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1. RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8.

Author

Takayuki Imanishi, Midori Unno, Natsumi Yoneda, Yasutaka Motomura, Miho Mochizuki, Takaharu Sasaki, Manolis Pasparakis, and Takashi Saito

Subjects
*T-cell exhaustion, *SARCOPENIA, *T cells, *CELL death, *CASPASES, *APOPTOSIS, *REGULATORY T cells
Abstract

The article discusses a research study which found that T cell–specific Receptor-interacting protein kinase 1 (RIPK1) deficiency leads to the premature senescence in T cells, which is accompanied by the senescent-associated secretory phenotype (SASP). The study also clarified the function of RIPK3 and caspase-8 in inducing CD4 T cell senescence, which is modulated by environmental signals.

Published
2023
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