9,954 results on '"Meng, Y."'
Search Results
102. Synthesis and Structural Characterization of a Di-nuclear Uranyl Complex with Quinoline-6-carboxylate
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Meng, Y., Cai, B., Lan, Q., Niu, F., Zhang, X., and Yang, Y.
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- 2022
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103. Observation of ultra-strong spin-motion coupling for cold atoms in optical microtraps
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Dareau, A., Meng, Y., Schneeweiss, P., and Rauschenbeutel, A.
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Quantum Physics - Abstract
We realize a mechanical analogue of the Dicke model, achieved by coupling the spin of individual neutral atoms to their quantized motion in an optical trapping potential. The atomic spin states play the role of the electronic states of the atomic ensemble considered in the Dicke model, and the in-trap motional states of the atoms correspond to the states of the electromagnetic field mode. The coupling between spin and motion is induced by an inherent polarization gradient of the trapping light fields, which leads to a spatially varying vector light shift. We experimentally show that our system reaches the ultra-strong coupling regime, i.e., we obtain a coupling strength which is a significant fraction of the trap frequency. Moreover, with the help of an additional light field, we demonstrate the in-situ tuning of the coupling strength. Beyond its fundamental interest, the demonstrated one-to-one mapping between the physics of optically trapped cold atoms and the Dicke model paves the way for implementing protocols and applications that exploit extreme coupling strengths.
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- 2018
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104. Projected WIMP sensitivity of the LUX-ZEPLIN (LZ) dark matter experiment
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Akerib, D. S., Akerlof, C. W., Alsum, S. K., Araújo, H. M., Arthurs, M., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bauer, D., Belle, J., Beltrame, P., Benson, T., Bernard, E. P., Biesiadzinski, T. P., Boast, K. E., Boxer, B., Brás, P., Buckley, J. H., Bugaev, V. V., Burdin, S., Busenitz, J. K., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Chan, C., Cherwinka, J. J., Cole, A., Cottle, A., Craddock, W. W., Currie, A., Cutter, J. E., Dahl, C. E., de Viveiros, L., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edberg, T. K., Edwards, W. R., Fan, A., Fayer, S., Fiorucci, S., Fruth, T., Gaitskell, R. J., Genovesi, J., Ghag, C., Gilchriese, M. G. D., van der Grinten, M. G. D., Hall, C. R., Hans, S., Hanzel, K., Haselschwardt, S. J., Hertel, S. A., Hillbrand, S., Hjemfelt, C., Hoff, M. D., Hor, J. Y-K., Huang, D. Q., Ignarra, C. M., Ji, W., Kaboth, A. C., Kamdin, K., Keefner, J., Khaitan, D., Khazov, A., Kim, Y. D., Kocher, C. D., Korolkova, E. V., Kraus, H., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kyre, S., Lee, J., Lenardo, B. G., Leonard, D. S., Lesko, K. T., Levy, C., Li, J., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, X., Lopes, M. I., Paredes, B. López, Lorenzon, W., Luitz, S., Lyle, J. M., Majewski, P., Manalaysay, A., Mannino, R. L., Maupin, C., McKinsey, D. N., Meng, Y., Miller, E. H., Mock, J., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Nelson, H. N., Neves, F., Nikoleyczik, J., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Palladino, K. J., Patton, S. J., Pease, E. K., Penning, B., Piepke, A., Powell, S., Preece, R. M., Pushkin, K., Ratcliff, B. N., Reichenbacher, J., Rhyne, C. A., Richards, A., Rodrigues, J. P., Rosero, R., Rossiter, P., Saba, J. S., Sarychev, M., Schnee, R. W., Schubnell, M., Scovell, P. R., Shaw, S., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Solmaz, M., Solovov, V. N., Sorensen, P., Stancu, I., Stark, M. R., Stiegler, T. M., Stifter, K., Szydagis, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Terman, P. A., Thomas, K. J., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tull, C. E., Tvrznikova, L., Utku, U., Va'vra, J., Vacheret, A., Verbus, J. R., Voirin, E., Waldron, W. L., Watson, J. R., Webb, R. C., White, D. T., Whitis, T. J., Wisniewski, W. J., Witherell, M. S., Wolfs, F. L. H., Woodward, D., Worm, S. D., Yeh, M., Yin, J., and Young, I.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
LUX-ZEPLIN (LZ) is a next generation dark matter direct detection experiment that will operate 4850 feet underground at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. Using a two-phase xenon detector with an active mass of 7~tonnes, LZ will search primarily for low-energy interactions with Weakly Interacting Massive Particles (WIMPs), which are hypothesized to make up the dark matter in our galactic halo. In this paper, the projected WIMP sensitivity of LZ is presented based on the latest background estimates and simulations of the detector. For a 1000~live day run using a 5.6~tonne fiducial mass, LZ is projected to exclude at 90\% confidence level spin-independent WIMP-nucleon cross sections above $1.4 \times 10^{-48}$~cm$^{2}$ for a 40~$\mathrm{GeV}/c^{2}$ mass WIMP. Additionally, a $5\sigma$ discovery potential is projected reaching cross sections below the exclusion limits of recent experiments. For spin-dependent WIMP-neutron(-proton) scattering, a sensitivity of $2.3 \times 10^{-43}$~cm$^{2}$ ($7.1 \times 10^{-42}$~cm$^{2}$) for a 40~$\mathrm{GeV}/c^{2}$ mass WIMP is expected. With underground installation well underway, LZ is on track for commissioning at SURF in 2020., Comment: 14 pages, 11 figures
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- 2018
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105. Evaluation of anticorrosion and contact resistance behavior of poly(orthophenylenediamine)- coated 316L SS bipolar plate for proton exchange membrane fuel cell
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Mani, S. Pugal, Kalaiyarasan, M., Agilan, P., Ravichandran, K., Rajendran, N., and Meng, Y.
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- 2022
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106. Near-ground-state cooling of atoms optically trapped 300nm away from a hot surface
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Meng, Y., Dareau, A., Schneeweiss, P., and Rauschenbeutel, A.
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Quantum Physics - Abstract
Laser-cooled atoms coupled to nanophotonic structures constitute a powerful research platform for the exploration of new regimes of light-matter interaction. While the initialization of the atomic internal degrees of freedom in these systems has been achieved, a full preparation of the atomic quantum state also requires controlling the center of mass motion of the atoms at the quantum level. Obtaining such control is not straightforward, due to the close vicinity of the atoms to the photonic system that is at ambient temperature. Here, we demonstrate cooling of individual neutral Cesium atoms, that are optically interfaced with light in an optical nanofiber, preparing them close to their three-dimensional motional ground state. The atoms are localized less than 300nm away from the hot fiber surface. Ground-state preparation is achieved by performing degenerate Raman cooling, and the atomic temperature is inferred from the analysis of heterodyne fluorescence spectroscopy signals. Our cooling method can be implemented either with externally applied or guided light fields. Moreover, it relies on polarization gradients which naturally occur for strongly confined guided optical fields. Thus, this method can be implemented in any trap based on nanophotonic structures. Our results provide an ideal starting point for the study of novel effects such as light-induced self-organization, the measurement of novel optical forces, and the investigation of heat transfer at the nanoscale using quantum probes.
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- 2017
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107. Future energy, fuel cells, and solid-oxide fuel-cell technology
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Minh, Nguyen Q and Shirley Meng, Y
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Affordable and Clean Energy ,Macromolecular and Materials Chemistry ,Materials Engineering ,Mechanical Engineering ,Applied Physics - Abstract
According to the US Department of Energy’s Energy Infomation Administration (EIA) (International Energy Outlook 2017), world energy consumption will increase 28% between 2015 and 2040, rising from 575 quadrillion Btu (∼606 quadrillion kJ) in 2015 to 736 quadrillion Btu (∼776 quadrillion kJ) in 2040. EIA predicts increases in consumption for all energy sources (excluding coal, which is estimated to remain flat)—fossil (petroleum and other liquids, natural gas), renewables (solar, wind, hydropower), and nuclear. Although renewables are the world’s fastest growing form of energy, fossil fuels are expected to continue to supply more than three-quarters of the energy used worldwide. Among the various fossil fuels, natural gas is the fastest growing, with a projected increase of 43% from 2015 to 2040. As the use of fossil fuels increases, the EIA projects world energy-related carbon dioxide emission to grow from ∼34 billion metric tons in 2015 to ∼40 billion metric tonnes in 2040 (an average 0.6% increase per year).
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- 2019
108. High-Efficiency Lithium-Metal Anode Enabled by Liquefied Gas Electrolytes
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Yang, Yangyuchen, Davies, Daniel M, Yin, Yijie, Borodin, Oleg, Lee, Jungwoo Z, Fang, Chengcheng, Olguin, Marco, Zhang, Yihui, Sablina, Ekaterina S, Wang, Xuefeng, Rustomji, Cyrus S, and Meng, Y Shirley
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- 2019
109. Wearable thermoelectrics for personalized thermoregulation.
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Hong, Sahngki, Gu, Yue, Seo, Joon Kyo, Wang, Joseph, Liu, Ping, Meng, Y Shirley, Xu, Sheng, and Chen, Renkun
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Thermoregulation has substantial implications for energy consumption and human comfort and health. However, cooling technology has remained largely unchanged for more than a century and still relies on cooling the entire space regardless of the number of occupants. Personalized thermoregulation by thermoelectric devices (TEDs) can markedly reduce the cooling volume and meet individual cooling needs but has yet to be realized because of the lack of flexible TEDs with sustainable high cooling performance. Here, we demonstrate a wearable TED that can deliver more than 10°C cooling effect with a high coefficient of performance (COP > 1.5). Our TED is the first to achieve long-term active cooling with high flexibility, due to a novel design of double elastomer layers and high-ZT rigid TE pillars. Thermoregulation based on these devices may enable a shift from centralized cooling toward personalized cooling with the benefits of substantially lower energy consumption and improved human comfort.
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- 2019
110. Pathways for practical high-energy long-cycling lithium metal batteries
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Liu, Jun, Bao, Zhenan, Cui, Yi, Dufek, Eric J, Goodenough, John B, Khalifah, Peter, Li, Qiuyan, Liaw, Bor Yann, Liu, Ping, Manthiram, Arumugam, Meng, Y Shirley, Subramanian, Venkat R, Toney, Michael F, Viswanathan, Vilayanur V, Whittingham, M Stanley, Xiao, Jie, Xu, Wu, Yang, Jihui, Yang, Xiao-Qing, and Zhang, Ji-Guang
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Affordable and Clean Energy ,Electrical and Electronic Engineering ,Environmental Engineering - Abstract
State-of-the-art lithium (Li)-ion batteries are approaching their specific energy limits yet are challenged by the ever-increasing demand of today’s energy storage and power applications, especially for electric vehicles. Li metal is considered an ultimate anode material for future high-energy rechargeable batteries when combined with existing or emerging high-capacity cathode materials. However, much current research focuses on the battery materials level, and there have been very few accounts of cell design principles. Here we discuss crucial conditions needed to achieve a specific energy higher than 350 Wh kg −1 , up to 500 Wh kg −1 , for rechargeable Li metal batteries using high-nickel-content lithium nickel manganese cobalt oxides as cathode materials. We also provide an analysis of key factors such as cathode loading, electrolyte amount and Li foil thickness that impact the cell-level cycle life. Furthermore, we identify several important strategies to reduce electrolyte-Li reaction, protect Li surfaces and stabilize anode architectures for long-cycling high-specific-energy cells.
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- 2019
111. Cryogenic Focused Ion Beam Characterization of Lithium Metal Anodes
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Lee, Jungwoo Z, Wynn, Thomas A, Schroeder, Marshall A, Alvarado, Judith, Wang, Xuefeng, Xu, Kang, and Meng, Y Shirley
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Engineering ,Materials Engineering ,Chemical Sciences ,Physical Chemistry ,Chemical sciences - Abstract
Lithium metal is viewed as the ultimate battery anode because of its high theoretical capacity and low electrode potential, but its implementation has been limited by low Coulombic efficiency and dendrite formation above a critical current density. Determining the fundamental properties dictating lithium metal plating-stripping behavior is challenging because characterization techniques are limited by the sensitivity of lithium metal to damage by external probes, which regularly results in altered morphology and chemistry. Motivated by recent application of cryogenic transmission electron microscopy (cryo-TEM) to characterize lithium metal at the atomic scale, we explore the cryogenic focused ion beam (cryo-FIB) method as a quantitative tool for characterizing the bulk morphology of electrochemically deposited lithium and as a technique that enables TEM observation of Li-metal/solid-state electrolyte interfaces. This work highlights the importance of cryo-FIB methodology for preparing sensitive battery materials and elucidates the impact of electrolyte selection on the density and morphology of plated lithium.
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- 2019
112. Effects of Different 0.2% Ropivacaine Infusion Regimens for Continuous Interscalene Brachial Plexus Block on Postoperative Analgesia and Respiratory Function After Shoulder Arthroscopic Surgery: A Randomized Clinical Trial
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Meng Y, Wang S, Zhang W, Xie C, Chai X, Shu S, and Zong Y
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continuous interscalene brachial plexus block ,programmed intermittent bolus infusion ,shoulder arthroscopic surgery ,perioperative analgesic therapy ,respiratory function ,Medicine (General) ,R5-920 - Abstract
Yan Meng,1,2 Sheng Wang,1 Wei Zhang,1 Chunlin Xie,1 Xiaoqing Chai,1 Shuhua Shu,1 Yu Zong1,2 1Department of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China (USTC)/Anhui Provincial Hospital, Hefei, People’s Republic of China; 2Core Facility Center, The First Affiliated Hospital of USTC/Anhui Provincial Hospital, Hefei, People’s Republic of ChinaCorrespondence: Yu Zong, Department of Anesthesiology, The First Affiliated Hospital of USTC, 17 Lujiang Road, Hefei, Anhui, People’s Republic of China, Email zongyu3540@163.comObjective: Continuous interscalene brachial plexus block (cIBPB) is an effective perioperative analgesic therapy for shoulder arthroscopic surgery (SAS) patients. This trial aimed to compare the effect of different cIBPB infusion methods on postoperative analgesia and respiratory function in patients undergoing SAS.Methods: After SAS, 88 patients were randomly assigned to four groups. Through interscalene catheter, all the patients received an initial dose of 10 mL 0.2% ropivacaine. The CI group received 0.2% ropivacaine 4 mL/h, and the PIBI1, PIBI2, and PIBI3 groups received intermittent 0.2% ropivacaine boluses at 4 mL/h, 8 mL/2 h, and 12 mL/3 h, respectively. The patients could also use a patient-controlled analgesia (PCA) pump to self-inject a tramadol bolus each time he/she felt pain. The primary outcome was the cumulative tramadol consumption over the 48 h after surgery. Secondary outcome measures included PCA frequency, pain (visual analogue scale, VAS) score, patient satisfaction, diaphragmatic excursion, pulmonary function, and adverse events.Results: The cumulative tramadol consumption and PCA frequency over the 48 h after surgery in groups PIBI2 and PIBI3 were lower than in both the CI and PIBI1 groups (p< 0.001). The VAS scores (at rest and on movement) in groups PIBI2 and PIBI3 were lower than those in the CI and PIBI1 groups at 8 and 12 h after surgery (all p< 0.001). Patient satisfaction scores were significantly higher in the PIBI2 group than in the other three groups (all p< 0.001). Diaphragmatic excursion was significantly decreased in the PIBI3 group compared to the other three groups (p< 0.05). The incidence of adverse events over the 48 h after surgery was significantly higher in the PIBI3 group compared to the other three groups (p< 0.001).Conclusion: Programmed intermittent bolus infusion with 0.2% ropivacaine 8 mL/2 h for cIBPB can achieve lower tramadol consumption, along with better analgesia after surgery, lower reduction in diaphragmatic excursion, lower incidence of adverse events, and higher patient satisfaction.Keywords: continuous interscalene brachial plexus block, programmed intermittent bolus infusion, shoulder arthroscopic surgery, perioperative analgesic therapy, respiratory function
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- 2022
113. Using Weighted Gene Co-Expression Network Analysis to Identify Increased MND1 Expression as a Predictor of Poor Breast Cancer Survival
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Bao Z, Cheng J, Zhu J, Ji S, Gu K, Zhao Y, Yu S, and Meng Y
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breast neoplasms ,immunohistochemistry ,polymerase chain reaction ,biomarker ,Medicine (General) ,R5-920 - Abstract
Zhaokang Bao,1,* Jiale Cheng,1,* Jiahao Zhu,2,* Shengjun Ji,3 Ke Gu,2 Yutian Zhao,2 Shiyou Yu,1 You Meng1 1Department of Oncology Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, People’s Republic of China; 2Department of Radiotherapy and Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; 3Department of Radiotherapy and Oncology, The affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: You Meng, Department of Oncology Surgery, The affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, 16 West Baita Road, Suzhou, Jiangsu, People’s Republic of China, Email drmengyou@163.comObjective: We used bioinformatics analysis to identify potential biomarker genes and their relationship with breast cancer (BC).Materials and Methods: We used a weighted gene co-expression network analysis (WGCNA) to create a co-expression network based on the top 25% genes in the GSE24124, GSE33926, and GSE86166 datasets obtained from the Gene Expression Omnibus. We used the DAVID online platform to perform GO and KEGG pathway enrichment analyses and the Cytoscape CytoHubba plug-in to screen the potential genes. Then, we related the genes to prognostic values in BC using the Oncomine, GEPIA, and Kaplan–Meier Plotter databases. Findings were validated by immunohistochemical (IHC) staining in the Human Protein Atlas and the TCGA-BRCA cohort. LinkedOmics identified the interactive expressions of hub genes. We used UALCAN to evaluate the methylation levels of these hub genes. MethSurv and SurvivalMeth were used to assess the multilevel prognostic value. Finally, we assessed hub gene association with immune cell infiltration using TIMER.Results: The mRNA levels of MKI67, UBE2C, GTSE1, CCNA2, and MND1 were significantly upregulated in BC, whereas ESR1, THSD4, TFF1, AGR2, and FOXA1 were significantly downregulated. The DNA methylation signature analysis showed a better prognosis in the low-risk group. Further subgroup analyses revealed that MND1 might serve as an independent risk factor for unfavorable BC prognosis. Additionally, MND1 expression levels positively correlate with the immune infiltration statuses of CD4+ T cells, CD8+ T cells, B cells, neutrophils, dendritic cells, and macrophages.Conclusion: Our results indicate that the ten hub genes may be involved in BC’s carcinogenesis, development, or metastasis, and MND1 may be a potential biomarker and therapeutic target for BC.Keywords: breast neoplasms, immunohistochemistry, polymerase chain reaction, biomarker
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- 2022
114. Clinical Impact of 11q13.3 Amplification on Immune Cell Infiltration and Prognosis in Breast Cancer
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Zhou R, Zhu X, Peng Y, Zhong L, Peng L, Yang B, Meng Y, Chen X, and Lu Y
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breast cancer ,chromosomal amplification ,11q13.3 amplicon ,prognosis ,immune microenvironment ,Medicine (General) ,R5-920 - Abstract
Renyu Zhou,1 Xiaoxi Zhu,2 Yulong Peng,1 Lijuan Zhong,1 Lilin Peng,1 Bo Yang,1 Yuhua Meng,3 Xuanzhao Chen,4 Yuanzhi Lu1,4 1Department of Pathology, First Affiliated Hospital of Jinan University, Guangzhou, 510630, People’s Republic of China; 2Department of Oncology, First Affiliated Hospital of Jinan University, Guangzhou, 510630, People’s Republic of China; 3Department of Pathology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde), Foshan, 528300, People’s Republic of China; 4The Center of Pathological Diagnosis and Research, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524023, People’s Republic of ChinaCorrespondence: Yuanzhi Lu, Tel +86-20 38688984, Email yuanzhi.lu@jnu.edu.cnIntroduction: Amplification of the 11q13.3 locus has been observed in various tumors. This study sought to determine the correlation of gene amplification at the 11q13.3 locus with the immune status and survival of breast cancer.Methods: Amplification of the 11q13.3 locus was characterized by analyzing a publicly available database from the cBioPortal platform (TCGA). The correlation of amplified genes with immune cell infiltration in breast cancer was further analyzed using the TIMER2.0 platform. Immunohistochemical staining was used to determine the expression levels of Cyclin D1 (CCND1), Fas-associated death domain (FADD) and P53 in 156 clinical breast cancer samples.Results: This study revealed that amplification of the 11q13.3 amplicon in breast cancer is likely more frequently detected in luminal B breast cancer. Moreover, high expression or amplification of CCND1, fibroblast growth factor 3 (FGF3), fibroblast growth factor 4 (FGF4), fibroblast growth factor 19 (FGF19) and FADD was inversely correlated with the abundance of CD4+ T cells and dendritic cell infiltration in breast cancer (P < 0.05). Data analysis also demonstrated that high expression of CCND1, FGF4 and FADD mRNA levels was closely correlated with shorter recurrence-free survival (RFS) in patients with breast cancer (P < 0.05). The results of immunohistochemical staining from clinical samples further confirmed that high expression of CCND1 and FADD was frequently detected in luminal B and high-grade breast cancer with shorter metastasis-free survival times (P < 0.05).Conclusion: This study demonstrated that coamplification of genes located on the 11q13.3 amplicon is frequently detected in luminal B subtype breast cancer and is closely associated with worse survival in patients with breast cancer. Moreover, coamplification of the CCND1-FGF locus might decrease antitumor immune activity in breast cancer, indicating that coamplification of the 11q13.3 amplicon is likely to be a key determinant of therapeutic resistance and accelerate the aggressive evolution of breast cancer.Keywords: breast cancer, chromosomal amplification, 11q13.3 amplicon, prognosis, immune microenvironment
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- 2022
115. On the fatigue ductile-brittle transition of EA4T steel for high-speed railway axle
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Tian, Z., Yin, H., Meng, Y., and Zhao, Z
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- 2022
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116. Effect of Early Swimming on the Behavior and Striatal Transcriptome of the Shank3 Knockout Rat Model of Autism
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Meng Y, Xu D, Zhang W, Meng W, Lan XY, Wang X, Li M, Zhang X, Zhao Y, Yang H, Zhang R, and Zhen Z
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shank3 ,autism ,early swimming ,behavior ,transcriptome ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Yunchen Meng,1 Dan Xu,1 Weinan Zhang,1 Wenshu Meng,2 Xingyu Lan,3 Xiaoxi Wang,3 Mingjuan Li,3 Xiaoyan Zhang,1 Yu Zhao,1 Haodong Yang,1 Rong Zhang,3– 6 Zhiping Zhen1 1College of P.E and Sports, Beijing Normal University, Beijing, People’s Republic of China; 2College of Life Sciences, Beijing Normal University, Beijing, People’s Republic of China; 3Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, People’s Republic of China; 4Neuroscience Research Institute, Peking University, Beijing, People’s Republic of China; 5Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing, People’s Republic of China; 6Autism Research Center of Peking University Health Science Center, Beijing, People’s Republic of ChinaCorrespondence: Zhiping Zhen; Rong Zhang, Email zzpxt@bnu.edu.cn; zhangrong@bjmu.edu.cnBackground: Autism spectrum disorder (ASD) is a developmental disorder characterized by social behavior deficits and stereotyped behaviors in childhood that lacks satisfactory medical intervention. Early swimming intervention is a noninvasive method combining enriched environment and exercise, which has been proven to improve brain development in young children and to treat neurodevelopmental diseases.Methods: In this study, we tested the autism-like behavior of rats with deletions in exons 11– 21 of the Shank3 gene and evaluated the effect of early swimming intervention (from postnatal day 8 to 60) on the behavior of this animal model of autism. In addition, the transcriptomes of the striatal tissues of wild-type, Shank3 knockout and Shank3 knockout swimming groups rats were analyzed.Results: Shank3 knockout rats exhibit core symptoms of autism, and early swimming improved the social and stereotyped behaviors in this autism rat model. Transcriptomics results revealed that compared to the wild-type group, 291 differentially expressed genes (DEGs) were identified in the striatum of the Shank3 knockout group. Compared to Shank3 knockout group, 534 DEGs were identified in the striatum of Shank3 knockout swimming group. The DEGs annotated by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway shows that the impacts of Shank3 deletion were primarily reflected in synaptic structure, development, morphology, receptor function and signaling, and swimming primarily changed the terms related to the synapses in the striatum of Shank3 knockout rats, including the morphology, structure, composition, development and regulation of synapses.Conclusion: Early swimming intervention can ameliorate behavioral abnormalities caused by Shank3 knockout, by a mechanism that may involve the process of striatal synaptic development and should be further investigated.Keywords: Shank3, autism, early swimming, behavior, transcriptome
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- 2022
117. Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS
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Yuan Y, Wang W, Zhang Y, Hong Q, Huang W, Li L, Xie Z, Chen Y, Li X, and Meng Y
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acute lung injury ,inflammation ,mice ,apelin-13 ,nadph oxidase 4 ,glycolysis ,pfkfb3 ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Yafei Yuan,1 Wei Wang,1 Yue Zhang,1 Qiaohui Hong,1 Wenhui Huang,1 Lijuan Li,1 Zhanzhan Xie,1 Yixin Chen,1 Xu Li,2,3 Ying Meng1 1Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 3Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, College of Emergency and Trauma, Hainan Medical University, Haikou, 571199, People’s Republic of ChinaCorrespondence: Ying Meng, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic of China, Tel/Fax +86 20-62787112, Email nfyymengy@163.com Xu Li, Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic of China, Email mylx99@163.comPurpose: Acute lung injury (ALI) is a life-threatening condition with limited therapeutic options. Macrophage inflammation plays a key role in the development of ALI. Abnormal glycolysis of macrophages contributes to the inflammatory response. However, the role of macrophage glycolysis in ALI still requires investigation. Apelin-13 has been shown to protect against ALI, whereas the underlying mechanisms remain unclear. In this study, we explored the effect of apelin-13 on lipopolysaccharide (LPS)-induced inflammation and ALI via regulation of glycolysis by modulating redox homeostasis in macrophages.Methods: Serums from 34 patients with sepsis and 13 healthy volunteers were analyzed. In vivo, the protective effect of apelin-13 against LPS-induced ALI was evaluated using a mouse model of LPS-induced ALI. In vitro, mouse bone marrow macrophages (BMDMs) were pretreated with the antioxidant, NADPH oxidase (NOX) 4 (NOX4) small-interfering RNA (siRNA), the 6-phosphofructo-2 -kinase/fructose- 2,6-biphosphatase 3 (PFKFB3) siRNA, or the PFKFB3 overexpression plasmid before exposure to LPS.Results: Serum apelin-13 levels were significantly elevated in patients with sepsis and sepsis-associated acute respiratory distress syndrome (ARDS) (P< 0.0001). In vivo, apelin-13 suppressed LPS-induced ALI and inflammatory cytokine production (P< 0.05). Furthermore, apelin-13 reduced hydrogen peroxide (H2O2) content, NOX4 protein levels, and glycolysis. In vitro, LPS stimulation elevated NOX4 protein levels and reactive oxygen species (ROS) production (P< 0.05). These changes resulted in the accumulation of glycolysis in BMDMs. Treatment with antioxidant or NOX4 siRNA inhibited LPS-induced glycolysis and inflammatory cytokine production (P< 0.05). Moreover, in vitro experiments revealed that PFKFB3 regulates the release of pro-inflammatory cytokines by modulating glycolysis. In contrast, the action of apelin-13 opposed the effects of LPS.Conclusion: In conclusion, apelin-13 protects against LPS-induced inflammatory responses and ALI by regulating PFKFB3-driven glycolysis induced by NOX4-dependent ROS.Keywords: acute lung injury, inflammation, mice, apelin-13, NADPH oxidase 4, glycolysis, PFKFB3
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- 2022
118. Effect of Continuous Positive Airway Pressure on Chronic Cough in Patients with Obstructive Sleep Apnea and Concomitant Gastroesophageal Reflux
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Su J, Fang Y, Meng Y, Zhao C, Liu Y, Sun L, Wang M, Dai L, and Ouyang S
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obstructive sleep apnea ,gastroesophageal reflux ,chronic cough ,continuous positive airway pressure ,Psychiatry ,RC435-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Jiao Su,1 Yifei Fang,1 Yang Meng,1 Chunling Zhao,1 Yanjun Liu,1 Linge Sun,1 Mengge Wang,1 Liping Dai,2 Songyun Ouyang1 1Department of Respiratory and Sleep Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China; 2Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of ChinaCorrespondence: Songyun OuyangDepartment of Respiratory and Sleep Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of ChinaTel +86 371-6629 5091Email ouyangsy@163.comBackground: Obstructive sleep apnea (OSA) and/or gastroesophageal reflux (GER) may be the contributors to chronic cough in patients with OSA and concomitant GER. This study aimed to explore whether continuous positive airway pressure (CPAP), antireflux treatment and lifestyle modifications improve chronic cough in patients with OSA and concomitant GER.Methods: Patients with OSA and concomitant GER who also experienced chronic cough were enrolled, and were divided into two groups. Patients who were treated with general treatment (antireflux treatment and lifestyle modifications) as the control group, and patients who were treated with CPAP and general treatment as the treatment group. Effects of different treatments on chronic cough were assessed, and the association among chronic cough, GER and OSA was evaluated by Pearson’s correlation analysis.Results: The Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale were better in the treatment group after 1 week of treatment; further, the improvement became stronger with the duration of therapy. The gastroesophageal reflux disease questionnaire, visual analog scale (VAS) for cough, and daytime and nighttime cough symptom scores significantly improved in both groups after treatment, whereas this improvement was more significant in the treatment group. Significant associations between the apnea-hypopnea index (AHI) and VAS, weak acid reflux and VAS, and weak acid reflux and AHI were observed.Conclusion: CPAP improved the symptoms of chronic cough and GER in patients with OSA and concomitant GER. AHI and weak acid reflux may be important factors affecting the therapeutic effect of chronic cough in patients with OSA and concomitant GER.Keywords: obstructive sleep apnea, gastroesophageal reflux, chronic cough, continuous positive airway pressure
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- 2022
119. Real-time monitoring for the next core-collapse supernova in JUNO
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Liu, Hui, Liu, Jianglai, Liu, Jiaxi, Liu, Jinchang, Liu, Min, Liu, Qian, Liu, Qin, Liu, Runxuan, Liu, Shenghui, Liu, Shubin, Liu, Shulin, Liu, Xiaowei, Liu, Xiwen, Liu, Xuewei, Liu, Yankai, Liu, Zhen, Lokhov, Alexey, Lombardi, Paolo, Lombardo, Claudio, Loo, Kai, Lu, Chuan, Lu, Haoqi, Lu, Jingbin, Lu, Junguang, Lu, Peizhi, Lu, Shuxiang, Lu, Xianguo, Lubsandorzhiev, Bayarto, Lubsandorzhiev, Sultim, Ludhova, Livia, Lukanov, Arslan, Luo, Daibin, Luo, Fengjiao, Luo, Guang, Luo, Jianyi, Luo, Shu, Luo, Wuming, Luo, Xiaojie, Lyashuk, Vladimir, Ma, Bangzheng, Ma, Bing, Ma, Qiumei, Ma, Si, Ma, Xiaoyan, Ma, Xubo, Maalmi, Jihane, Magoni, Marco, Mai, Jingyu, Malyshkin, Yury, Mandujano, Roberto Carlos, Mantovani, Fabio, Mao, Xin, Mao, Yajun, Mari, Stefano M., Marini, Filippo, Martini, Agnese, Mayer, Matthias, Mayilyan, Davit, Mednieks, Ints, Meng, Yue, Meraviglia, Anita, Meregaglia, Anselmo, Meroni, Emanuela, Meyhöfer, David, Miramonti, Lino, Mohan, Nikhil, Montuschi, Michele, Müller, Axel, Nastasi, Massimiliano, Naumov, Dmitry V., Naumova, Elena, Navas-Nicolas, Diana, Nemchenok, Igor, Thi, Minh Thuan Nguyen, Nikolaev, Alexey, Ning, Feipeng, Ning, Zhe, Nunokawa, Hiroshi, Oberauer, Lothar, Ochoa-Ricoux, Juan Pedro, Olshevskiy, Alexander, Orestano, Domizia, Ortica, Fausto, Othegraven, Rainer, Paoloni, Alessandro, Parmeggiano, Sergio, Pei, Yatian, Pelicci, Luca, Peng, Anguo, Peng, Haiping, Peng, Yu, Peng, Zhaoyuan, Perrot, Frédéric, Petitjean, Pierre-Alexandre, Petrucci, Fabrizio, Pilarczyk, Oliver, Rico, Luis Felipe Piñeres, Popov, Artyom, Poussot, Pascal, Previtali, Ezio, Qi, Fazhi, Qi, Ming, Qi, Xiaohui, Qian, Sen, Qian, Xiaohui, Qian, Zhen, Qiao, Hao, Qin, Zhonghua, Qiu, Shoukang, Qu, Manhao, Qu, Zhenning, Ranucci, Gioacchino, Rasheed, Reem, Re, Alessandra, Rebii, Abdel, Redchuk, Mariia, Ren, Bin, Ren, Jie, Ricci, Barbara, Rientong, Komkrit, Rifai, Mariam, Roche, Mathieu, Rodphai, Narongkiat, Romani, Aldo, Roskovec, Bedřich, Ruan, Xichao, Rybnikov, Arseniy, Sadovsky, Andrey, 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Dongmei, Xiao, Fei, Xiao, Xiang, Xie, Xiaochuan, Xie, Yuguang, Xie, Zhangquan, Xin, Zhao, Xing, Zhizhong, Xu, Benda, Xu, Cheng, Xu, Donglian, Xu, Fanrong, Xu, Hangkun, Xu, Jilei, Xu, Jing, Xu, Meihang, Xu, Xunjie, Xu, Yin, Xu, Yu, Yan, Baojun, Yan, Qiyu, Yan, Taylor, Yan, Xiongbo, Yan, Yupeng, Yang, Changgen, Yang, Chengfeng, Yang, Jie, Yang, Lei, Yang, Xiaoyu, Yang, Yifan, Yao, Haifeng, Ye, Jiaxuan, Ye, Mei, Ye, Ziping, Yermia, Frédéric, You, Zhengyun, Yu, Boxiang, Yu, Chiye, Yu, Chunxu, Yu, Guojun, Yu, Hongzhao, Yu, Miao, Yu, Xianghui, Yu, Zeyuan, Yu, Zezhong, Yuan, Cenxi, Yuan, Chengzhuo, Yuan, Ying, Yuan, Zhenxiong, Yue, Baobiao, Zafar, Noman, Zavadskyi, Vitalii, Zeng, Fanrui, Zeng, Shan, Zeng, Tingxuan, Zeng, Yuda, Zhan, Liang, Zhang, Aiqiang, Zhang, Bin, Zhang, Binting, Zhang, Feiyang, Zhang, Haosen, Zhang, Honghao, Zhang, Jialiang, Zhang, Jiawen, Zhang, Jie, Zhang, Jingbo, Zhang, Jinnan, ZHANG, Lei, Zhang, Mohan, Zhang, Peng, Zhang, Ping, Zhang, Qingmin, Zhang, Shiqi, Zhang, Shu, Zhang, Shuihan, Zhang, Siyuan, Zhang, Tao, Zhang, Xiaomei, Zhang, Xin, Zhang, Xuantong, Zhang, Yinhong, Zhang, Yiyu, Zhang, Yongpeng, Zhang, Yu, Zhang, Yuanyuan, Zhang, Yumei, Zhang, Zhenyu, Zhang, Zhijian, Zhao, Jie, Zhao, Rong, Zhao, Runze, Zhao, Shujun, Zheng, Dongqin, Zheng, Hua, Zheng, Yangheng, Zhong, Weirong, Zhou, Jing, Zhou, Li, Zhou, Nan, Zhou, Shun, Zhou, Tong, Zhou, Xiang, Zhu, Jingsen, Zhu, Kangfu, Zhu, Kejun, Zhu, Zhihang, Zhuang, Bo, Zhuang, Honglin, Zong, Liang, Zou, Jiaheng, Züfle, Jan, and null, null
- Abstract
The core-collapse supernova (CCSN) is considered one of the most energetic astrophysical events in the universe. The early and prompt detection of neutrinos before (pre-SN) and during the supernova (SN) burst presents a unique opportunity for multi-messenger observations of CCSN events. In this study, we describe the monitoring concept and present the sensitivity of the system to pre-SN and SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton liquid scintillator detector currently under construction in South China. The real-time monitoring system is designed to ensure both prompt alert speed and comprehensive coverage of progenitor stars. It incorporates prompt monitors on the electronic board as well as online monitors at the data acquisition stage. Assuming a false alert rate of 1 per year, this monitoring system exhibits sensitivity to pre-SN neutrinos up to a distance of approximately 1.6 (0.9) kiloparsecs and SN neutrinos up to about 370 (360) kiloparsecs for a progenitor mass of 30 solar masses, considering both normal and inverted mass ordering scenarios. The pointing ability of the CCSN is evaluated by analyzing the accumulated event anisotropy of inverse beta decay interactions from pre-SN or SN neutrinos. This, along with the early alert, can play a crucial role in facilitating follow-up multi-messenger observations of the next galactic or nearby extragalactic CCSN.
- Published
- 2024
120. Preparation and performance study of magnetorheological (MR) foam
- Author
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Huang, J. F., Meng, Y. F., Huang, J. F., and Meng, Y. F.
- Abstract
Porous material performs good deformation compression and has been widely used in soft actuators and sensors. In this study, a new kind of magnetorheological (MR) sponge was prepared by combining carbonyl iron particles with polyurethane porous structure. The static compressive property of MR foam was studied using a commercial rheometer. The relationship between magnetic particle composition, magnetic field and rheological properties was summarized and analyzed. The research contributes to a deeper understanding of magnetorheological sponge materials, and provides inspiration and theoretical basis for the design of soft actuators ,which may provide inspiration for novel application field.
- Published
- 2024
121. Fluorine Chemistry in Rechargeable Batteries: Challenges, Progress, and Perspectives.
- Author
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Wang, Y, Yang, X, Meng, Y, Wen, Z, Han, R, Hu, X, Sun, B, Kang, F, Li, B, Zhou, D, Wang, C, Wang, G, Wang, Y, Yang, X, Meng, Y, Wen, Z, Han, R, Hu, X, Sun, B, Kang, F, Li, B, Zhou, D, Wang, C, and Wang, G
- Abstract
The renewable energy industry demands rechargeable batteries that can be manufactured at low cost using abundant resources while offering high energy density, good safety, wide operating temperature windows, and long lifespans. Utilizing fluorine chemistry to redesign battery configurations/components is considered a critical strategy to fulfill these requirements due to the natural abundance, robust bond strength, and extraordinary electronegativity of fluorine and the high free energy of fluoride formation, which enables the fluorinated components with cost effectiveness, nonflammability, and intrinsic stability. In particular, fluorinated materials and electrode|electrolyte interphases have been demonstrated to significantly affect reaction reversibility/kinetics, safety, and temperature tolerance of rechargeable batteries. However, the underlining principles governing material design and the mechanistic insights of interphases at the atomic level have been largely overlooked. This review covers a wide range of topics from the exploration of fluorine-containing electrodes, fluorinated electrolyte constituents, and other fluorinated battery components for metal-ion shuttle batteries to constructing fluoride-ion batteries, dual-ion batteries, and other new chemistries. In doing so, this review aims to provide a comprehensive understanding of the structure-property interactions, the features of fluorinated interphases, and cutting-edge techniques for elucidating the role of fluorine chemistry in rechargeable batteries. Further, we present current challenges and promising strategies for employing fluorine chemistry, aiming to advance the electrochemical performance, wide temperature operation, and safety attributes of rechargeable batteries.
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- 2024
122. Design of Solid Polycationic Electrolyte to Enable Durable Chloride-Ion Batteries.
- Author
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Yang, X, Fu, Z, Han, R, Lei, Y, Wang, S, Zhao, X, Meng, Y, Liu, H, Zhou, D, Aurbach, D, Wang, G, Yang, X, Fu, Z, Han, R, Lei, Y, Wang, S, Zhao, X, Meng, Y, Liu, H, Zhou, D, Aurbach, D, and Wang, G
- Abstract
The high energy density and cost-effectiveness of chloride-ion batteries (CIBs) make them promising alternatives to lithium-ion batteries. However, the development of CIBs is greatly restricted by the lack of compatible electrolytes to support cost-effective anodes. Herein, we present a rationally designed solid polycationic electrolyte (SPE) to enable room-temperature chloride-ion batteries utilizing aluminum (Al) metal as an anode. This SPE endows the CIB configuration with improved air stability and safety (i.e. free of flammability and liquid leakage). A high ionic conductivity (1.3×10-2 S cm-1 at 25 °C) has been achieved by the well-tailored solvation structure of the SPE. Meanwhile, the solid polycationic electrolyte ensures stable electrodes|electrolyte interfaces, which effectively inhibit the growth of dendrites on the Al anodes and degradation of the FeOCl cathodes. The Al|SPE|FeOCl chloride-ion batteries showcased a high discharge capacity around 250 mAh g-1 (based on the cathodes) and extended lifespan. Our electrolyte design opens a new avenue for developing low-cost chloride-ion batteries.
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- 2024
123. Effect of multilayer CrN/CrAlN coating on the corrosion and contact resistance behavior of 316L SS bipolar plate for high temperature proton exchange membrane fuel cell
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Mani, S. Pugal, Agilan, P., Kalaiarasan, M., Ravichandran, K., Rajendran, N., and Meng, Y.
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- 2022
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124. Nucleation of dislocations and their dynamics in layered oxides cathode materials during battery charging
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Singer, A., Hy, S., Zhang, M., Cela, D., Fang, C., Qiu, B., Xia, Y., Liu, Z., Ulvestad, A., Hua, N., Wingert, J., Liu, H., Sprung, M., Zozulya, A. V., Maxey, E., Harder, R., Meng, Y. S., and Shpyrko, O. G.
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Condensed Matter - Materials Science - Abstract
Defects and their interactions in crystalline solids often underpin material properties and functionality as they are decisive for stability, result in enhanced diffusion, and act as a reservoir of vacancies. Recently, lithium-rich layered oxides have emerged among the leading candidates for the next-generation energy storage cathode material, delivering 50 % excess capacity over commercially used compounds. Oxygen-redox reactions are believed to be responsible for the excess capacity, however, voltage fading has prevented commercialization of these new materials. Despite extensive research the understanding of the mechanisms underpinning oxygen-redox reactions and voltage fade remain incomplete. Here, using operando three-dimensional Bragg coherent diffractive imaging, we directly observe nucleation of a mobile dislocation network in nanoparticles of lithium-rich layered oxide material. Surprisingly, we find that dislocations form more readily in the lithium-rich layered oxide material as compared with a conventional layered oxide material, suggesting a link between the defects and the anomalously high capacity in lithium-rich layered oxides. The formation of a network of partial dislocations dramatically alters the local lithium environment and contributes to the voltage fade. Based on our findings we design and demonstrate a method to recover the original high voltage functionality. Our findings reveal that the voltage fade in lithium-rich layered oxides is reversible and call for new paradigms for improved design of oxygen-redox active materials.
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- 2017
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125. Optical and structural study of the pressure-induced phase transition of CdWO$_4$
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Ruiz-Fuertes, J., Friedrich, A., Errandonea, D., Segura, A., Morgenroth, W., Rodriguez-Hernandez, P., Muñoz, A., and Meng, Y.
- Subjects
Condensed Matter - Materials Science - Abstract
The optical absorption of CdWO$_4$ is reported at high pressures up to 23 GPa. The onset of a phase transition was detected at 19.5 GPa, in good agreement with a previous Raman spectroscopy study. The crystal structure of the high-pressure phase of CdWO$_4$ was solved at 22 GPa employing single-crystal synchrotron x-ray diffraction. The symmetry changes from space group $P$2/$c$ in the low-pressure wolframite phase to $P2_1/c$ in the high-pressure post-wolframite phase accompanied by a doubling of the unit-cell volume. The octahedral oxygen coordination of the tungsten and cadmium ions is increased to [7]-fold and [6+1]-fold, respectively, at the phase transition. The compressibility of the low-pressure phase of CdWO$_4$ has been reevaluated with powder x-ray diffraction up to 15 GPa finding a bulk modulus of $B_0$ = 123 GPa. The direct band gap of the low-pressure phase increases with compression up to 16.9 GPa at 12 meV/GPa. At this point an indirect band gap crosses the direct band gap and decreases at -2 meV/GPa up to 19.5 GPa where the phase transition starts. At the phase transition the band gap collapses by 0.7 eV and another direct band gap decreases at -50 meV/GPa up to the maximum measured pressure. The structural stability of the post-wolframite structure is confirmed by \textit{ab initio} calculations finding the post-wolframite-type phase to be more stable than the wolframite at 18 GPa. Lattice dynamic calculations based on space group $P2_1/c$ explain well the Raman-active modes previously measured in the high-pressure post-wolframite phase. The pressure-induced band gap crossing in the wolframite phase as well as the pressure dependence of the direct band gap in the high-pressure phase are further discussed with respect to the calculations., Comment: 9 pages, 9 figures
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- 2017
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126. LUX-ZEPLIN (LZ) Technical Design Report
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Mount, B. J., Hans, S., Rosero, R., Yeh, M., Chan, C., Gaitskell, R. J., Huang, D. Q., Makkinje, J., Malling, D. C., Pangilinan, M., Rhyne, C. A., Taylor, W. C., Verbus, J. R., Kim, Y. D., Lee, H. S., Lee, J., Leonard, D. S., Li, J., Belle, J., Cottle, A., Lippincott, W. H., Markley, D. J., Martin, T. J., Sarychev, M., Tope, T. E., Utes, M., Wang, R., Young, I., Araújo, H. M., Bailey, A. J., Bauer, D., Colling, D., Currie, A., Fayer, S., Froborg, F., Greenwood, S., Jones, W. G., Kasey, V., Khaleeq, M., Olcina, I., Paredes, B. López, Richards, A., Sumner, T. J., Tomás, A., Vacheret, A., Brás, P., Lindote, A., Lopes, M. I., Neves, F., Rodrigues, J. P., Silva, C., Solovov, V. N., Barry, M. J., Cole, A., Dobi, A., Edwards, W. R., Faham, C. H., Fiorucci, S., Gantos, N. J., Gehman, V. M., Gilchriese, M. G. D., Hanzel, K., Hoff, M. D., Kamdin, K., Lesko, K. T., McConnell, C. T., O'Sullivan, K., Oliver-Mallory, K. C., Patton, S. J., Saba, J. S., Sorensen, P., Thomas, K. J., Tull, C. E., Waldron, W. L., Witherell, M. S., Bernstein, A., Kazkaz, K., Xu, J., Akimov, D. Yu., Bolozdynya, A. I., Khromov, A. V., Konovalov, A. M., Kumpan, A. V., Sosnovtsev, V. V., Dahl, C. E., Temples, D., Carmona-Benitez, M. C., de Viveiros, L., Akerib, D. S., Auyeung, H., Biesiadzinski, T. P., Breidenbach, M., Bramante, R., Conley, R., Craddock, W. W., Fan, A., Hau, A., Ignarra, C. M., Ji, W., Krebs, H. J., Linehan, R., Lee, C., Luitz, S., Mizrachi, E., Monzani, M. E., O'Neill, F. G., Pierson, S., Racine, M., Ratcliff, B. N., Shutt, G. W., Shutt, T. A., Skarpaas, K., Stifter, K., To, W. H., Va'vra, J., Whitis, T. J., Wisniewski, W. J., Bai, X., Bunker, R., Coughlen, R., Hjemfelt, C., Leonard, R., Miller, E. H., Morrison, E., Reichenbacher, J., Schnee, R. W., Stark, M. R., Sundarnath, K., Tiedt, D. R., Timalsina, M., Bauer, P., Carlson, B., Horn, M., Johnson, M., Keefner, J., Maupin, C., Taylor, D. J., Balashov, S., Ford, P., Francis, V., Holtom, E., Khazov, A., Kaboth, A., Majewski, P., Nikkel, J. A., O'Dell, J., Preece, R. M., van der Grinten, M. G. D., Worm, S. D., Mannino, R. L., Stiegler, T. M., Terman, P. A., Webb, R. C., Levy, C., Mock, J., Szydagis, M., Busenitz, J. K., Elnimr, M., Hor, J. Y-K., Meng, Y., Piepke, A., Stancu, I., Kreczko, L., Krikler, B., Penning, B., Bernard, E. P., Jacobsen, R. G., McKinsey, D. N., Watson, R., Cutter, J. E., El-Jurf, S., Gerhard, R. M., Hemer, D., Hillbrand, S., Holbrook, B., Lenardo, B. G., Manalaysay, A. G., Morad, J. A., Stephenson, S., Thomson, J. A., Tripathi, M., Uvarov, S., Haselschwardt, S. J., Kyre, S., Nehrkorn, C., Nelson, H. N., Solmaz, M., White, D. T., Cascella, M., Dobson, J. E. Y., Ghag, C., Liu, X., Manenti, L., Reichhart, L., Shaw, S., Utku, U., Beltrame, P., Davison, T. J. R., Marzioni, M. F., Murphy, A. St. J., Nilima, A., Boxer, B., Burdin, S., Greenall, A., Powell, S., Rose, H. J., Sutcliffe, P., Balajthy, J., Edberg, T. K., Hall, C. R., Silk, J. S., Hertel, S., Akerlof, C. W., Arthurs, M., Lorenzon, W., Pushkin, K., Schubnell, M., Boast, K. E., Carels, C., Fruth, T., Kraus, H., Liao, F. -T., Lin, J., Scovell, P. R., Druszkiewicz, E., Khaitan, D., Koyuncu, M., Skulski, W., Wolfs, F. L. H., Yin, J., Korolkova, E. V., Kudryavtsev, V. A., Rossiter, P., Woodward, D., Chiller, A. A., Chiller, C., Mei, D. -M., Wang, L., Wei, W. -Z., While, M., Zhang, C., Alsum, S. K., Benson, T., Carlsmith, D. L., Cherwinka, J. J., Dasu, S., Gregerson, G., Gomber, B., Pagac, A., Palladino, K. J., Vuosalo, C. O., Xiao, Q., Buckley, J. H., Bugaev, V. V., Olevitch, M. A., Boulton, E. M., Emmet, W. T., Hurteau, T. W., Larsen, N. A., Pease, E. K., Tennyson, B. P., and Tvrznikova, L.
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Physics - Instrumentation and Detectors ,Astrophysics - Instrumentation and Methods for Astrophysics ,High Energy Physics - Experiment - Abstract
In this Technical Design Report (TDR) we describe the LZ detector to be built at the Sanford Underground Research Facility (SURF). The LZ dark matter experiment is designed to achieve sensitivity to a WIMP-nucleon spin-independent cross section of three times ten to the negative forty-eighth square centimeters., Comment: 392 pages. Submitted to the Department of Energy as part of the documentation for the Critical Decision Numbers Two and Three (CD-2 and CD-3) management processes. Report also available by chapter at this URL
- Published
- 2017
127. Online $^{222}$Rn removal by cryogenic distillation in the XENON100 experiment
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XENON Collaboration, Aprile, E., Aalbers, J., Agostini, F., Alfonsi, M., Amaro, F. D., Anthony, M., Arneodo, F., Barrow, P., Baudis, L., Bauermeister, B., Benabderrahmane, M. L., Berger, T., Breur, P. A., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Bütikofer, L., Calvén, J., Cardoso, J. M. R., Cervantes, M., Cichon, D., Coderre, D., Colijn, A. P., Conrad, J., Cussonneau, J. P., Decowski, M. P., de Perio, P., Di Gangi, P., Di Giovanni, A., Diglio, S., Duchovni, E., Eurin, G., Fei, J., Ferella, A. D., Fieguth, A., Franco, D., Fulgione, W., Rosso, A. Gallo, Galloway, M., Gao, F., Garbini, M., Geis, C., Goetzke, L. W., Grandi, L., Greene, Z., Grignon, C., Hasterok, C., Hogenbirk, E., Itay, R., Kaminsky, B., Kessler, G., Kish, A., Landsman, H., Lang, R. F., Lellouch, D., Levinson, L., Calloch, M. Le, Lin, Q., Lindemann, S., Lindner, M., Manfredini, J. A. M. Lopes A., Maris, I., Undagoitia, T. Marrodán, Masbou, J., Massoli, F. V., Masson, D., Mayani, D., Meng, Y., Messina, M., Micheneau, K., Miguez, B., Molinario, A., Murra, M., Naganoma, J., Ni, K., Oberlack, U., Orrigo, S. E. A., Pakarha, P., Pelssers, B., Persiani, R., Piastra, F., Pienaar, J., Piro, M. -C., Pizzella, V., Plante, G., Priel, N., Rauch, L., Reichard, S., Reuter, C., Rizzo, A., Rosendahl, S., Rupp, N., Saldanha, R., Santos, J. M. F. dos, Sartorelli, G., Scheibelhut, M., Schindler, S., Schreiner, J., Schumann, M., Lavina, L. Scotto, Selvi, M., Shagin, P., Shockley, E., Silva, M., Simgen, H., Sivers, M. v., Stein, A., Thers, D., Tiseni, A., Trinchero, G., Tunnell, C., Upole, N., Wang, H., Wei, Y., Weinheimer, C., Wulf, J., Ye, J., Zhang, Y., and Cristescu, I.
- Subjects
Physics - Instrumentation and Detectors - Abstract
We describe the purification of xenon from traces of the radioactive noble gas radon using a cryogenic distillation column. The distillation column is integrated into the gas purification loop of the XENON100 detector for online radon removal. This enabled us to significantly reduce the constant $^{222}$Rn background originating from radon emanation. After inserting an auxiliary $^{222}$Rn emanation source in the gas loop, we determined a radon reduction factor of R > 27 (95% C.L.) for the distillation column by monitoring the $^{222}$Rn activity concentration inside the XENON100 detector.
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- 2017
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128. Identification of Radiopure Titanium for the LZ Dark Matter Experiment and Future Rare Event Searches
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Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alsum, S. K., Araújo, H. M., Arnquist, I. J., Arthurs, M., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Barry, M. J., Belle, J., Beltrame, P., Benson, T., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boast, K. E., Bolozdynya, A., Boxer, B., Bramante, R., Brás, P., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Cottle, A., Coughlen, R., Craddock, W. W., Currie, A., Dahl, C. E., Davison, T. J. R., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edberg, T. K., Edwards, W. R., Emmet, W. T., Faham, C. H., Fiorucci, S., Fruth, T., Gaitskell, R. J., Gantos, N. J., Gehman, V. M., Gerhard, R. M., Ghag, C., Gilchriese, M. G. D., Gomber, B., Hall, C. R., Hans, S., Hanzel, K., Haselschwardt, S. J., Hertel, S. A., Hillbrand, S., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hoppe, E. W., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Jacobsen, R. G., Ji, W., Kaboth, A., Kamdin, K., Kazkaz, K., Khaitan, D., Khazov, A., Khromov, A. V., Konovalov, A. M., Korolkova, E. V., Koyuncu, M., Kraus, H., Krebs, H. J., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lee, C., Lee, H. S., Lee, J., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Liao, F. -T., Lin, J., Lindote, A., Linehan, R. E., Lippincott, W. H., Liu, X., Lopes, M. I., Paredes, B. Lopez, Lorenzon, W., Luitz, S., Majewski, P., Manalaysay, A., Manenti, L., Mannino, R. L., Markley, D. J., Martin, T. J., Marzioni, M. F., McConnell, C. T., McKinsey, D. N., Mei, D. -M., Meng, Y., Miller, E. H., Mizrachi, E., Mock, J., Monzani, M. E., Morad, J. A., Mount, B. J., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., Nikkel, J. A., O'Dell, J., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Piepke, A., Powell, S., Preece, R. M., Pushkin, K., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Saba, J. S., Sarychev, M., Schnee, R. W., Schubnell, M., Scovell, P. R., Shaw, S., Shutt, T. A., Silva, C., Skarpaas, K., Skulski, W., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stiegler, T. M., Stifter, K., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Temples, D., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tvrznikova, L., Va'vra, J., Vacheret, A., van der Grinten, M. G. D., Verbus, J. R., Vuosalo, C. O., Waldron, W. L., Wang, R., Watson, R., Webb, R. C., Wei, W. -Z., While, M., White, D. T., Whitis, T. J., Wisniewski, W. J., Witherell, M. S., Wolfs, F. L. H., Woodward, D., Worm, S., Xu, J., Yeh, M., Yin, J., and Zhang, C.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The LUX-ZEPLIN (LZ) experiment will search for dark matter particle interactions with a detector containing a total of 10 tonnes of liquid xenon within a double-vessel cryostat. The large mass and proximity of the cryostat to the active detector volume demand the use of material with extremely low intrinsic radioactivity. We report on the radioassay campaign conducted to identify suitable metals, the determination of factors limiting radiopure production, and the selection of titanium for construction of the LZ cryostat and other detector components. This titanium has been measured with activities of $^{238}$U$_{e}$~$<$1.6~mBq/kg, $^{238}$U$_{l}$~$<$0.09~mBq/kg, $^{232}$Th$_{e}$~$=0.28\pm 0.03$~mBq/kg, $^{232}$Th$_{l}$~$=0.25\pm 0.02$~mBq/kg, $^{40}$K~$<$0.54~mBq/kg, and $^{60}$Co~$<$0.02~mBq/kg (68\% CL). Such low intrinsic activities, which are some of the lowest ever reported for titanium, enable its use for future dark matter and other rare event searches. Monte Carlo simulations have been performed to assess the expected background contribution from the LZ cryostat with this radioactivity. In 1,000 days of WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute only a mean background of $0.160\pm0.001$(stat)$\pm0.030$(sys) counts., Comment: 13 pages, 3 figures, accepted for publication in Astroparticle Physics
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- 2017
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129. Formation damage remediation with novel blend of anionic-cationic surfactants in high temperature and low permeability sandstone reservoirs.
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Li, Yingcheng, Li, Q., Zhang, W., Jin, J., Bao, X., Meng, Y., Zhang, X., Wu, X., Zhang, L., Guo, R., He, X., Shen, Z., Cui, L., and Sha, O.
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LOW temperatures ,PERMEABILITY ,HIGH temperatures ,SURFACE active agents ,SANDSTONE ,ANIONIC surfactants ,CATIONIC surfactants - Abstract
Formation damage caused by organic contaminates is one of the most important issues that undermine well injectivity and productivity. Anionic surfactants are commonly used to mobilize the organic contaminates trapped by capillary forces. The electrostatic repulsion between anionic surfactant heads reduces the surfactant density at the oil-water interface, consequently reducing the interfacial efficiency. In this paper, a novel surfactant blend of anionic-cationic surfactants (S
a/c ) was designed and showed much higher efficiency than traditional ones because of the strong electrostatic attraction between anionic and cationic surfactants. The oil-water interfacial tension (IFT) was reduced to 3 × 10−4 mN/m, and the viscosity of crude oil was reduced by 92%. In addition, the freezing point of the residual oil was decreased by 20.9%. Moreover, Sa/c altered the wettability and inhibited the clay swelling. Field applications were conducted in sandstone reservoirs at temperatures of about 120 °C and permeabilities below 10 mD. The average injection pressure drops were greater than 30%. The findings of this study can help for better understanding the advantages of Sa/c with high interfacial activity and revealed that formation damage caused by the organic contaminates in high temperature and low permeability sandstone reservoirs can be effectively remediated by this novel surfactant blend. [ABSTRACT FROM AUTHOR]- Published
- 2024
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130. Property Analysis of Laser Welded Dissimilar Q345D/20Mn2 Steel Joints.
- Author
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Li, X. X., Li, J. H., Yao, F. P., and Meng, Y. Y.
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LASER welding ,DISSIMILAR welding ,STEEL welding ,STEEL ,WELDING ,POWDERS - Abstract
A fibre laser was used to weld Q345D/20Mn2 dissimilar steel with and without a Ni60 powder filler. Finite element (FE) simulation of the temperature and stress fields in the laser beam welding (LBW) was conducted COMSOL. Experimental investigation determined the effect of Ni-based powder filled welding on the microstructure, morphology, element content, microhardness and fracture morphology of the weld cross-section. The results show that when the laser power was 2700 W, the scanning speed was 1 mm/s and the out-of-focus amount was 0 mm, the tensile properties of Q345D/20Mn2 steel welds were optimal and deformation was minimal. Under such conditions the depth of the weld pool can reach 2.7 mm and the width 2.8 mm. After the Ni-based powder melts and penetrates the bottom of the base material (BM) along the weld seam, small cytosolic, equiaxed and columnar crystal grains can be observed near the fusion line, and the Ni-based filler powder can achieve a good metallurgical bond with the BM. The location of tensile fracture is at the weld and small tough nests can be observed in the cross-section leading to judgment that the fracture mode is ductile. [ABSTRACT FROM AUTHOR]
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- 2024
131. Removing krypton from xenon by cryogenic distillation to the ppq level
- Author
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XENON Collaboration, Aprile, E., Aalbers, J., Agostini, F., Alfonsi, M., Amaro, F. D., Anthony, M., Arneodo, F., Barrow, P., Baudis, L., Bauermeister, B., Benabderrahmane, M. L., Berger, T., Breur, P. A., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Bütikofer, L., Calvén, J., Cardoso, J. M. R., Cervantes, M., Cichon, D., Coderre, D., Colijn, A. P., Conrad, J., Cussonneau, J. P., Decowski, M. P., de Perio, P., Di Gangi, P., Di Giovanni, A., Diglio, S., Duchovni, E., Eurin, G., Fei, J., Ferella, A. D., Fieguth, A., Franco, D., Fulgione, W., Rosso, A. Gallo, Galloway, M., Gao, F., Garbini, M., Geis, C., Goetzke, L. W., Grandi, L., Greene, Z., Grignon, C., Hasterok, C., Hogenbirk, E., Itay, R., Kaminsky, B., Kessler, G., Kish, A., Landsman, H., Lang, R. F., Lellouch, D., Levinson, L., Calloch, M. Le, Lin, Q., Lindemann, S., Lindner, M., Manfredini, J. A. M. Lopes A., Maris, I., Undagoitia, T. Marrodán, Masbou, J., Massoli, F. V., Masson, D., Mayani, D., Meng, Y., Messina, M., Micheneau, K., Miguez, B., Molinario, A., Murra, M., Naganoma, J., Ni, K., Oberlack, U., Orrigo, S. E. A., Pakarha, P., Pelssers, B., Persiani, R., Piastra, F., Pienaar, J., Piro, M. -C., Pizzella, V., Plante, G., Priel, N., Rauch, L., Reichard, S., Reuter, C., Rizzo, A., Rosendahl, S., Rupp, N., Saldanha, R., Santos, J. M. F. dos, Sartorelli, G., Scheibelhut, M., Schindler, S., Schreiner, J., Schumann, M., Lavina, L. Scotto, Selvi, M., Shagin, P., Shockley, E., Silva, M., Simgen, H., Sivers, M. v., Stein, A., Thers, D., Tiseni, A., Trinchero, G., Tunnell, C., Upole, N., Wang, H., Wei, Y., Weinheimer, C., Wulf, J., Ye, J., Zhang, Y., and Cristescu, I.
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Physics - Instrumentation and Detectors - Abstract
The XENON1T experiment aims for the direct detection of dark matter in a cryostat filled with 3.3 tons of liquid xenon. In order to achieve the desired sensitivity, the background induced by radioactive decays inside the detector has to be sufficiently low. One major contributor is the $\beta$-emitter $^{85}$Kr which is an intrinsic contamination of the xenon. For the XENON1T experiment a concentration of natural krypton in xenon $\rm{^{nat}}$Kr/Xe < 200 ppq (parts per quadrillion, 1 ppq = 10$^{-15}$ mol/mol) is required. In this work, the design of a novel cryogenic distillation column using the common McCabe-Thiele approach is described. The system demonstrated a krypton reduction factor of 6.4$\cdot$10$^5$ with thermodynamic stability at process speeds above 3 kg/h. The resulting concentration of $\rm{^{nat}}$Kr/Xe < 26 ppq is the lowest ever achieved, almost one order of magnitude below the requirements for XENON1T and even sufficient for future dark matter experiments using liquid xenon, such as XENONnT and DARWIN.
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- 2016
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132. Results from a Calibration of XENON100 Using a Source of Dissolved Radon-220
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The XENON Collaboration, Aprile, E., Aalbers, J., Agostini, F., Alfonsi, M., Amaro, F. D., Anthony, M., Arneodo, F., Barrow, P., Baudis, L., Bauermeister, B., Benabderrahmane, M. L., Berger, T., Breur, P. A., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Butikofer, L., Calven, J., Cardoso, J. M. R., Cervantes, M., Cichon, D., Coderre, D., Colijn, A. P., Conrad, J., Cussonneau, J. P., Decowski, M. P., dePerio, P., DiGangi, P., DiGiovanni, A., Diglio, S., Duchovni, E., Eurin, G., Fei, J., Ferella, A. D., Fieguth, A., Franco, D., Fulgione, W., Rosso, A. Gallo, Galloway, M., Gao, F., Garbini, M., Geis, C., Goetzke, L. W., Grandi, L., Greene, Z., Grignon, C., Hasterok, C., Hogenbirk, E., Itay, R., Kaminsky, B., Kessler, G., Kish, A., Landsman, H., Lang, R. F., Lellouch, D., Levinson, L., LeCalloch, M., Lin, Q., Lindemann, S., Lindner, M., Lopes, J. A. M., Manfredini, A., Maris, I., Undagoitia, T. Marrodan, Masbou, J., Massoli, F. V., Masson, D., Mayani, D., Meng, Y., Messina, M., Micheneau, K., Miguez, B., Molinario, A., Murra, M., Naganoma, J., Ni, K., Oberlack, U., Orrigo, S. E. A., Pakarha, P., Pelssers, B., Persiani, R., Piastra, F., Pienaar, J., Piro, M. -C., lante, G. P, Priel, N., Rauch, L., Reichard, S., Reuter, C., Rizzo, A., Rosendahl, S., Rupp, N., Saldanha, R., dosSantos, J. M. F., Sartorelli, G., Scheibelhut, M., Schindler, S., Schreiner, J., Schumann, M., Lavina, L. Scotto, Selvi, M., Shagin, P., Shockley, E., Silva, M., Simgen, H., Sivers, M. v., Stein, A., Thers, D., Tiseni, A., Trinchero, G., Tunnell, C., Upole, N., Wang, H., Wei, Y., Weinheimer, C., Wulf, J., Ye, J., and Zhang, Y.
- Subjects
Physics - Instrumentation and Detectors - Abstract
A Rn-220 source is deployed on the XENON100 dark matter detector in order to address the challenges in calibration of tonne-scale liquid noble element detectors. We show that the Pb-212 beta emission can be used for low-energy electronic recoil calibration in searches for dark matter. The isotope spreads throughout the entire active region of the detector, and its activity naturally decays below background level within a week after the source is closed. We find no increase in the activity of the troublesome Rn-222 background after calibration. Alpha emitters are also distributed throughout the detector and facilitate calibration of its response to Rn-222. Using the delayed coincidence of Rn-220/Po-216, we map for the first time the convective motion of particles in the XENON100 detector. Additionally, we make a competitive measurement of the half-life of Po-212, t = 293.9+-(1.0)+-(0.6) ns.
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- 2016
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133. Predicting Calendar Aging in Lithium Metal Secondary Batteries: The Impacts of Solid Electrolyte Interphase Composition and Stability
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Wood, Sean M, Fang, Chengcheng, Dufek, Eric J, Nagpure, Shrikant C, Sazhin, Sergiy V, Liaw, Boryann, and Meng, Y Shirley
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electrolyte volume ,electrolyte salt concentration ,lithium metal calendar life ,rechargeable lithium batteries ,solid electrolyte interphase (SEI) layer stability ,Aging ,Macromolecular and Materials Chemistry ,Materials Engineering ,Interdisciplinary Engineering - Published
- 2018
134. Batteries: Predicting Calendar Aging in Lithium Metal Secondary Batteries: The Impacts of Solid Electrolyte Interphase Composition and Stability (Adv. Energy Mater. 26/2018)
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Wood, Sean M, Fang, Chengcheng, Dufek, Eric J, Nagpure, Shrikant C, Sazhin, Sergiy V, Liaw, Boryann, and Meng, Y Shirley
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Affordable and Clean Energy ,Macromolecular and Materials Chemistry ,Materials Engineering ,Interdisciplinary Engineering - Published
- 2018
135. Localized High-Concentration Sulfone Electrolytes for High-Efficiency Lithium-Metal Batteries
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Ren, Xiaodi, Chen, Shuru, Lee, Hongkyung, Mei, Donghai, Engelhard, Mark H, Burton, Sarah D, Zhao, Wengao, Zheng, Jianming, Li, Qiuyan, Ding, Michael S, Schroeder, Marshall, Alvarado, Judith, Xu, Kang, Meng, Y Shirley, Liu, Jun, Zhang, Ji-Guang, and Xu, Wu
- Subjects
Affordable and Clean Energy ,Macromolecular and Materials Chemistry - Abstract
To enable next-generation high-energy-density lithium (Li)-metal batteries (LMBs), an electrolyte that has simultaneous high Li-metal Coulombic efficiency (CE) and high anodic stability on cathodes is of significant importance. Sulfones are known for strong resistance against oxidation, yet their application in LMBs is restricted because of their poor compatibility with Li-metal anodes, high viscosity, and poor wettability. Here, we demonstrate that a high Li CE over 98% can be achieved in concentrated sulfone-based electrolytes. Furthermore, the viscosity and wettability issues of sulfones are resolved by the addition of a fluorinated ether, 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether, to form a localized high-concentration electrolyte (LHCE), which not only provides further improvement in Li CE (98.8%) but also remains anodically stable with high-voltage cathodes, suppresses Al corrosion, and enables LMBs to operate in a wide temperature range. As a result, significantly improved cycling performance of LMBs has been realized with sulfone-based LHCE. For high-voltage rechargeable lithium (Li)-metal batteries (LMBs), electrolytes with good stabilities on both the highly oxidative cathodes and the highly reductive Li-metal anodes are urgently desired. Sulfones have excellent oxidative stability, yet their high viscosity, poor wettability, and, in particular, incompatibility with Li anodes greatly hinder their applications in LMBs. Here, we demonstrate that a high Li Coulombic efficiency (CE) of 98.2% during repeated Li plating and stripping cycles can be realized in concentrated lithium bis(fluorosulfonyl)imide (LiFSI)-tetramethylene sulfone electrolyte. More importantly, the localized high-concentration electrolyte, formed by the dilution of the high-concentration electrolyte with a non-solvating fluorinated ether, 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether, solves the viscosity and wettability issues, further improves Li CE (98.8%), and improves the high-voltage (4.9 V) performance of LMBs with effective Al protection. High-voltage batteries with Li-metal anodes can offer desirable high energy densities. Despite their excellent oxidative stability, sulfones have various limitations to be useful in Li-metal batteries, in particular their instability with Li metal. Here, we achieved a high Li Coulombic efficiency of nearly 99% in a sulfone-based localized high-concentration electrolyte (LHCE) with the addition of a non-solvating co-solvent. In addition, this co-solvent is highly beneficial for realizing stable battery cycling up to 4.9 V.
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- 2018
136. Intercalation and Conversion Reactions of Nanosized β‑MnO2 Cathode in the Secondary Zn/MnO2 Alkaline Battery
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Seo, Joon Kyo, Shin, JaeWook, Chung, Hyeseung, Meng, Po Yu, Wang, Xuefeng, and Meng, Y Shirley
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Affordable and Clean Energy ,Chemical Sciences ,Engineering ,Technology ,Physical Chemistry - Published
- 2018
137. Intercalation and Conversion Reactions of Nanosized beta-MnO2 Cathode in the Secondary Zn/MnO2 Alkaline Battery
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Seo, Joon Kyo, Shin, JaeWook, Chung, Hyeseung, Meng, Po Yu, Wang, Xuefeng, and Meng, Y Shirley
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Physical Chemistry ,Engineering ,Chemical Sciences ,Technology - Published
- 2018
138. Constraining radon backgrounds in LZ
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Miller, EH, Busenitz, J, Edberg, TK, Ghag, C, Hall, C, Leonard, R, Lesko, K, Liu, X, Meng, Y, Piepke, A, and Schnee, RW
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Nuclear and Plasma Physics ,Physical Sciences ,physics.ins-det - Abstract
The LZ dark matter detector, like many other rare-event searches, will suffer from backgrounds due to the radioactive decay of radon daughters. In order to achieve its science goals, the concentration of radon within the xenon should not exceed 2 μBq/kg, or 20 mBq total within its 10 tonnes. The LZ collaboration is in the midst of a program to screen all significant components in contact with the xenon. The four institutions involved in this effort have begun sharing two cross-calibration sources to ensure consistent measurement results across multiple distinct devices. We present here five preliminary screening results, some mitigation strategies that will reduce the amount of radon produced by the most problematic components, and a summary of the current estimate of radon emanation throughout the detector. This best estimate totals < 17.3 mBq, sufficiently low to meet the detector's science goals.
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- 2018
139. Effects of electrode pattern on thermal runaway of lithium-ion battery
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Wang, Meng, Le, Anh V, Noelle, Daniel J, Shi, Yang, Yoon, Hyojung, Zhang, Minghao, Meng, Y Shirley, and Qiao, Yu
- Subjects
Affordable and Clean Energy ,Thermal runaway ,lithium-ion battery ,electrode pattern ,impact ,nail penetration ,Civil Engineering ,Materials Engineering ,Mechanical Engineering ,Mechanical Engineering & Transports - Abstract
In the current study, through a set of nail penetration and impact tests on modified lithium-ion battery coin half-cells, we examine the effects of electrode pattern on the heat generation behaviors associated with internal shorting. The results show that the temperature profile is quite insensitive to the openings in cathode layer, which may be attributed to the high specific energy as well as the secondary conductive paths. This finding will considerably influence the study in the area of thermal runaway mitigation of energy storage systems.
- Published
- 2018
140. Modified Frailty Index Independently Predicts Postoperative Pulmonary Infection in Elderly Patients Undergoing Radical Gastrectomy for Gastric Cancer
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Meng Y, Zhao P, and Yong R
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gastric cancer ,elderly ,radical gastrectomy ,postoperative pulmonary ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Yongsheng Meng, Pengfei Zhao, Rong Yong Department of Anesthesiology, Taizhou People’s Hospital, Taizhou, Jiangsu, People’s Republic of ChinaCorrespondence: Rong YongDepartment of Anesthesiology, Taizhou People’s Hospital, No.366, Taihu Road, Taizhou Pharmaceutical High-Tech Zone, Taizhou, 225300, Jiangsu Province, People’s Republic of ChinaEmail tz_134233591@126.comBackground: Pulmonary infection is one of the most common postoperative complications after radical gastrectomy for gastric cancer (GC) and is associated with a poorer prognosis. This study aimed to investigate potential predictive factors for pulmonary infection in elderly GC patients.Methods: This study retrospectively enrolled 346 elderly GC patients undergoing elective radical gastrectomy between January 2017 and December 2020. Pulmonary infection within postoperative 30 days was set as the primary observational endpoint. The baseline demographic, clinicopathological, and laboratory data were compared between patients with or without pulmonary infection. ROC curves were plotted to evaluate the cut-off and predictive values of factors. Binary univariate and multivariate logistic regression analyses were employed to determine risk factors for postoperative pulmonary infection.Results: Of the enrolled 346 patients, pulmonary infection was observed in 51 patients within postoperative 30 days, with an incidence of 14.7%. mFI was a significant predictor for pulmonary infection by ROC curve analysis (AUC: 0.770, P < 0.001). Moreover, preoperative mFI was the only independent risk factor for pulmonary infection (OR: 2.72, 95% CI: 2.02– 3.31, P = 0.011) by univariate and multivariate logistic regression analyses.Conclusion: Our study indicates that mFI independently predicts pulmonary infection in elderly GC patients.Keywords: gastric cancer, elderly, radical gastrectomy, postoperative pulmonary infection, modified frailty index
- Published
- 2021
141. Concurrence of Gastric Cancer and Incidental Pulmonary Embolism May Be a Prognostic Factor for Advanced Gastric Cancer Patients with Incidental Pulmonary Embolism
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Qiu M, Meng Y, Wang H, Sun L, Liu Z, Kan S, Wang T, and Zhang S
- Subjects
incidental pulmonary embolism ,gastric cancer ,anticoagulation therapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Meiqing Qiu,1– 3 Ying Meng,3 Huijun Wang,3 Li Sun,3 Zhen Liu,3 Shifeng Kan,2 Tao Wang,2 Shu Zhang3 1Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Oncology, Zaozhuang Municipal Hospital, Zaozhuang, 277100, People’s Republic of China; 3Department of Gastroenterology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People’s Republic of ChinaCorrespondence: Shu ZhangDepartment of Gastroenterology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People’s Republic of ChinaTel/ Fax +86-531-67626836Email zhangshu@csco.org.cnObjective: Cancer is well known as the most important risk factor for the emergence of pulmonary embolism (PE). The incidence of incidental PE (IPE) has increased with widely use of multi-detector-row computed tomography (CT) technology. Simultaneously, more new cancer patients diagnosed concomitantly with IPE are found. No study has examined the presentation and prognosis of incidental pulmonary embolism (IPE) in gastric cancer patients. The aim of this study was to analyse prognostic factors in patients with advanced gastric cancer complicated with IPE.Patients and Methods: Ninety patients with histologically confirmed advanced gastric adenocarcinoma diagnosed with IPE were enrolled. Continuous variables were compared using Student’s t-test or the Mann–Whitney U-test if non-normally distributed. The Chi-squared test (or Fisher’s exact test where appropriate) was used to compare categorical variables. The Kaplan–Meier method and the Log rank test were used for survival analysis. Independent prognostic factors for survival were determined using a Cox proportional hazards model. A two-sided P-value < 0.05 was considered statistically significant.Results: Nineteen patients were diagnosed with IPE concomitantly with gastric cancer. Concurrence of gastric cancer and IPE, lack of anticoagulation therapy, and location of IPE were associated with survival. After adjusting for age and sex, the concurrence of gastric cancer and IPE, lack of anticoagulation, and central IPE independently influenced the survival of advanced gastric cancer patients with IPE. Subgroup analysis of patients with peripheral pulmonary embolisms confirmed that anticoagulant therapy provided a survival benefit.Conclusion: Concurrence of gastric cancer and IPE may be a prognostic factor for advanced gastric cancer patients with IPE.Keywords: incidental pulmonary embolism, gastric cancer, anticoagulation therapy
- Published
- 2021
142. Green Synthesized Gold Nanoparticles Using Viola betonicifolia Leaves Extract: Characterization, Antimicrobial, Antioxidant, and Cytobiocompatible Activities
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Wang M, Meng Y, Zhu H, Hu Y, Xu CP, Chao X, Li W, Pan C, and Li C
- Subjects
viola betonicifolia ,gold nps ,antimicrobial ,biofilm inhibition ,antioxidant ,Medicine (General) ,R5-920 - Abstract
Mincong Wang,1,* Yue Meng,1,* Huifeng Zhu,1 Yong Hu,1 Chang-Peng Xu,2 Xiaomin Chao,1 Wenqiang Li,3 Chengguo Li,1 Chenglong Pan1 1Department of Joint Surgery, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, People’s Republic of China; 3Engineering Technology Research Center for Sports Assistive Devices of Guangdong, Guangzhou Sport University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chenglong Pan; Chengguo Li Email pclgjwk@163.com; 356846516@qq.comIntroduction: Viola betonicifolia is a rich source of numerous secondary metabolites, such as alkaloids, flavonoids, tannins, phenolic compounds, saponins, triterpenoids, and so on, that are biologically active towards different potential biomedical applications. To broaden the potential use of Viola betonicifolia in the realm of bionanotechnology, we investigated the plant’s ability to synthesize gold nanoparticles (Au NPs) in a green and efficient manner for the very first time.Methods: The gold nanoparticles (VB-Au NPs) were synthesized using the leaves extract of Viola betonicifolia, in which plant’s secondary metabolites function as both reducing and capping agents. The VB-Au NPs were successfully characterized with spectroscopic techniques. The antimicrobial properties of the VB-Au NPs were further explored against bacterial and mycological species. Additionally, their antioxidant, cytotoxic, and cytobiocompatibility properties were examined in vitro against linoleic acid peroxidation, MCF-7 cancer cells, and human mesenchymal stem cells (hMSCs), respectively.Results: Results demonstrated that VB-Au NPs presented excellent antibacterial, antifungal, and biofilm inhibition performance against all the tested microbial species compared to plant leaves extract and commercially purchased chemically synthesized gold NPs (CH-Au NPs). Moreover, they also exhibited significant antioxidant potential, comparable to the external standard. The VB-Au NPs displayed good cytobiocompatibility with hMSCs and demonstrated excellent cytotoxic potential against MCF-7 cancer cells compared to CH-Au NPs. The current work presents a green method for synthesizing VB-Au NPs with enhanced antioxidant, antimicrobial, cytotoxic and biofilm inhibition efficacy compared to CH-Au NPs might be attributed to the synergistic effect of the nanoparticle’s physical properties and the adsorbed biologically active phytomolecules from the plant leaves extract on their surface.Conclusion: Thus, our study establishes a novel ecologically acceptable route for nanomaterials’ fabrication with increased and/or extra medicinal functions derived from their herbal origins.Keywords: Viola betonicifolia, gold NPs, antimicrobial, biofilm inhibition, antioxidant
- Published
- 2021
143. The β3/5 Integrin-MMP9 Axis Regulates Pulmonary Inflammatory Response and Endothelial Leakage in Acute Lung Injury
- Author
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Tong Y, Bao C, Xu YQ, Tao L, Zhou Y, Zhuang L, Meng Y, Zhang H, Xue J, Wang W, Zhang L, Pan Q, Shao Z, Hu T, Guo Q, Xue Q, Lu H, and Luo Y
- Subjects
acute lung injury ,endothelial cells ,integrin ,mmp-9 ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Yao Tong,* Chengrong Bao,* Yi-Qiong Xu,* Lei Tao,* Yao Zhou, Lei Zhuang, Ying Meng, Hui Zhang, Jingjing Xue, Weijun Wang, Lele Zhang, Qingbo Pan, Zhenzhen Shao, Tianran Hu, Qian Guo, Qingsheng Xue, Han Lu, Yan Luo Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Luo; Han Lu Email ly11087@rjh.com.cn; luhan0301@163.comBackground: Acute lung injury (ALI) is a severe respiratory disease with high rates of morbidity and mortality. Many mediators regarding endogenous or exogenous are involved in the pathophysiology of ALI. Here, we have uncovered the involvement of integrins and matrix metalloproteinases, as critical determinants of excessive inflammation and endothelial permeability, in the regulation of ALI.Methods: Inflammatory cytokines were measured by quantitative real-time PCR for mRNA levels and ELISA for secretion levels. Endothelial permeability assay was detected by the passage of rhodamine B isothiocyanate-dextran. Mice lung permeability was assayed by Evans blue albumin (EBA). Western blot was used for protein level measurements. The intracellular reactive oxygen species (ROS) were evaluated using a cell-permeable probe, DCFH-DA. Intratracheal injection of lipopolysaccharide (LPS) into mice was conducted to establish the lung injury model.Results: Exogenous MMP-9 significantly aggravated the inflammatory response and permeability in mouse pulmonary microvascular endothelial cells (PMVECs) treated by LPS, whereas knockdown of MMP-9 exhibited the opposite phenotypes. Knockdown of integrin β 3 or β 5 in LPS-treated PMVECs significantly downregulated MMP-9 expression and decreased inflammatory response and permeability in the presence or absence of exogenous MMP-9. Additionally, the interaction of MMP-9 and integrin β 5 was impaired by a ROS scavenger, which further decreased the pro-inflammatory cytokines production and endothelial leakage in PMVECs subjected to co-treatment (LPS with exogenous MMP-9). In vivo studies, exogenous MMP-9 treatment or knockdown β 3 integrin significantly decreased survival in ALI mice. Notably, knockdown of β 5 integrin alone had no remarkable effect on survival, but which combined with anti-MMP-9 treatment significantly improved the survival by ameliorating excessive lung inflammation and permeability in ALI mice.Conclusion: These findings support the β 3/5 integrin-MMP-9 axis as an endogenous signal that could play a pivotal role in regulating inflammatory response and alveolar-capillary permeability in ALI.Keywords: acute lung injury, endothelial cells, integrin, MMP-9
- Published
- 2021
144. Role of Crystal Symmetry in the Reversibility of Stacking-Sequence Changes in Layered Intercalation Electrodes
- Author
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Radin, Maxwell D, Alvarado, Judith, Meng, Y Shirley, and Van der Ven, Anton
- Subjects
Li-ion batteries ,Na-ion batteries ,layered materials ,two-dimensional materials ,fracture ,Nanoscience & Nanotechnology - Abstract
The performance of many technologies, such as Li- and Na-ion batteries as well as some two-dimensional (2D) electronics, is dependent upon the reversibility of stacking-sequence-change phase transformations. However, the mechanisms by which such transformations lead to degradation are not well understood. This study explores lattice-invariant shear as a source of irreversibility in stacking-sequence changes, and through an analysis of crystal symmetry shows that common electrode materials (graphitic carbon, layered oxides, and layered sulfides) are generally susceptible to lattice-invariant shear. The resulting irreversible changes to microstructure upon cycling ("electrochemical creep") could contribute to the degradation of the electrode and capacity fade.
- Published
- 2017
145. Revisiting the conversion reaction voltage and the reversibility of the CuF2 electrode in Li-ion batteries
- Author
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Seo, Joon Kyo, Cho, Hyung-Man, Takahara, Katsunori, Chapman, Karena W, Borkiewicz, Olaf J, Sina, Mahsa, and Shirley Meng, Y
- Subjects
Affordable and Clean Energy ,Li-ion battery ,conversion material ,reaction voltage ,nanoparticle ,reversibility ,coating ,Nanoscience & Nanotechnology - Published
- 2017
146. Using high‐HFP‐content cathode binder for mitigation of heat generation of lithium‐ion battery
- Author
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Le, Anh V, Wang, Meng, Noelle, Daniel J, Shi, Yang, Meng, Y Shirley, Wu, Dengguo, Fan, Jiang, and Qiao, Yu
- Subjects
binder ,electrode ,lithium-ion battery ,PVDF-HFP ,thermal runaway ,Chemical Engineering ,Electrical and Electronic Engineering ,Mechanical Engineering ,Energy - Published
- 2017
147. Narrowing the Gap between Theoretical and Practical Capacities in Li-Ion Layered Oxide Cathode Materials
- Author
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Radin, Maxwell D, Hy, Sunny, Sina, Mahsa, Fang, Chengcheng, Liu, Haodong, Vinckeviciute, Julija, Zhang, Minghao, Whittingham, M Stanley, Meng, Y Shirley, and Van der Ven, Anton
- Subjects
energy storage ,layered oxides ,Li-ion batteries ,phase transformations ,Macromolecular and Materials Chemistry ,Materials Engineering ,Interdisciplinary Engineering - Published
- 2017
148. Three-Dimensional Nanoscale Mapping of State-of-the-Art Field-Effect Transistors (FinFETs)
- Author
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Parikh, Pritesh, Senowitz, Corey, Lyons, Don, Martin, Isabelle, Prosa, Ty J, DiBattista, Michael, Devaraj, Arun, and Meng, Y Shirley
- Subjects
Engineering ,Nanotechnology ,atom probe tomography ,finFET ,energy-dispersive X-ray spectroscopy ,chemical mapping ,correlative microscopy ,Condensed Matter Physics ,Biochemistry and Cell Biology ,Materials Engineering ,Microscopy ,Biochemistry and cell biology ,Materials engineering - Abstract
The semiconductor industry has seen tremendous progress over the last few decades with continuous reduction in transistor size to improve device performance. Miniaturization of devices has led to changes in the dopants and dielectric layers incorporated. As the gradual shift from two-dimensional metal-oxide semiconductor field-effect transistor to three-dimensional (3D) field-effect transistors (finFETs) occurred, it has become imperative to understand compositional variability with nanoscale spatial resolution. Compositional changes can affect device performance primarily through fluctuations in threshold voltage and channel current density. Traditional techniques such as scanning electron microscope and focused ion beam no longer provide the required resolution to probe the physical structure and chemical composition of individual fins. Hence advanced multimodal characterization approaches are required to better understand electronic devices. Herein, we report the study of 14 nm commercial finFETs using atom probe tomography (APT) and scanning transmission electron microscopy-energy-dispersive X-ray spectroscopy (STEM-EDS). Complimentary compositional maps were obtained using both techniques with analysis of the gate dielectrics and silicon fin. APT additionally provided 3D information and allowed analysis of the distribution of low atomic number dopant elements (e.g., boron), which are elusive when using STEM-EDS.
- Published
- 2017
149. Ultrafast carrier and phonon dynamics in Bi2Se3 under high pressure
- Author
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Yang, Y., primary, Meng, Y. H., additional, Lu, B. R., additional, Jin, F., additional, Shi, Y. G., additional, Hong, F., additional, Zhang, S. S., additional, Yu, X. H., additional, Wang, X. B., additional, and Luo, J. L., additional
- Published
- 2024
- Full Text
- View/download PDF
150. Subwavelength broadband perfect absorption for unidimensional open-duct problems
- Author
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Meng, Y., primary, Romero-Garcia, V., additional, Gabard, G., additional, Bricault, C., additional, Goudé, S., additional, and Groby, J.-P., additional
- Published
- 2024
- Full Text
- View/download PDF
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