13 results on '"Zoeller, R. Thomas"'
Search Results
2. Neuroendocrine effects of polychlorinated biphenyls (PCBs)
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Gore, Andrea C., primary, Zoeller, R. Thomas, additional, and Currás-Collazo, Margarita, additional
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- 2023
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3. Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort
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Hall, Meaghan, Lanphear, Bruce, Chevrier, Jonathan, Hornung, Rick, Green, Rivka, Goodman, Carly, Ayotte, Pierre, Martinez-Mier, Esperanza Angeles, Zoeller, R. Thomas, and Till, Christine
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- 2023
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4. Letter to the editor regarding Hall et al. (2023): Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort
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Hall, Meaghan, primary, Lanphear, Bruce, additional, Chevrier, Jonathan, additional, Hornung, Rick, additional, Green, Rivka, additional, Goodman, Carly, additional, Ayotte, Pierre, additional, Martinez-Mier, Esperanza Angeles, additional, Zoeller, R. Thomas, additional, and Till, Christine, additional
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- 2024
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5. The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA)
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vom Saal, Frederick S., primary, Antoniou, Michael, additional, Belcher, Scott M., additional, Bergman, Ake, additional, Bhandari, Ramji K., additional, Birnbaum, Linda S., additional, Cohen, Aly, additional, Collins, Terrence J., additional, Demeneix, Barbara, additional, Fine, Anne Marie, additional, Flaws, Jodi A., additional, Gayrard, Veronique, additional, Goodson, William H., additional, Gore, Andrea C., additional, Heindel, Jerrold J., additional, Hunt, Patricia A., additional, Iguchi, Taisen, additional, Kassotis, Christopher D., additional, Kortenkamp, Andreas, additional, Mesnage, Robin, additional, Muncke, Jane, additional, Myers, John Peterson, additional, Nadal, Angel, additional, Newbold, Retha R., additional, Padmanabhan, Vasantha, additional, Palanza, Paola, additional, Palma, Zandra, additional, Parmigiani, Stefano, additional, Patrick, Lyn, additional, Prins, Gail S., additional, Rosenfeld, Cheryl S., additional, Skakkebaek, Niels E., additional, Sonnenschein, Carlos, additional, Soto, Ana M., additional, Swan, Shanna H., additional, Taylor, Julia A., additional, Toutain, Pierre-Louis, additional, von Hippel, Frank A., additional, Welshons, Wade V., additional, Zalko, Daniel, additional, and Zoeller, R. Thomas, additional
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- 2024
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6. European Medicines Agency Conflicts With the European Food Safety Authority (EFSA) on Bisphenol A Regulation
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Zoeller, R Thomas, primary, Birnbaum, Linda S, additional, Collins, Terrence J, additional, Heindel, Jerrold, additional, Hunt, Patricia A, additional, Iguchi, Taisen, additional, Kortenkamp, Andreas, additional, Myers, John Peterson, additional, vom Saal, Frederick S, additional, Sonnenschein, Carlos, additional, and Soto, Ana M, additional
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- 2023
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7. A vision for safer food contact materials: public health concerns as drivers for improved testing
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Muncke, Jane, Andersson, Anna-Maria, Backhaus, Thomas, Belcher, Scott M., Boucher, Justin M., Carney Almroth, Bethanie, Collins, Terrence J., Geueke, Birgit, Groh, Ksenia J., Heindel, Jerrold J., von Hippel, Frank A., Legler, Juliette, Maffini, Maricel V., Martin, Olwenn V., Myers, John Peterson, Nadal, Angel, Nerin, Cristina, Soto, Ana M., Trasande, Leonardo, Vandenberg, Laura N., Wagner, Martin, Zimmermann, Lisa, Zoeller, R. Thomas, and Scheringer, Martin
- Abstract
Food contact materials and articles are ubiquitous in today’s globalized food system. Chemicals migrate from food contact materials into foodstuffs, but current regulatory requirements do not sufficiently protect public health from hazardous food contact chemicals (FCCs) because only individual substances used to make food contact materials are tested and mostly only for genotoxicity while endocrine disruption and other hazard properties are disregarded. Indeed, food contact materials are a known source of a wide range of hazardous chemicals, and they likely contribute to highly prevalent non-communicable diseases. Food contact materials can also include non-intentionally added substances (NIAS), which often are unknown and therefore not subject to risk assessment. To address these important shortcomings, we outline how the safety of food contact materials may be improved by (1) testing the overall migrate, including (unknown) NIAS, and (2) expanding toxicological testing beyond genotoxicity to multiple endpoints associated with non-communicable diseases relevant to human health. To identify mechanistic endpoints for testing, we group chronic health outcomes associated with chemical exposure into Six Clusters of Disease (SCOD) and we propose that finished food contact materials should be tested for their impacts on these SCOD. Future research should focus on development of robust, relevant and sensitive in vitro assays based on mechanistic information linked to the SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics of Toxicants. Implementing this vision will improve prevention of chronic diseases that are associated with hazardous chemical exposures, including from food contact materials.
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- 2023
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8. Gestational thyroid hormone concentrations and risk of attention‐deficit hyperactivity disorder in the Norwegian Mother, Father and Child Cohort Study
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Engel, Stephanie M., primary, Villanger, Gro D., additional, Herring, Amy, additional, Nethery, Rachel C., additional, Drover, Samantha S. M., additional, Zoeller, R. Thomas, additional, Meltzer, Helle M., additional, Zeiner, Pal, additional, Knudsen, Gun Peggy, additional, Reichborn‐Kjennerud, Ted, additional, Longnecker, Matthew P., additional, and Aase, Heidi, additional
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- 2022
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9. 137 - Endocrine-Disrupting Chemicals and Human Health
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Zoeller, R. Thomas and Heindel, Jerrold J.
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- 2023
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10. Gestational thyroid hormone concentrations and risk of attention‐deficit hyperactivity disorder in the Norwegian Mother, Father and Child Cohort Study.
- Author
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Engel, Stephanie M., Villanger, Gro D., Herring, Amy, Nethery, Rachel C., Drover, Samantha S. M., Zoeller, R. Thomas, Meltzer, Helle M., Zeiner, Pal, Knudsen, Gun Peggy, Reichborn‐Kjennerud, Ted, Longnecker, Matthew P., and Aase, Heidi
- Subjects
ATTENTION-deficit hyperactivity disorder ,THYROID hormones ,LOGISTIC regression analysis ,MISSING data (Statistics) ,THYROTROPIN receptors ,THYROID hormone receptors ,COHORT analysis ,FETAL development ,ODDS ratio - Abstract
Background: Maternal thyroid function plays an important role in foetal brain development; however, little consensus exists regarding the relationship between normal variability in thyroid hormones and common neurodevelopmental disorders, such as attention‐deficit hyperactivity disorder (ADHD). Objective: We sought to examine the association between mid‐pregnancy maternal thyroid function and risk of clinically diagnosed ADHD in offspring. Methods: We conducted a nested case–control study in the Norwegian Mother, Father and Child Cohort Study. Among children born 2003 or later, we randomly sampled singleton ADHD cases obtained through linkage with the Norwegian Patient Registry (n = 298) and 554 controls. Concentrations of maternal triiodothyronine (T3), thyroxine (T4), T3‐Uptake, thyroid‐stimulating hormone (TSH) and thyroid peroxidase antibody (TPO‐Ab) were measured in maternal plasma, collected at approximately 17 weeks' gestation. Indices of free T4 (FT4i) and free T3 (FT3i) were calculated. We used multivariable adjusted logistic regression to calculate odds ratios and accounted for missing covariate data using multiple imputation. We used restricted cubic splines to assess non‐linear trends and provide flexible representations. We examined effect measure modification by dietary iodine and selenium intake. In sensitivity analyses, we excluded women with clinically significant thyroid disorders (n = 73). Results: High maternal T3 was associated with increased risk of ADHD (5th vs 1st quintile odds ratio 2.27, 95% confidence interval 1.21, 4.26). For FT4i, both the lowest and highest quintiles were associated with an approximate 1.6‐fold increase in risk of ADHD, with similar trends found for T4. The FT4i association was modified by dietary iodine intake such that the highest risk strata were confined to the low intake group. Conclusions: Both high and low concentrations of maternal thyroid hormones, although within population reference ranges, increase the risk of ADHD in offspring. Increased susceptibility may be found among women with low dietary intake of iodine and selenium. [ABSTRACT FROM AUTHOR]
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- 2023
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11. The Price We Pay for the Convenience of Plastics.
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Zoeller, R Thomas
- Subjects
PLASTICS ,FLUOROALKYL compounds ,MARKETING ,ENDOCRINE disruptors - Abstract
A recent study published in the Journal of the Endocrine Society estimates that the healthcare costs associated with chemicals in plastics in the United States amount to approximately $250 billion per year, or 1.22% of the country's gross domestic product. However, this figure is considered to be a significant underestimate. Plastics are widely used in single-use packaging, construction materials, medical devices, and various industries. Plastics contain thousands of chemicals that can leach into products and pose risks to human health. The study highlights the need to reduce the production of new plastics in order to mitigate the disease burden and economic costs associated with plastic use. [Extracted from the article]
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- 2024
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12. Toward the Production of Safer Chemicals: A new protocol for safer chemical design is helping to overcome gaps in 'traditional' toxicology and improve upon federal regulations for endocrine-disrupting chemicals.
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Zoeller, R. Thomas and Myers, Pete
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ENDOCRINE disruptors ,FEDERAL regulation ,MEDICAL sciences ,CHEMICAL testing ,CHEMICAL engineering ,THYROID hormone receptors - Abstract
The Tiered Protocol for Endocrine Disruption (TiPED) is a new protocol being developed to improve regulations for endocrine-disrupting chemicals (EDCs). These chemicals can have harmful effects on human health and the environment, even at low concentrations. TiPED consists of five testing tiers to evaluate the potential endocrine disruption of chemicals, saving time and resources by only conducting expensive testing on a small fraction of chemicals. The proposed European "Chemical Strategy for Sustainability" also emphasizes the need for safer chemicals and supports funding for sustainable replacements for hazardous chemicals. [Extracted from the article]
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- 2022
13. Contributors
- Author
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Abu Dayyeh, Barham K., Agostini, Maura, Aiello, Lloyd Paul, Alicic, Radica Z., Anawalt, Bradley D., Ang, Lynn, Angelidi, Angeliki M., Antonio, Leen, Armstrong, David G., Arner, Peter, Assié, Guillaume, Athonvarangkul, Diana, Auchus, Richard J., Avery, Michael B., Avram, Anca M., Baloch, Zubair W., Bancos, Irina, Barb, Diana, Barkhoudarian, Garni, Basaria, Shehzad, Basham, Kaitlin J., Bashari, Waiel, Bastepe, Murat, Batterham, Rachel L., Bauer, Elizabeth M., Bellin, Melena D., Bertherat, Jérôme, Berthon, Annabel, Bhasin, Shalender, Bilezikian, John P., Billington, Emma O., Boelen, Anita, Bouillon, Roger, Brada, Michael, Brent, Gregory A., Broekmans, Frank J., Bronstein, Marcello D., Brown, Edward M., Bulun, Serdar E., Burch, Henry B., Burghard, Anne Claire, Burney, Richard O., Pop-Busui, Rodica, Cagliero, Enrico, Cameron, Sharon, Caoili, Elaine M., Carmeliet, Geert, Cavallerano, Jerry D., Chatterjee, Krishna, Chen, Zi-Jiang, Cheung, N. Wah, Christian, Helen C., Cidlowski, John A., Clavijo, Leonardo C., Clifton-Bligh, Roderick J., Considine, Robert V., Conti, Marco, Copps, Kyle D., Corcuff, Jean- Benoît, D’Alessio, David, Dattani, Mehul T., Davey, Rachel A., Davis, Stephen N., De Felice, Mario, de Kretser, David, DeFranco, Donald B., Demay, Marie B., DeMayo, Francesco J., De Santis, Pascual, Deutsch, Madeline B., Dhatariya, Ketan, Dhillon, Vaninder K., Di Lauro, Roberto, Dillon, Joseph S., Dinneen, Sean F., Doherty, Gerard M., Donahoo, William Troy, Econs, Michael J., Egan, Aoife M., Ehrhardt, Nicole, Ehrmann, David A., Eisenhofer, Graeme, El-Khairi, Ranna, Elisei, Rossella, Else, Tobias, Erickson, Lori A., Erinjeri, Neeta J., Eszlinger, Markus, Eugster, Erica A., Evert, Alison B., Faix, James D., Farooqi, I. Sadaf, Fassnacht, Martin, Fauser, Bart C.J.M., Findlay, David M., Fliers, Eric, Freeman, Mason W., Frydenberg, Mark, Fuller, Peter J., Gagliano-Jucá, Thiago, Gardella, Thomas J., Garrahy, Aoife, Garvey, W. Timothy, German, Michael S., Gershengorn, Marvin C., Gild, Matti, Gilliam, Lisa K., Giudice, Linda C., Glezer, Andrea, Glorieux, Francis H., Goodpaster, Bret H., Grinman, Diego Y., Guasti, Leonardo, Gurnell, Mark, Habra, Mouhammed Amir, Haddad, Nadine G., Halperin, Daniel M., Hammes, Stephen R., Hardman, Sarah, Harmon, Jamie S., Haugen, Bryan R., Hebrok, Matthias, Hedger, Mark P., Heindel, Jerrold J., Hirsch, Irl B., Hobbs, Robin M., Hollenberg, Anthony N., Hruska, Keith A., Husebye, Eystein, Iacovazzo, Donato, Ilie, Mirela Diana, Imel, Erik A., Isaac, Adam L., Jameson, J. Larry, Jasuja, Ravi, Jayasena, Channa N., Johannsson, Gudmundur, Jones, Glenville, Jonklaas, Jacqueline, Jørgensen, Niels, Jüppner, Harald, Juul, Anders, Kahaly, George J., Karavitaki, Niki, Katugampola, Harshini, Keevil, Brian, Kelley, David E., Kellogg, Todd Andrew, Kelly, David F., Klein, Ronald, Kleinau, Gunnar, Koniares, Katherine, Kopp, Peter, Korbonits, Márta, Korevaar, Tim I.M., Koulouri, Olympia, Krausz, Csilla, Kronenberg, Henry M., La Greca, Amanda, Lamos, Elizabeth M., Lebovitz, Harold E., Hong Lee, Alan Chun, Legro, Richard S., Lenders, Jacques W.M., Lerario, Antonio M., Lernmark, Åke, Lightman, Stafford L., Lin, David S., Liu, Eva S., Lo, Janet, Loomba, Lindsey A., Loveland, Kate L., Lue, Tom F., Lundgren, Markus, MacFarlane, James Robert, Magee, Gregory A., Maes, Christa, Maharaj, Avinaash, Main, Katharina M., Makaronidis, Janine M., Malina, Robert, Mannstadt, Michael, Manohar, Paul, Mantzoros, Christos S., Marazuela, Mónica, Matrone, Antonio, Maxwell, Jessica E., McCartney, Christopher R., McGee, Elizabeth A., Melanson, Edward L., Melmed, Shlomo, Mendelson, Carole R., Merke, Deborah P., Mesiano, Sam, Metherell, Louise A., Miller, Barbra S., Mizokami-Stout, Kara, Mohan, Dipika R., Molitch, Mark E., Moran, Carla, Moravek, Molly B., Neumann, Susanne, Neumiller, Joshua J., Newell-Price, John D.C., Newey, Paul J., Norwitz, Errol R., O’Donnell, Liza, O’Rahilly, Stephen, Oakley, Robert H., Oberfield, Sharon E., Orellana, Minerva, Mete, Ozgur, Pacak, Karel, Pace-Asciak, Pia, Page, Stephanie T., Paschke, Ralf, Pasquel, Francisco J., Pearce, Elizabeth N., Peters, Anne L., Pook, David W., Potts, Callum A., Potts, John T., Jr, Purcell, Sarah A., Raff, Hershel, Ragnarsson, Oskar, Rajpert-De Meyts, Ewa, Ramos-Levi, Ana M., Rao, Sarika N., Rastrelli, Giulia, Raverot, Gérald, Ray, David W., Razavi, Christopher R., Reed-Maldonado, Amanda B., Reid, Ian R., Retnakaran, Ravi, Rickels, Michael R., Riddell, Michael Charles, Rinaudo, Paolo, Risbridger, Gail P., Robertson, R. Paul, Robinson, Bruce G., Rogol, Alan D., Romei, Cristina, Rosenfelder, Nicola, Rowen, Tami S., Ruderman, Neil B., Rushing, John, Russell, Jonathon O., Russo, Jose, Rydén, Mikael, Santoro, Nanette, Schlegel, Peter N., Schoenmakers, Erik, Schoenmakers, Nadia, Senanayake, Russell Martin, Shaear, Mohammad, Shalev, Anath, Shields, James, Shimy, Kim, Shindel, Alan W., Shulman, Gerald I., Silva, Paolo S., Simmons, David, Simon, James A., Singer, Frederick R., Sipos, Jennifer A., Skaznik-Wikiel, Malgorzata E., Smallridge, Robert C., Smith, Christopher J., Smith, Roger, Smith, Ulf, Snyder, Peter J., Solda, Francesca, Speiser, Phyllis W., St-Arnaud, René, Stewart, Elizabeth A., Stowasser, Michael, Straseski, Joely, Strauss, Jerome F., III, Styne, Dennis M., Swerdloff, Ronald S., Tabarin, Antoine, Tanavde, Ved, Taïeb, David, Thakker, Rajesh V., Thompson, Christopher J., Timmers, Henri J.L.M., Toppari, Jorma, Torpy, David J., Tsang, Venessa, Tsoukas, Michael A., Tufano, Ralph P., Tuttle, Katherine R., Udelsman, Robert, Umpierrez, Guillermo, Upton, Thomas J., Vaidya, Anand, Val, Pierre, Vasiljevic, Alexandre, Vaughan, Denis A., Vella, Adrian, Verlinden, Lieve, Vietor, Nicole O., Viglianti, Benjamin L., Vilain, Eric, Barisson Villares Fragoso, Maria Candida, Visser, W. Edward, Walford, Geoffrey, Walker, Marcella D., Wang, Christina, Weetman, Anthony P., Wei, Daimin, White, Kenneth E., White, Morris F., White, Perrin C., Whyte, Michael P., Williams, Matthew James, Witchel, Selma Feldman, Wong, Ka Kit, Wu, Frederick C.W., Wysolmerski, John J., Young, Morag J., Zennaro, Maria-Christina, Zimmerman, Michael B., and Zoeller, R. Thomas
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- 2023
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