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Acute retinal ischemia and ischemia-reperfusion injury are the primary causes of retinal neural cell death and vision loss in retinal artery occlusion (RAO). The absence of an accurate mouse model for simulating the retinal ischemic process has hindered progress in developing neuroprotective agents for RAO. We developed a unilateral pterygopalatine ophthalmic artery occlusion (UPOAO) mouse model using silicone wire embolization combined with carotid artery ligation. The survival of retinal ganglion cells and visual function were evaluated to determine the duration of ischemia. Immunofluorescence staining, optical coherence tomography, and haematoxylin and eosin staining were utilized to assess changes in major neural cell classes and retinal structure degeneration at two reperfusion durations. Transcriptomics was employed to investigate alterations in the pathological process of UPOAO following ischemia and reperfusion, highlighting transcriptomic differences between UPOAO and other retinal ischemia-reperfusion models. The UPOAO model successfully replicated the acute interruption of retinal blood supply observed in RAO. 60 min of Ischemia led to significant loss of major retinal neural cells and visual function impairment. Notable thinning of the inner retinal layer, especially the ganglion cell layer, was evident post-UPOAO. Temporal transcriptome analysis revealed various pathophysiological processes related to immune cell migration, oxidative stress, and immune inflammation during the non-reperfusion and reperfusion periods. A pronounced increase in microglia within the retina and peripheral leukocytes accessing the retina was observed during reperfusion periods. Comparison of differentially expressed genes (DEGs) between the UPOAO and high intraocular pressure models revealed specific enrichments in lipid and steroid metabolism-related genes in the UPOAO model. The UPOAO model emerges as a novel tool for screening pathogenic genes and promoting further therapeutic research in RAO.

Numerous studies have demonstrated the benefits of understory spaces and plants on human well-being, but most spatial research has focused on a horizontal perspective. Additionally, there is a lack of research on the effects of plant color on human recovery, especially with respect to color proportions. This study classifies the leaf colors of trees in autumn, which are observed from a looking-up perspective, into green, red, and yellow. On this basis, we created monochromatic, two-color, and three-color groups with varying color proportions to assess their recovery effects and preferences. A total of 30 participants participated in this experiment, and their physiological, psychological, and preference-related indicators were evaluated. The results revealed that the following. (1) The two-color groups had the greatest reduction effect on systolic blood pressure. Monochromatic groups were most effective at reducing diastolic blood pressure. The three-color groups had the greatest effect on lowering the pulse rate. (2) EEG responses varied by color type. (3) The three-color groups had the best recovery effects on the psychological measures. (4) The three-color groups were most favored by participants, with a red–yellow–green ratio of 0.2/0.4/0.4 being the most preferred. These findings demonstrate the differing recovery potentials of various leaf color proportions from a looking-up perspective. This study can provide valuable references for the planning and design of urban forest parks, supplementing the theoretical foundation and research framework for evaluating and creating environments that meet people’s restorative needs.

IntroductionAs global urbanization intensifies, the physical and mental stressors of modern life have led to the growing prevalence of suboptimal health conditions. Spending time in a forest benefits human health and well-being. In this context, based on the forest spatial types (forest interior and forest edge spaces), landscape elements (architecture, water and roads) and forest stands (coniferous, broadleaf and bamboo forests), this study investigated the effects of different forest spatial landscape characteristics on the restorative potential for college students, aesthetic preference and eye movement behavior (total fixation duration and fixation count).MethodsIn this study, a total of 60 subjects were exposed to 42 photographs depicting typical forest landscapes acquired through field studies. The Short-version Revised Restoration and Preference Scale and eye-tracking technology, were employed to study the recovery efficiency and visual attraction of forest spatial of different forest spatial types, element compositions and forest stands.Results(1) The restorative potential and aesthetic preference score of forest edge spaces were significantly higher than those of forest interior spaces. (2) The restorative potential of bamboo forests was significantly higher than those of coniferous and broadleaf forests. (3) In terms of forest interior space, the restorative potential of “forest + 1 element” composition and “forest + 2 elements” composition was significantly higher than that of pure forest, and the restorative potential of interior space of bamboo forest was significantly higher than those of coniferous and broadleaf forests. (4) In terms of forest edge space, the restorative potential of “forest + 2 elements” composition was significantly higher than that of pure forest, and the restorative potential of pure forests was significantly higher than that of the “forest + 1 element” composition. (5) The restorative potential of forest spatial landscape characteristics positively correlated with aesthetic preference and negatively correlated with total fixation duration and fixation count. These results can provide a reference for future forest landscape research, construction and management.

Numerous studies have demonstrated that urban green spaces (UGSs) benefit human health, but few have focused on the influence of weather on environmental restorativeness. This study assessed how different weather conditions and environments affect human health. We exposed 50 participants to different UGS environments under cloudy and sunny conditions and collected physiological, psychological and aesthetic preference data. The result showed that the physical and mental benefits of UGSs were stronger on sunny days (pulse: [t = 2.169, p

Indocalamus, characterized by its expansive leaves, low height, strong reproductive capacity, and abundant bioactive compounds, has extensive utility in the realms of food processing, the manufacturing of packaging materials, and the advancement of novel pharmaceuticals. Two light environments, CK (100% full light) and ST (50% full light), were established to explore the effects of low-light environments on the reproductive ability, morphological characteristics, photosynthetic properties, and leaf active substances of 14 Indocalamus species. The findings revealed that in comparison to the CK treatment, for 14 species of Indocalamus under the ST treatment, (1) the diameter, single leaf area, and leaf area index increased by 8.27%, 8.14%, and 17.88%, respectively; (2) the net photosynthetic rate decreased by 15.14%, and the total chlorophyll contents increased by 20.25%; and (3) the total flavonoid contents increased by 18.28% in autumn, the total polyphenol contents increased by 48.96% in spring, and the total polysaccharide contents increased by 31.44% and 30.81% in summer and winter, respectively. In summary, Indocalamus are adapted to survive in low-light environments; the growth and physiological indices differ significantly between the two light environments, and the low-light environment can effectively promote the growth and development of the leaves. Furthermore, the leaves are rich in flavonoids, polyphenols, polysaccharides, and active substances, which are affected by the light intensity and the season to varying degrees, and autumn and winter are the best times for harvesting the leaves. The leaves of I. hunanensis and I. lacunosus are richest in flavonoids and polyphenols, while the leaves of I. kunmingensis cv. fuminer are richest in polysaccharides. The main findings of this study demonstrate that Indocalamus has strong shade tolerance and tremendous leaf value, laying the foundation for broadening the application of their leaves and for their industrial development in understory composite planting systems.

Abstract To match national development goals and increase in the tax base, the government must embed a taxation system in economic and social contexts. Since the founding of the People's Republic of China, the development of taxation can be divided into three stages: one that is embedded in danwei, one that is embedded in enterprises, and one that is embedded in society. The corresponding national development goals include stimulating economic growth, promoting coordinated economic and social development, and propelling state governance. As the tax base in China shifts from production to redistribution and wealth accumulation in the circulation of the national income, the taxation system will gradually shift from embedment in the economy to embedment in society, posing new challenges to taxation system reform. Future reform should deepen the extent to which taxation is embedded in society while keeping taxation embedded in a broad economic base. This will help to achieve the goal of building a “consensually strong state.”

Forest thermal environments and health-related factors have a significant impact on user experience and physical benefits. Therefore, it is important to study changes in the thermal environment and health-related factors in recreational forests. Clustered bamboo forests have unique structures featuring high canopy density and extensive understory spaces suitable for recreational activities. However, there is no relevant report on the recreational use of these forests. This study investigated seasonal characteristics in the thermal comfort and health-related factors in two clustered bamboo forests in Southwest China. Microenvironmental parameters and health-related factors (negative air oxygen ions (NAI), airborne particulate matter, airborne microorganisms, and biogenic volatile organic compounds (BVOCs)) were measured in four seasons. The microenvironmental parameters were converted into a physiological equivalent temperature (PET) for each period. The results showed that (1) most of the time, the thermal comfort, air particle, NAI, and bacteria concentrations in the two bamboo forests were superior to the controls and met the standard for recreational activities; (2) thermal comfort environments and health-related factors levels varied between two bamboo forests; and (3) the most abundant compounds in the two bamboo forests in each season were leaf alcohol and 2-hexenal. The two clustered bamboo forests provided a comfortable thermal environment and had clean air and bactericidal abilities in all seasons. The forests emitted BVOCs with fresh grass and leaf fragrances, helping to alleviate the sense of depression among visitors. The results confirm that clustered bamboo forests can provide suitable recreational conditions. The results can be used to guide the management of recreational forests and provide support for the development of bamboo forests.

Soundscape perception (SP) plays an important role in promoting tourist-place interaction and enhancing tourists’ environmentally responsible behavior (ERB). In this study, we defined SP as a second-order factor and investigated its relationships with place attachment (PA) and tourists’ ERB using structural equation modeling (SEM). Our aim was to identify how a soundscape could be improved to enhance the ERB of forest park tourists. Our results confirm the multidimensionality of SP, i.e., the three subdimensions of physical soundscape perception (PSP), psychological soundscape perception (SSP), and regional soundscape perception (RSP). Furthermore, our SEM results show that PA mediates the effect of the three subdimensions of SP on high-effort ERB (HERB). Our empirical results also reveal that the enhancement of tourists’ SSP will foster their ERB. This study therefore extends the multisensory landscape literature by offering insights into the relationship between SP, PA, and tourists’ ERB. Our findings provide empirical evidence for understanding the influence of SP on tourists’ ERB in forest parks and demonstrate that PA should be considered an important context for soundscape design.

The construction of the high-speed railway (HSR) system in China has improved cities' interconnectedness. We contend that the improved interconnectedness will likely strengthen economic interaction among cities, particularly cross-border trade integration. Employing a spatial panel fixed effect error model with prefecture-level city data from 2008 to 2013, this paper evaluates how cities' proximity to the HSR system affects urban market integration in China. We find that cities' proximity to the HSR system exerts a positive influence on reducing market segmentation, ceteris paribus. This study for the first time assesses the impacts of cities' proximity to HSR on inter-city market integration in China. The study will facilitate proactive regional policy decisions related to the future development of HSR and other critical infrastructure investment and development. Results obtained from the study could be of broader impact on policies of marketization reform and development for Eurasian countries. [ABSTRACT FROM AUTHOR]