional, D'Haene, Nicky, additional, D'Onle, Dominique, additional, Dugauquier, Christian, additional, Racu, Marie-Lucie, additional, Rocq, Laureen, additional, Segers, Valérie, additional, Verocq, Camille, additional, Avni, Ephraim Freddy, additional, Cassart, Marie, additional, Massez, Anne, additional, Blaumeiser, Bettina, additional, Brischoux-Boucher, Elise, additional, Bulk, Saskia, additional, De Ravel, Thomy, additional, Debray, Guillaume, additional, Dimitrov, Boyan, additional, Janssens, Sandra, additional, Keymolen, Kathelijn, additional, Laterre, Marie, additional, van Berkel, Kim, additional, Van Maldergem, Lionel, additional, Vandernoot, Isabelle, additional, Vilain, Catheline, additional, Donner, Catherine, additional, Tecco, Laura, additional, Thomas, Dominique, additional, Désir, Julie, additional, Abramowicz, Marc, additional, and Migeotte, Isabelle, additional

Published
2022
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14. Maternal and perinatal outcomes in high vs low risk-pregnancies affected by SARS-COV-2 infection (Phase-2): The WAPM (World Association of Perinatal Medicine) working group on COVID-19

Author

D'Antonio, Francesco, Sen, Cihat, Mascio, Daniele DI, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Arısoy, Resul, Ovayolu, Ali, Eroğlu, Hasan, Canales, Manuel Guerra, Ladella, Subhashini, Cojocaru, Liviu, Turan, Ozhan, Turan, Sifa, Hadar, Eran, Brzezinski-Sinai, Noa A, Dollinger, Sarah, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, Druškovič, Mirjam, Ples, Liana, Gündüz, Reyhan, Ağaçayak, Elif, Schvartzman, Javier Alfonso, Malbran, Mercedes Negri, Liberati, Marco, Sebastiano, Francesca Di, Oronzi, Ludovica, Cerra, Chiara, Buca, Danilo, Cagnacci, Angelo, Ramone, Arianna, Barra, Fabio, Carosso, Andrea, Benedetto, Chiara, Cosma, Stefano, Pintiaux, Axelle, Daelemans, Caroline, Costa, Elena, Özel, Ayşegül, Muhçu, Murat, Jimenez Lopez, Jesús S, Alvarado, Clara, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Schera, Giovanni Battista Luca, Volpe, Nicola, Frusca, Tiziana, Samardjiski, Igor, Simeonova, Slagjana, Papestiev, Irena Aleksioska, Hojman, Javier, Turkcuoglu, Ilgin, Cromi, Antonella, Laganà, Antonio Simone, Ghezzi, Fabio, Sirico, Angelo, Familiari, Alessandra, Scambia, Giovanni, Sukhikh, Zulfiya Khodjaeva Gennady T, Gorina, Ksenia A, de Sa, Renato Augusto Moreira, Vaz, Mariana, Feuerschuette, Otto Henrique May, Gatta, Anna Nunzia Della, Youssef, Aly, Donna, Gaetana Di, Martinez-Varea, Alicia, Loscalzo, Gabriela, Roselló, José Morales, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Ayala, Rodrigo, Molpeceres, Rebeca Garrote, Vázquez, Asunción Pino, Sandri, Fabrizio, Cataneo, Ilaria, Lenzi, Marinella, Haberal, Esra Tustas, Huertas, Erasmo, Sanchez, Amadeo, Arango, Pedro, Bermejo, Amanda, Alcantara, María Monica Gonzalez, Göynümer, Gökhan, Okuyan, Erhan, Madalina, Ciuhodaru, Guisan, Ana Concheiro, Schulte, Alejandra Martínez, Esposito, Valentina, De Robertis, Valentina, Zdjelar, Snezana, Lackovic, Milan, Mihajlovic, Sladjana, Jekova, Nelly, Saccone, Gabriele, Aslan, Mehmet Musa, Dedda, Maria Carmela Di, Chalid, Maisuri, Canache, Jose Enrique Moros, Daskalakis, George, Antsaklis, Panos, Vega, Enrique Criado, Cueto, Elisa, Taccaliti, Chiara, Aykanat, Alicia Yeliz, Özlem Genç, Şerife, Froessler, Bernd, Radulova, Petya Angelova, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Meccariello, Gabriella, Rohatgi, Bindu, Schiattarella, Antonio, Morlando, Maddalena, Colacurci, Nicola, Villasco, Andrea, Biglia, Nicoletta, Marques, Ana Luiza Santos, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Pittaro, Alejandro, Lila, Albert, Zlatohlávková, Blanka, D'Antonio, Francesco, Sen, Cihat, Mascio, Daniele DI, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Arısoy, Resul, Ovayolu, Ali, Eroğlu, Hasan, Canales, Manuel Guerra, Ladella, Subhashini, Cojocaru, Liviu, Turan, Ozhan, Turan, Sifa, Hadar, Eran, Brzezinski-Sinai, Noa A, Dollinger, Sarah, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, Druškovič, Mirjam, Ples, Liana, Gündüz, Reyhan, Ağaçayak, Elif, Schvartzman, Javier Alfonso, Malbran, Mercedes Negri, Liberati, Marco, Sebastiano, Francesca Di, Oronzi, Ludovica, Cerra, Chiara, Buca, Danilo, Cagnacci, Angelo, Ramone, Arianna, Barra, Fabio, Carosso, Andrea, Benedetto, Chiara, Cosma, Stefano, Pintiaux, Axelle, Daelemans, Caroline, Costa, Elena, Özel, Ayşegül, Muhçu, Murat, Jimenez Lopez, Jesús S, Alvarado, Clara, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Schera, Giovanni Battista Luca, Volpe, Nicola, Frusca, Tiziana, Samardjiski, Igor, Simeonova, Slagjana, Papestiev, Irena Aleksioska, Hojman, Javier, Turkcuoglu, Ilgin, Cromi, Antonella, Laganà, Antonio Simone, Ghezzi, Fabio, Sirico, Angelo, Familiari, Alessandra, Scambia, Giovanni, Sukhikh, Zulfiya Khodjaeva Gennady T, Gorina, Ksenia A, de Sa, Renato Augusto Moreira, Vaz, Mariana, Feuerschuette, Otto Henrique May, Gatta, Anna Nunzia Della, Youssef, Aly, Donna, Gaetana Di, Martinez-Varea, Alicia, Loscalzo, Gabriela, Roselló, José Morale, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Ayala, Rodrigo, Molpeceres, Rebeca Garrote, Vázquez, Asunción Pino, Sandri, Fabrizio, Cataneo, Ilaria, Lenzi, Marinella, Haberal, Esra Tusta, Huertas, Erasmo, Sanchez, Amadeo, Arango, Pedro, Bermejo, Amanda, Alcantara, María Monica Gonzalez, Göynümer, Gökhan, Okuyan, Erhan, Madalina, Ciuhodaru, Guisan, Ana Concheiro, Schulte, Alejandra Martínez, Esposito, Valentina, De Robertis, Valentina, Zdjelar, Snezana, Lackovic, Milan, Mihajlovic, Sladjana, Jekova, Nelly, Saccone, Gabriele, Aslan, Mehmet Musa, Dedda, Maria Carmela Di, Chalid, Maisuri, Canache, Jose Enrique Moro, Daskalakis, George, Antsaklis, Pano, Vega, Enrique Criado, Cueto, Elisa, Taccaliti, Chiara, Aykanat, Alicia Yeliz, Özlem Genç, Şerife, Froessler, Bernd, Radulova, Petya Angelova, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Meccariello, Gabriella, Rohatgi, Bindu, Schiattarella, Antonio, Morlando, Maddalena, Colacurci, Nicola, Villasco, Andrea, Biglia, Nicoletta, Marques, Ana Luiza Santo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Pittaro, Alejandro, Lila, Albert, and Zlatohlávková, Blanka

Subjects
Asia, COVID19, SARS-CoV-2, Coronaviru, Australia, Infant, Newborn, Pregnancy Outcome, COVID-19, South America, infection, Coronavirus, Europe, Pregnancy, Intensive Care Units, Neonatal, Humans, Female, Pregnancy Complications, Infectious, SARS-COV-2, pregnancy, Original Research, Retrospective Studies
Abstract

It has still to be ascertained whether severe acute respiratory syndrome coronavirus 2 infection in pregnancy is associated with worse maternal and fetal outcomes compared to low risk gestations.This study aimed to evaluate maternal and perinatal outcomes in high- and low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection.This was a multinational retrospective cohort study involving women with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection from 76 centers from 25 countries in Europe, the United States, South America, Asia, and Australia from April 4, 2020, to October 28, 2020. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit, use of mechanical ventilation, or death. The secondary outcome was a composite measure of adverse perinatal outcome, including miscarriage, fetal loss, neonatal and perinatal death, and admission to the neonatal intensive care unit. All outcomes were assessed in high- and low-risk pregnancies. Pregnancies were considered high risk in case of either preexisting chronic medical conditions in pregnancy or obstetrical disorders occurring in pregnancy. The Fisher exact test and logistic regression analysis were used to analyze the data.A total of 887 singleton pregnancies who tested positive for severe acute respiratory syndrome coronavirus 2 infection using reverse transcription-polymerase chain reaction of nasal and pharyngeal swab specimens were included in the study. The risk of composite adverse maternal outcomes was higher in high-risk pregnancies than in low-risk pregnancies (odds ratio, 1.52; 95% confidence interval, 1.03-2.24; P=.035). In addition, women carrying high-risk pregnancies were at higher risk of hospital admission (odds ratio, 1.48; 95% confidence interval, 1.07-2.04; P=.002), presence of severe respiratory symptoms (odds ratio, 2.13; 95% confidence interval, 0.41-3.21; P=.001), admission to the intensive care unit (odds ratio, 2.63; 95% confidence interval, 1.42-4.88), and invasive mechanical ventilation (odds ratio, 2.65; 95% confidence interval, 1.19-5.94; P=.002). When exploring perinatal outcomes, high-risk pregnancies were at high risk of adverse perinatal outcomes (odds ratio, 1.78; 95% confidence interval, 0.15-2.72; P=.009). However, such association was mainly because of the higher incidence of miscarriage in high-risk pregnancies compared with that in low-risk pregnancies (5.3% vs 1.6%, P=.008); furthermore, there was no difference in other explored outcomes between the 2 study groups. At logistic regression analysis, maternal age (odds ratio, 1.12; 95% confidence interval, 1.02-1.22; P=.023) and high-risk pregnancy (odds ratio, 4.21; 95% confidence interval, 3.90-5.11; P.001) were independently associated with adverse maternal outcomes.High-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection were at higher risk of adverse maternal outcomes than low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection.

Published
2021

17. An exploratory cost-effectiveness analysis: Comparison between a midwife-led birth unit and a standard obstetric unit within the same hospital in Belgium

Author

Van Tielen Rudy, Gonze Isaline, Closon Marie-Christine, Englert Yvon, and Daelemans Caroline

Subjects
Obstétrique, Adult, medicine.medical_specialty, Nurse Midwives, Cost-Benefit Analysis, Psychological intervention, Birth rate, Unit (housing), 03 medical and health sciences, 0302 clinical medicine, Belgium, Pregnancy, Maternity and Midwifery, Health care, Humans, Medicine, Obstetrics and Gynecology Department, Hospital, Retrospective Studies, Practice Patterns, Nurses', 030219 obstetrics & reproductive medicine, Intention-to-treat analysis, 030504 nursing, business.industry, Medical record, Obstetrics and Gynecology, Cost-effectiveness analysis, medicine.disease, Sciences humaines, Perinatal Care, Family medicine, Female, 0305 other medical science, business
Abstract

Objective The objective of this study was to compare midwife-led and consultant-led obstetrical care for women with uncomplicated low-risk pregnancies. We estimated costs and maternal outcomes in both units to achieve a cost-effectiveness ratio. Design The cost-analysis was made according to the “intention to treat” concept in order to minimize bias associated with the non-randomization of participants. At the obstetric-led unit, women received care from both midwives and medical staff while those in the alternative structure called ‘Le Cocon’ only received care from midwives. Setting The obstetric-led unit of the Erasme University-Hospital in Brussels and its alongside midwife-led unit. Participants The study population included all low-risk pregnant women from 1 March 2014 until 31 October 2015 who were affiliated to the MLOZ (Mutualites Libres-Onafhankelijke Ziekenfondsen; third Belgian statutory health care insurer). Interventions The cost calculation involved a bottom-up approach. The health care consumption of each participant was obtained from MLOZ's data. The study included costs occurred the beginning of pregnancy until 3 months post-partum. Clinical data were extracted from the patient medical records. Findings Compared to the traditional obstetric-led unit, the alternative midwife-led unit was associated with a cost reduction for the national payer (∆ = −€397.39, p = 0.046) and for the patient (∆ = − €44.19, p = 0.016). There were no significant differences in rates of caesarean, instrumental birth and epidural analgesia between MLU and OLU. A sensitivity analysis was performed (Appendix C) but does not change the overall results and conclusions. Key conclusions Due to the small size of the samples, no statistical differences were found. More analysis is needed to evaluate the cost-effectiveness regarding the use of epidural analgesia, caesarean and instrumental birth rates in the midwife-led unit. Implications for practice Given the economical findings, this could contribute to reduce health expenditures for both women (out of pocket) and state (public payer via health care insurers).

Published
2019

18. Severe X-linked chondrodysplasia punctata in nine new female fetuses

Author

Lefebvre, Mathilde, Dufernez, Fabienne, Bruel, Ange-Line, Gonzales, Marie, Aral, Bernard, Saint-Onge, Judith, Gigot, Nadège, Desir, Julie, Daelemans, Caroline, Jossic, Frédérique, Schmitt, Sébastien, Mangione, Raphaele, Pelluard, Fanny, Vincent-Delorme, Catherine, Labaune, Jean-Marc, Bigi, Nicole, DʼOlne, Dominique, Delezoide, Anne-Lise, Toutain, Annick, Blesson, Sophie, Cormier-Daire, Valérie, Thevenon, Julien, El Chehadeh, Salima, Masurel-Paulet, Alice, Joyé, Nicole, Vibert-Guigue, Claude, Rigonnot, Luc, Rousseau, Thierry, Vabres, Pierre, Hervé, Philippe, Lamazière, Antonin, Rivière, Jean-Baptiste, Faivre, Laurence, Laurent, Nicole, and Thauvin-Robinet, Christel

Published
2015
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19. Le BAMM analyse des cas rares de mortalité maternelle en Belgique

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'obstétrique, Vandenberghe, Griet, Benoit, Karolien, Daelemans, Caroline, Belhomme, Julie, Debiève, Frédéric, Logghe, Hilde, Devlieger, Roland, Roelens, Kristien, Clercx, Anne, Van der Brempt, Isabelle, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'obstétrique, Vandenberghe, Griet, Benoit, Karolien, Daelemans, Caroline, Belhomme, Julie, Debiève, Frédéric, Logghe, Hilde, Devlieger, Roland, Roelens, Kristien, Clercx, Anne, and Van der Brempt, Isabelle

Published
2021

20. BAMM analyseert de zeldzame gevallen van maternale sterfte in België

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'obstétrique, Vandenberghe, Griet, Benoit, Karolien, Daelemans, Caroline, Belhomme, Julie, Debiève, Frédéric, Logghe, Hilde, Devlieger, Roland, Roelens, Kristien, Clercx, Anne, Van der Brempt, Isabelle, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'obstétrique, Vandenberghe, Griet, Benoit, Karolien, Daelemans, Caroline, Belhomme, Julie, Debiève, Frédéric, Logghe, Hilde, Devlieger, Roland, Roelens, Kristien, Clercx, Anne, and Van der Brempt, Isabelle

Published
2021

21. Implementation of fetal clinical exome sequencing: Comparing prospective and retrospective cohorts.

Author

Marangoni, Martina, Smits, Guillaume, Ceysens, Gilles, Costa, Elena, Coulon, Robert, Daelemans, Caroline, De Coninck, Caroline, Derisbourg, Sara, Gajewska, Kalina, Garofalo, Giulia, Gounongbe, Caroline, Guizani, Meriem, Holoye, Anne, Houba, Catherine, Makhoul, Jean, Norgaard, Christian, Regnard, Cecile, Romée, Stephanie, Soto, Jamil, Stagel-Trabbia, Aurore, Van Rysselberge, Michel, Vercoutere, An, Zaytouni, Siham, Bouri, Sarah, D'Haene, Nicky, D'Onle, Dominique, Dugauquier, Christian, Racu, Marie-Lucie, Rocq, Laureen, Segers, Valérie, Verocq, Camille, Avni, Ephraïm Freddy, Cassart, Marie, Massez, Anne, Blaumeiser, Bettina, Brischoux-Boucher, Elise, Bulk, Saskia, De Ravel, Thomy, Debray, Francois-Guillaume, Dimitrov, Boyan, Janssens, Sandra, Keymolen, Kathelijn, Laterre, Marie, van Berkel, Kim, Van Maldergem, Lionel, Vandernoot, Isabelle, Vilain, Catheline, donner, catherine, Tecco, Laura, Thomas, Dominique, Désir, Julie, Abramowicz, Marc, Migeotte, Isabelle, Marangoni, Martina, Smits, Guillaume, Ceysens, Gilles, Costa, Elena, Coulon, Robert, Daelemans, Caroline, De Coninck, Caroline, Derisbourg, Sara, Gajewska, Kalina, Garofalo, Giulia, Gounongbe, Caroline, Guizani, Meriem, Holoye, Anne, Houba, Catherine, Makhoul, Jean, Norgaard, Christian, Regnard, Cecile, Romée, Stephanie, Soto, Jamil, Stagel-Trabbia, Aurore, Van Rysselberge, Michel, Vercoutere, An, Zaytouni, Siham, Bouri, Sarah, D'Haene, Nicky, D'Onle, Dominique, Dugauquier, Christian, Racu, Marie-Lucie, Rocq, Laureen, Segers, Valérie, Verocq, Camille, Avni, Ephraïm Freddy, Cassart, Marie, Massez, Anne, Blaumeiser, Bettina, Brischoux-Boucher, Elise, Bulk, Saskia, De Ravel, Thomy, Debray, Francois-Guillaume, Dimitrov, Boyan, Janssens, Sandra, Keymolen, Kathelijn, Laterre, Marie, van Berkel, Kim, Van Maldergem, Lionel, Vandernoot, Isabelle, Vilain, Catheline, donner, catherine, Tecco, Laura, Thomas, Dominique, Désir, Julie, Abramowicz, Marc, and Migeotte, Isabelle

Abstract

We compared the diagnostic yield of fetal clinical exome sequencing (fCES) in prospective and retrospective cohorts of pregnancies presenting with anomalies detected using ultrasound. We evaluated factors that led to a higher diagnostic efficiency, such as phenotypic category, clinical characterization, and variant analysis strategy., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

22. COVID-19 in pregnancy. Results of Belgian registration

Author

IGO Doelencongres (23: 30/03/2021: Rotterdam), Vercoutere, An, ZINA, Mbiton Joel M.J., Benoit, Karolien, Derisbourg, Sara, Costa, Elena, Roelens, Kristien, Daelemans, Caroline, Vandenberghe, Griet, IGO Doelencongres (23: 30/03/2021: Rotterdam), Vercoutere, An, ZINA, Mbiton Joel M.J., Benoit, Karolien, Derisbourg, Sara, Costa, Elena, Roelens, Kristien, Daelemans, Caroline, and Vandenberghe, Griet

Abstract

info:eu-repo/semantics/nonPublished

Published
2021

23. Impact du Covid en Belgique sur la périnatalité à partir du registre Boss

Author

Pathologies maternelles et grossesse du CRGOLFB (12-06-2021: Liège), Vercoutere, An, ZINA, Mbiton Joel M.J., Derisbourg, Sara, Costa, Elena, Benoit, Karolien, Roelens, Kristien, Vandenberghe, Griet, Daelemans, Caroline, Pathologies maternelles et grossesse du CRGOLFB (12-06-2021: Liège), Vercoutere, An, ZINA, Mbiton Joel M.J., Derisbourg, Sara, Costa, Elena, Benoit, Karolien, Roelens, Kristien, Vandenberghe, Griet, and Daelemans, Caroline

Abstract

info:eu-repo/semantics/nonPublished

Published
2021

24. Impact of implementation of a breech clinic in a tertiary hospital.

Author

Derisbourg, Sara, Costa, Elena, De Luca, Laura, Amirgholami, Soraya, Bogne Kamdem, Valery, Vercoutere, An, Zhang, Wei Hong, Alexander, S., Buekens, Pierre, Englert, Yvon, Pintiaux, A., Daelemans, Caroline, Derisbourg, Sara, Costa, Elena, De Luca, Laura, Amirgholami, Soraya, Bogne Kamdem, Valery, Vercoutere, An, Zhang, Wei Hong, Alexander, S., Buekens, Pierre, Englert, Yvon, Pintiaux, A., and Daelemans, Caroline

Abstract

The incidence of breech presentation in single pregnancies at term is between three to 5 %. In order to support eligible women in their choice of mode of delivery, a dedicated breech clinic with a care pathway was developed in December 2015 in a tertiary referral centre in Brussels. The primary objective of this study was to evaluate the vaginal birth rate before and after the introduction of a dedicated breech clinic. The secondary objective was to compare the early neonatal outcomes before and after the breech clinic was introduced., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

25. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19

Author

Di Mascio, Daniele, primary, Sen, Cihat, additional, Saccone, Gabriele, additional, Galindo, Alberto, additional, Grünebaum, Amos, additional, Yoshimatsu, Jun, additional, Stanojevic, Milan, additional, Kurjak, Asım, additional, Chervenak, Frank, additional, Rodríguez Suárez, María José, additional, Gambacorti-Passerini, Zita Maria, additional, Baz, María de los Angeles Anaya, additional, Aguilar Galán, Esther Vanessa, additional, López, Yolanda Cuñarro, additional, De León Luis, Juan Antonio, additional, Hernández, Ignacio Cueto, additional, Herraiz, Ignacio, additional, Villalain, Cecilia, additional, Venturella, Roberta, additional, Rizzo, Giuseppe, additional, Mappa, Ilenia, additional, Gerosolima, Giovanni, additional, Hellmeyer, Lars, additional, Königbauer, Josefine, additional, Ameli, Giada, additional, Frusca, Tiziana, additional, Volpe, Nicola, additional, Luca Schera, Giovanni Battista, additional, Fieni, Stefania, additional, Esposito, Eutalia, additional, Simonazzi, Giuliana, additional, Di Donna, Gaetana, additional, Youssef, Aly, additional, Della Gatta, Anna Nunzia, additional, Di Donna, Mariano Catello, additional, Chiantera, Vito, additional, Buono, Natalina, additional, Sozzi, Giulio, additional, Greco, Pantaleo, additional, Morano, Danila, additional, Bianchi, Beatrice, additional, Lombana Marino, Maria Giulia, additional, Laraud, Federica, additional, Ramone, Arianna, additional, Cagnacci, Angelo, additional, Barra, Fabio, additional, Gustavino, Claudio, additional, Ferrero, Simone, additional, Ghezzi, Fabio, additional, Cromi, Antonella, additional, Laganà, Antonio Simone, additional, Laurita Longo, Valentina, additional, Stollagli, Francesca, additional, Sirico, Angelo, additional, Lanzone, Antonio, additional, Driul, Lorenza, additional, Cecchini D, Fabiana, additional, Xodo, Serena, additional, Rodriguez, Brian, additional, Mercado-Olivares, Felipe, additional, Elkafrawi, Deena, additional, Sisti, Giovanni, additional, Esposito, Rosanna, additional, Coviello, Antonio, additional, Cerbone, Marco, additional, Morlando, Maddalena, additional, Schiattarella, Antonio, additional, Colacurci, Nicola, additional, De Franciscis, Pasquale, additional, Cataneo, Ilaria, additional, Lenzi, Marinella, additional, Sandri, Fabrizio, additional, Buscemi, Riccardo, additional, Gattei, Giorgia, additional, Sala, Francesca della, additional, Valori, Eleonora, additional, Rovellotti, Maria Cristina, additional, Done, Elisa, additional, Faron, Gilles, additional, Gucciardo, Leonardo, additional, Esposito, Valentina, additional, Vena, Flaminia, additional, Giancotti, Antonella, additional, Brunelli, Roberto, additional, Muzii, Ludovico, additional, Nappi, Luigi, additional, Sorrentino, Felice, additional, Vasciaveo, Lorenzo, additional, Liberati, Marco, additional, Buca, Danilo, additional, Leombroni, Martina, additional, Di Sebastiano, Francesca, additional, Di Tizio, Luciano, additional, Gazzolo, Diego, additional, Franchi, Massimo, additional, Ianniciello, Quintino Cesare, additional, Garzon, Simone, additional, Petriglia, Giuliano, additional, Borrello, Leonardo, additional, Nieto-Calvache, Albaro Josè, additional, Burgos-Luna, Juan Manuel, additional, Kadji, Caroline, additional, Carlin, Andrew, additional, Bevilacqua, Elisa, additional, Moucho, Marina, additional, Pinto, Pedro Viana, additional, Figueiredo, Rita, additional, Morales Roselló, José, additional, Loscalzo, Gabriela, additional, Martinez-Varea, Alicia, additional, Diago, Vincente, additional, Jimenez Lopez, Jesús S, additional, Aykanat, Alicia Yeliz, additional, Cosma, Stefano, additional, Carosso, Andrea, additional, Benedetto, Chiara, additional, Bermejo, Amanda, additional, May Feuerschuette, Otto Henrique, additional, Uyaniklar, Ozlem, additional, Ocakouglu, Sakine Rahimli, additional, Atak, Zeliha, additional, Gündüz, Reyhan, additional, Haberal, Esra Tustas, additional, Froessler, Bernd, additional, Parange, Anupam, additional, Palm, Peter, additional, Samardjiski, Igor, additional, Taccaliti, Chiara, additional, Okuyan, Erhan, additional, Daskalakis, George, additional, Moreira de Sa, Renato Augusto, additional, Pittaro, Alejandro, additional, Gonzalez-Duran, Maria Luisa, additional, Guisan, Ana Concheiro, additional, Genç, Şerife Özlem, additional, Zlatohlávková, Blanka, additional, Piqueras, Anna Luengo, additional, Oliva, Dolores Esteban, additional, Cil, Aylin Pelin, additional, Api, Olus, additional, Antsaklis, Panos, additional, Ples, Liana, additional, Kyvernitakis, Ioannis, additional, Maul, Holger, additional, Malan, Marcel, additional, Lila, Albert, additional, Granese, Roberta, additional, Ercoli, Alfredo, additional, Zoccali, Giuseppe, additional, Villasco, Andrea, additional, Biglia, Nicoletta, additional, Madalina, Ciuhodaru, additional, Costa, Elena, additional, Daelemans, Caroline, additional, Pintiaux, Axelle, additional, Cueto, Elisa, additional, Hadar, Eran, additional, Dollinger, Sarah, additional, Brzezinski Sinai, Noa A., additional, Huertas, Erasmo, additional, Arango, Pedro, additional, Sanchez, Amadeo, additional, Schvartzman, Javier Alfonso, additional, Cojocaru, Liviu, additional, Turan, Sifa, additional, Turan, Ozhan, additional, Di Dedda, Maria Carmela, additional, Molpeceres, Rebeca Garrote, additional, Zdjelar, Snezana, additional, Premru-Srsen, Tanja, additional, Cerar, Lilijana Kornhauser, additional, Druškovič, Mirjam, additional, De Robertis, Valentina, additional, Stefanovic, Vedran, additional, Nupponen, Irmeli, additional, Nelskylä, Kaisa, additional, Khodjaeva, Zulfiya, additional, Gorina, Ksenia A., additional, Sukhikh, Gennady T., additional, Maruotti, Giuseppe Maria, additional, Visentin, Silvia, additional, Cosmi, Erich, additional, Ferrari, Jacopo, additional, Gatti, Alessandra, additional, Luvero, Daniela, additional, Angioli, Roberto, additional, Puri, Ludovica, additional, Palumbo, Marco, additional, D’Urso, Giusella, additional, Colaleo, Francesco, additional, Chiara Rapisarda, Agnese Maria, additional, Carbone, Ilma Floriana, additional, Mollo, Antonio, additional, Nazzaro, Giovanni, additional, Locci, Mariavittoria, additional, Guida, Maurizio, additional, Di Spiezio Sardo, Attilio, additional, Panici, Pierluigi Benedetti, additional, Berghella, Vincenzo, additional, Flacco, Maria Elena, additional, Manzoli, Lamberto, additional, Bifulco, Giuseppe, additional, Scambia, Giovanni, additional, Zullo, Fulvio, additional, and D’Antonio, Francesco, additional

Published
2020
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26. Impact of Implementation of a Breech Clinic in a Tertiary Hospital.

Author

Derisbourg, Sara, primary, Costa, Elena, additional, De Luca, Laura, additional, Amirgholami, Soraya, additional, Kamdem, Valery Bogne, additional, Vercoutere, An, additional, Zhang, Wei Hong, additional, Alexander, Sophie, additional, Buekens, Pierre, additional, Englert, Yvon, additional, Pintiaux, Axelle, additional, and Daelemans, Caroline, additional

Published
2020
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28. The “Cocoon,” first alongside midwifery‐led unit within a Belgian hospital: Comparison of the maternal and neonatal outcomes with the standard obstetric unit over 2 years

Author

Welffens, Karine, primary, Derisbourg, Sara, additional, Costa, Elena, additional, Englert, Yvon, additional, Pintiaux, Axelle, additional, Warnimont, Michèle, additional, Kirkpatrick, Christine, additional, Buekens, Pierre, additional, and Daelemans, Caroline, additional

Published
2019
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31. The “Cocoon,” first alongside midwifery-led unit within a Belgian hospital: Comparison of the maternal and neonatal outcomes with the standard obstetric unit over 2 years

Author

Welffens, K., Derisbourg, Sara, Costa, Elena, Englert, Yvon, Pintiaux, Axelle, Warnimont, Michele, Kirkpatrick, Christine, Buekens, Pierre, Daelemans, Caroline, Welffens, K., Derisbourg, Sara, Costa, Elena, Englert, Yvon, Pintiaux, Axelle, Warnimont, Michele, Kirkpatrick, Christine, Buekens, Pierre, and Daelemans, Caroline

Abstract

Objectives: Our aim was to compare maternal and neonatal outcomes of women with a low-risk pregnancy attending the “Cocoon,” an alongside midwifery-led birth center and care pathway, with women with a low-risk pregnancy attending the traditional care pathway in a tertiary care hospital in Belgium. Methods: We performed a retrospective cohort study of maternal and neonatal outcomes of women with a low-risk pregnancy who chose to adhere to the Cocoon pathway of care (n = 590) and women with a low-risk pregnancy who chose the traditional pathway of care (n = 394) from March 1, 2014, to February 29, 2016. We performed all analyses using an intention-to-treat approach. Results: In this setting, the cesarean birth rate was 10.3% compared with 16.0% in the traditional care pathway (adjusted odds ratios [aOR] 0.42 [95% CI 0.25-0.69]), the induction rate was 16.3% compared with 30.5% (0.46 [0.30-0.69]), the epidural analgesia rate was 24.9% compared with 59.1% (0.15 [0.09-0.22]), and the episiotomy rate was 6.8% compared with 14.5% (0.31 [0.17-0.56]). There was no increase in adverse neonatal outcomes. Intrapartum and postpartum transfer rates to the traditional pathway of care were 21.1% and 7.1%, respectively. Conclusions: Women planning their births in the midwifery-led unit, the Cocoon, experienced fewer interventions with no increase in adverse neonatal outcomes. Our study gives initial support for the introduction of similar midwifery-led care pathways in other hospitals in Belgium., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2019

32. Defining definitions: a Delphi study to develop a core outcome set for conditions of severe maternal morbidity

Author

Schaap, T, Bloemenkamp, K, Deneux-Tharaux, Cairns, Knight, Megan, Langhoff-Roos, J., Sullivan, Elizabeth, van den Akker, T, Rigouzzo, Agnes, Univ, Comenius, Creanga, Andreea, Koopman, Ankie, Franx, Arie, Nemethova, Bianka, Bateman, Brian, Daelemans, Caroline, Zelop, Carolyn, Medicine, Boston University School, Nagata, Chie, Farquhar, Cindy M., Huisman, Claartje, von Kaisenberg, Constantin, Henruquez, Dacia, Ellwood, David, Moolenaar, David, Kuklina, Elena, Main, Elliott, Stekkinger, Eva, Gollo, Evelina, Goffinet, Francois, Kainer, Franz, Africa, University of Pretoria Kalafong Academic Hospital, Stralen, Giel, Kayem, Gilles, Duvekot, Hans, Franz, Heiko B G, Engjom, Hilde, Beenakkers, Ingrid, Al-Zirqi, Iqbal, Danis, Jakub, Berlac, Foss, UK, Leicester Royal, Parsonage, Will, Zwart, Joost, van Roosmalen, Jos, Klungsor, Kari, Lust, Karin, Vetter, Klaus, Calsteren, Kristel, Roelens, Kristien, Krebs, Lone, Colmorn, Berdiin, Tanaka, Mamoru, Rijken, Marcus, Bonnet, Marie-Pierre, Boer, Marjon, Jokinen, Mervi, Belfort, Michael, Peek, Michael, Gisler, Mika, Foley, Mike, Tikkanen, Minna, Korbel, Miroslav, laubach, Monika, Schuitemaker, Nico, Engel, Nicole, McDonnell, Nolan, Emonts, Patrick, Rozenberg, Patrick, Hillemanns, Peter, Rauskolb, Rudiger, Takeda, Satoru, Donati, Serena, Ferrazzani, Sergio, Saito, Shigeru, Jesudason, Shilpanjali, Satoh, Shoji, Health, Norwegian Institute of, Clark, Steven, Koenen, Steven, Grussner, Susanne, Miyashita, Susumu, Fischer, Thorsten, Todros, Tullia, Mijatovic, Veljia, Basevi, Vittorio, Pollock, Wendy, Callaghan, William, Henrich, Wolfgang, Fujita, Yasuyuki, Matsuda, Yoshio, Garnier, Yves, Zentner, Dominica, other, and, Schaap, T, Bloemenkamp, K, Deneux-Tharaux, Cairns, Knight, Megan, Langhoff-Roos, J., Sullivan, Elizabeth, van den Akker, T, Rigouzzo, Agnes, Univ, Comenius, Creanga, Andreea, Koopman, Ankie, Franx, Arie, Nemethova, Bianka, Bateman, Brian, Daelemans, Caroline, Zelop, Carolyn, Medicine, Boston University School, Nagata, Chie, Farquhar, Cindy M., Huisman, Claartje, von Kaisenberg, Constantin, Henruquez, Dacia, Ellwood, David, Moolenaar, David, Kuklina, Elena, Main, Elliott, Stekkinger, Eva, Gollo, Evelina, Goffinet, Francois, Kainer, Franz, Africa, University of Pretoria Kalafong Academic Hospital, Stralen, Giel, Kayem, Gilles, Duvekot, Hans, Franz, Heiko B G, Engjom, Hilde, Beenakkers, Ingrid, Al-Zirqi, Iqbal, Danis, Jakub, Berlac, Foss, UK, Leicester Royal, Parsonage, Will, Zwart, Joost, van Roosmalen, Jos, Klungsor, Kari, Lust, Karin, Vetter, Klaus, Calsteren, Kristel, Roelens, Kristien, Krebs, Lone, Colmorn, Berdiin, Tanaka, Mamoru, Rijken, Marcus, Bonnet, Marie-Pierre, Boer, Marjon, Jokinen, Mervi, Belfort, Michael, Peek, Michael, Gisler, Mika, Foley, Mike, Tikkanen, Minna, Korbel, Miroslav, laubach, Monika, Schuitemaker, Nico, Engel, Nicole, McDonnell, Nolan, Emonts, Patrick, Rozenberg, Patrick, Hillemanns, Peter, Rauskolb, Rudiger, Takeda, Satoru, Donati, Serena, Ferrazzani, Sergio, Saito, Shigeru, Jesudason, Shilpanjali, Satoh, Shoji, Health, Norwegian Institute of, Clark, Steven, Koenen, Steven, Grussner, Susanne, Miyashita, Susumu, Fischer, Thorsten, Todros, Tullia, Mijatovic, Veljia, Basevi, Vittorio, Pollock, Wendy, Callaghan, William, Henrich, Wolfgang, Fujita, Yasuyuki, Matsuda, Yoshio, Garnier, Yves, Zentner, Dominica, and other, and

Abstract

Objective: Develop a core outcome set of international consensus definitions for severe maternal morbidities. Design: Electronic Delphi study. Setting: International. Population: Eight expert panels. Methods: All 13 high-income countries represented in the International Network of Obstetric Surveillance Systems (INOSS) nominated five experts per condition of morbidity, who submitted possible definitions. From these suggestions, a steering committee distilled critical components: eclampsia: 23, amniotic fluid embolism: 15, pregnancy-related hysterectomy: 11, severe primary postpartum haemorrhage: 19, uterine rupture: 20, abnormally invasive placentation: 12, spontaneous haemoperitoneum in pregnancy: 16, and cardiac arrest in pregnancy: 10. These components were assessed by the expert panel using a 5-point Likert scale, following which a framework for an encompassing definition was constructed. Possible definitions were evaluated in rounds until a rate of agreement of more than 70% was reached. Expert commentaries were used in each round to improve definitions. Main outcome measures: Definitions with a rate of agreement of more than 70%. Results: The invitation to participate in one or more of eight Delphi processes was accepted by 103 experts from 13 high-income countries. Consensus definitions were developed for all of the conditions. Conclusion: Consensus definitions for eight morbidity conditions were successfully developed using the Delphi process. These should be used in national registrations and international studies, and should be taken up by the Core Outcomes in Women's and Newborn Health initiative. Tweetable abstract: Consensus definitions for eight morbidity conditions were successfully developed using the Delphi process.

Published
2019

33. First trimester ultrasound prediction of velamentous cord insertions: a prospective study

Author

Derisbourg, Sara, Boulay, Amélie, Lamy, C, Barlow, Patricia, Van Rysselberge, Michel, Thomas, D., Rozenberg, Serge, Daelemans, Caroline, Derisbourg, Sara, Boulay, Amélie, Lamy, C, Barlow, Patricia, Van Rysselberge, Michel, Thomas, D., Rozenberg, Serge, and Daelemans, Caroline

Abstract

Introduction: The marginal and velamentous cord insertions complicate around 8% of pregnancies and are at higher risk of adverse perinatal outcomes. Their visualisation seems to decrease with advancing gestational age. Our aim was to analyse whether an umbilical cord insertion in the lower third of the uterus during the first trimester could predict abnormal cord insertions later in pregnancy. Methods: This was a prospective multicentre study in two hospitals. During the first trimester, the cord insertions were inspected as well as their location (lower third of the uterus or not). Finally, all cord insertions were described at delivery. Results: During the study period the cord insertion was described in 1620 patients of which 87.7% had a normal cord insertion, 11.9% (n = 192) a low cord insertion, and in 3.8% the insertion could not be situated. We find that 4.7% of those who have a low-lying cord insertion versus 0.7% in the normal cord insertion group during the first trimester will have a velamentous cord insertion subsequently (OR = 6.67; 95% CI = 2.67-16.63). Conclusion: The detection of a low lying umbilical cord insertion during the first-trimester ultrasound can help to predict an abnormal cord insertion at delivery particularly a velamentous cord insertion., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2019

34. Socio-economic impact for the health system of female genital mutilation in Burkina Faso

Author

Third G3 International Expert Meeting on FGM/C. (21 & 22 May 2019: Bruxelles, Belgique), ZINA, Mbiton Joel M.J., Akotionga, Michel, Nitièma, Abdoulaye, Sawadogo, Albert, Van Wilder, Philippe, Pintiaux, Axelle, Daelemans, Caroline, Leye, Els, Vercoutere, An, Third G3 International Expert Meeting on FGM/C. (21 & 22 May 2019: Bruxelles, Belgique), ZINA, Mbiton Joel M.J., Akotionga, Michel, Nitièma, Abdoulaye, Sawadogo, Albert, Van Wilder, Philippe, Pintiaux, Axelle, Daelemans, Caroline, Leye, Els, and Vercoutere, An

Abstract

info:eu-repo/semantics/published

Published
2019

37. First trimester ultrasound prediction of velamentous cord insertions: a prospective study.

Author

Derisbourg, Sara, Boulay, Amélie, Lamy, Clotilde, Barlow, Patricia, Van Rysselberge, Michel, Thomas, Dominique, Rozenberg, Serge, and Daelemans, Caroline

Subjects
ULTRASONIC imaging, LONGITUDINAL method, HIGH-risk pregnancy, UMBILICAL cord, GESTATIONAL age
Abstract

Introduction: The marginal and velamentous cord insertions complicate around 8% of pregnancies and are at higher risk of adverse perinatal outcomes. Their visualisation seems to decrease with advancing gestational age. Our aim was to analyse whether an umbilical cord insertion in the lower third of the uterus during the first trimester could predict abnormal cord insertions later in pregnancy. Methods: This was a prospective multicentre study in two hospitals. During the first trimester, the cord insertions were inspected as well as their location (lower third of the uterus or not). Finally, all cord insertions were described at delivery. Results: During the study period the cord insertion was described in 1620 patients of which 87.7% had a normal cord insertion, 11.9% (n=192) a low cord insertion, and in 3.8% the insertion could not be situated. We find that 4.7% of those who have a low-lying cord insertion versus 0.7% in the normal cord insertion group during the first trimester will have a velamentous cord insertion subsequently (OR=6.67; 95% CI=2.67-16.63). Conclusion: The detection of a low lying umbilical cord insertion during the first-trimester ultrasound can help to predict an abnormal cord insertion at delivery particularly a velamentous cord insertion. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Data analysis issues for allele-specific expression using Illumina's GoldenGate assay

Author

Dermitzakis Emmanouil T, Daelemans Caroline, Dimas Antigone S, Forrest Matthew S, Ritchie Matthew E, Deloukas Panagiotis, and Tavaré Simon

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5
Abstract

Abstract Background High-throughput measurement of allele-specific expression (ASE) is a relatively new and exciting application area for array-based technologies. In this paper, we explore several data sets which make use of Illumina's GoldenGate BeadArray technology to measure ASE. This platform exploits coding SNPs to obtain relative expression measurements for alleles at approximately 1500 positions in the genome. Results We analyze data from a mixture experiment where genomic DNA samples from pairs of individuals of known genotypes are pooled to create allelic imbalances at varying levels for the majority of SNPs on the array. We observe that GoldenGate has less sensitivity at detecting subtle allelic imbalances (around 1.3 fold) compared to extreme imbalances, and note the benefit of applying local background correction to the data. Analysis of data from a dye-swap control experiment allowed us to quantify dye-bias, which can be reduced considerably by careful normalization. The need to filter the data before carrying out further downstream analysis to remove non-responding probes, which show either weak, or non-specific signal for each allele, was also demonstrated. Throughout this paper, we find that a linear model analysis of the data from each SNP is a flexible modelling strategy that allows for testing of allelic imbalances in each sample when replicate hybridizations are available. Conclusions Our analysis shows that local background correction carried out by Illumina's software, together with quantile normalization of the red and green channels within each array, provides optimal performance in terms of false positive rates. In addition, we strongly encourage intensity-based filtering to remove SNPs which only measure non-specific signal. We anticipate that a similar analysis strategy will prove useful when quantifying ASE on Illumina's higher density Infinium BeadChips.

Published
2010
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41. High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta

Author

Clark Taane G, Campino Susana, Forrest Matthew S, Sudbery Ian M, Abu-Amero Sayeda, Smits Guillaume, Ritchie Matthew E, Daelemans Caroline, Stanier Philip, Kwiatkowski Dominic, Deloukas Panos, Dermitzakis Emmanouil T, Tavaré Simon, Moore Gudrun E, and Dunham Ian

Subjects
Genetics, QH426-470
Abstract

Abstract Background Imprinted genes show expression from one parental allele only and are important for development and behaviour. This extreme mode of allelic imbalance has been described for approximately 56 human genes. Imprinting status is often disrupted in cancer and dysmorphic syndromes. More subtle variation of gene expression, that is not parent-of-origin specific, termed 'allele-specific gene expression' (ASE) is more common and may give rise to milder phenotypic differences. Using two allele-specific high-throughput technologies alongside bioinformatics predictions, normal term human placenta was screened to find new imprinted genes and to ascertain the extent of ASE in this tissue. Results Twenty-three family trios of placental cDNA, placental genomic DNA (gDNA) and gDNA from both parents were tested for 130 candidate genes with the Sequenom MassArray system. Six genes were found differentially expressed but none imprinted. The Illumina ASE BeadArray platform was then used to test 1536 SNPs in 932 genes. The array was enriched for the human orthologues of 124 mouse candidate genes from bioinformatics predictions and 10 human candidate imprinted genes from EST database mining. After quality control pruning, a total of 261 informative SNPs (214 genes) remained for analysis. Imprinting with maternal expression was demonstrated for the lymphocyte imprinted gene ZNF331 in human placenta. Two potential differentially methylated regions (DMRs) were found in the vicinity of ZNF331. None of the bioinformatically predicted candidates tested showed imprinting except for a skewed allelic expression in a parent-specific manner observed for PHACTR2, a neighbour of the imprinted PLAGL1 gene. ASE was detected for two or more individuals in 39 candidate genes (18%). Conclusions Both Sequenom and Illumina assays were sensitive enough to study imprinting and strong allelic bias. Previous bioinformatics approaches were not predictive of new imprinted genes in the human term placenta. ZNF331 is imprinted in human term placenta and might be a new ubiquitously imprinted gene, part of a primate-specific locus. Demonstration of partial imprinting of PHACTR2 calls for re-evaluation of the allelic pattern of expression for the PHACTR2-PLAGL1 locus. ASE was common in human term placenta.

Published
2010
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42. Beliefs and attitudes regarding FGM in a rural village in Region Kankan, Guinea, before the start of an awareness campaign.

Author

2nd International Expert Meeting on Female Genital Mutilation/Cutting (28/05/2018: Montréal, Canada), Vercoutere, An, ZINA, Mbiton Joel M.J., Tatout, Jessica, Costa, Elena, Derisbourg, Sara, Kaba, Bintou Mady B.M., KABA, Abdoulaye, Leye, Els, Daelemans, Caroline, 2nd International Expert Meeting on Female Genital Mutilation/Cutting (28/05/2018: Montréal, Canada), Vercoutere, An, ZINA, Mbiton Joel M.J., Tatout, Jessica, Costa, Elena, Derisbourg, Sara, Kaba, Bintou Mady B.M., KABA, Abdoulaye, Leye, Els, and Daelemans, Caroline

Abstract

info:eu-repo/semantics/published

Published
2018

43. The external cephalic version is a safe option to reduce the cesarean section rate

Author

Birth Congress Clinical Challenges in Labor and Delivery (14-11-2018), Derisbourg, Sara, Costa, Elena, Vercoutere, An, Romnee, Stéphanie, Zaytouni, Siham, Daelemans, Caroline, Birth Congress Clinical Challenges in Labor and Delivery (14-11-2018), Derisbourg, Sara, Costa, Elena, Vercoutere, An, Romnee, Stéphanie, Zaytouni, Siham, and Daelemans, Caroline

Abstract

info:eu-repo/semantics/published

Published
2018

44. Change in prevalence of Gestational Diabetes and obstetric complications when applying IADPSG screening criteria in a Belgian French population

Author

International Society of Endocrinological Gynecology ISGE 2018, Costa, Elena, Gerday, Colette, Joubran, Mansour, Gironi, Pamela, Van Keymeulen, Laetitia, Kirkpatrick, Christine, Daelemans, Caroline, Pintiaux, Axelle, International Society of Endocrinological Gynecology ISGE 2018, Costa, Elena, Gerday, Colette, Joubran, Mansour, Gironi, Pamela, Van Keymeulen, Laetitia, Kirkpatrick, Christine, Daelemans, Caroline, and Pintiaux, Axelle

Abstract

info:eu-repo/semantics/published

Published
2018

45. Perinatal outcomes in women screened negative for GDM with Carpenter and Coustan criteria but positive for WHO2013 criteria in a Belgian University Hospital: a retrospective cohort study

Author

Birth clinical challenges in labour and delivery, Costa, Elena, Gerday, Colette, Haumont, Sophie, Kirkpatrick, Christine, Daelemans, Caroline, Pintiaux, Axelle, Birth clinical challenges in labour and delivery, Costa, Elena, Gerday, Colette, Haumont, Sophie, Kirkpatrick, Christine, Daelemans, Caroline, and Pintiaux, Axelle

Abstract

info:eu-repo/semantics/published

Published
2018

46. Maternal and fetal complications of Induction of Labor in singletons Classified according to Nippita et al. in a Belgian University Hospital

Author

Birth Clinical challenges in labour and delivery, Costa, Elena, Romnee, Stéphanie, Vercoutere, An, Derisbourg, Sara, Van Leeuw, Virginie, Daelemans, Caroline, Birth Clinical challenges in labour and delivery, Costa, Elena, Romnee, Stéphanie, Vercoutere, An, Derisbourg, Sara, Van Leeuw, Virginie, and Daelemans, Caroline

Abstract

info:eu-repo/semantics/published

Published
2018

47. The "Cocoon," first alongside midwifery‐led unit within a Belgian hospital: Comparison of the maternal and neonatal outcomes with the standard obstetric unit over 2 years.

Author

Welffens, Karine, Derisbourg, Sara, Costa, Elena, Englert, Yvon, Pintiaux, Axelle, Warnimont, Michèle, Kirkpatrick, Christine, Buekens, Pierre, and Daelemans, Caroline

Subjects
CESAREAN section, CHI-squared test, COMPARATIVE studies, CONFIDENCE intervals, EPISIOTOMY, FISHER exact test, LENGTH of stay in hospitals, LONGITUDINAL method, MATERNAL health services, EVALUATION of medical care, MEDICAL records, EPIDURAL anesthesia, PREGNANCY, PREGNANT women, MIDWIFERY, LOGISTIC regression analysis, DEPARTMENTS, RETROSPECTIVE studies, DATA analysis software, DESCRIPTIVE statistics, ACQUISITION of data methodology, ODDS ratio, MANN Whitney U Test, INTRAPARTUM care
Abstract

Objectives: Our aim was to compare maternal and neonatal outcomes of women with a low‐risk pregnancy attending the "Cocoon," an alongside midwifery‐led birth center and care pathway, with women with a low‐risk pregnancy attending the traditional care pathway in a tertiary care hospital in Belgium. Methods: We performed a retrospective cohort study of maternal and neonatal outcomes of women with a low‐risk pregnancy who chose to adhere to the Cocoon pathway of care (n = 590) and women with a low‐risk pregnancy who chose the traditional pathway of care (n = 394) from March 1, 2014, to February 29, 2016. We performed all analyses using an intention‐to‐treat approach. Results: In this setting, the cesarean birth rate was 10.3% compared with 16.0% in the traditional care pathway (adjusted odds ratios [aOR] 0.42 [95% CI 0.25‐0.69]), the induction rate was 16.3% compared with 30.5% (0.46 [0.30‐0.69]), the epidural analgesia rate was 24.9% compared with 59.1% (0.15 [0.09‐0.22]), and the episiotomy rate was 6.8% compared with 14.5% (0.31 [0.17‐0.56]). There was no increase in adverse neonatal outcomes. Intrapartum and postpartum transfer rates to the traditional pathway of care were 21.1% and 7.1%, respectively. Conclusions: Women planning their births in the midwifery‐led unit, the Cocoon, experienced fewer interventions with no increase in adverse neonatal outcomes. Our study gives initial support for the introduction of similar midwifery‐led care pathways in other hospitals in Belgium. [ABSTRACT FROM AUTHOR]

Published
2020
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49. Accouchement dans un lieu non médicalisé et nationalité des patientes ,poster session presented at ,Belgium

Author

Trajectoires Migratoires et santé autour de la naissance 2017, Costa, Elena, Derisbourg, Sara, Warnimont, M., Kirkpatrick, Christine, Welffens, K., Daelemans, Caroline, Trajectoires Migratoires et santé autour de la naissance 2017, Costa, Elena, Derisbourg, Sara, Warnimont, M., Kirkpatrick, Christine, Welffens, K., and Daelemans, Caroline

Abstract

info:eu-repo/semantics/nonPublished

Published
2017

50. L'accouchement à domicile

Author

Welffens, K., Kirkpatrick, Christine, Daelemans, Caroline, Derisbourg, Sara, Welffens, K., Kirkpatrick, Christine, Daelemans, Caroline, and Derisbourg, Sara

Abstract

In Belgium, very few women give birth outside the delivery room. In the United Kingdom and in the Netherlands, they are more numerous. Several studies evaluated obstetric and neonatal outcomes of home births compared with hospital births. We selected seven recent and large studies (with cohorts of more than 5.000 women) using PubMed, Science Direct and Cochrane Database of Systematic Reviews. Several questions were examined. Is there any difference in maternal and neonatal outcomes depending on the intended place of birth? Does parity affect outcomes ?What are the characteristics of women who choose to deliver at home ?We conclude that giving birth at home improves obstetric outcomes but is riskier for the baby, especially for the first one. The women delivering at home are mainly white Europeans, between 25 and 35 years old, in a relationship, multiparous and wealthier. In order to avoid this increased risk for the baby while preserving the obstetric advantages, alongside birth centers offer an intermediate solution. They combine the reassuring home-like atmosphere with the safety of the hospital. In Belgium, the first alongside birth center " Le Cocon " (a low technicity unit distinct from the delivery room) offers now this type of alternative place of birth for women in Hôpital Erasme in Brussels., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

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