1. Characterization and Pathogenicity of the Novel Porcine Reproductive and Respiratory Syndrome Virus 1 Strain SL-01 in China.
- Author
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Zheng, Jiaying, Wu, Yu, Gao, Xiaopeng, Lin, Limiao, Chang, Hao, Zhu, Guojun, Fang, Siyun, Li, Wei, Ren, Bohua, Li, Qunhui, and Zhang, Xiangbin
- Subjects
PORCINE reproductive & respiratory syndrome ,ANIMAL herds ,SWINE farms - Abstract
Currently, PRRSV-1 causes a large number of clinical infections in Chinese swine herds, and the prevalence of new strains has presented great challenges. In this study, the novel PRRSV-1 strain SL-01 was isolated, with a genome length of 14,978 bp, and genetic evolution analysis revealed that it belonged to a new subtype branch. Sequence homology analysis showed that the strain was only 82.2%–86.7% identical to the current classical PRRSV-1 strains. In particular, the novel strain exhibited a unique deletion pattern in Nsp2. In addition, GP3 and GP4 of the SL-01 strain showed four consecutive amino acid deletions in the highly variable regions at amino acids 243–248 and 63–68, respectively. Further challenges in piglet and pregnant sow demonstrated that the SL-01 strain could cause the piglet fever and death but less pathogenic to pregnant sow. Overall, the characterization and pathogenicity of a novel PRRSV-1 strain were first explored and provide a prevention for pig farms. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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