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8. Long‐term safety of dietary salt: A 5‐year ProspEctive rAndomized bliNded and controlled stUdy in healThy aged cats (PEANUT study).

Author

Reynolds, Brice S., Chetboul, Valerie, Elliott, Jonathan, Laxalde, Jeremy, Nguyen, Patrick, Testault, Isabelle, Dorso, Laëticia, Abadie, Jérôme, Lefebvre, Hervé P., and Biourge, Vincent

Subjects
SALT-free diet, HIGH-salt diet, CATS, GLOMERULAR filtration rate, SPECIFIC gravity, CHRONIC kidney failure
Abstract

Background: High‐salt diets promote urine dilution and decrease urolithiasis risk. Objective: Prospectively evaluate the safety of chronic high dietary salt intake (randomized controlled trial). Animals: Twenty research colony neutered, healthy aged cats (11.5 years [10.0‐11.6], median [interquartile range]). Methods: Healthy cats were randomized to control or high‐salt dry diets (sodium: 1.02 ± 0.16 [mean, SD] and 3.26 ± 0.30 g/Mcal metabolizable energy [ME], respectively; chloride: 2.26 ± 0.33 and 5.71 ± 0.28 g/Mcal ME, respectively), fed for up to 60 months. Assessments included CBC, plasma biochemistry, urinalysis, glomerular filtration rate (GFR), blood pressure, renal and cardiac (conventional Doppler and 2‐dimensional color tissue Doppler) imaging, annually. Cats that died or were euthanized underwent necropsy. Diet effects over time were evaluated with linear mixed models. Results: Follow‐up duration (median [Interquartile range]) was similar between the control (38.7 months [28.6‐48.2]) and high‐salt group (51.4 months [45.7‐59.0]). Diet had no significant effect on changes in GFR, blood pressure, plasma creatinine concentration, end‐diastolic left ventricular (LV) wall thicknesses, LV internal diameters, LV systolic function, left atrial size, or systolic and diastolic Doppler variables. One control cat developed hypertension. One high‐salt group cat developed persistent azotemia. Serial plasma biochemistry and urine specific gravity suggested early chronic kidney disease in 4 nonazotemic cats (2 per group), consistent with necropsy findings. Conclusions and Clinical Importance: In healthy aged cats, a commercial veterinary diet containing 3.26 ± 0.30 g/Mcal ME sodium was safe with regard to renal and cardiac function for up to 5 years. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Evaluation of in vitro intrinsic radiosensitivity and characterization of five canine high-grade glioma cell lines.

Author

Cartiaux, Benjamin, Deviers, Alexandra, Delmas, Caroline, Abadie, Jérôme, Pumarola Battle, Martí, Moyal, Elizabeth Cohen-Jonathan, and Mogicato, Giovanni

Subjects
CELL lines, GLIOMAS, RADIATION tolerance, BRAIN tumors, DOGS, CELL morphology
Abstract

Glioma is the most common primary brain tumor in dogs and predominantly affects brachycephalic breeds. Diagnosis relies on CT or MRI imaging, and the proposed treatments include surgical resection, chemotherapy, and radiotherapy depending on the tumor's location. Canine glioma from domestic dogs could be used as a more powerful model to study radiotherapy for human glioma than the murine model. Indeed, (i) contrary to mice, immunocompetent dogs develop spontaneous glioma, (ii) the canine brain structure is closer to human than mice, and (iii) domestic dogs are exposed to the same environmental factors than humans. Moreover, imaging techniques and radiation therapy used in human medicine can be applied to dogs, facilitating the direct transposition of results. The objective of this study is to fully characterize 5 canine glioma cell lines and to evaluate their intrinsic radiosensitivity. Canine cell lines present numerous analogies between the data obtained during this study on different glioma cell lines in dogs. Cell morphology is identical, such as doubling time, clonality test and karyotype. Immunohistochemical study of surface proteins, directly on cell lines and after stereotaxic injection in mice also reveals close similarity. Radiosensitivity profile of canine glial cells present high profile of radioresistance. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Figure S2 from Discovery of Human-Similar Gene Fusions in Canine Cancers

Author

Ulvé, Ronan, primary, Rault, Mélanie, primary, Bahin, Mathieu, primary, Lagoutte, Laetitia, primary, Abadie, Jérôme, primary, De Brito, Clotilde, primary, Coindre, Jean-Michel, primary, Botherel, Nadine, primary, Rousseau, Audrey, primary, Wucher, Valentin, primary, Cadieu, Edouard, primary, Thieblemont, Catherine, primary, Hitte, Christophe, primary, Cornevin, Laurence, primary, Cabillic, Florian, primary, Bachelot, Laura, primary, Gilot, David, primary, Hennuy, Benoit, primary, Guillaudeux, Thierry, primary, Le Goff, Arnaud, primary, Derrien, Thomas, primary, Hédan, Benoît, primary, and André, Catherine, primary

Published
2023
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11. Table S2 from Discovery of Human-Similar Gene Fusions in Canine Cancers

Author

Ulvé, Ronan, primary, Rault, Mélanie, primary, Bahin, Mathieu, primary, Lagoutte, Laetitia, primary, Abadie, Jérôme, primary, De Brito, Clotilde, primary, Coindre, Jean-Michel, primary, Botherel, Nadine, primary, Rousseau, Audrey, primary, Wucher, Valentin, primary, Cadieu, Edouard, primary, Thieblemont, Catherine, primary, Hitte, Christophe, primary, Cornevin, Laurence, primary, Cabillic, Florian, primary, Bachelot, Laura, primary, Gilot, David, primary, Hennuy, Benoit, primary, Guillaudeux, Thierry, primary, Le Goff, Arnaud, primary, Derrien, Thomas, primary, Hédan, Benoît, primary, and André, Catherine, primary

Published
2023
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15. A Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for Irritant/Vesicant Drugs

Author

Bordat, Alexandre, primary, Boissenot, Tanguy, additional, Ibrahim, Nada, additional, Ferrere, Marianne, additional, Levêque, Manon, additional, Potiron, Léa, additional, Denis, Stéphanie, additional, Garcia-Argote, Sébastien, additional, Carvalho, Olivia, additional, Abadie, Jérôme, additional, Cailleau, Catherine, additional, Pieters, Grégory, additional, Tsapis, Nicolas, additional, and Nicolas, Julien, additional

Published
2022
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19. Canine Oral Melanoma Genomic and Transcriptomic Study Defines Two Molecular Subgroups with Different Therapeutical Targets

Author

Prouteau, Anais, primary, Mottier, Stephanie, additional, Primot, Aline, additional, Cadieu, Edouard, additional, Bachelot, Laura, additional, Botherel, Nadine, additional, Cabillic, Florian, additional, Houel, Armel, additional, Cornevin, Laurence, additional, Kergal, Camille, additional, Corre, Sébastien, additional, Abadie, Jérôme, additional, Hitte, Christophe, additional, Gilot, David, additional, Lindblad-Toh, Kerstin, additional, André, Catherine, additional, Derrien, Thomas, additional, and Hedan, Benoit, additional

Published
2022
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20. A Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for Irritant/Vesicant Drugs

Author

Bordat, Alexandre, primary, Boissenot, Tanguy, additional, Ibrahim, Nada, additional, Ferrere, Marianne, additional, Levêque, Manon, additional, Denis, Stéphanie, additional, Garcia-Argote, Sébastien, additional, Carvalho, Olivia, additional, Abadie, Jérôme, additional, Cailleau, Catherine, additional, Pieters, Gregory, additional, Tsapis, Nicolas, additional, and Nicolas, Julien, additional

Published
2021
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25. Supplementary_methods_1 – Supplemental material for Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer

Author

Dagher, Elie, Simbault, Laura, Abadie, Jérôme, Loussouarn, Delphine, Campone, Mario, and Nguyen, Frédérique

Subjects
FOS: Clinical medicine, Cell Biology, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_methods_1 for Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer by Elie Dagher, Laura Simbault, Jérôme Abadie, Delphine Loussouarn, Mario Campone and Frédérique Nguyen in Tumor Biology

Published
2020
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26. SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human

Author

Etienne, Floriane, Berthaud, Maxime, Nguyen, Frédérique, Bernardeau, Karine, Maurel, Catherine, Bodet-Milin, Caroline, Diab, Maya, Abadie, Jérôme, Gouilleux-Gruart, Valérie, Vidal, Aurélien, Bourgeois, Mickael, Chouin, Nicolas, Ibisch, Catherine, Davodeau, François, Oncologie nucléaire (CRCINA - Département NOHMAD - Equipe 13), Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers (CRCINA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Animaux Modèles pour la Recherche en Oncologie [Nantes] (AMaROC), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Stress Adaptation and Tumor Escape in breast cancer - SATE (CRCINA - Département ONCO - Equipe 8), Plateforme 'Production de protéines recombinantes' (P2R - INSERM UMS016/CNRS UMS3556/UN FED4203), Structure fédérative de recherche François Bonamy (SFR François Bonamy), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Santé de l'Université de Nantes (IRS-UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Santé de l'Université de Nantes (IRS-UN), Service de Médecine Nucléaire [Nantes], Hôpital Laennec, Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours, Cyclotron ARRONAX [Saint-Herblain], ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), This work was supported by the Institut Thématique MultiOrganismes (ITMO) Cancer of the Alliance pour les sciences de la vie et de la santé (AVIESAN) jointly with the Institut National du Cancer (INCA) under one grant entitled: Spontaneous tumor models in animals for translational research in oncology no. A11196NS (CANIMAB). Financial support was also provided by a Physics, Mathematics and Engineering sciences applied to the Cancer Research grant (DogPPK project) awarded by INSERM and INCa., Nuclear Oncology (CRCINA-ÉQUIPE 13), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Animaux modèles pour la recherche en oncologie comparée (AMaROC), Stress Adaptation and Tumor Escape in Breast Cancer (CRCINA-ÉQUIPE 8), Université de Tours (UT), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), and Bernardo, Elizabeth

Subjects
comparative oncology, diffuse large B-cell lymphoma, [SDV.CAN]Life Sciences [q-bio]/Cancer, SPECT-CT imaging, internalization, [SDV.CAN] Life Sciences [q-bio]/Cancer, Oncology, immune system diseases, monoclonal antibody, hemic and lymphatic diseases, dog, internalization Etienne et al Radiolabeled Anti-canine CD22 Antibodies, CD22, Original Research
Abstract

International audience; Antibodies directed against CD22 have been used in radioimmunotherapy (RIT) clinical trials to treat patients with diffuse large B-cell lymphoma (DLBCL) with promising results. However, relevant preclinical models are needed to facilitate the evaluation and optimization of new protocols. Spontaneous DLBCL in dogs is a tumor model that may help accelerate the development of new methodologies and therapeutic strategies for RIT targeting CD22. Seven murine monoclonal antibodies specific for canine CD22 were produced by the hybridoma method and characterized. The antibodies' affinity and epitopic maps, their internalization capability and usefulness for diagnosis in immunohistochemistry were determined. Biodistribution and PET imaging on a mouse xenogeneic model of dog DLBCL was used to choose the most promising antibody for our purposes. PET-CT results confirmed biodistribution study observations and allowed tumor localization. The selected antibody, 10C6, was successfully used on a dog with spontaneous DLBCL for SPECT-CT imaging in the context of disease staging, validating its efficacy for diagnosis and the feasibility of future RIT assays. This first attempt at phenotypic imaging on dogs paves the way to implementing quantitative imaging methodologies that would be transposable to humans in a theranostic approach. Taking into account the feedback of existing human radioimmunotherapy clinical trials targeting CD22, animal trials are planned to investigate protocol improvements that are difficult to consider in humans due to ethical concerns.

Published
2020

28. What is your diagnosis? Intestinal mass in a cat.

Author

Rouillé, Elodie, Soetart, Nicolas, Drut, Amandine, Abadie, Jérôme, and Jaillardon, Laetitia

Subjects
INTESTINES, DIAGNOSIS, CATS
Abstract

Roche), ×100 objective gl DISCUSSION Intestinal osteosarcoma is an extremely rare neoplasm of domestic animals, with three cases currently reported in cats.1,2 Histologically, the diagnosis of osteosarcoma is supported by the presence of malignant mesenchymal cells associated with the production of osteoid and/or tumorous bone tissue. The histopathologic morphology of osteosarcoma can vary because of the pleomorphism of malignant osteoblasts (spindle-shaped, ovoid, or rounded cells) and the variable amount and appearance of osteoid.3 Cytologic preparations from osteosarcomas are usually moderately to highly cellular. Lymph node cytology revealed marked lymphoid hyperplasia with a neoplastic cell infiltration with the same neoplastic cells seen in the intestinal masses. [Extracted from the article]

Published
2022
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31. Interest of circulating tumor DNA as a biomarker for canine cancers: illustration in histiocytic sarcoma, oral malignant melanoma and multicentric lymphoma

Author

Prouteau, Anaïs, primary, Denis, Jérôme Alexandre, additional, De Fornel, Pauline, additional, Cadieu, Edouard, additional, Derrien, Thomas, additional, Kergal, Camille, additional, Botherel, Nadine, additional, Ulvé, Ronan, additional, Rault, Mélanie, additional, Bouzidi, Amira, additional, François, Romain, additional, Dorso, Laetitia, additional, Lespagnol, Alexandra, additional, Devauchelle, Patrick, additional, Abadie, Jérôme, additional, André, Catherine, additional, and Hédan, Benoît, additional

Published
2020
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32. PTPN11 mutations in canine and human disseminated histiocytic sarcoma

Author

Hédan, Benoit, primary, Rault, Mélanie, additional, Abadie, Jérôme, additional, Ulvé, Ronan, additional, Botherel, Nadine, additional, Devauchelle, Patrick, additional, Copie‐Bergman, Christiane, additional, Cadieu, Edouard, additional, Parrens, Marie, additional, Alten, Julia, additional, Zalcman, Emmanuelle L., additional, Cario, Gunnar, additional, Damaj, Gandhi, additional, Mokhtari, Karima, additional, Le Loarer, Francois, additional, Coulomb‐Lhermine, Aurore, additional, Derrien, Thomas, additional, Hitte, Christophe, additional, Bachelot, Laura, additional, Breen, Matthew, additional, Gilot, David, additional, Blay, Jean Y., additional, Donadieu, Jean, additional, and André, Catherine, additional

Published
2020
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36. Supplemental_material – Supplemental material for Plasma cell leukemia with plasmablastic morphology in a dog

Author

Dagher, Elie, Soetart, Nicolas, Chocteau, Florian, Dequéant, Bérengère, Piccirillo, Esther, Ibisch, Catherine, Abadie, Jérôme, and Jaillardon, Laëtitia

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, Supplemental_material for Plasma cell leukemia with plasmablastic morphology in a dog by Elie Dagher, Nicolas Soetart, Florian Chocteau, Bérengère Dequéant, Esther Piccirillo, Catherine Ibisch, Jérôme Abadie and Laëtitia Jaillardon in Journal of Veterinary Diagnostic Investigation

Published
2019
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37. Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma

Author

Nader, Joëlle, Abadie, Jérôme, Deshayes, Sophie, Boissard, Alice, Blandin, Stéphanie, Blanquart, Christophe, Boisgerault, Nicolas, Coqueret, Olivier, Guette, Catherine, Grégoire, Marc, Pouliquen, Daniel, Immunogenic Cell Death and Mesothelioma Therapy (CRCINA-ÉQUIPE 4), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Senescence Escape and Soluble Markers of Cancer Progression (CRCINA-ÉQUIPE 12), ONIRIS [Nantes], Université de Nantes (UN), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Plateforme MicroPicell [Nantes], The research leading to these results has received funding from the National Health and Medical Research Institute (Inserm), the 'Ligue contre le Cancer' (Ligue Nationale and the Ligue inter-régionale du Grand Ouest, Comités 16, 44 et 72), the 'Fondation pour la Recherche Médicale' (FRM), the 'Région Pays de la Loire', the Institut de Recherche en Santé Respiratoire (IRSR) des Pays de la Loire, and the ARSMESO44 association., Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), and Bernardo, Elizabeth

Subjects
immune cells, [SDV.CAN] Life Sciences [q-bio]/Cancer, rat model, invasiveness, stroma, [SDV.CAN]Life Sciences [q-bio]/Cancer, sarcomatoid mesothelioma, Research Paper
Abstract

International audience; Sarcomatoid mesothelioma (SM) is a devastating cancer associated with one of the poorest outcome. Therefore, representative preclinical models reproducing different tumor microenvironments (TME) observed in patients would open up new prospects for the identification of markers and evaluation of innovative therapies. Histological analyses of four original models of rat SM revealed their increasing infiltrative and metastatic potential were associated with differences in Ki67 index, blood-vessel density, and T-lymphocyte and macrophage infiltration. In comparison with the noninvasive tumor M5-T2, proteomic analysis demonstrated the three invasive tumors F4-T2, F5-T1 and M5-T1 shared in common a very significant increase in the abundance of the multifunctional proteins galectin-3, prohibitin and annexin A5, and a decrease in proteins involved in cell adhesion, tumor suppression, or epithelial differentiation. The increased metastatic potential of the F5-T1 tumor, relative to F4-T2, was associated with an increased macrophage vs T-cell infiltrate, changes in the levels of expression of a panel of cytokine genes, an increased content of proteins involved in chromatin organization, ribosome structure, splicing, or presenting anti-adhesive properties, and a decreased content of proteins involved in protection against oxidative stress, normoxia and intracellular trafficking. The most invasive tumor, M5-T1, was characterized by a pattern of specific phenotypic and molecular features affecting the presentation of MHC class I-mediated antigens and immune cell infiltration, or involved in the reorganization of the cytoskeleton and composition of the extracellular matrix. These four preclinical models and data represent a new resource available to the cancer research community to catalyze further investigations on invasiveness.

Published
2018

42. One‐year conditional survival of dogs and cats with invasive mammary carcinomas: A concept inspired from human breast cancer.

Author

Chocteau, Florian, Mordelet, Valentin, Dagher, Elie, Loussouarn, Delphine, Abadie, Jérôme, and Nguyen, Frédérique

Subjects
BREAST cancer, CATS, PROGNOSIS, INVASIVE diagnosis, EARLY death, FELIDAE, DOGS
Abstract

Numerous studies have described the prognostic factors of canine and feline mammary carcinomas (MCs), that is, variables that predict patient survival after diagnosis. But how does survival estimation evolve in patients that escaped early death from their cancer? In human oncology, conditional survival (CS), the probability of surviving X further years when cancer patients have already survived Y years, is used to analyse cancer outcomes in a long‐term perspective. In this cohort of 344 dogs and 342 cats with surgically removed stage I to III invasive MCs, with a minimal follow‐up of 2 years, we calculated the 1‐year CS, that is, the probability for patients that have survived 1 year, to survive or to die from cancer during the subsequent year. The 1‐year conditional specific survival probabilities were 59% and 48% at diagnosis of invasive MC respectively in dogs and cats, and 80% and 52% in 1‐year surviving dogs and cats respectively, suggesting that 1‐year surviving dogs were relatively protected from cancer‐related death, whereas feline MCs remained life‐threatening cancers for longer periods of time. Among the most significant parameters associated with CS in surviving dogs and cats were the nodal stage and lymphovascular invasion, as well as patient age, cancer stage and margin status in surviving dogs. By comparison, tumour size and the histological grade did not significantly alter CS probabilities in surviving dogs and cats. Conditional survival may be considered a very interesting tool for veterinary practitioners to estimate the likely outcome of cancer survivors. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Production and characterization of monoclonal antibodies specific for canine CD138 (syndecan-1) for nuclear medicine preclinical trials on spontaneous tumours

Author

Diab, Maya, Nguyen, Frédérique, Berthaud, Maxime, Maurel, Catherine, Gaschet, J., Verger, Elise, Ibisch, Catherine, Chérel, Michel, Abadie, Jérôme, Davodeau, François, Rousseau, Caroline, Bernardo, Elizabeth, Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, and Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)

Subjects
Mammary Neoplasms, Animal, [SDV.CAN]Life Sciences [q-bio]/Cancer, Mice, Dogs, breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, immune system diseases, hemic and lymphatic diseases, Animals, Humans, Dog Diseases, Mice, Inbred BALB C, Hybridomas, B-cell lymphoma, comparative, Antibodies, Monoclonal, syndecan-1, Radioimmunotherapy, Flow Cytometry, monoclonal antibody, dog, oncology, Female, Lymphoma, Large B-Cell, Diffuse, Epitope Mapping, diffuse large
Abstract

International audience; We isolated 11 antibodies specific for canine CD138 (cCD138) to validate the interest of CD138 antigen targeting in dogs with spontaneous mammary carcinoma. The affinity of the monoclonal antibodies in the nanomolar range is suitable for immunohistochemistry and nuclear medicine applications. Four distinct epitopes were recognized on cCD138 by this panel of antibodies. CD138 expression in canine healthy tissues is comparable to that reported in humans. CD138 is frequently expressed in canine mammary carcinomas corresponding to the human triple negative breast cancer subtype, with cytoplasmic and membranous expression. In canine diffuse large B-cell lymphoma, CD138 expression is associated with the 'non-germinal center' phenotype corresponding to the most aggressive subtype in humans. This homology of CD138 expression between dogs and humans confirms the relevance of tumour-bearing dogs as spontaneous models for nuclear medicine applications, especially for the evaluation of new tumour targeting strategies for diagnosis by phenotypic imaging and radio-immunotherapy.

Published
2016

48. Cartographie des forêts anciennes de France : objectifs, bilan et perspectives

Author

Dupouey, Jean-Luc, Amiaud, Bernard, Chauchard, Sandrine, Bergès, Laurent, Abadie, Jérôme, Archaux, Frédéric, Avon, Catherine, Bec, Raphaël, Bonnevialle, Marie, Burst, Maxime, Cordonnier, Thomas, Deconchat, Marc, Decocq, Guillaume, Delcourte, Marie, Fuhr, Marc, Grel, Audrey, Heintz, Wilfried, Janssen, Philippe, Landmann, Guy, LARRIEU, Laurent, LEROY, Nathalie, Montpied, Pierre, Panaïotis, Christophe, Renaux, Benoît, Rochel, Xavier, Thomas, Marie, Salvaudon, Aline, Vallauri, Daniel, Villemey, Anne, Institut National Polytechnique de Toulouse - INPT (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), Institut national de Recherche en Sciences et Technologies pour l'Environnement et l'Agriculture - IRSTEA (FRANCE), Université de Picardie Jules Verne (FRANCE), Université de Lorraine (FRANCE), Université de Valenciennes et du Hainaut-Cambrésis - UVHC (FRANCE), Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] (EEF), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Ecosystèmes montagnards (UR EMGR), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Ecosystèmes méditerranéens et risques (UR EMAX), Ecosystèmes forestiers (UR EFNO), Parcs naturels du Massif central (IPAMAC), Parcs Nationaux de France, Dynamiques Forestières dans l'Espace Rural (DYNAFOR), Institut National de la Recherche Agronomique (INRA)-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 (EDYSAN), Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Cultures, Arts, Littératures, Histoire, Imaginaires, Sociétés, Territoires, Environnement - EA 4343 (CALHISTE), Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université Polytechnique Hauts-de-France (UPHF), WWF France Fondation, Groupement d’Intérêt Public 'Ecosystèmes Forestiers' (GIP ECOFOR), Centre Régional de la Propriété Forestière de Midi-Pyrénées (CRPF Midi-Pyrénées), Conservatoire Botanique National, Centre de Recherche en Géographie (LOTERR), Université de Lorraine (UL), Parc Naturel Régional du Luberon (PNRL), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Toulouse-Institut National Polytechnique (Toulouse) (Toulouse INP), Ecologie et dynamique des systèmes anthropisés, Centre National de la Recherche Scientifique (CNRS), Université Polytechnique Hauts-de-France (UPHF)-Université Polytechnique Hauts-de-France (UPHF), and Centre d'Etude et de Recherche en Géographie de l'Aménagement des Paysages et de l'Environnement (CERGAPE - LOTERR)

Subjects
Forêt ancienne, Cartographie, [SDV]Life Sciences [q-bio], carte d'état-major, Synthèse, Carte d'état-major, forêt ancienne, biodiversité, synthèse, cartographie, France, Biodiversité, Environnement et Société, france, Géographie
Abstract

Session 7 b: Géohistoire des forêts; Il y a dix ans démarraient les premiers travaux de vectorisation, à l'échelle régionale, des forêts de la carte d'Etat-Major, en vue de l'établissement d'une carte nationale des forêts à longue continuité de l'état boisé. Où en est-on aujourd'hui ? Nous faisons le point de l'avancement des travaux et en tirons les premiers enseignements, en répondant aux questions suivantes : Quels sont les définitions et concepts sous-jacents à ces travaux ? Pourquoi cartographier les forêts dites "anciennes" ou "récentes" ? L'analyse des institutions ayant réalisé le travail montre que ce sont principalement les milieux de la conservation qui ont été moteurs dans ces travaux. Mais la production et la qualité des produits bois sont aussi concernés par cette cartographie. Le rôle actuel de puits de carbone des forêts françaises ne peut par exemple se comprendre qu'au travers de cette dynamique forestière ancienne. Pourquoi une focalisation sur la première moitié du XIXe siècle comme date de référence ? Que signifie la notion de minimum forestier ? Quelles en sont les limites ? Quels sont les supports de données les plus intéressantes pour cette cartographie ? Pourquoi la carte d'Etat-Major est une source particulière d'information, dans l'objectif de la cartographie des forêts anciennes, parmi la multitude de cartes ou statistiques disponibles à différentes dates et échelles ? Quelles sont les méthodes d'acquisition de la donnée ? Quelle est la précision spatiale des cartes d'occupation du sol obtenues ? Les principaux problèmes posés par l'utilisation de la carte d'Etat-Major seront présentés, ainsi que la façon dont différents projets y ont répondu. Quels résultats ont été obtenus ? Nous reviendrons entre autres sur l'estimation de la surface forestière française à la date de son minimum. Les cartes déjà réalisées, sur 33% du territoire, permettent de dessiner avec précision et de comparer les changements d'occupation du sol dans différentes régions de France, en termes de pourcentage de déboisement, reboisement et taux de forêt ancienne dans la forêt actuelle. Les évolutions du couvert forestier issues d'autres sources non cartographiques sont-elles confirmées ? Le lien avec le type de propriété foncière est particulièrement intéressant à analyser. Dans plusieurs zones de France (Pyrénées, Luberon, Alpes, Lorraine, Nord-Pas-de-Calais...) ont été réalisés des croisements entre ces cartes et les bases de données régionales de relevés floristiques (Inventaire forestier national, conservatoires botaniques). Ce nouveau type d'analyse permet d'identifier rapidement les espèces végétales liées à la continuité de l'état boisé, dites espèces de forêts anciennes, et les traits de vie qui leur sont associés. Nous présenterons une synthèse de ces résultats. Dans la moitié des zones déjà cartographiées, ce sont toutes les occupations du sol anciennes qui ont été numérisées et non seulement les forêts. Nous évoquerons l'intérêt de ce cadastre ancien, au-delà des seules questions forestières, pour le suivi de la dynamique à long terme des prairies, des milieux humides, des vignes ou des milieux urbanisés. Les techniques de vectorisation des occupations anciennes du sol évoluent vers une simplification et une accélération qui laisse présager une fin du travail plus rapide que prévue initialement, parfois au détriment de la qualité. L'extension à la France entière permettra une vision à la fois à petite échelle mais localement précise des mouvements des masses forestières. Nous discuterons les perspectives de recherche et les développements en cours, ouverts par ces progrès.

Published
2016

49. Discovery of Human-Similar Gene Fusions in Canine Cancers

Author

Ulvé, Ronan, primary, Rault, Mélanie, additional, Bahin, Mathieu, additional, Lagoutte, Laetitia, additional, Abadie, Jérôme, additional, De Brito, Clotilde, additional, Coindre, Jean-Michel, additional, Botherel, Nadine, additional, Rousseau, Audrey, additional, Wucher, Valentin, additional, Cadieu, Edouard, additional, Thieblemont, Catherine, additional, Hitte, Christophe, additional, Cornevin, Laurence, additional, Cabillic, Florian, additional, Bachelot, Laura, additional, Gilot, David, additional, Hennuy, Benoit, additional, Guillaudeux, Thierry, additional, Le Goff, Arnaud, additional, Derrien, Thomas, additional, Hédan, Benoît, additional, and André, Catherine, additional

Published
2017
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50. Neu5Gc and α1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs

Author

Salama, Apolline, primary, Mosser, Mathilde, additional, Lévêque, Xavier, additional, Perota, Andrea, additional, Judor, Jean-Paul, additional, Danna, Corentin, additional, Pogu, Sylvie, additional, Mouré, Anne, additional, Jégou, Dominique, additional, Gaide, Nicolas, additional, Abadie, Jérôme, additional, Gauthier, Olivier, additional, Concordet, Jean-Paul, additional, Le Bas-Bernardet, Stéphanie, additional, Riochet, David, additional, Le Berre, Ludmilla, additional, Hervouet, Jérémy, additional, Minault, David, additional, Weiss, Pierre, additional, Guicheux, Jérôme, additional, Brouard, Sophie, additional, Bosch, Steffi, additional, Lagutina, Irina, additional, Duchi, Roberto, additional, Lazzari, Giovanna, additional, Cozzi, Emanuele, additional, Blancho, Gilles, additional, Conchon, Sophie, additional, Galli, Cesare, additional, Soulillou, Jean-Paul, additional, and Bach, Jean-Marie, additional

Published
2017
Full Text
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