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The world’s energy demand is currently rising as a result of the expanding population. Because of the rising worry about climate change brought on by the greenhouse gas emissions created by fossil and coal fuel, bio-briquette, especially those made from agricultural waste, are a sustainable energy source that have a great chance of becoming alternative energy sources. Hence, this review paper provides overview on the principles, processing, densification, storage and economics of Briquetting.

A chatbot is a computer program that runs a conversation in the form of a text. Chat-bot usually provides user-based communication that allows input from the user and receives text from the outgoing. Chat-bot information is stored on a website provided by the owner and the user needs. This program will be given the answers to the user's question with great success. The user must place a requirement on the chat-bot used for the transport-related chat. This model is based on supervised learning strategies with pre-packaged information to focus and create productive models against a training set. The system will use an AI algorithm to provide relevant information about transit to the user.

JUICE’s and Europa Clipper’s synergistic contribution to the Galilean moons’ ephemerides An accurate determination of the ephemerides of natural satellites is critical to our understanding of planetary systems’ evolution, and of tidal dissipation mechanisms in particular. Diverse interior or dissipation-related parameters can be retrieved when reconstructing the moons’ dynamics from space missions’ radiometric data [1,2,3]. For the Galilean moons of Jupiter, unique challenges complicate the estimation of the satellites’ dynamics, as the Laplace resonances between Io, Europa and Ganymede result in a strongly coupled dynamical problem. Efficiently improving the current ephemerides solution would thus ideally require a balanced data distribution between these moons. In this context, the synergy between the upcoming JUICE and Europa Clipper missions is of primary importance. In particular, the ~ 50 flybys at Europa to be performed by the Clipper spacecraft will efficiently supplement JUICE’s trajectory (2 flybys at Europa, 7 at Ganymede, 21 at Callisto, followed by a long orbital phase around Ganymede), leading to complementary radiometric data sets. Most importantly, in-system concurrent observations will be possible according to current missions’ schedules. Preliminary analyses show that a joint solution from JUICE and Europa Clipper range and Doppler measurements can improve the estimation solution for the Galilean satellites’ ephemerides and related dynamical properties (e.g. tidal dissipation parameters) [4]. Contribution of PRIDE multi-spacecraft observations The Planetary Radio Interferometry and Doppler Experiment (PRIDE) has been selected as one of the eleven experiments of the JUICE (JUpiter ICy moons Explorer) mission [5]. It relies on Very Long Baseline Interferometry (VLBI) techniques to process radiometric signals used for tracking, communications and/or radioscience. The main PRIDE observables are measurements of the spacecraft’s lateral position with respect to a phase calibrator (VLBI), expressed in the ICRF (International Celestial Reference Frame) [6], but by-product Doppler observables are also generated [7]. Compared to range and Doppler measurements, which are collected in the line-of-sight direction, PRIDE VLBI data are sensitive to the spacecraft’s position in the two other directions. They thus provide very complementary information, which could help achieving an improved solution for the spacecraft’s and moons’ states in particular. A previous analysis has quantified the contribution of PRIDE VLBI observations to the Galilean moons’ ephemerides for the JUICE test case [2], using a simplified non-coupled model [8]. A noticeable improvement was indeed obtained in the out-of-plane direction when including VLBI data, especially for Ganymede and Callisto (more data collected at these two moons). In addition to these single-spacecraft VLBI measurements, the concurrent in-system tracking of the JUICE and Europa Clipper spacecraft will offer PRIDE a unique opportunity to fully exploit the synergy between the two missions’ trajectories. If the two spacecraft are both visible from a telescope (i.e. in-beam or within the same telescope beam) and simultaneously transmitting a radio signal, it is possible to realise multi-spacecraft VLBI observations, which will directly provide accurate measurements of the relative lateral position of the two spacecraft (right ascension and declination difference in the ICRF). Such observations were already successfully collected between several Martian orbiters (MRO, MEX, TGO) in 2019 [9], as shown in Figure 1. Figure 1: Simultaneous detection of the signals transmitted by several Martian orbiters and landers, from [9]. Given the synergistic nature of the JUICE and Clipper trajectories, the signals of the two spacecraft are expected to be visible in the same beam of ground-based telescopes during a significant fraction of their Jovian tours. Looking in detail at JUICE and Clipper flybys’ sequences displayed in Figure 2, the two spacecraft will occasionally perform near-simultaneous flybys around different moons, with typically only a coupled of days between JUICE’s and Clipper’s flybys. The relative angular measurements derived from PRIDE VLBI observations might then translate into direct constraints of the moons’ relative states, expected to be extremely valuable for the ephemerides solutions. Figure 2: JUICE and Europa Clipper trajectories (altitude with respect to the moons) Contribution of these observations to the Galilean satellites’ ephemerides Our open-source estimation tool (Tudat(py)1) is now able to concurrently simulate several missions with different trajectories and observation schedules in a single estimation [10]. It is also linked with a VLBI prediction tool allowing to search for suitable phase calibrators close to the spacecraft at any potential observation epoch. Using these functionalities, we perform a simulation study to quantify the potential contribution of multi-spacecraft (in-beam) VLBI observations, also analysing its sensitivity to the observations’ cadence and accuracy. To this end, we will investigate when multi-spacecraft VLBI observations could be obtained from the JUICE and Clipper spacecraft. This involves searching for suitable phase calibrators and ensuring that both spacecraft are visible from ground telescopes at a given epoch. We will also further investigate promising observation geometries (e.g. near-simultaneous flybys, see Figure 2). The simulated multi-spacecraft observables will then be added to a joint JUICE – Clipper estimation, which also includes nominal (single-spacecraft) PRIDE VLBI observations for JUICE. We will then precisely quantify the contribution of these simulated multi-spacecraft VLBI observations to the estimation solution, focusing on the moons’ ephemerides and related dynamical parameters in particular. If proven beneficial, this will motivate the acquisition of such observations during the JUICE and Clipper missions. Additionally, our sensitivity analysis will provide direct recommendations regarding observation scheduling. If need be (i.e. particularly interesting multi-spacecraft VLBI observation but no phase calibrator in the angular vicinity of the spacecraft), this could also highlight the need to search for yet unknown calibrators in a certain region of the sky. References [1] Dirkx et al., Planetary and Space Science 134 (2016): 82-95. [2] Dirkx et al., Planetary and Space Science 147 (2017): 14-27. [3] Lainey et al., Nature Astronomy 4.11 (2020): 1053-1058. [4] A. Magnanini et al., in preparation. [5] Gurvits et al., European Planetary Science Congress (2013). [6] Duev et al., Astronomy & Astrophysics 541 (2012): A43. [7] Bocanegra-Bahamon et al., Astronomy & Astrophysics 609 (2018): A59. [8] Fayolle et al., submitted to Planetary & Space science (under revision) [9] Molera Calvés et al., Publications of the Astronomical Society of Australia, 38, E065 [10] Fayolle et al., EGU General Assembly (2022). 1 https://docs.tudat.space

BackgroundOver the years, a number of methods have been introduced in the field of herbal medicine. Amongst these, metabolomics has rapidly emerged as a method of choice due to its wide applicability and versatility. High performance liquid chromatography (HPLC) is a preferred method for fingerprinting with advantages such as easy and wide availability, and relatively low maintenance cost. The current study used HPLC profiling and attempted to correlate it to anti-diarrhoeal activity of Psidium guajava (guava) extracts.MethodsNinety samples of guava leaves were collected from three locations in Maharashtra, India over three seasons. Hydroalcoholic extracts (50:50, ethanol:water) were prepared and the HPLC chromatogram of all 90 extracts obtained. A total of eight bioassays representing the important features of diarrhoeal pathogenesis were performed and the extracts were differentiated as ‘good’ or ‘poor’ according to cut-offs for each assay. The numerical data of the bioassays and the HPLC chromatogram was correlated using suitable mathematical models comprising Principal component analysis (PCA), orthogonal partial least squares (OPLS, regression) and orthogonal partial least squares discriminant analysis (OPLS-DA).ResultsOPLS-DA showed good seasonal and regional segregation of extracts. For most of the bioassays, PCA was unsuccessful in showing significant discrimination. Hence, OPLS plots were further developed; differentiation of good and poor extracts among the 90 extracts was successfully demonstrated for antibacterial activity against Shigella flexneri and Vibrio cholerae, inhibition of invasion of enteropathogenic Escherichia coli into HEp-2 epithelial cells, and cholera toxin (CT) production by V. cholerae. However, for other assays, namely, inhibition of adherence of E. coli, invasion of S. flexneri into HEp-2 cells, and inhibition of E. coli labile toxin (LT), subsets of 90 extracts were selected to demonstrate a significant correlation.ConclusionHPLC-based metabolomics has the potential to differentiate good and poor activities of guava leaf extracts. This approach can be extended for identifying phytoconstituents responsible for the anti-diarrhoeal activity of guava leaf and help standardization of crude extracts.

Suryavarta is one of the Shiro Rogas mentioned by Brihatrayis. Suryavarta is produced by Pitta and Vata as per Acharya Sushruta who mentioned that it is ldquoSarvatmakam Kastatamam Vikaramrdquo. Most of its clinical features can be correlated to the features of frontal sinusitis which is also known as vacuum headache or office headache as it affects routine and day-to-day activities of the people. Nasya Siravyadha Lepas etc. are the treatment options for Suryavarta. In the present case study a 27-year-old female patient complaining of Shirashoola Nasavarodha Shiroguruthwa and frontal sinus tenderness came to the outpatient department OPD. The patient was treated with Nasya Karma with Nirgundi Patra Swarasa added with Ghrita and Saindhava for 7 days and got relief from her symptoms.nbsp