Search

Abstract The energy consumption for cooling takes up 50% of all the consumed final energy in Europe, which still highly depends on the utilization of fossil fuels. Thus, it is required to propose and develop new technologies for cooling driven by renewable energy. Also, thermal energy storage is an emerging technology to relocate intermittent low-grade heat source, like solar thermal energy and industrial waste heat as well as to exploit off-peak electricity, for cooling applications. This review aims to summarize the recent advances in thermally driven cooling and cold storage technologies, focusing on the formation and fabrication of adopted composites materials, including sorption materials, phase change materials, and slurries. Herein, first the classifications, selection criteria, and properties for these three types of materials is discussed. Then, the application potentials of all the materials are prospected in terms of economic analysis and sustainability.

A case of bullous pilomatricoma is reported. A 22-year-old female had brown blue nodule on the right shoulder for 3 months and blisters for over 2 months. Dermatological examination revealed a demarcated 1.6 cm×1.0 cm×0.7 cm light purple semitranslucent bulla with loose wall and movable base on the right shoulder. A movable hard mass sized 0.4 cm×0.3 cm could be palpated. Histopathological examination of the lesion showed a mass with clear boundaries, and filtrates of basophils, transitional cells and shadow cells, along with proliferation and dilation of lymphatic vessels. The diagnosis was bullous pilomatricoma. Following surgical removal of the tumor, no recurrence was observed during 6 months of follow-up.

A diode-pumped continuous wave (CW) Nd:Na2La4(WO4)7 (Nd:NLW) laser operating at 0.9 μm on 4F3/2 → 4I9/2 transition was demonstrated. Four single- wavelengths (the 889 nm and 912 nm in σ-polarization, the 890 nm and 905 nm in π-polarization) were obtained by rotating an intracavity birefringent filter (BF).At an absorbed pump power of 17.4 W at 808 nm, the highest output power of single-wavelength at 912 nm was 3.4 W. Furthermore, the dual-wavelength at 889 and 912 nm in σ-polarization and the dual-wavelength at 890 and 905 nm in π-polarization were also achieved, respectively. At an absorbed pump power of 17.4 W, the maximum total output powers of the dual-wavelengths at 889 and 912 nm was 2.12 W. To the best of our knowledge, this is the first quasi-three-level Nd:NLW laser operating at 0.9 μm.

Abstract Objective To construct a nutrition support program for middle-aged and elderly patients with acute decompensated heart failure (ADHF) during hospitalization. Methods Based on the JBI Evidence-Based Health Care Model as the theoretical framework, the best evidence was extracted through literature analysis and a preliminary nutrition support plan for middle-aged and elderly ADHF patients during hospitalization was formed. Two rounds of expert opinion consultation were conducted using the Delphi method. The indicators were modified, supplemented and reduced according to the expert’s scoring and feedback, and the expert scoring was calculated. Results The response rates of the experts in the two rounds of consultation were 86.7% and 100%, respectively, and the coefficient of variation (CV) for each round was between 0.00% and 29.67% (all

Aqueous zinc‐ion batteries (AZIBs) suffer from rampant Zn dendrites growth, corrosion and sluggish transport kinetics, all of which have a serious impact on their performance and practical applications. Therefore, porous carbon nanofibers (BTO@PCNFs) loaded with BaTiO3 nanoparticles (BTO NPs) are constructed as a multifunctional interlayer for stabilizing the Zn anodes. Owing to the synergistic effect of BTO NPs and 3D porous carbon framework, this interlayer can achieve uniform electric field distribution, accelerate Zn2+ migration, and promote ion flux homogenization, thus leading to uniform Zn deposition. Meanwhile, the BTO@PCNFs interlayer demonstrates excellent anti‐corrosion effect, which can effectively prevent the side reactions. Benefiting from the synergistic effect of interlayers, the BTO@PCNFs multifunctional interlayers achieve a comprehensive optimization of the Zn anodes. The BTO@PCNFs‐Zn electrode exhibits lower nucleation overpotential (33.5 mV) at 0.5 mA cm−2. The Zn//Zn symmetrical cell with BTO@PCNFs interlayer exhibits ultra‐low overpotential (14 mV) and ultra‐long cycle life (5250 h at 0.5 mA cm−2). Even at high current density (30 mA cm−2), the BTO@PCNFs‐Zn electrode can be stably cycled for more than 830 h, achieving an ultra‐high cumulative capacity of 12 450 mAh cm−2. The multifunctional interlayers can provide a reference for the design of high‐performance Zn anodes.

Abstract Objective In patients undergoing laparoscopic radical gastrectomy, the use of subcostal transversus abdominis plane block (STAPB) for completely opioid-free postoperative pain management lacks convincing clinical evidence. Methods This study included 112 patients who underwent laparoscopic radical gastrectomy at the 900TH Hospital of the Joint Logistics Support Force from October 2020 to March 2022. Patients were randomly divided into (1:1) continuous opioid-free STAPB (C-STAPB) group and conventional group. In the C-STAPB group, 0.2% ropivacaine (bilateral, 20 ml per side) was injected intermittently every 12 h through a catheter placed on the transverse abdominis plane for postoperative pain management. The conventional group was treated with a conventional intravenous opioid pump (2.5 μg/kg sufentanil and 10 mg tropisetron, diluted to 100 ml with 0.9% NS). The primary outcomes were the accumulative area under the curve of the numeric rating scale (NRS) score at 24 and 48 h postoperatively at rest and during movement. The secondary outcomes were postoperative recovery outcomes, postoperative daily food intake, and postoperative complications. Results After exclusion (n = 16), a total of 96 patients (C-STAPB group, n = 46; conventional group, n = 49) were included. We found there were no significant differences in the cumulative AUC of NRS score PACU-24 h and PACU-48 h between the C-STAPB group and conventional group at rest [(mean difference, 1.38; 95% CI, − 2.21 to 4.98, P = 0.447), (mean difference, 1.22; 95% CI, − 6.20 to 8.65, P = 0.744)] and at movement [(mean difference, 2.90; 95% CI, − 3.65 to 9.46; P = 0.382), (mean difference, 4.32; 95% CI, − 4.46 to 13.1; P = 0.331)]. The 95% CI upper bound of the difference between rest and movement in the C-STAPB group was less than the inferior margin value (9.5 and 14 points), indicating the non-inferiority of the analgesic effect of C-STPAB. The C-STAPB group had faster postoperative recovery profiles including earlier bowel movement, defecation, more volume of food intake postoperative, and lower postoperative nausea and vomiting compared to conventional groups (P

Polyester enamelled copper wire plays an important role in the manufacturing of electric motors. In line with the electrification of transport, the demand for electric motors and the future waste generated from their end-of-life cannot be ignored. The waste from the polyester enamelled copper wire is expected to increase steadily. Methods proposed by researchers are mainly focused on thermal treatment to either pyrolyse or burn off the polyester enamel. However, thermal treatments fail to consider the potential risk of air pollution and to recover the polyester enamel.In this manuscript, we propose two-stage processes comprised of methanol washing and room temperature methanolysis with dichloromethane as co-solvent and K2CO3 as catalyst to delaminate multilayered type enamelled copper wire. The methanol washing recovers polyvinyl butyral as it is, via dissolution. Whereas the methanolysis products are dimethyl terephthalate (DMT) and dimethyl isophthalate (DMI) which are precursors to the polyester and could be used to make new polyester. At room temperature, the parameters of solid to liquid, DCM to methanol, and K2CO3 to Cuwireratio, of 500 g/L, 1.00 mol/mol, and 0.10 wt%, respectively, allow complete removal of polyester enamel in 24 h. The methanolysis parameters described manage to give a modest DMT and DMI yield of 86.0% and 92.2%, respectively. The reaction time can be sped up by increasing the temperature by 10 °C, leading to complete depolymerisation in 4 h. Compared to thermal treatment, the proposed method requires 80.7% lower energy with the products contained within the solution.

Considering that fluctuations in temperature can cause variations in both the internal structure as well as the mineral composition of rocks, their fracture characteristics must be impacted accordingly. With the exponential development of geotechnical engineering in cold regions, it is urgent to study the influence of the sub-zero temperature environment on the mechanical properties and dynamic properties of rocks. In order to investigate the influence of sub-zero temperature gradient on the dynamic fracture characteristics of rocks, red sandstone was used for the preparation of notched semi-circular bend specimens. First, a water-saturated machine and a sub-zero temperature incubator were utilized to pretreat the rock for 48 h, conducive for both satiation and freezing processes. Subsequently, the dynamic tests were carried out utilizing an improved split Hopkinson bar experimental system with a cryogenic sub-system. Concurrently, the striker velocity was modulated by setting distinctive air pressures, following which the rock was loaded at various loading rates. The test results demonstrate that the fracture toughness of the rock has an evident loading rate effect, and the fracture toughness proliferates exponentially with the increase in the loading rate. In the event that the loading rate is certain, the fracture toughness of the rock primarily increases gradually and then expeditiously over the course of advancement from room temperature to −20 ℃. Contradictorily, the rock fracture toughness diminishes abruptly with plummeting temperature. Analysis of the rock fracture process, accommodated by a high-speed camera, revealed that the fracture process of the rock at distinctive temperatures is fundamentally equivalent, and the crack propagation speed is negligibly influenced by the temperature. Furthermore, the rock fracture mode was analyzed by employing a scanning electron microscope (SEM) system. The SEM images of the rock depicted that the fracture of red sandstone at sub-zero temperature is predominantly intergranular fracture and cement tearing, accompanied by a trace of transgranular fracture. Meanwhile, the experimentation also revealed that the number of micro-cracks in the rock significantly multiplied when the temperature declined to −25 ℃, illustrating that sub-zero temperature has a deteriorating effect on the rock. Conclusively, the influence mechanism of temperature on the internal structure of the rock is discussed, and it is assumed that the change in the internal structure of the rock is the collaborative effect of thermal expansion-cold contraction and ice-water phase transition. The interpretation of this study has substantial reference significance for the further consequential analysis of frigidity on the fracture properties of the rock.

Deep buried rock is often in a non-hydrostatic initial ground stress field, and the different stress states lead to different rock response under dynamic loading. To study the dynamic behavior of rocks under coupled non-hydrostatic pressure and dynamic loading, the dynamic compression tests under different initial stress are carried out by using the split Hopkinson pressure bar (SHPB) experimental system, and the influence of different non-hydrostatic pressure on energy dissipation and failure characteristics of rock is analyzed. Based on the test results, it is found that both axial and lateral confining pressure have a significant impact on the rock dynamic strength. Taking 8 MPa as the critical point, the rock dynamic strength first increases and then decreases with the increase of axial confining pressure, but the rock dynamic strength will continue to increase with the increase of lateral confining pressure. The rock dissipative energy gradually decreases with the increase of axial confining pressure, but the trend of dissipative energy changes with confining pressure is complicated. When the axial confining pressure is low, the dissipative energy decreases with the increase of the confining pressure, and when the axial confining pressure is high, the dissipative energy shows a characteristic of increasing first and then decreasing with the increase of lateral confining pressure. According to the apparent and internal damage patterns of the specimens, combined with fractal theory and CT scanning technology, the influence of the damage pattern of rocks under different non-hydrostatic pressure conditions is analyzed. It is found that there is a significant correlation between the apparent cracks of rock and the ratio of axial-confining pressure. When the axial confining pressure ratio is low, there are fewer cracks on the side and end faces of rock. With the increase of the axial confining pressure ratio, the number of apparent cracks of rock increases. Through the analysis of the cross-sectional and vertical slices of the rock, it is found that there are circumferential and radial cracks in the rock simultaneously, and the rock failure is controlled by the penetrating shear cracks. It also can be found that the damage of rocks under non-hydrostatic pressure conditions can be divided into two parts: the central spherical rock mass and the peripheral broken rock mass, and the damage degree of rocks increases when the axial pressure increases, while the elevation of the surrounding pressure makes the damage degree of rocks decrease.

A dynamic modeling framework based on an intelligent approach is proposed to identify the complex behaviors of solid-gas sorption systems. An experimental system was built and tested to assist in developing a model of the system performance during the adsorption and desorption processes. The variations in the thermal effects and gaseous environment accompanying the reactions were considered when designing the model. An optimization platform based on a multi-population genetic algorithm and artificial criteria was established to identify the modeling coefficients and quantify the effects of condition changes on the reactions. The calibration of the simulation results against the tested data showed good accuracy, where the coefficient of determination was greater than 0.988. The outcome of this study could provide a modeling basis for the optimization of solid-gas sorption systems and contribute a potential tool for uncovering key characteristics associated with materials and components.

Abstract Background The peripatellar fat pads are critical for protective cushioning during movement, and their endocrine function has been shown to affect osteoarthritis. Magnetic resonance imaging (MRI) is frequently used to visualize edema of the peripatellar fat pads due to injury. In this study, we aimed to assess the relationship between peripatellar fat pad edema and patellofemoral maltracking MRI parameters and investigate the association among cases of peripatellar fat pad edema. Methods Age- and sex-matched peripatellar fat pad edema cases were identified and divided into superolateral Hoffa, quadriceps, and prefemoral groups. Images were assessed according to tibial tuberosity lateralization, trochlear dysplasia, patellar alta, patellar tilt, and bisect offset. McNemar’s test or paired t-tests and Spearman’s correlation were used for statistical analysis. Interobserver agreement was assessed with the intraclass correlation coefficient. Results Of 1210 MRI scans, 50, 68, and 42 cases were in the superolateral Hoffa, quadriceps, and prefemoral groups, respectively. Subjects with superolateral Hoffa fat pad edema had a lower lateral trochlear inclination (p = 0.028), higher Insall-Salvati (p

A plate-fin heat sink is usually used for the hot side of thermoelectric coolers. The plate-fin heat sink should be optimized to improve its heat dissipation capability and eventually elevate the thermoelectric cooler performance. In this paper, a heat dissipation model of the thermoelectric cooler hot side with a plate-fin sink is established, to explore the performances of the plate-fin sink with two types of fins (rectangular and V-type), two convective conditions (lateral and vertical) and three arrangements (single-row, double-row aligned, and double-row staggered). The results show that under vertical jet conditions, double-row aligned rectangular fins have the best heat dissipation capability for the thermoelectric cooler hot side. In order to optimize the fin geometry and maximize its overall performance, a multi-objective optimization of the fins was performed using a machine learning approach based on artificial neural networks (ANN) and non-dominated sorting genetic algorithm (NSGA-ІІ). The corresponding Pareto front is obtained and the technique for order preference by similarity to ideal solution (TOPSIS) method is applied to take the point. Compared with the base case at the same mass flow rate, the fins designed by this method resulted in a 23.3 % reduction in the mean temperature of the hot side.

To promote the formation of CO2 hydrate for cold energy storage, the influence of gas-inducing agitation at varying operating speeds were studied experimentally. A comparison was made with normal stirring (without gas inducing) from the perspectives of deviation from equilibrium condition, subcooling, agglomeration, and hydrate production. The test results revealed that gas-inducing agitation contributed to a closer shift of the hydrate formation profiles towards equilibrium conditions when compared to normal stirring. However, this advantage became less pronounced as the stirring speed increased. Notably, a substantial improvement in subcooling phenomena was observed when transitioning from 250 rpm normal stirring to 500 rpm, decreasing the induction time to 19.3%. Comparing normal stirring, the incorporation of a gas-inducing stirrer further reduced the induction time by 68.6% at 400 rpm. Nevertheless, further increasing agitation speed for both sets did not yield apparent improvement in the subcooling phenomenon. In contrast to normal stirring, gas-inducing agitation effectively prevented hydrate agglomeration at a lower speed and led to increased hydrate production at the same rotation speed. An ascending trend in hydrate production was achieved as agitation accelerated from a low speed to a specific speed, e.g., 400 rpm for gas-inducing stirring and 500 rpm for normal stirring. However, further elevating the stirring speed did not stimulate greater hydrate production. The findings of this study indicated the existence of double-sided effects in using gas-inducing stirring for hydrate promotion and a crucial speed range (e.g., 400∼450 rpm in this study) essential for the efficient implementation of gas-inducing technology. Operating at this prescribed speed range was recommended to improve the energy Return on Investment, maintaining high hydrate production, and enhancing the controllability of cold storage systems. This study provides practical insights for applying gas-inducing technology in gas hydrate reactors, contributing to the development of green cold energy storage.

ABSTRACTEffective control of gene expression is crucial for understanding gene function in both eukaryotic and prokaryotic cells. While several inducible gene expression systems have been reported in Streptococcus mutans, a conditional pathogen that causes dental caries, the significant non-inducible basal expression in these systems seriously limits their utility, especially when studying lethal gene functions and molecular mechanisms. We introduce a tightly controlled xylose-inducible gene expression system, TC-Xyl, for Streptococcus mutans. Western blot results and fluorescence microscopy analysis indicate that TC-Xyl exhibits an extremely low non-inducible basal expression level and a sufficiently high expression level post-induction. Further, by constructing a mutation in which the only source FtsZ is under the control of TC-Xyl, we preliminarily explored the function of the ftsz gene. We found that FtsZ depletion is lethal to Streptococcus mutans, resulting in abnormal round cell shape and mini cell formation, suggesting FtsZ’s role in maintaining cell shape stability.

The mitogen-activated protein kinase (MAPK) cascades act as crucial signaling modules that regulate plant growth and development, response to biotic/abiotic stresses, and plant immunity. MAP3Ks can be activated through MAP4K phosphorylation in non-plant systems, but this has not been reported in plants to date. Here, we identified a total of 234 putative TaMAPK family members in wheat (Triticum aestivum L.). They included 48 MAPKs, 17 MAP2Ks, 144 MAP3Ks, and 25 MAP4Ks. We conducted systematic analyses of the evolution, domain conservation, interaction networks, and expression profiles of these TaMAPK–TaMAP4K (representing TaMAPK, TaMAP2K, TaMAP3K, and TaMAP4K) kinase family members. The 234 TaMAPK–TaMAP4Ks are distributed on 21 chromosomes and one unknown linkage group (Un). Notably, 25 of these TaMAP4K family members possessed the conserved motifs of MAP4K genes, including glycine-rich motif, invariant lysine (K) motif, HRD motif, DFG motif, and signature motif. TaMAPK3 and 6, and TaMAP4K10/24 were shown to be strongly expressed not only throughout the growth and development stages but also in response to drought or heat stress. The bioinformatics analyses and qRT-PCR results suggested that wheat may activate the MAP4K10–MEKK7–MAP2K11–MAPK6 pathway to increase drought resistance in wheat, and the MAP4K10–MAP3K8–MAP2K1/11-MAPK3 pathway may be involved in plant growth. In general, our work identified members of the MAPK–MAP4K cascade in wheat and profiled their potential roles during their response to abiotic stresses and plant growth based on their expression pattern. The characterized cascades might be good candidates for future crop improvement and molecular breeding.

Highlights A new class of γ-cyclodextrin based metal–organic framework -derived strategy was used to fabricate highly active M–N-C catalysts containing both single-atom sites and nanoparticles. The obtained Co@C-CoNC exhibits remarkable bifunctional oxygen reduction (ORR)/oxygen evolution reactions (OER) performance, which further delivered a high power density and excellent cyclic stability in rechargeable zinc-air batteries. Density functional theory calculation suggests that the mutual self-regulation of d-electron density of both Co NP and Co SAC conjointly reduce the reaction energy barriers and thus boost the ORR/OER kinetics through their fast adsorption/desorption ability of reaction intermediates.

In the process of autonomous vehicle lane changing, a reliable decision-making system is crucial for driving safety and comfort. However, traditional decision-making systems have short-term characteristics, which makes them susceptible to real-time inference from surrounding vehicles. Usually, system sacrifices driving comfort to ensure the safety of the lane change. Balancing driving safety and comfort has always been a research challenge. Long-term trajectory prediction can provide accurate future trajectories of target vehicles, providing reliable long-term information to compensate for the short-term variability of decision systems. This paper proposes a novel decision-making model with long-term trajectory prediction for lane-changing. First, we constructed a long-term trajectory prediction model to predict the trajectories of surrounding vehicles. Besides, we built a lane change decision-making model based on fuzzy inferencing, considering the predicted trajectories to infer the relative relationship between other vehicles and the self-driving car. The establishment of the fuzzy rule library considered the vehicle speed, acceleration, system delay time, driver delay time and the distance between vehicles. Finally, we created a dataset for training and testing the trajectory prediction model, and we built 4 cases simulation environments, for two or three vehicles on a straight road or curved road, respectively, to test the decision-making model. Experimental results show that our proposed model can ensure driving safety and improve driving comfort.

Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins. However, the underlying mechanism(s) remain not completely understood. The aim of this study is thus to elucidate the possible mechanisms related to the melanogenesis suppression by glabridin in cultured B16 murine melanoma cells and in UVA radiation induced hyperpigmentation model of BALB/c mice as well. Molecular docking simulations revealed that between catalytic core residues and the compound. The treatment by glabridin significantly downregulated both transcriptional and/or protein expression of melanogenesis-related factors including melanocyte stimulating hormone receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), TYR-related protein-1 (TRP-1) and TRP-2 in B16 cells. Both PKA/MITF and MAPK/MITF signaling pathways were found to be involved in the suppression of melanogenesis by glabridin in B16 cells. Also in vivo glabridin therapy significantly reduced hyperpigmentation, epidermal thickening, roughness and inflammation induced by frequent UVA exposure in mice skins, thus beneficial for skin healthcare. These data further look insights into the molecular mechanisms of melanogenesis suppression by glabridin, rationalizing the application of the natural compound for skin healthcare.

Phase change materials (PCMs) when amalgamated in a shell material to form microencapsulated-PCMs (MPCMs) usually exhibit high levels of supercooling due to the limited crystallization process. In the present study, various efforts were made to reduce this phenomenon, including increasing the MPCM size, employing nucleating agents, and embedding copper nanoparticles into the MPCM shells. It was observed that with an increase in the microcapsule size from 43 μm to 76 μm, the supercooling was reduced by a value of 10.2 °C from melting/freeing point peak temperature differences of 37.6 to 27.4 for the 1200 rpm and 800 rpm samples respectively. Comparatively, the implementation of octadecanol nucleating agent 30 wt % resulted in a reduction of supercooling by 22.9 °C. The introduction of Cu nanoparticles with a decane core can also reduce the supercooling degree by 4.6 °C, while the thermal conductivity the MPCM samples with a hexadecane core increased from 0.173 to 0.182 W m−1 K−1 before and after the addiction of the Cu nanoparticles. Furthermore, di(propylene glycol) methyl ether was used as a carrier fluid for the MPCMs to study the slurry rheological behaviors with various MPCM compositions. It was observed that the MPCM suspension with 10–20% MPCM mass concentration did not exhibit shear thinning, while the 30% sample conveyed shear thinning properties. Furthermore, near the crystallization temperature of the PCM, the slurry viscosity sharply rose, attributed to the volume changes and non-cooperative motion of MPCM microcapsules.

Abstract Background RING (Really Interesting New Gene) zinc finger (RING-zf) proteins belong to an important subclass of zinc fingers superfamily, which play versatile roles during various developmental stages and in abiotic stress responses. Based on the conserved cysteine and histidine residues, the RING-zf domains are classified into RING-HC (C3HC4), RING-H2 (C3H2C3), RING-v, RING-D, RING-S/T, RING-G, and RING-C2. However, little is known about the function of the RING-zfs of wheat. Results In this study, 129 (93.5%) of 138 members were found in nucleus, indicating TaRING-zf were primarily engaged in the degradation of transcription factors and other nuclear-localized proteins. 138 TaRING-zf domains can be divided into four canonical or modified types (RING-H2, RING-HC, RING-D, and RING-M). The RING-M was newly identified in T. aestivum, and might represent the intermediate other states between RING-zf domain and other modified domains. The consensus sequence of the RING-M domain can be described as M-X2-R-X14-Cys-X1-H-X2-Cys-X2-Cys-X10-Cys-X2-Cys. Further interspecies collinearity analyses showed that TaRING-zfs were more closely related to the genes in Poaceae. According to the public transcriptome data, most of the TaRING-zfs were expressed at different 15 stages of plant growth, development, and some of them exhibited specific responses to drought/heat stress. Moreover, 4 RING-HC (TraesCS2A02G526800.1, TraesCS4A02G290600.1, TraesCS4B02G023600.1 and TraesCS4D02G021200.1) and 2 RING-H2 (TraesCS3A02G288900.1 and TraesCS4A02G174600.1) were significantly expressed at different development stages and under drought stress. These findings provide valuable reference data for further study of their physiological functions in wheat varieties. Conclusions Taken together, the characterization and classifications of the TaRING-zf family were extensively studied and some new features about it were revealed. This study could provide some valuable targets for further studies on their functions in growth and development, and abiotic stress responses in wheat.

Abstract A fuel cell is an energy conversion device that can continuously input fuel and oxidant into the device through an electrochemical reaction to release electrical energy. Although noble metals show good activity in fuel cell‐related electrochemical reactions, their ever‐increasing price considerably hinders their industrial application. Improvement of atom utilization efficiency is considered one of the most effective strategies to improve the mass activity of catalysts, and this allows for the use of fewer catalysts, saving greatly on the cost. Thus, single‐atom catalysts (SACs) with an atom utilization efficiency of 100% have been widely developed, which show remarkable performance in fuel cells. In this review, we will describe recent progress on the development of SACs for membrane electrode assembly of fuel cell applications. First, we will introduce several effective routes for the synthesis of SACs. The reaction mechanism of the involved reactions will also be introduced as it is highly determinant of the final activity. Then, we will systematically summarize the application of Pt group metal (PGM) and nonprecious group metal (non‐PGM) catalysts in membrane electrode assembly of fuel cells. This review will offer numerous experiences for developing potential industrialized fuel cell catalysts in the future.

Background: More and more studies have suggested that hepatocellular carcinoma (HCC) patients with high-risk recurrence factors can benefit the most from postoperative adjuvant transarterial chemoembolization (PA-TACE) for its potential effect in delaying cancer recurrence. However, it remains unclear if solitary HCC (SHCC) patients particularly those without high-risk recurrence factors should also receive PA-TACE. This study aimed to analyze the efficacy of PA-TACE in them. Methods: Retrospectively, we enrolled 123 SHCC patients who either received radical hepatectomy alone (No TACE group, n = 39) or followed by PA-TACE (PA-TACE group, n = 84) in our institution. Prognostic risk factors, disease-free survival (DFS), and overall survival (OS) were analyzed using the Cox proportional hazard regression model, the Kaplan-Meier method, and the log-rank test. Results: Liver cirrhosis was the only independent risk factor for SHCC patients. Overall, the PA-TACE group had no improved OS (P = 0.977) but worse DFS compared with the No TACE group (P = 0.045). Consistently, in subgroup analysis, SHCC patients with negative microvascular invasion (MVI), tumor size ≤ 5 cm and preoperative alpha-fetoprotein (AFP) < 400 ng/ml had similar OS (P = 0.466, P = 0.864, P = 0.488, respectively) but even worse DFS (P = 0.035, P = 0.040, P = 0.019, respectively) than those in the No TACE group. Besides, there was no significant difference in DFS and OS between the two groups of SHCC patients with liver cirrhosis (P = 0.342, P = 0.941, respectively). Conclusions: PA-TACE may not improve the long-term survival of SHCC patients, but may even potentially promote their postoperative tumor recurrence, especially for those with MVI-negative, tumor size ≤ 5 cm, and preoperative AFP < 400 ng/ml.

The ubiquitin-specific protease (UBP) family represents a type of deubiquitinase (DUB) that plays a significant role in plant abiotic stress responses, growth, and development. Although UBP genes have been characterized in many species, a genome-wide systematic analysis and the potential functions under abiotic stresses have not yet been reported in rice (Oryza sativa L.). In this study, we identified 21 UBP gene family members in the genome of rice, all of which had UCH domains containing short but highly conserved Cys-box and His-box. The DUF4220 and DUF594 domains, which are found in monocotyledonous plants, were unique. Phylogenetic analysis suggested that OsUBP7 and OsUBP12 genes had the closest genetic relationships with AtUBP12 and AtUBP13, implying that OsUBP7 and OsUBP12 might have similar biological functions to AtUBP12 and AtUBP13. Synteny analysis revealed that OsUBP genes were expanded through segmental duplication under purifying selection. Meanwhile, they had closer evolutionary relationships with monocotyledonous plants. Additionally, all OsUBP genes had an ABRE cis-element, which was related to abscisic acid (ABA) stress hormone response. Protein interaction analysis suggested that OsUBP22 might modulate gene regulation through OsGCN5- and OsADA2-mediated chromatin modification, and OsUBP10 might regulate salt stress through modulating OsDNA2_4 stability. Specifically, the expression profiles and the transcriptional levels of 11 representative OsUBPs suggested the potential important functions of OsUBP9 and OsUBP17 under drought and cold stresses. Taken together, our study provided a systematic analysis of OsUBPs and preliminarily explored their potential roles under abiotic stresses. Our results lay a foundation for further research on the functions of the OsUBP gene family under abiotic stresses.

Abstract There is great variation in the lithology and lamination thickness of composite roof in coal-measure strata; thus, the roof is prone to delamination and falling, and it is difficult to control the surrounding rock when developing roadway in such rock strata. In deep mining, the stress environment of surrounding rock is complex, and the mechanical response of the rock mass is different from that of the shallow rock mass. For composite-roof roadway excavated in deep rock mass, the key to safe and efficient production of the mine is ensuring the stability of the roadway. The present paper obtains typical failure characteristics and deformation and failure mechanisms of composite-roof roadway with a buried depth of 650 m at Zhaozhuang Coal Mine (Shanxi Province, China). On the basis of determining a reasonable cross-section shape of the roadway and according to the failure characteristics of the composite roof in different regions, the roof is divided into an unstable layer, metastable layer, and stable layer. The controlled unstable layer and metastable layer are regarded as a small structure while the stable layer is regarded as a large structure. A superimposed coupling support technology of large and small structures with a multi-level prestressed bearing arch formed by strong rebar bolts and highly prestressed cable bolts is put forward. The support technology provides good application results in the field. The study thus provides theoretical support and technical guidance for ground control under similar geological conditions.

PurposeThis study aimed to assess the value of 18F-PSMA-1007 positron emission tomography/computed tomography (PET/CT)-derived semi-quantitative parameters of primary tumor for risk stratification of newly diagnosed prostate cancer (PCa).MethodsSixty patients referred for 18F-PSMA-1007 PET/CT imaging for primary PCa were retrospectively analyzed and classified into the low-intermediate-risk (LIR) or high-risk (HR) group. The maximum standardized uptake value (SUVmax) of primary tumor, prostate total lesion PSMA (TL-PSMAp), and prostate PSMA-tumor volume (PSMA-TVp) were measured, and group differences were evaluated using the Mann–Whitney U test. Spearman’s correlation was performed to assess the correlation between the above parameters with prostate-specific antigen (PSA) levels and Gleason score (GS). Receiver operating characteristic (ROC) curve analysis was used to determine optimal cut-off values for SUVmax, TL-PSMAp, and PSMA-TVp to identify high-risk PCa and compare diagnostic efficacy.ResultsAmong 60 patients, 46 were assigned to the HR group and 16 to the LIR group. In all patients, SUVmax, TL-PSMAp, and PSMA-TVp were moderately correlated with pre-treatment PSA values (r = 0.411, p = 0.001; r = 0.663, p < 0.001; and r = 0.549, p < 0.001, respectively). SUVmax and TL-PSMAp were moderately correlated with GS (r = 0.457 and r = 0.448, respectively; p < 0.001), while PSMA-TVp was weakly correlated with GS (r = 0.285, p = 0.027). In the ROC curve analysis, the optimal cut-off values of SUVmax, TL-PSMAp, and PSMA-TVp for identifying high-risk PCa were 9.61, 59.62, and 10.27, respectively, and the areas under the operating curve were 0.828, 0.901, and 0.809, respectively. The sensitivities of SUVmax, TL-PSMAp, and PSMA-TVp were 91.03%, 71.74%, and 63.04%, respectively, and the specificities were 71.43%, 100.00%, and 92.86%, respectively.ConclusionsTL-PSMAp had a superior ability to identify high-risk PCa. The semi-quantitative parameters of primary tumor on 18F-PSMA-1007 PET/CT imaging can be an objective imaging reference index to determine PCa risk stratification.

Background Mainland China, the world’s most populous region, experienced a large-scale coronavirus disease 2019 (COVID-19) outbreak in 2020 and 2021, respectively. Existing infodemiology studies have primarily concentrated on the prospective surveillance of confirmed cases or symptoms which met the criterion for investigators; nevertheless, the actual impact regarding COVID-19 on the public and subsequent attitudes of different groups towards the COVID-19 epidemic were neglected. Methods This study aimed to examine the public web-based search trends and behavior patterns related to COVID-19 outbreaks in mainland China by using hot words and Baidu Index (BI). The initial hot words (the high-frequency words on the Internet) and the epidemic data (2019/12/01–2021/11/30) were mined from infodemiology platforms. The final hot words table was established by two-rounds of hot words screening and double-level hot words classification. Temporal distribution and demographic portraits of COVID-19 were queried by search trends service supplied from BI to perform the correlation analysis. Further, we used the parameter estimation to quantitatively forecast the geographical distribution of COVID-19 in the future. Results The final English-Chinese bilingual table was established including six domains and 32 subordinate hot words. According to the temporal distribution of domains and subordinate hot words in 2020 and 2021, the peaks of searching subordinate hot words and COVID-19 outbreak periods had significant temporal correlation and the subordinate hot words in COVID-19 Related and Territory domains were reliable for COVID-19 surveillance. Gender distribution results showed that Territory domain (the male proportion: 67.69%; standard deviation (SD): 5.88%) and Symptoms/Symptom and Public Health (the female proportion: 57.95%, 56.61%; SD: 0, 9.06%) domains were searched more by male and female groups respectively. The results of age distribution of hot words showed that people aged 20–50 (middle-aged people) had a higher online search intensity, and the group of 20–29, 30–39 years old focused more on Media and Symptoms/Symptom (proportion: 45.43%, 51.66%; SD: 15.37%, 16.59%) domains respectively. Finally, based on frequency rankings of searching hot words and confirmed cases in Mainland China, the epidemic situation of provinces and Chinese administrative divisions were divided into 5 levels of early-warning regions. Central, East and South China regions would be impacted again by the COVID-19 in the future.

Osteoporosis is an age-related systemic skeletal disease leading to bone mass loss and microarchitectural deterioration. It affects a large number of patients, thereby economically burdening healthcare systems worldwide. The low bioavailability and complications, associated with systemic drug consumption, limit the efficacy of anti-osteoporosis drugs currently available. Thus, a combination of therapies, including local treatment and systemic intervention, may be more beneficial over a singular pharmacological treatment. Hydrogels are attractive materials as fillers for bone injuries with irregular shapes and as carriers for local therapeutic treatments. They exhibit low cytotoxicity, excellent biocompatibility, and biodegradability, and some with excellent mechanical and swelling properties, and a controlled degradation rate. This review reports the advantages of hydrogels for adjuvants loading, including nature-based, synthetic, and composite hydrogels. In addition, we discuss functional adjuvants loaded with hydrogels, primarily focusing on drugs and cells that inhibit osteoclast and promote osteoblast. Selecting appropriate hydrogels and adjuvants is the key to successful treatment. We hope this review serves as a reference for subsequent research and clinical application of hydrogel-based delivery systems in osteoporosis therapy.

This work explored a new idea for enhancing the resistance to stress corrosion cracking (SCC) of mining anchor steel through microalloying. Microalloyed anchor steels with Nb, Cu, Ni, Sb, and C were prepared through vacuum smelting and hot rolling. Electrochemical measurements, slow strain rate tensile (SSRT) tests, and fracture morphology observations were used to study the electrochemical and SCC behavior in the simulated mine environment. The results proved that the microstructure of microalloyed steels varies slightly. Adding Ni, Cu, and Sb can improve the mechanical properties of the anchor steel, while reducing C content decreases tensile strength as a result of loss of the solution-strengthening effect. The addition of Sb, Cu, Ni, and reducing the content of C enhances the resistance to corrosion and SCC by mitigating anodic dissolution (AD), while adding Nb improves SCC resistance by inhibiting hydrogen embrittlement (HE). The combined addition of 1% Ni, 0.5% Cu, 0.05% Nb, 0.1% Sb, and 0.5% C presented the highest SCC resistance, which is a promising prospect for the development of high-performance, low-alloy anchor steels. The combined addition of 1% Ni, 0.5% Cu, 0.05% Nb, and 0.1% Sb resulted in the inhibition of electrochemical reactions and corrosion. As a result of the synergistic effect of the microalloy, both AD and HE mechanisms were simultaneously inhibited, which greatly enhanced SCC resistance.

This paper explores the potential of thermal storage as an energy storage technology with cost advantages. The study uses numerical simulations to investigate the impact of adding porous material to the HTF side during solidification to improve the heat transfer effect of TES using AlSi12 alloy as the phase-change material. The research also examines the effects of adding porous dielectric materials and increasing air velocity on the discharge temperature, discharge power, and discharge time of high-temperature phase-change energy storage systems. The study found that the temperature difference of the PCM (increased), solidification time (reduced more than 85%), the outlet temperature of the air, and heat discharge power of the LHS did not vary significantly across different porous materials (copper foam, nickel foam, and silicon carbide foam) added to the HTF tube. These findings offer important information for the design of high-temperature phase-change energy storage devices and can guide future developments in this field.

Abstract Most near‐infrared (NIR) light‐responsive photocatalysts inevitably suffer from low charge separation due to the elevated Coulomb interaction between electrons and holes. Here, an n‐type doping strategy of alkaline earth metal ions is proposed in crystalline K+ implanted polymeric carbon nitride (KCN) for visible and NIR photoactivity. The n‐type doping significantly increases the electron densities and activates the n→π* electron transitions, producing NIR light absorption. In addition, the more localized valence band (VB) and the regulation of carrier effective mass and band decomposed charge density, as well as the improved conductivity by 1–2 orders of magnitude facilitate the charge transfer and separation. The proposed n‐type doping strategy improves the carrier mobility and conductivity, activates the n→π* electron transitions for NIR light absorption, and breaks the limitation of poor charge separation caused by the elevated Coulomb interaction.

Due to their unique properties, vortex lasers have high application value in frontier fields such as optical micromanipulation, super-resolution imaging, quantum entanglement, and optical communication. In this study, we demonstrated a 946/1030 nm Laguerre-Gaussian (LG01) mode dual-wavelength vortex laser by using an intracavity cascade pumped structure and a spot-defect output mirror. Using a coaxial linear cavity structure, the 808 nm laser diode (LD) was used to end-pump the Nd:YAG crystal to generate a 946 nm laser and then use it to directly pump the Yb:YAG crystal in the cavity to generate a 1030 nm laser, and finally a 946/1030 nm dual-wavelength laser came out. By making a spot defect in the center of the output mirror to suppress the oscillation of the fundamental Gaussian mode laser and carefully adjusting the position of the laser crystals, the LG01 mode dual-wavelength vortex laser was output in single handedness. When the pump power was 40 W, the total output was 664 mW (356 and 308 mW at 946 and 1030 nm LG01 mode vortex lasers), and the total optical-optical conversion efficiency was 1.7%; the output power fluctuations of 946 and 1030 nm LG01 mode vortex lasers within 1 h were 3.43% and 3.13%, respectively; the beam quality factors M2 of 946 and 1030 nm LG01 mode vortex lasers were 2.35 and 2.40, respectively. It was proved that the generated dual-wavelength vortex laser had the wavefront phase expiϕ by the self-interference method.

In this paper, the 946/1030 nm dual-wavelength LG01 mode vortex laser is obtained by applying the intracavity cascade pumped structure and annular-beam end-pumped method, an innovative and pioneering exploration of the transverse mode of the dual-wavelength laser. First, we demonstrate the oscillation characteristic theoretical model of the dual-wavelength LG01 mode laser, considering the reabsorption effect. Then the length of the laser crystal and the transmittance of the output mirror are simulated and analyzed, respectively, related to the oscillation characteristics of the 946 and 1030 nm LG01 mode vortex lasers. Finally, a 946/1030 nm LG01 mode vortex laser with the same handedness is successfully achieved in our experiment. With 20 W of annular-beam pump power, the output power of 946 and 1030 nm LG01 mode vortex lasers is 0.404 and 0.510 W, the slope efficiency is 3.6% and 6.2%, and the total optical-optical conversion efficiency is 4.6%. At the maximum output power, the fluctuations of output power within 1 h are 4.02% and 4.23%, and the beam quality factors M2 are 2.32 and 2.27, respectively, for 946 and 1030 nm LG01 mode vortex lasers. The wavefront phase exp(iϕ) of the 946/1030 nm dual-wavelength is also proved by the self-interference method.

Penile metastasis of prostate cancer is rare, with a poor prognosis, and only a limited number of relevant cases have been reported so far. With the application of 18F-PSMA-1007 PET/CT, the biochemical recurrence of prostate cancer can be detected at an early stage for providing important evidence, facilitating clinical decision-making. Here, we have reported a case of solitary penile metastatic recurrence in the context of mild PSA progression (PSA: 0.072 ng/ml). This case highlights the preferable sensitivity of 18F-PSMA-1007 PET/CT imaging in prostate cancer.

The CCHC-type zinc finger proteins (CCHC-ZFPs) play versatile roles in plant growth, development and adaptation to the environment. However, little is known about functions of CCHC-ZFP gene family memebers in Triticum aestivum. In the present study, we identified a total of 50 TaCCHC-ZFP genes from the 21 wheat chromosomes, which were phylogenetically classified into eight groups based on their specific motifs and gene structures. The 43 segmentally duplicated TaCCHC-ZFP genes were retrieved, which formed 36 segmental duplication gene pairs. The collinearity analyses among wheat and other eight mono/dicots revealed that no gene pairs were found between wheat and the three dicots. The promoter analyses of the TaCCHC-ZFP genes showed that 636 environmental stress-responsive and phytohormone-responsive cis-elements. The gene ontology enrichment analysis indicated that all the TaCCHC-ZFP genes were annotated under nucleic acid binding and metal ion binding. A total of 91 MicroRNA (miRNA) binding sites were identified in 34 TaCCHC-ZFP genes according to the miRNA target analysis. Based on the public transcriptome data, the 38 TaCCHC-ZFP genes were identified as differentially expressed gene. The expression profiles of 15 TaCCHC-ZFP genes were verified by the quantitative real-time PCR assays, and the results showed that these genes were responsive to drought or heat treatments. Our work systematically investigated the gene structures, evolutionary features, and potential functions of TaCCHC-ZFP genes. It lays a foundation for further research and application of TaCCHC-ZFP genes in genetic improvement of T. aestivum.

We previously demonstrated that a synthetic monomer peptide derived from the C-terminus of p53 (aa 361–382) induced preferential apoptosis in mutant p53 malignant cells, but not normal cells. The major problem with the peptide was its short half-life (half-life < 10 min.) due to a random coil topology found in 3D proton NMR spectroscopy studies. To induce secondary/tertiary structures to produce more stability, we developed a peptide modelled after the tetrameric structure of p53 essential for activation of target genes. Starting with the above monomer peptide (aa 361–382), we added the nuclear localization sequence of p53 (aa 353–360) and the end of the C-terminal sequence (aa 383–393), resulting in a monomer spanning aa 353–393. Four monomers were linked by glycine to maximize flexibility and in a palindromic order that mimics p53 tetramer formation with four orthogonal alpha helices, which is required for p53 transactivation of target genes. This is now known as the 4 repeat-palindromic-p53 peptide or (4R-Pal-p53p). We explored two methods for testing the activity of the palindromic tetrapeptide: (1) exogenous peptide with a truncated antennapedia carrier (Ant) and (2) a doxycycline (Dox) inducer for endogenous expression. The exogenous peptide, 4R-Pal-p53p-Ant, contained a His tag at the N-terminal and a truncated 17aa Ant at the C-terminal. Exposure of human breast cancer MB-468 cells and human skin squamous cell cancer cells (both with mutant p53, 273 Arg->His) with purified peptide at 7 µM and 15 µM produced 52% and 75%, cell death, respectively. Comparatively, the monomeric p53 C-terminal peptide-Ant (aa 361–382, termed p53p-Ant), at 15 µM and 30 µM induced 15% and 24% cell death, respectively. Compared to the p53p-Ant, the exogenous 4R-pal-p53p-Ant was over five-fold more potent for inducing apoptosis at an equimolar concentration (15 µM). Endogenous 4R-Pal-p53p expression (without Ant), induced by Dox, resulted in 43% cell death in an engineered MB468 breast cancer stable cell line, while endogenous p53 C-terminal monomeric peptide expression produced no cell death due to rapid peptide degradation. The mechanism of apoptosis from 4R-Pal-p53p involved the extrinsic and intrinsic pathways (FAS, caspase-8, Bax, PUMA) for apoptosis, as well as increasing reactive oxygen species (ROS). All three death pathways were induced from transcriptional/translational activation of pro-apoptotic genes. Additionally, mRNA of p53 target genes (Bax and Fas) increased 14-fold and 18-fold, respectively, implying that the 4R-Pal-p53p restored full apoptotic potential to mutant p53. Monomeric p53p only increased Fas expression without a transcriptional or translational increase in Fas, and other genes and human marrow stem cell studies revealed no toxicity to normal stem cells for granulocytes, erythrocytes, monocytes, and macrophages (CFU-GEMM). Additionally, the peptide specifically targeted pre-malignant and malignant cells with mutant p53 and was not toxic to normal cells with basal levels of WT p53.

(1) Background: TDMQ20 is a specific regulator of copper homeostasis in the brain, able to inhibit cognitive impairment in the early stages of Alzheimer’s disease (AD) in mouse models of AD. To promote the further development of this drug-candidate, preliminary data on the pharmacokinetics of TDMQ20 in a mammal model have been collected. Since TDMQ20 should be administered orally, its absorption by the gastrointestinal tract was evaluated by comparison of blood concentrations after administration by oral and IV routes, and its ability to reach its target (the brain) was confirmed by comparison between blood and brain concentrations after oral administration. (2) Methods: plasmatic and brain concentrations of the drug after oral or intravenous treatment of rats at pharmacologically relevant doses were determined as a function of time. (3) Results: oral absorption of TDMQ20 was rapid and bioavailability was high (66% and 86% for males and females, respectively). The drug accumulated in the brain for several hours (brain–plasma ratio 3 h after oral administration = 2.6), and was then efficiently cleared. (4) Conclusions: these data confirm that TDMQ20 efficiently crosses the brain–blood barrier and is a relevant drug-candidate to treat AD.

Phase change slurries (PCSs) have great potential as both a heat transfer fluid and an energy storage medium for cooling processes, cold energy storage, and cold energy transportation due to desirable thermophysical properties. One of the major benefits of PCSs compared to pure phase change materials is their fluidity, thus making them cooled or heated by a heat exchanger, pumped through pipes, discharged, and stored directly in a thermal energy storage tank. The use of encapsulated phase change slurries and gas hydrate slurry has thus attracted considerable interest as reflected in the literature with a rising number of publications and institutions involved in the area. The use of bibliometric techniques has found a recent interest in the literature to define the progress of different scientific topics and inspire researchers to identify novelties. In this paper, bibliometric analysis and a detailed systematic review are carried out to show the state-of-the-art development of PCSs for cooling applications. Research gaps and hotspots are identified to help define future perspectives on this topic.

In this work, low-temperature Schottky source/drain (S/D) MOSFETs are investigated as the top-tier devices for 3D sequential integration. Complementary Schottky S/D FinFETs are successfully fabricated with a maximum processing temperature of 500 °C. Through source/drain extension (SDE) engineering, competitive driving capability and switching properties are achieved in comparison to the conventional devices fabricated with a standard high-temperature (≥1000 °C) process flow. Schottky S/D PMOS exhibits an ON-state current (ION) of 76.07 μA/μm and ON-state to OFF-state current ratio (ION/IOFF) of 7 × 105, and those for NMOS are 48.57 μA/μm and 1 × 106. The CMOS inverter shows a voltage gain of 18V/V, a noise margin for high (NMH) of 0.17 V and for low (NML) of 0.43 V, with power consumption less than 0.9 μW at VDD of 0.8 V. Full functionality of CMOS ring oscillators (RO) are further demonstrated.

This paper investigates the cryogenic heat transfer phenomena of nitrogen flowing in helically coiled tubes under the combined effects of pseudocritical conditions, buoyancy, and coil curvature. The ultimate goal was to design optimum heat exchangers for liquid air energy storage. Local heat transfer coefficients were evaluated peripherally across tube cross sections. The pressure, mass flux, and heat flux effects on the heat transfer were examined. The dual effect of buoyancy and coil curvature on heat transfer coefficients was interpreted via a dimensionless number Ψ, which denotes a ratio between the two effects. Results reveal that the heat transfer coefficients increase with increasing mass flux but decreasing pressure and heat flux. The buoyancy effect dominates the heat transfer at fluid temperatures below the pseudocritical temperature (e.g., −146.3 °C at 35 bar), while the coil curvature-induced centrifugal effect dominates at higher temperatures. The heat transfer coefficients for the helical coil were approximately 13% lower compared with those in straight tube at fluid temperatures below the pseudocritical temperature, but their difference shrinks (

In this paper, the fabrication and electrical performance optimization of a four-levels vertically stacked Si0.7Ge0.3 channel nanowires gate-all-around transistor are explored in detail. First, a high crystalline quality and uniform stacked Si0.7Ge0.3/Si film is achieved by optimizing the epitaxial growth process and a vertical profile of stacked Si0.7Ge0.3/Si fin is attained by further optimizing the etching process under the HBr/He/O2 plasma. Moreover, a novel ACT@SG-201 solution without any dilution at the temperature of 40 °C is chosen as the optimal etching solution for the release process of Si0.7Ge0.3 channel. As a result, the selectivity of Si to Si0.7Ge0.3 can reach 32.84 with a signature of “rectangular” Si0.7Ge0.3 extremities after channel release. Based on these newly developed processes, a 4-levels vertically stacked Si0.7Ge0.3 nanowires gate-all-around device is prepared successfully. An excellent subthreshold slope of 77 mV/dec, drain induced barrier-lowering of 19 mV/V, Ion/Ioff ratio of 9 × 105 and maximum of transconductance of ~83.35 μS/μm are demonstrated. However, its driven current is only ~38.6 μA/μm under VDS = VGS = −0.8 V due to its large resistance of source and drain (9.2 × 105 Ω). Therefore, a source and drain silicide process is implemented and its driven current can increase to 258.6 μA/μm (about 6.7 times) due to the decrease of resistance of source and drain to 6.4 × 104 Ω. Meanwhile, it is found that a slight increase of leakage after the silicide process online results in a slight deterioration of the subthreshold slope and Ion/Ioff ratio. Its leakage performance needs to be further improved through the co-optimization of source and drain implantation and silicide process in the future.

Al-Sn bearing alloys were prepared with different electromagnetic stirring (EMS) currents. Electrochemical and immersion corrosion experiments were carried out on the samples. Optical microscope, SEM, EDS, and XPS were used to characterize the samples to study the effect of stirring current on the microstructure and corrosion properties of the alloy. The results show that the structure of the sample without EMS is all dendrites. With the increase of stirring current, the number of primary phase agglomerates is less and the grain size decreases. When the stirring parameter is 60A, 20Hz, the grain size is the most round and small, and the stirring effect is the best. In the later stage of immersion, the corrosion product film formed on the surface is more dense and uniform, which can effectively block the erosion of ions in the solution. The equivalent circuit fitting calculation shows that the R _total value is the largest, which is 1.79 × 10 ^6 Ω·cm ^2 , and the corrosion resistance is the best.

An accurate constitutive model is essential for designing the process of hot precision forging and numerical simulation. Based on the isothermal compression tests of as-extruded HMn64–8–5–15 manganese brass alloy at the deformation temperature of 873–1073 K and strain rate of 001–10 s ^−1 , the effect of the friction and deformation temperature rise on the flow stress during the hot compression process was analyzed, and the flow stress curves were corrected. Three constitutive models based on the modified Zerilli-Armstrong, Arrhenius, and a back-propagation neural network (BPNN) optimized by the grey wolf optimization (GWO) algorithm (GWO-BPNN) models were established to describe the high-temperature flow stress of this alloy. Meanwhile, the prediction ability of the three models was evaluated by the calculated values of mean absolute percentage error ( MAPE ) and root mean square error ( RMSE ). The values of MAPE for the modified Zerilli-Armstrong, Arrhenius, and GWO-BPNN models were computed to be, 3139 %, 2448 % and 1265 %, and the values of RMSE were calculated to be 1804, 1482 and 0467 MPa, respectively. The GWO-BPNN model was with the greatest prediction ability for the flow stress among these models. The GWO algorithm was introduced to optimize the initial weights and thresholds of the BPNN model, and it has good prediction accuracy and better stability. It can better describe the high-temperature flow behavior of HMn64–8–5–15 alloy.

Due to their broadband optical absorption ability and fast response times, carbon nanotube (CNT)-based materials are considered promising alternatives to the toxic compounds used in commercial infrared sensors. However, the direct use of pure CNT networks as infrared sensors for simple resistance read-outs results in low sensitivity values. In this work, MoS2 nanoflowers are composited with CNT networks via a facile hydrothermal process to increase the bolometric performance. The thermal diffusivity (α) against temperature (T) is measured using the transient electro-thermal (TET) technique in the range of 320 K to 296 K. The α-T curve demonstrates that the composite containing MoS2 nanoflowers provides significant phonon scattering and affects the intertube interfaces, decreasing the α value by 51%. As the temperature increases from 296 K to 320 K, the relative temperature coefficient of resistance (TCR) increases from 0.04%/K to 0.25%/K. Combined with the enhanced light absorption and strong anisotropic structure, this CNT–MoS2 composite network exhibits a more than 5-fold greater surface temperature increase under the same laser irradiation. It shows up to 18-fold enhancements in resistive responsivity ((Ron − Roff)/Roff) compared with the pure CNT network for a 1550 nm laser at room temperature (RT).

The convective heat transfer behavior of supercritical nitrogen (S-N2) has played a significant role in optimizing the design of recently emerging cryogenic cold storage and recovery systems. However, studies on S-N2 heat transfer have been relatively scarce, not to mention that there is a legitimate urge for a robust numerical model to accurately predict and explain S-N2 heat transfer under various working conditions. In this paper, both experimental and numerical studies were conducted for convective heat transfer of S-N2 in a small vertical tube. The results demonstrated that the standard k-ε model performed better for predicting the key heat transfer characteristics of S-N2 than the SST k-ω model. The effects of heat flux and inlet pressure on the heat transfer characteristics under a large mass flux were evaluated. The variation mechanisms of local heat transfer performance were revealed by illustrating radial profiles of thermophysical properties and turbulent parameters of N2. It was found that the local performance variation along the flow direction was mainly determined by the radial profile of specific heat while the variation of the best local performance with the ratio of heat flux to mass flux was mainly determined by the radial profile of turbulent viscosity.