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1. Amyloidose

Author

Hagmeyer, Lars, Hegenbart, Ute, Schönland, Stefan, Kleibrink, Björn, Teschler, Helmut, Kreuter, Michael, editor, Costabel, Ulrich, editor, Herth, Felix JF, editor, and Kirsten, Detlef, editor

Published
2022
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2. Effect of adaptive servo-ventilation for central sleep apnoea in systolic heart failure on muscle sympathetic nerve activity: a SERVE-HF randomised ancillary study

Author

Tamisier, Renaud, primary, Pépin, Jean-Louis, additional, Woehrle, Holger, additional, Salvat, Muriel, additional, Barone-Rochette, Gilles, additional, Rocca, Cécile, additional, Vettorazzi, Eik, additional, Teschler, Helmut, additional, Cowie, Martin, additional, and Lévy, Patrick, additional

Published
2022
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3. The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort

Author

von Siemens, Sarah Marietta, Perneczky, Robert, Waschki, Benjamin, Lutter, Johanna I, Welte, Tobias, Jörres, Rudolf A, Kahnert, Kathrin, group, COSYCONET study, Andreas, Stefan, Bals, Robert, Behr, Jürgen, Vogelmeier, Claus F, Bewig, Burkhard, Buhl, Roland, Ewert, Ralf, Stubbe, Beate, Gogol, Manfred, Grohé, Christian, Hauck, Rainer, Held, Matthias, Jany, Berthold, Henke, Markus, Herth, Felix, Höffken, Gerd, Katus, Hugo A, Kirsten, Anne-Marie, Watz, Henrik, Koczulla, Rembert, Kenn, Klaus, Kronsbein, Juliane, Kropf-Sanchen, Cornelia, Lange, Christoph, Kauffmann-Guerrero, Diego, Zabel, Peter, Pfeifer, Michael, Randerath, Winfried J, Seeger, Werner, Studnicka, Michael, Taube, Christian, Teschler, Helmut, Timmermann, Hartmut, Virchow, J Christian, Vogelmeier, Claus, Alter, Peter, Wagner, Ulrich, Wirtz, Hubert, Trudzinski, Franziska C, and Söhler, Sandra

Subjects
Male, medicine.medical_specialty, epidemiology [Cognitive Dysfunction], psychology [Pulmonary Disease, Chronic Obstructive], Medizin, Comorbidity, Cohort Studies, 03 medical and health sciences, FEV1/FVC ratio, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Cognition, epidemiology [Pulmonary Disease, Chronic Obstructive], Surveys and Questionnaires, medicine, Dementia, Humans, COPD, Cognitive Dysfunction, ddc:610, Cognitive skill, Path analysis (statistics), Aged, lcsh:RC705-779, business.industry, Research, physiology [Cognition], diagnosis [Pulmonary Disease, Chronic Obstructive], lcsh:Diseases of the respiratory system, Middle Aged, medicine.disease, Mental Status and Dementia Tests, humanities, Cross-Sectional Studies, Cognitive impairment, diagnosis [Cognitive Dysfunction], 030228 respiratory system, Cohort, Physical therapy, Female, psychology [Cognitive Dysfunction], business, 030217 neurology & neurosurgery, Cognitive load
Abstract

Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1–4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George‘s respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment.

Published
2022
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4. Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the SERVE‐HF major sub study

Author

Tamisier, Renaud, primary, Pepin, Jean‐Louis, additional, Cowie, Martin R., additional, Wegscheider, Karl, additional, Vettorazzi, Eik, additional, Suling, Anna, additional, Angermann, Christiane, additional, d'Ortho, Marie‐Pia, additional, Erdmann, Erland, additional, Simonds, Anita K., additional, Somers, Virend K., additional, Teschler, Helmut, additional, Lévy, Patrick, additional, and Woehrle, Holger, additional

Published
2022
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5. Effects of Adaptive Servo-Ventilation on Nocturnal Ventricular Arrhythmia in Heart Failure Patients With Reduced Ejection Fraction and Central Sleep Apnea–An Analysis From the SERVE-HF Major Substudy

Author

Fisser, Christoph, primary, Gall, Lara, additional, Bureck, Jannis, additional, Vaas, Victoria, additional, Priefert, Jörg, additional, Fredersdorf, Sabine, additional, Zeman, Florian, additional, Linz, Dominik, additional, Woehrle, Holger, additional, Tamisier, Renaud, additional, Teschler, Helmut, additional, Cowie, Martin R., additional, and Arzt, Michael, additional

Published
2022
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6. Prevalence and predictors of sleep-disordered breathing in chronic heart failure: the SchlaHF-XT registry

Author

Arzt, Michael, Oldenburg, Olaf, Graml, Andrea, Schnepf, Jurgen, Erdmann, Erland, Teschler, Helmut, Schoebel, Christoph, Woehrle, Holger, Arzt, Michael, Oldenburg, Olaf, Graml, Andrea, Schnepf, Jurgen, Erdmann, Erland, Teschler, Helmut, Schoebel, Christoph, and Woehrle, Holger

Abstract

Aims Heart failure with preserved ejection fraction (HFpEF) is a condition with increasing prevalence. Sleep-disordered breathing (SDB) is an important co-morbidity in HFpEF. The SchlaHF-XT registry evaluated the sex-specific prevalence and predictors of SOB, including obstructive (OSA) and central sleep apnoea, in patients with HFpEF compared with heart failure with mildly reduced (HFmrEF) or reduced (HFrEF) ejection fraction. Methods and results Consecutive adults with chronic heart failure treated according to current guidelines were enrolled. The presence of moderate-to-severe SDB (apnoea-hypopnoea index >= 15/h) was determined using Type 3 polygraphic devices. Of 3289 patients included, 2032 had HFpEF, 559 had HFmrEF, and 698 had HFrEF, of whom 34, 21, 23, and 42%, respectively, were female. Prevalence of SDB in HFpEF was high, but significantly lower than in HFmrEF or HFrEF (36% vs. 41 and 48%, respectively). Rates of SDB in males and females were 41 and 28% in HFpEF, 44 and 30% in HFmrEF, and 50 and 40% in HFrEF. The proportion of males and females with SDB who had OSA was significantly greater in those with HFpEF vs. HFrEF. Male sex, older age, higher body mass index, and New York Heart Association functional Class III/IV were significant predictors of moderate-to-severe SDB in HFpEF patients. Conclusions Prevalence of SDB in HFpEF was high, but lower than in patients with HFmrEF or HFrEF. Moderate-to-severe SDB occurred more frequently in males than in females across the whole spectrum of heart failure. In both sexes, the proportion of OSA in SDB patients with HFpEF was higher than in those with HFrEF.

Published
2022

7. Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the SERVE-HF major sub study

Author

Tamisier, Renaud, Pepin, Jean-Louis, Cowie, Martin R., Wegscheider, Karl, Vettorazzi, Eik, Suling, Anna, Angermann, Christiane, D'Ortho, Marie-Pia, Erdmann, Erland, Simonds, Anita K., Somers, Virend K., Teschler, Helmut, Levy, Patrick, Woehrle, Holger, Tamisier, Renaud, Pepin, Jean-Louis, Cowie, Martin R., Wegscheider, Karl, Vettorazzi, Eik, Suling, Anna, Angermann, Christiane, D'Ortho, Marie-Pia, Erdmann, Erland, Simonds, Anita K., Somers, Virend K., Teschler, Helmut, Levy, Patrick, and Woehrle, Holger

Abstract

This SERVE-HF (Treatment of Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure) sub study analysis evaluated polysomnography (PSG) data in patients with heart failure with reduced ejection fraction (HFrEF) and predominant central sleep apnea (CSA) randomised to guideline-based medical therapy, with or without adaptive servo ventilation (ASV). Patients underwent full overnight PSG at baseline and at 12 months. All PSG recordings were analysed by a core laboratory. Only data for patients with baseline and 3- or 12-month values were included. The sub study included 312 patients; the number with available PSG data differed for each variable (94-103 in the control group, 77-99 in the ASV group). After 12 months, baseline-adjusted respiratory measures were significantly better in the ASV group versus control. Although some between-group differences in sleep measures were seen at 12 months (e.g., better sleep efficiency in the ASV group), these were unlikely to be clinically significant. The number of periodic leg movements during sleep (PLMS) increased in the ASV group (p = 0.039). At 12 months, the respiratory arousal index was significantly lower in the ASV versus control group (p < 0.001), whilst the PLMS-related arousal index was significantly higher in the ASV group (p = 0.04 versus control). ASV attenuated the respiratory variables characterising sleep apnea in patients with HFrEF and predominant CSA in SERVE-HF. Sleep quality improvements during ASV therapy were small and unlikely to be clinically significant. The increase in PLMS and PLMS-related arousals during ASV warrants further investigation, particularly relating to their potential association with increased cardiovascular risk.

Published
2022

8. Effects of Adaptive Servo-Ventilation on Nocturnal Ventricular Arrhythmia in Heart Failure Patients With Reduced Ejection Fraction and Central Sleep Apnea–An Analysis From the SERVE-HF Major Substudy

Author

Fisser, Christoph, Gall, Lara, Bureck, Jannis, Vaas, Victoria, Priefert, Jörg, Fredersdorf, Sabine, Zeman, Florian, Linz, Dominik, Woehrle, Holger, Tamisier, Renaud, Teschler, Helmut, Cowie, Martin R., Arzt, Michael, Fisser, Christoph, Gall, Lara, Bureck, Jannis, Vaas, Victoria, Priefert, Jörg, Fredersdorf, Sabine, Zeman, Florian, Linz, Dominik, Woehrle, Holger, Tamisier, Renaud, Teschler, Helmut, Cowie, Martin R., and Arzt, Michael

Abstract

Background: The SERVE-HF trial investigated the effect of treating central sleep apnoea (CSA) with adaptive servo-ventilation (ASV) in patients with heart failure with reduced ejection fraction (HFrEF). Objective: The aim of the present ancillary analysis of the SERVE-HF major substudy (NCT01164592) was to assess the effects of ASV on the burden of nocturnal ventricular arrhythmias as one possible mechanism for sudden cardiac death in ASV-treated patients with HFrEF and CSA. Methods: Three hundred twelve patients were randomized in the SERVE-HF major substudy [no treatment of CSA (control) vs. ASV]. Polysomnography including nocturnal ECG fulfilling technical requirements was performed at baseline, and at 3 and 12 months. Premature ventricular complexes (events/h of total recording time) and non-sustained ventricular tachycardia were assessed. Linear mixed models and generalized linear mixed models were used to analyse differences between the control and ASV groups, and changes over time. Results: From baseline to 3- and 12-month follow-up, respectively, the number of premature ventricular complexes (control: median 19.7, 19.0 and 19.0; ASV: 29.1, 29.0 and 26.0 events/h; p = 0.800) and the occurrence of ≥1 non-sustained ventricular tachycardia/night (control: 18, 25, and 18% of patients; ASV: 24, 16, and 24% of patients; p = 0.095) were similar in the control and ASV groups. Conclusion: Addition of ASV to guideline-based medical management had no significant effect on nocturnal ventricular ectopy or tachyarrhythmia over a period of 12 months in alive patients with HFrEF and CSA. Findings do not further support the hypothesis that ASV may lead to sudden cardiac death by triggering ventricular tachyarrhythmia.

Published
2022

11. Neuropsychologische Veränderungen von Kurzzeit- und Arbeitsgedächtnisfunktionen sowie Lern- und Merkfähigkeit bei Patienten nach Lungentransplantation

Author

Neurath, Michael, Teschler, Helmut (Akademische Betreuung), and Teschler, Helmut

Subjects
Lungentransplantation -- Neurokognition -- Gedächtnis, Medizinische Fakultät » Universitätsklinikum Essen » Ruhrlandklinik Essen – Universitätsklinik, Medizin, Neurokognition, ddc:610, Lungentransplantation, Gedächtnis
Abstract

Die neurokognitive Leistungsfähigkeit (NKLF) von Patienten nach Lungentransplantation (LTX) ist bisher nur schlecht untersucht und nur wenige Studien befassen sich mit diesem Thema. Klinische Erfahrungen von behandelnden Ärzten lassen jedoch eine Beeinträchtigung der NKLF mit zunehmender Dauer nach LTX vermuten. Daher wurde in dieser Querschnittsstudie die Gedächtnisleistung von 106 Patienten mit bis zu einem Jahr (n=13), ein bis fünf (n=36) Jahre und mehr als fünf Jahre (n=57) nach LTX analysiert. Zusätzlich wurde in diesen 3 Gruppen die Lebensqualität, das Vorhandensein von Depression und Angst und die allgemeine Alltagsaktivität erfasst. Im Verbalen Lern- und Merkfähigkeitstest zeigten Patienten, die schon länger als 1 Jahr transplantiert waren, eine höhere Leistung in der Encodierungs- und Abrufleistung des verbalen Gedächtnisses als Patienten, deren LTX kürzer als 1 Jahr zurücklag. Mittels Blockspannbrett und Zahlenspanne wurde das Kurz- und Arbeitsgedächtnis getestet. Hier zeigte sich kein signifikanter Unterschied. Die figurale Merkfähigkeit und die visuo-konstruktiven Fähigkeiten wurden mittels Benton-Test erfasst, der ebenfalls keine signifikanten Unterschiede zeigte. Unklar ist allerdings, ob tatsächlich kein Effekt vorhanden war oder ein vorhandener Effekt nicht nachgewiesen werden konnte. Angst und Depression wurden mittels Hospital Anxiety and Depression Scale gescreent. Verdächtig auf Depression waren 8,6% der Befunde, was in etwa der deutschen Normalbevölkerung entspricht. Allerdings wurden 24,6% der Erhebungen im Bereich Angst durch den verwendete Screnningfragebogen als „suspekt“ klassifiziert. Im SF-36 Fragebogen zum Gesundheitszustand erreichte Gruppe 1 im Vergleich zu den beiden anderen Gruppen signifikant höhere Werte im Bereich „Vitalität“. In den anderen Subgruppen des SF-36 gab es zwischen den 3 Gruppen keine signifikanten Unterschiede. Ein follow-up der untersuchten Kohorte wäre sinnvoll, um den Verlauf der Gedächtnisleistung verfolgen zu können, da sich durch die vorliegende Arbeit hier kein eindeutiges Bild ergibt. Auch die hohe Prävalenz von Angst verdient eine eingehendere Betrachtung in folgenden Untersuchungen und insbesondere auch in der routinemäßigen Inkludierung dieser Testbatterie bei den Untersuchungen zur Listung und zur Nachsorge von Patienten nach LTX. Dissertation, Universität Duisburg-Essen, 2023

Published
2023

13. Vibrationstraining (WBV)

Author

Glöckl, Rainer, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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18. Pulmonale Rehabilitation

Author

Rezek, Spencer, Unger, Ines, Ott, Natalie, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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22. Dyspnoemanagement

Author

von Gaudecker, Maximilian, Dohm, Michael, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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25. Lebensqualität

Author

Steier, Jörg, Rausch-Osthoff, Anne-Kathrin, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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26. Harninkontinenz bei COPD

Author

Köhler, Barbara, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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29. Hustenassessment

Author

Lüscher, Barbara, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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32. Atemmuster

Author

Weinhofer, Barbara, Schmidt, Ingrid, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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33. Dyspnoe und Ermüdung

Author

Müller, Alexander, Schmidt, Ingrid, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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37. Untersuchung der Gefäße

Author

Schwarz, Esther I., Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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38. Krankheitslehre

Author

Steier, Jörg, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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42. Thoraxmobilität

Author

Cerini, Tamara, Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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43. Pulmonalkreislauf

Author

Schwarz, Esther I., Steier, Jörg, editor, Rausch-Osthoff, Anne-Kathrin, editor, van Gestel, Arnoldus J.R., and Teschler, Helmut

Published
2022
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