Based on domestic high-resolution remote sensing images, this paper carried out remote sensing monitoring of human activities in the scope of management and protection of hydraulic engineering works and downstream flood channels. On this basis, it analyzed the interactive relationship between human activities and the security of engineering flood control and proposed the risk assessment methods and models of human activities in hydraulic engineering works. Lastly, an application demonstration was shown by using Hekoucun Reservoir as an example. The monitoring results show that there are less human activities within the scope of the reservoir management and protection, but more human activities within the scope of the downstream Qinhe River management and protection. After the completion and acceptance of the project, human activities within the scope of the reservoir management and protection are decreased, while human activities within the scope of the downstream Qinhe River management and protection are increased. Before and after the flood season, there is no significant change in human activities within the scope of the reservoir management and protection, but in the scope of downstream Qinhe River management and protection, human activities are affected by heavy rainfall, and the occupied area changed. After calculation, the average interference index of the reservoir is 17.6, and that of Qinhe River is 67.22. After the completion and acceptance of the project, the interference index of the reservoir is decreased significantly, while the interference index of Qinhe River is increased slightly. Before and after the flood season, the interference index of human activities in Hekoucun Reservoir remains unchanged, and the interference index of Qinhe River human activity fluctuates to a certain extent. Application demonstration proves that remote sensing technology can effectively monitor the risk sources of human activities in water conservancy projects during operation, and can quantitatively assess the impact of risk sources of human activities on flood control of hydraulic engineering works. [ABSTRACT FROM AUTHOR]