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[Prenatal diagnosis of Thailand deletion of alpha-thalassemia 1].
- Source :
-
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2007 Jun; Vol. 24 (3), pp. 247-50. - Publication Year :
- 2007
-
Abstract
- Objective: To conduct prenatal diagnosis on the couples carrying Thailand deletion (--THAI) alpha-thalassemia 1 and at high risk of having fetus with alpha-thalassemia.<br />Methods: Genotypes of couples and fetuses were analyzed by PCR and DNA sequencing.<br />Results: Four pregnant women were patients with Hb H diseases of --THAI compounding with alpha-thalassemia 2, while their husbands were heterozygote of the Southeast Asian type alpha-thalassemia 1 (--SEA). Another 5 families, either husbands or wives were heterozygote of --THAI or --SEA. The genotypes of their fetuses were as follows: 2 cases with Hb Bart's hydrops fetalis syndrome, 1 Hb H disease, 4 alpha-thalassemia heterozygote and 2 normal. The DNA sequencing approved the PCR results.<br />Conclusion: The study on prenatal diagnosis of Thailand deletion alpha-thalassemia 1 is of importance to the genetic counseling and prenatal diagnosis of alpha-thalassemia.
- Subjects :
- Adult
Base Sequence
Female
Fetal Diseases blood
Genotype
Hemoglobins analysis
Humans
Male
Pregnancy
Sequence Analysis, DNA
alpha-Thalassemia blood
Fetal Diseases diagnosis
Fetal Diseases genetics
Prenatal Diagnosis
Sequence Deletion genetics
alpha-Thalassemia diagnosis
alpha-Thalassemia genetics
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1003-9406
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 17557230