5 results on '"Zhu, Hao"'
Search Results
2. Influence of age on the relationship between apixaban concentration and anti-factor Xa activity in older patients with non-valvular atrial fibrillation
- Author
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Kalaria, Shamir N, Zhu, Hao, Liu, Qi, Florian, Jeffrey, Wang, Yaning, and Schwartz, Janice
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Clinical Research ,Aging ,Cardiovascular ,Adult ,Aged ,Anticoagulants ,Atrial Fibrillation ,Factor Xa Inhibitors ,Humans ,Pyrazoles ,Pyridones ,Retrospective Studies ,Stroke ,Exposure-response ,Apixaban ,Non-valvular atrial fibrillation ,Geriatrics ,Anti-Factor Xa activity ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology - Abstract
Background/objectivesDespite lower major bleeding rates associated with direct oral anticoagulants (DOACs) as compared to conventional warfarin therapy, bleeding rates remain higher in older patients compared to younger patients suggesting a potential role for DOAC measurements. The objective of this study is to examine the effect of age on the relationship between apixaban concentrations and anti-Factor Xa activity in patients with non-valvular atrial fibrillation (NVAF).MethodsThis is a retrospective analysis based on a database created using data from the ARISTOTLE study. Outpatient, stable adult patients with NVAF receiving apixaban were included in this study. Data collection consisted of apixaban concentration, anti-Factor Xa activity, age, weight, creatinine, and co-medications.ResultsThe database composed of 2058 patients receiving apixaban. Distribution of race, NVAF subtype, and aspirin use was fairly similar across each age quantile. Older patients received a higher number of co-medications and received the 2.5 mg apixaban dose more often as compared to younger patients (22% vs. < 1%). Linear regression demonstrated that the unadjusted slope for apixaban concentration effect on anti-Factor Xa activity was similar across each age quantile. Although, the overall adjusted linear regression analysis demonstrated that the age by concentration interaction was statistically significant, relative differences in anti-Factor Xa activity (< 8%) were not clinically meaningful.ConclusionData on apixaban concentrations and anti-Factor Xa activity from a pivotal randomized double-blind study of apixaban for the prevention of stroke in NVAF patients have confirmed that the chromogenic anti-Factor Xa activity assay can accurately assess apixaban concentrations in patients regardless of age. Age was not associated with a clinically relevant change in the apixaban vs. anti-Factor Xa activity response relationship and target ranges are unchanged.
- Published
- 2021
3. Temporal evolution of microstructure and its influence on micromechanical and tribological properties of Stellite-6 cladding under aging treatment.
- Author
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Xiong, Jiankun, Guo, Yang, Nie, Fuheng, Mao, Guijun, Yang, Jianping, Zhou, Qinghua, Zhu, Hao, and Li, Xia
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FIELD emission electron microscopes ,NANOINDENTATION ,NANOINDENTATION tests ,WEAR resistance ,SURFACE preparation ,MICROSTRUCTURE ,AGING - Abstract
The degradation of components resulted from wear is unavoidable in service, which could be partly solved by applying surface treatment technique. Stellite-6 cobalt-based alloy is considered as a potential cladding material to improve the wear resistance of base materials owing to its excellent hardness and strength. The microstructural evolution and local mechanical properties of Co-rich matrix and Cr-rich eutectic carbide of Stellite-6 cladding with different aging times at 900 °C are investigated by optical microscopy, field emission scanning electron microscope and nanoindentation testing. The tribological characteristics of the matrix and eutectic carbide itself are systematically investigated using the single-pass nano-scratch testing. In the matrix region, the carbide precipitations occur after 5 h and coarsens after 10 h aging. The nanoindentation results indicate that the hardness of the matrix regions is significantly increased due to the presence of dispersed carbide and fine stripe-like precipitations. The nano-scratch tests depict that the wear resistance is improved with higher matrix hardness to support eutectic carbide based on aging treatment. Potential improvement on tribological performance through the aging treatment procedure is proved based on the micromechanical and wear behaviors of matrix and eutectic carbide were identified. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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4. Prognostic Value of a New Integrated Parameter—Both Collateral Circulation and Permeability Surface—in Hemorrhagic Transformation of Middle Cerebral Artery Occlusion Acute Ischemic Stroke: Retrospective Cohort Study
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Zhenwei Yao, Yan-Mei Yang, Chengfeng Sun, Chan-Chan Li, Xiao-Zhu Hao, Xiaoyuan Feng, Hai Yu, and Luyi Lin
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Aging ,medicine.medical_specialty ,Cognitive Neuroscience ,perfusion imaging ,Perfusion scanning ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Internal medicine ,Medicine ,angiography ,cardiovascular diseases ,collateral circulation ,Stroke ,Original Research ,cerebral hemorrhage ,medicine.diagnostic_test ,business.industry ,Aging Neuroscience ,Area under the curve ,Retrospective cohort study ,Odds ratio ,Collateral circulation ,medicine.disease ,stroke ,Confidence interval ,Angiography ,Cardiology ,business ,RC321-571 - Abstract
BackgroundMultimodal CT, including CT angiography (CTA) and CT perfusion (CTP), was increasingly used in stroke triage. This study was to determine the relationship between a new integrated parameter—both collateral circulation and relative permeability surface (PS)—and the hemorrhagic transformation (HT) in acute ischemic stroke (AIS) with middle cerebral artery occlusion (MCAO).MethodsWe retrospectively reviewed consecutive AIS patients with MCAO who underwent baseline CTA/CTP within 4 h of symptom onset and follow-up susceptibility-weighted imaging (SWI) within 3 weeks. Collateral circulation was assessed on the baseline CTA. Baseline CTP data were postprocessed to generate PS parameter. The patients with poor collateral circulation and at the same time with high relative PS were classified as the group of both poor collateral circulation and high relative PS. HT was defined according to European Cooperative Acute Stroke Study II criteria on follow-up SWI imaging. Multivariate logistic regression analysis was performed using HT as an outcome variable.ResultsThe group of patients with both poor collateral circulation and high relative PS was thirteen and thirty-three (52%) developed HT of the final cohort sixty-three AIS patients with MCAO. Multivariate logistic analysis revealed the new integrated parameter—both collateral circulation and relative PS (odds ratio, 16.59; 95% confidence interval, 13.09–19.10; P < 0.001) was independent predictor of HT. The area under the curve was 0.85 (95% confidence interval, 0.81–0.89). The sensitivity was 57%, specificity 97% and positive predictive value 92%, negative predictive value 58%.ConclusionsFor AIS patients with MCAO, these with poor collateral circulation on CTA and at the same time with high relative PS on CTP were at high risk for HT.
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- 2021
5. Abnormal Gray Matter Structural Networks in Idiopathic Normal Pressure Hydrocephalus
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Le-Kang Yin, Jia-Jun Zheng, Jia-Qi Tian, Xiao-Zhu Hao, Chan-Chan Li, Jian-Ding Ye, Yu-Xuan Zhang, Hong Yu, and Yan-Mei Yang
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medicine.medical_specialty ,normal pressure hydrocephalus ,Aging ,Cognitive Neuroscience ,network modularity ,Neurological disorder ,030218 nuclear medicine & medical imaging ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,Betweenness centrality ,Normal pressure hydrocephalus ,Internal medicine ,medicine ,Dementia ,magnetic resonance imaging ,structural networks ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Original Research ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Limbic lobe ,gray matter ,medicine.disease ,(Idiopathic) normal pressure hydrocephalus ,Right posterior ,Cardiology ,business ,030217 neurology & neurosurgery ,Neuroscience - Abstract
Purpose: Idiopathic normal pressure hydrocephalus (iNPH) is known as a treatable form of dementia. Network analysis is emerging as a useful method to study neurological disorder diseases. No study has examined changes of structural brain networks of iNPH patients. We aimed to investigate alterations in the gray matter (GM) structural network of iNPH patients compared with normal elderly volunteers.Materials and Methods: Structural networks were reconstructed using covariance between regional GM volumes extracted from three-dimensional T1-weighted images of 29 possible iNPH patients and 30 demographically similar normal-control (NC) participants and compared with each other.Results: Global network modularity was significantly larger in the iNPH network (P < 0.05). Global network measures were not significantly different between the two networks (P > 0.05). Regional network analysis demonstrated eight nodes with significantly decreased betweenness located in the bilateral frontal, right temporal, right insula and right posterior cingulate regions, whereas only the left anterior cingulate was detected with significantly larger betweenness. The hubs of the iNPH network were mostly located in temporal areas and the limbic lobe, those of the NC network were mainly located in frontal areas.Conclusions: Network analysis was a promising method to study iNPH. Increased network modularity of the iNPH group was detected here, and modularity analysis should be paid much attention to explore the biomarker to select shunting-responsive patients.
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- 2018
- Full Text
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