1. Large Pre-and Postexercise Rapid- Acting Insulin Reductions Preserve Glycemia and Prevent Early - but Not Late-Onset Hypoglycemia in Patients With Type 1 Diabetes.
- Author
-
CAMPBELL, MATTHEW D., WALKER, MARK, TRENELL, MICHAEL I., JAKOVLJEVIC, DJORDJE G., STEVENSON, EMMA J., BRACKEN, RICHARD M., BAIN, STEPHEN C., and WEST, DANIEL J.
- Subjects
- *
INSULIN therapy , *DIABETES , *BLOOD sugar , *HYPOGLYCEMIA , *EXERCISE physiology - Abstract
OBJECTIVE -- To examine the acute and 24-h glycemic responses to reductions in postexercise rapid-acting insulin dose in type 1 diabetic patients. RESEARCH DESIGN AND METHODS -- After preliminary testing, 11 male patients d (24 ± 2 years, HbA1c 7.7 ± 0.3%; 61 ± 3.4 mmol/mol) attended the laboratory on three mornings. Patients consumed a standardized breakfast (1 g carbohydrate ⋅ kg-1 BM; 380 ± 10 kcal) and self-administered a 25% rapid-acting insulin dose 60 min prior to performing 45 min of treadmill running at 72.5 ± 0.9% VO2peak. At 60 min postexercise, patients ingested a meal (1 g carbohydrate ⋅ kg-1 BM; 660 ± 21 kcal) and administered a Full, 75%, or 50% rapid-acting insulin dose. Blood glucose concentrations were measured for 3 h postmeal. Interstitial glucose was recorded for 20 h after leaving the laboratory using a continuous glucosemonitoring system. RESULTS -- All glycemic responses were similar across conditions up to 60 min postexercise. d After the postexercise meal, blood glucose was preserved under 50%, but declined under Full and 75%. Thence at 3 h, blood glucose was highest under 50%(50%[10.4 ± 1.2] vs. Full [6.2±0.7] and 75% [7.6 ± 1.2 mmol ⋅ L ], P = 0.029); throughout this period, all patients were protected against hypoglycemia under 50%(blood glucose#3.9; Full, n =5 ;7 5%, n =2 ;5 0%, n = 0). Fifty percent continued to protect patients against hypoglycemia for a further 4 h under free-living conditions. However, late-evening and nocturnal glycemia were similar; as a consequence, late-onset hypoglycemia was experienced under all conditions. CONCLUSIONS -- A 25% pre-exercise and 50% postexercise rapid-acting insulin dose preserves glycemia and protects patients against early-onset hypoglycemia (≤8 h). However, this strategy does not protect against late-onset postexercise hypoglycemia. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF