1. Regulatory effect of isovitexin on MAPK/NF-κB signal in mice with acute ulcerative colitis.
- Author
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Liu, Ming-Xiu, Li, Ting, Wang, Wei-Guang, Guo, Jing, Wang, Rui-Rui, He, Hong-Ping, Li, Shu-Quan, and Li, Yan-Ping
- Subjects
ULCERATIVE colitis ,EXPERIMENTAL design ,IN vivo studies ,ANIMAL experimentation ,ONE-way analysis of variance ,IMMUNOHISTOCHEMISTRY ,NF-kappa B ,CELLULAR signal transduction ,T-test (Statistics) ,COMPARATIVE studies ,FLAVONES ,DESCRIPTIVE statistics ,RESEARCH funding ,ENZYME-linked immunosorbent assay ,FLUORESCENT antibody technique ,MITOGEN-activated protein kinases ,MOLECULAR structure ,DATA analysis software ,ACUTE diseases ,MICE - Abstract
The aim of this study was to investigate the anti-inflammatory effects and mechanism of isovitexin on ulcerative colitis mice and RAW264.7 cells. The results showed that isovitexin had strong antioxidant and anti-inflammatory effects, and could restore intestinal barrier integrity (p < 0.01). In addition, isovitexin inhibited the expression of MyD88, TLR4 and NF-κB p65 proteins. At the same time, isovitexin can inhibit the activation of MAPK/NF-κB signaling pathway in RAW264.7 cells. In conclusion, isovitexin has a protective effect on UC mice, and its improvement mechanism of UC might be related to MAPK/NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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