1. Chiral Proton-Transfer Shuttle Catalysts Promoted Enantio-selective Nazarov Cyclization.
- Author
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Cao, Jin and Zhu, Shou-Fei
- Subjects
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RING formation (Chemistry) , *BRONSTED acids , *CATALYSTS , *ACID catalysts , *LEWIS acids , *PHOSPHORIC acid , *CARBONYL compounds , *CATALYSIS - Abstract
The Nazarov cyclization reaction is a convenient, widely used method for the synthesis of cyclopentenones. In this account, we reviewed our recent efforts on the chiral proton-transfer shuttle catalysts promoted enantioselective Nazarov cyclization. We have synthesized various chiral cyclopenta[ b ]indoles and chiral α,α′-disubstituted cyclopentenones by means of cooperative catalysis of a Lewis acid and a chiral spiro phosphoric acid. The mechanistic studies revealed that the chiral spiro phosphoric acid acts as a multifunctional catalyst: it co-catalyzes the cyclization of the dienone and enantioselectively catalyzes a proton-transfer reaction of the enol intermediate via a hydrogen--bonding network. 1 Introduction 2 Enantioselective Nazarov Cyclization of Indole Enones 3 Enantioselective Silicon-Directed Nazarov Cyclization 4 Conclusion [ABSTRACT FROM AUTHOR]
- Published
- 2023
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