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In the present study, the effect of 6-((4-fluorophenyl) selanyl)-9H-purine (FSP) was tested against memory impairment and sensitivity to nociception induced by intracerebroventricular injection of amyloid-beta peptide (Aβ) (25-35 fragment), 3 nmol/3 μl/per site in mice. Memory impairment was determined by the object recognition task (ORT) and nociception by the Von-Frey test (VFT). Aβ caused neuroinflammation with upregulation of glial fibrillary acidic protein (GFAP) (in hippocampus), nuclear factor-κB (NF-κB), and the proinflammatory cytokines interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) in cerebral cortex and hippocampus. Additionally, Aβ increased oxidant levels and lipid peroxidation in cerebral cortex and hippocampus, but decreased heme oxygenase-1 (HO-1) and peroxiredoxin-1 (Prdx1) expression in the hippocampus. Anti-neuroinflammatory effects of FSP were demonstrated by a decrease in the expression of GFAP and NF-κB in the hippocampus, as well as a decrease in proinflammatory cytokines in both the hippocampus and cerebral cortex FSP protected against oxidative stress by decreasing oxidant levels and lipid peroxidation and by increasing HO-1 and Prdx1 expressions in the hippocampus of mice. Moreover, FSP prevented the activation of nuclear factor erythroid 2-related factor 2 (Nrf-2) in the hippocampus of mice induced by Aβ. In conclusion, treatment with FSP attenuated memory impairment, nociception sensitivity by decreasing oxidative stress, and neuroinflammation in a mouse model of Alzheimer's disease.

Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders with high rates of prevalence and mortality. MDD is pathophysiologically complex, and treatment options are limited. Blueberries are rich in polyphenols and have neuroprotective potential. The aim of this study was to investigate the effects of blueberry extract on neuroinflammatory and neuroplasticity parameters, as well as Na

The “new normality” and the growing uncertainty that the world faces determine the development of different business and innovative ways of work. To this end, a new mindset and new competences are required to the actors that will participate in these new social and business contexts. Higher Education will certainly have its role in shaping this mindset and competences of the future managers who should be able to participate in the co-creation of value propositions for companies. The project COTADAS (CO-creation To Analyses and Development of Strategic Scenarios) aims to contribute to the training of these future managers. The project aims to analyse and develop strategic scenarios that facilitate intelligent and sustainable value propositions, through digital and intelligent tools. Supported in a multidisciplinary approach and using innovative methodologies, it is intended to facilitate the acquisition of knowledge in less attractive areas for students, namely the areas of finance, revealing how this knowledge can leverage emerging and important areas of knowledge such as innovation, entrepreneurship, and sustainability. The objective of this article is to describe and evaluate the COTADAS project, developed in two Higher Education Institutes (Polytechnic Institute of Setúbal and Federal Institute of Santa Catarina) with Portuguese and Brazilian students. This study is structured in two main parts. In the first part we present a theoretical approach and in the second part we describe the project and the results of the assessment. A questionnaire was applied to participants to evaluate the degree of satisfaction with the project and its impact on entrepreneurial skills. The results revealed a high degree of student’s satisfaction, as well as a valuable impact on the acquisition and development of entrepreneurial skills. Several advantages in participating in COTADAS were pointed out as well as some possible improvements that can enrich the next project edition. Finally, the results allowed us to understand that both successes and failures were important aspects in the students' learning and personal growth.

Diversas biotécnicas vem sendo utilizadas para a preservação de material genético e manutenção a medio e longo prazo de gametas e embrioes de elevado valor genético, contribuindo para o avanço das estratégias para produção pecuária. O processo de vitrificação de oocitos bovinos é uma delas, entretanto com aplicação ainda restrita, pois durante o processo podem ocorrer varias crio injurias. Afim de reduzir os danos causados pelo congelamento de oócitos e melhorar as taxas de clivagem e desenvolvimento embrionário obtidas no cultivo in vitro, utilizou-se a exposição a Y-27632, um inibidor seletivo de quinases de proteínas específicas associadas com Rho durante o estágio de pós-aquecimento. Nosso estudo demonstrou que a utilização de Y-27632 em oocitos bovinos maturados e submetidos a vitrificação promoveu taxas mais elevadas de sobrevivência bem como maior número de embriões atingindo o etágio de blastocisto.

Sustainable and highly proton conductive nanopapers were prepared from carboxycellulose nanofibers and applied in PEM fuel cells.

Biodiversity is commonly referred to as the biological diversity and variety of life forms, but these organisms should not be observed individually, but rather as a complex and functional structure that interacts with each other. Educating citizens from an early age to know the biodiversity of their region and then helping to conserve, preserve and protect it is a very important process. Our objective was to analyze the knowledge of students in the last year of high school on the topic of regional biodiversity. It is a qualitative and quantitative research, carried out in three schools, in three different municipalities, with 65 students. Among the three levels of biodiversity, students know the diversity of species. Most of them conceptualize native and endemic species, but do not know how to conceptualize exotic species. In general, they understand that the great importance of biodiversity is ecological balance and that the loss of biodiversity will lead to ecological imbalance. Native species, cited more frequently, are species present in urban areas and students with more contact with nature cite, on average, a greater number of species, indicating the importance of rescuing contact with nature. La biodiversidad se conoce comúnmente como la diversidad biológica y la variedad de formas de vida, pero estos organismos no deben observarse individualmente, sino como una estructura compleja y funcional que interactúa entre sí. Educar a los ciudadanos desde temprana edad para que conozcan la biodiversidad de su región y luego ayudar a conservarla, preservarla y protegerla es un proceso muy importante. Nuestro objetivo fue analizar los conocimientos de los estudiantes del último año de secundaria sobre el tema de la biodiversidad regional. Es una investigación cualitativa y cuantitativa, realizada en tres escuelas, en tres municipios diferentes, con 65 alumnos. Entre los tres niveles de biodiversidad, los alumnos conocen la diversidad de especies. La mayoría conceptualiza especies nativas y endémicas, pero no sabe conceptualizar especies exóticas. En general, entienden que la gran importancia de la biodiversidad es el equilibrio ecológico y que la pérdida de biodiversidad conducirá al desequilibrio ecológico. Las especies nativas, citadas con mayor frecuencia, son especies presentes en áreas urbanas y los estudiantes con más contacto con la naturaleza citan, en promedio, un mayor número de especies, lo que indica la importancia de rescatar el contacto con la naturaleza. A biodiversidade comumente é referenciada como a diversidade biológica e variedade de formas de vida, porém esses organismos não devem ser observados de uma forma individual, mas sim como uma estrutura complexa e funcional que interage entre si. Educar o cidadão desde cedo para conhecer a biodiversidade da sua região e então ajudar a conservá-la, preservá-la e protegê-la é um processo importantíssimo. Nosso objetivo foi analisar o conhecimento dos estudantes do último ano do Ensino Médio sobre o tema biodiversidade regional. É uma pesquisa qualitativa e quantitativa, realizada em três escolas, de três municípios distintos, com 65 estudantes. Dentre os três níveis da biodiversidade, os estudantes conhecem a diversidade de espécies. A maioria deles conceitua espécies nativas e endêmicas, mas não sabe conceituar espécies exóticas. De forma geral eles entendem que a grande importância da biodiversidade é o equilíbrio ecológico e que a perda da biodiversidade levará ao desequilíbrio ecológico. As espécies nativas, citadas com mais frequência, são espécies presentes nas áreas urbanas e os estudantes com mais contato com a natureza citam, em média, um número maior de espécies, indicando a importância de resgatar o contato com a natureza.

Anaplasma marginale is transmitted biologically by infected ticks or mechanically by biting flies and contaminated fomites. In tick-free areas, such southern Uruguay, horseflies could be the principal vectors of this pathogen to bovines, causing anaplasmosis occurrence. Therefore, the objective of this work was to detect the presence of A. marginale by MSP-5 PCR and Sanger sequencing in the most prevalent species of horseflies using different collection methods in the localities of Colonia, Taquarembó and Paysandú, Uruguay. Eight horsefly species were tested (Dasybasis missionum, Poeciloderas lindneri, Tabanus campestris, T. claripennis, T. fuscofasciatus, T. platensis, T. tacuaremboensis and T. triangulum); four species were found positive for A. marginale, with D. missionum and P. lindneri having the most frequent infections, while only one individual each of T. fuscofasciatus and T. tacuaremboensis was positive. Both D. missionum and P. lindneri were positive for A. marginale in tick-free areas, with implications that are discussed in this report.

Obstructive Sleep Apnea and Hypopnea Syndrome (OSAHS) is a progressive disorder of the respiratory system that seriously affects the general health and, consequently, the quality of life of an individual. The aim of the present study was to report a case of moderate OSAHS treated with the supervised use of the Gradual Mandibular Advancement Intraoral Appliance (AIO). The treatment was followed up through the patient's report, evaluation of the Epworth Sleepiness Scale, and its result was confirmed by the baseline polysomnography exam. After the treatment period, there was an improvement in the symptoms reported by the patient and in the polysomnographic parameters. The patient went from a moderate OSAHS condition, with an Apnea and Hypopnea Index (AHI) of 24.7 events per hour, to a mild condition with an AHI of 10.7 events per hour. Thus, it can be concluded based on the present case that the AIO was effective for the conservative treatment of moderate OSAHS. El síndrome de apnea e hipopnea obstructiva del sueño (SAHOS) es un trastorno progresivo del sistema respiratorio que afecta gravemente la salud general y, en consecuencia, la calidad de vida de un individuo. El objetivo del presente estudio fue reportar un caso de SAHOS moderado tratado con el uso supervisado del Aparato Intraoral de Avance Mandibular Gradual (AIO). El tratamiento fue seguido a través del informe del paciente, la evaluación de la Escala de Somnolencia de Epworth y su resultado fue confirmado por el examen de polisomnografía basal. Después del período de tratamiento, hubo una mejoría en los síntomas informados por el paciente y en los parámetros polisomnográficos. El paciente pasó de un estado de SAHOS moderado, con un índice de apnea e hipopnea (IAH) de 24.7 eventos por hora, a un estado leve con un IAH de 10.7 eventos por hora. Por lo tanto, se puede concluir con base en el presente caso que el AIO fue efectivo para el tratamiento conservador del SAHOS moderado. A Síndrome da Apneia e Hipopneia Obstrutiva do Sono (SAHOS) é uma desordem progressiva do sistema respiratório que afeta seriamente a saúde geral e, consequentemente, a qualidade de vida do indivíduo. O objetivo do presente estudo foi relatar um caso de SAHOS moderada tratado com o uso supervisionado do Aparelho Intraoral de Avanço Mandibular Gradual (AIO). O tratamento foi acompanhado através do relato do paciente, avaliação da Escala de Sonolência de Epworth, e seu resultado foi confirmado pelo exame de polissonografia de base. Após o período de tratamento, houve melhora nos sintomas relatados pelo paciente e nos parâmetros polissonográficos. O paciente passou de um quadro de SAHOS moderado, com Índice de Apnéia e Hipopnéia (IAH) de 24.7 eventos por hora, para um quadro leve com IAH de 10.7 eventos por hora. Assim, pode-se concluir com base no presente caso que o AIO foi eficaz para o tratamento conservador da SAHOS moderada.

In this study, granulated activated charcoal (GAC) and bio charcoal (BC) is used as a filler in P3 biosand bag filter to study their filtration performance against a range of fluoride impurities from 1–1400 mg/L. A set of experiments are done to analyze the filtration efficiency of the sandbag filter against fluoride impurities after incorporating different amounts (e.g., 0.2, 2 kg) and a combination of GAC and BC. A combination of filler GAC and BC (1 kg each) have exhibited excellent results with 100% fluoride removal efficiency against 5 mg/L fluoride impurities for an entire experimental time of 165 min. It is because of the synergetic effect of adsorption caused by the high surface area (739 m2/g) of GAC and hydroxyapatite groups in BC. The data from remediation experiments using individual GAC and BC are fitted into the Langmuir and Freundlich Isotherm Models to check their adsorption mechanism and determine GAC and BC’s maximum adsorption capacity (Qm). The remediation data for both GAC and BC have shown the better fitting to the Langmuir Isotherm Model with a high R2 value of 0.994 and 0.970, respectively, showing the excellent conformity with monolayer adsorption. While the GAC and BC have presented negative Kf values of −1.08 and −0.72, respectively, for Freundlich Model, showing the non-conformity to multilayer adsorption. The Qm values obtained from Langmuir Model for GAC is 6.23 mg/g, and for BC, it is 9.13 mg/g. The pH study on adsorption efficiency of individual GAC and BC against 5 mg/L of fluoride impurities indicates the decrease in removal efficiency with an increase in pH from 3 to 9. For example, BC has shown removal efficiency of 99.8% at pH 3 and 99.5% at pH 9, while GAC has exhibited removal efficiency of 96.1% at pH 3 and 95.9% at pH 9. Importantly, this study presents the significance of the synergetic application of GAC and BC in the filters, where GAC and BC are different in their origin, functionalities, and surface characteristics.

A biodiversidade comumente é referenciada como a diversidade biológica e variedade de formas de vida, porém esses organismos não devem ser observados de uma forma individual, mas sim como uma estrutura complexa e funcional que interage entre si. Educar o cidadão desde cedo para conhecer a biodiversidade da sua região e então ajudar a conservá-la, preservá-la e protegê-la é um processo importantíssimo. Nosso objetivo foi analisar o conhecimento dos estudantes do último ano do Ensino Médio sobre o tema biodiversidade regional. É uma pesquisa qualitativa e quantitativa, realizada em três escolas, de três municípios distintos, com 65 estudantes. Dentre os três níveis da biodiversidade, os estudantes conhecem a diversidade de espécies. A maioria deles conceitua espécies nativas e endêmicas, mas não sabe conceituar espécies exóticas. De forma geral eles entendem que a grande importância da biodiversidade é o equilíbrio ecológico e que a perda da biodiversidade levará ao desequilíbrio ecológico. As espécies nativas, citadas com mais frequência, são espécies presentes nas áreas urbanas e os estudantes com mais contato com a natureza citam, em média, um número maior de espécies, indicando a importância de resgatar o contato com a natureza.