Author: "Tani S." / Publication Year Range: Last 3 years - Searchworks@Jio Institute Digital Library Search Results

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175 results on '"Tani S."'

1. Time-, spin-, and angle-resolved photoemission spectroscopy with a 1-MHz 10.7-eV pulse laser

Author: Kawaguchi, Kaishu, Kuroda, Kenta, Zhao, Z., Tani, S., Harasawa, A., Fukushima, Y., Tanaka, H., Noguchi, R., Iimori, T., Yaji, K., Fujisawa, M., Shin, S., Komori, F., Kobayashi, Y., and Kondo, Takeshi
Subjects: Condensed Matter - Materials Science
Abstract: We describe a setup of time-, spin-, and angle-resolved photoemission spectroscopy (tr-SARPES) employing a 10.7-eV ($\lambda$=115.6 nm) pulse laser at 1-MHz repetition rate as a probe photon source. This equipment effectively combines technologies of a high-power Yb:fiber laser, ultraviolet-driven harmonic generation in Xe gas, and a SARPES apparatus equipped with very-low-energy-electron-diffraction (VLEED) spin detectors. A high repetition rate (1 MHz) of the probe laser allows experiments with the photoemission space-charge effects significantly reduced, despite a high flux of 10$^{13}$ photons/s on the sample. The relatively high photon energy (10.7 eV) also brings the capability of observing a wide momentum range that covers the entire Brillouin zone of many materials while ensuring high momentum resolution. The experimental setup overcomes a low efficiency of spin-resolved measurements, which gets even more severe for the pump-probed unoccupied states, and affords for investigating ultrafast electron and spin dynamics of modern quantum materials with energy and time resolutions of 25 meV and 360 fs, respectively., Comment: 11 pages, 7 figures
Published: 2023
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2. Detection and classification of man-made objects for the autonomy of underwater robots

Author: Gentili, A., Bresciani, M., Ruscio, F., Tani, S., Caiti, A., and Costanzi, R.
Published: 2023
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3. Coverage and Cost-of-Care Links: Addressing Financial Toxicity Among Patients With Hematologic Cancer and Their Caregivers

Author: Jean S. Edward, Laurie E. McLouth, Mary Kay Rayens, Lori P. Eisele, Tani S. Davis, and Gerhard Hildebrandt
Subjects: Oncology, Oncology (nursing), Health Policy
Abstract: PURPOSE This study examined the feasibility, acceptability, and preliminary effectiveness of an oncology financial navigation (OFN) intervention, Coverage and Cost-of-Care Links ( CC Links), among patients with hematologic cancer and their caregivers who are at increased risk of experiencing financial toxicity (FT). METHODS All patients who presented to the Division of Hematology and Bone and Marrow Transplant (BMT) at an National Cancer Institute–designated cancer center between April 2021 and January 2022 were screened for FT during inpatient and outpatient visits. Patients who screened positive for FT and met the inclusion criteria were recruited to participate in CC Links that provided financial navigation and assistance via a financial navigator. Caregivers of patients undergoing BMTs were also recruited to participate. Primary outcomes were defined as improvements in FT, distress, and physical and mental quality of life. RESULTS Fifty-four patients and 32 caregivers completed the intervention and pre-/postintervention surveys. CC Links resulted in statistically significant decreases in the Comprehensive Score for FT for both patients (| t| = 2.42, P = .019) and caregivers (| t| = 2.43, P = .021) and total FT (| t| = 2.13, P = .041) and material conditions scores (| t| = 2.25, P = .031) for caregivers only. Only 27% of eligible patients participated in the study, whereas 100% of eligible caregivers participated. The majority of participants rated the intervention highly for acceptability (89%) and appropriateness (88%). An average of $2,500 (USD) in financial benefits was secured per participant via CC Links. CONCLUSION CC Links was effective in decreasing FT among patients with hematologic cancer and their caregivers while demonstrating high acceptability and appropriateness ratings.
Published: 2023
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4. Time-, spin-, and angle-resolved photoemission spectroscopy with a 1-MHz 10.7-eV pulse laser

Author: Kawaguchi, Kaishu, primary, Kuroda, Kenta, additional, Zhao, Z., additional, Tani, S., additional, Harasawa, A., additional, Fukushima, Y., additional, Tanaka, H., additional, Noguchi, R., additional, Iimori, T., additional, Yaji, K., additional, Fujisawa, M., additional, Shin, S., additional, Komori, F., additional, Kobayashi, Y., additional, and Kondo, Takeshi, additional
Published: 2023
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5. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Author: Adisa, A, Bahrami-Hessari, M, Bhangu, A, George, C, Ghosh, D, Glasbey, J, Haque, P, Ingabire, J, Kamarajah, S, Kudrna, L, Ledda, V, Li, E, Lillywhite, R, Mittal, R, Nepogodiev, D, Ntirenganya, F, Picciochi, M, Simões, J, Booth, L, Elliot, R, Kennerton, A, Pettigrove, K, Pinney, L, Richard, H, Tottman, R, Wheatstone, P, Wolfenden, J, Smith, A, Sayed, A, Goswami, A, Malik, A, Mclean, A, Hassan, A, Nazimi, A, Aladna, A, Abdelgawad, A, Saed, A, Abdelmageed, A, Ghannam, A, Mahmoud, A, Alvi, A, Ismail, A, Adesunkanmi, A, Ebrahim, A, Al-Mallah, A, Alqallaf, A, Durrani, A, Gabr, A, Kirfi, A, Altaf, A, Almutairi, A, Sabbagh, A, Ajiya, A, Haddud, A, Alnsour, A, Singh, A, Mittal, A, Semple, A, Adeniran, A, Negussie, A, Oladimeji, A, Muhammad, A, Yassin, A, Gungor, A, Tarsitano, A, Soibiharry, A, Dyas, A, Frankel, A, Peckham-Cooper, A, Truss, A, Issaka, A, Ads, A, Aderogba, A, Adeyeye, A, Ademuyiwa, A, Sleem, A, Papa, A, Cordova, A, Appiah-Kubi, A, Meead, A, Nacion, A, Michael, A, Forneris, A, Duro, A, Gonzalez, A, Altouny, A, Ghazal, A, Khalifa, A, Ozair, A, Quzli, A, Haddad, A, Othman, A, Yahaya, A, Elsherbiny, A, Nazer, A, Tarek, A, Abu-Zaid, A, Al-Nusairi, A, Azab, A, Elagili, A, Elkazaz, A, Kedwany, A, Nuhu, A, Sakr, A, Shehta, A, Shirazi, A, Mohamed, A, Sherif, A, Awad, A, Abbas, A, Abdelrahman, A, Ammar, A, Azzam, A, Ciftci, A, Dural, A, Sanli, A, Rahy-Martín, A, Tantri, A, Khan, A, Al-Touny, A, Tariq, A, Gmati, A, Costas-Chavarri, A, Auerkari, A, Landaluce-Olavarria, A, Puri, A, Radhakrishnan, A, Ubom, A, Pradhan, A, Turna, A, Adepiti, A, Kuriyama, A, Kassam, A, Hassouneh, A, El-Hussuna, A, Habeebullah, A, Mousli, A, Biloslavo, A, Hoang, A, Kirk, A, Santini, A, Melero, A, Calvache, A, Baduell, A, Chan, A, Abrate, A, Balduzzi, A, Sánchez, A, Navarrete-Peón, A, Porcu, A, Brolese, A, Barranquero, A, Saibene, A, Adam, A, Vagge, A, Maquilón, A, Leon-Andrino, A, Sekulić, A, Trifunovski, A, Mako, A, Bedada, A, Broglia, A, Coppola, A, Giani, A, Grandi, A, Iacomino, A, Moro, A, D’Amico, A, Malagnino, A, Tang, A, Doyle, A, Alfieri, A, Haynes, A, Wilkins, A, Baldwin, A, Heriot, A, Laird, A, Lazarides, A, O'Connor, A, Trulson, A, Rokohl, A, Caziuc, A, Triantafyllou, A, Anesi, A, Nikova, A, Andrianakis, A, Charalabopoulos, A, Tsolakidis, A, Chirca, A, Arnaud, A, Narvaez-Rojas, A, Kavalakat, A, Spina, A, Recordare, A, Annicchiarico, A, Conti, A, Mohammed, A, Kocataş, A, Almhimid, A, Arnaout, A, Fahmy, A, Mangi, A, Modabber, A, Ulas, A, Mohamedahmed, A, Frontali, A, Moynihan, A, Yunus, A, Ahmad, A, Kent, A, Khamees, A, Ugwu, A, Turan, A, Navarro-Barrios, A, Yebes, A, De Sousa, Á, Moreno, A, Sethi, A, Dawson, A, Kaur, A, Wolde, A, Antonelli, A, Scifo, A, Alhamad, A, Davis, A, Alderazi, A, Harky, A, Mohammed-Durosinlorun, A, Seguya, A, Okhakhu, A, Chamakhi, A, Sebai, A, Souadka, A, Asla, A, Agrawal, A, Persad, A, Gupta, A, Elgazar, A, Kulkarni, A, Coates, A, Bellés, A, Hadzibegovic, A, Jotic, A, Kowark, A, Martins, A, Pineda, A, Peral, A, Gollarte, A, Senent-Boza, A, Camarena, A, Castaño-Leon, A, Bravo, A, Musina, A, Tapia-Herrero, A, Kothari, A, Raja, A, Aljaiuossi, A, Taha, A, Majbar, A, Prodromidou, A, Kanatas, A, Gupte, A, Zakaria, A, Balla, A, Barberis, A, Bondurri, A, Bottari, A, Costantino, A, Figus, A, Lauretta, A, Mingoli, A, Romanzi, A, Sagnotta, A, Scacchi, A, Picchetto, A, Valadez, A, Luzzi, A, Älgå, A, Fontalis, A, Hecker, A, Demetriades, A, Serban, A, Văcărașu, A, Cokan, A, Isaza-Restrepo, A, Beamish, A, Schache, A, Stevenson, A, Yiu, A, Cockbain, A, Litvin, A, Abad-Motos, A, Becerra, A, Ramos, Á, Chiaradia, A, Dell, A, Romano, A, Pascale, A, Marra, A, Dimas, A, Kolias, A, Cerovac, A, Koneru, A, Tidjane, A, Agbeko, A, Bajaj, A, Gosain, A, Allan, A, Carreras-Castañer, A, D'Amore, A, Dare, A, Maffioli, A, Palepa, A, Paspala, A, Konney, A, Gatta, A, Ezanno, A, Yiallourou, A, Kinnair, A, Rayner, A, Scafa, A, Bowan, A, Veglia, A, Russo, A, Maniaci, A, Castaldi, A, Gil-Moreno, A, Maffuz-Aziz, A, Meola, 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Shraddha, Abdulsalam, Shuaib, Lin, Shuxun, Hegde, Siddhi, Fiorelli, Silvia, Quaresima, Silvia, Redondo, Silvia Villacé, Palmisano, Silvia, Ruggiero, Silvia, Balogun, Simon, Cais, Simon, Cole, Simon, Federer, Simon, Le Roux, Simon, Ippoliti, Simona, Meneghini, Simona, Viola, Simona, Manfredelli, Simone, Novello, Simone, Gananadha, Sivakumar, Mesli, Smain Nabil, Kale, Smruti, Tani, Sobhana Iftekhar, Malik, Sobia, Anastasiadou, Sofia, Boligo, Sofia, Esposito, Sofia, Valanci, Sofia, Xenaki, Sofia, Pejkova, Sofija, Bandyopadhyay, Soham, Trungu, Sokol, Basu, Somprakas, Alkhatib, Sondos, Pérez-Bertólez, Sonia, Flores, Sonia Lopez, Donoghue, Sophie, Lunca, Sorinel, Orsoo, Soyombo, Potamianos, Spyridon, Devarakonda, Sreekar, Suresh, Sreelakshmi, Croghan, Stefanie M, Turi, Stefano, Capella, Stefano, Lucchini, Stefano, Magnone, Stefano, Salizzoni, Stefano, Scabini, Stefano, Scaringi, Stefano, Cioffi, Stefano Piero Bernardo, Seyfried, Steffen, Degener, Stephan, Potten, Stephanie, Taha-Mehlitz, Stephanie, Ali, Stephen, Angamuthu, Stephen, Mcaleer, Stephen, Knight, Stephen Richard, White, Stuart, Mantziari, Styliani, Kykalos, Stylianos, Goh, Su Kah, Chowdhury, Subhadip Pal, Ibrahim, Sufyan, Elzwai, Suha, Bansal, Sujesh, Tripathy, Sujit, Amrayev, Sultan, Anwar, Sumadi Lukman, Banerjee, Sumit, Thakar, Sumit, Saeed, Summaya, Venkatappa, Sunil Kumar, Das, Sunit, Techapongsatorn, Suphakarn, Dube, Surya Kumar, Lee, Susan, González-Suárez, Susana, Henriques, Susana, Konjevoda, Suzana, Gisbertz, Suzanne, Bravo, Sybil Lizanne, Mannan, Syed, Bukhari, Syed Imran, Zafar, Syed Nabeel, Batista, Sylvia, Chin, Synn Lynn, Arif, Tahera, Lawal, Taiwo Akeem, Aktokmakyan, Talar Vartanoglu, Osborn, Tamara, Szakmany, Tamas, Sztipits, Tamás, Triantafyllou, Tania, Valadez, Tania Abigail Cueto, Singh, Tanveer, Khaliq, Tanwir, Patel, Tapan, Fadalla, Tarig, Jichi, Tarik, Sammour, Tarik, Al-Shaiji, Tariq, Naggs, Taryn, Barišić, Tatjana, Nikolouzakis, Taxiarchis, Bisgin, Tayfun, Perra, Teresa, Uprak, Tevfik Kıvılcım, Dagklis, Themistoklis, Liakakos, Theodore, Sidiropoulos, Theodoros, Adjeso, Theophilus Justus Kofi, Dölker, Theresa, Oung, Thida, Aherne, Thomas, Diehl, Thomas, Pinkney, Thomas, Raymond, Thomas, Rhomberg, Thomas, Schmitz-Rixen, Thomas, Madhuri, Thumuluru Kavitha, Lohmann, Tibor Karl, Yeoh, Tien, Zaimis, Tilemachos, Bright, Tim, Vilz, Tim O, Glowka, Tim R, Board, Timothy, Hardcastle, Timothy, Cohnert, Tina, Mahečić, Tina Tomić, William, Tinka George, Klatte, Tobias, Abbott, Tom, Watcyn-Jones, Tom, Mendes, Tome, Kulis, Tomislav, Sečan, Tomislav, Campagnaro, Tommaso, Frisoni, Tommaso, Simoncini, Tommaso, Violante, Tommaso, Safranovs, Toms Janis, Risteski, Toni, Pang, Tony, Akinyemi, Tosin, Yotsov, Tsanko, Laeke, Tsegazeab, Kochiyama, Tsukasa, Sholadoye, Tunde T, Alekberli, Tural, Ezomike, Uchechukwu, Giustizieri, Ugo, Grossi, Ugo, Köksoy, Ülkü Ceren, Bork, Ulrich, Kisser, Ulrich, Ronellenfitsch, Ulrich, Saeed, Umar, Bracale, Umberto, Jayarajah, Umesh, Rauf, Umme Habiba Abdul, Bumbasirevic, Uros, Ferrer, Ursula María Jariod, Ahmed, Usama, Bello, Usman Mohammed, Jogiat, Uzair, Sadia, Uzma, Galandarov, Vagif, Narayanan, Vairavan, Calu, Valentin, Bianchi, Valentina, Ciniero, Valeria, Tonini, Valeria, Silvestri, Vania, Vijay, Vardhini, Dewan, Varun, Lohsiriwat, Varut, Thuduvage, Vasanthika, Mousafeiris, Vasileios, Dragisic, Vedran, Sasireka, Veerasamy, Santric, Veljko, Kusuma, Venkata Ramana Murthy, Kolli, Venkata Satish, Alonso, Veronica, De Simone, Veronica, Picotti, Veronica, Martínez, Verónica Martín, Panduro-Correa, Vicky, Kakotkin, Victor, Angulo, Victor Pinto, Turrado-Rodriguez, Victor, Krishnamoorthy, Vijay, Ban, Vin Shen, Shah, Vinay, Maiola, Vincenza, Giordano, Vincenzo, La Vaccara, Vincenzo, Lizzi, Vincenzo, Papagni, Vincenzo, Schiavone, Vincenzo, Satchithanantham, Vinojan, Garcia-Virto, Virginia, Jimenez, Virginia, Kumar, Vishal, Shelat, Vishal, Bhat, Vivek, Sodhai, Vivek, Graziadei, Vivien, Kutuzov, Vladislav, Stoyanov, Vladislav, Oktseloglou, Vlasios, Flis, Vojko, Elhassan, Wael Atif Fadl, Yang, Wah, Soon, Wai Cheong, Tashkandi, Wail, Al-Khyatt, Waleed, Mabood, Waleed, Bijou, Walid, Wijenayake, Wasantha, D, Wasim, Krawczyk, Wiktor, Atkins, William, Bolton, William, White, William, Ceelen, Wim, Vagena, Xanthoula, Gozal, Yaacov, Baba, Yabasin Iddrisu, Subramani, Yamini, Jansen, Yanina, Mittal, Yash, Kara, Yasi̇n, Zwain, Yasir, Noureldin, Yasser, Alawneh, Yazan, Aydin, Yener, Lam, Yick Ho, Tang, Yita, Lim, Yizhe, Dean, Yomna, Tanas, Yousef, Su, Yu-Xiong, Fujimoto, Yuki, Altinel, Yuksel, Frolova, Yulia, Oshodi, Yusuf, Fadel, Zahir T, Zahid, Zahra, Elahi, Zain, Djama, Zakarya, Zaheen, Zakia, Jawad, Zaynab, Demetrashvili, Zaza, Gebremeskel, Zersenay, Gudisa, Zewdie, Alyami, Ziyad, Garoufalia, Zoe, Li, Zoe, Zimak, Zoran, Radin, Zorana, and Balogh, Zsolt J
Abstract: Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was coprioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low-middle-income countries. Results: In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of 'single-use' consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low-middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion: This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high- and low-middle-income countries.
Published: 2023

6. Coverage and Cost-of-Care Links: Addressing Financial Toxicity Among Patients With Hematologic Cancer and Their Caregivers

Author: Edward, Jean S., primary, McLouth, Laurie E., additional, Rayens, Mary Kay, additional, Eisele, Lori P., additional, Davis, Tani S., additional, and Hildebrandt, Gerhard, additional
Published: 2023
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7. Strategies in Translating English Sports Terms into Indonesian in Official Volleyball Rules

Author: Tani S. Lestari
Subjects: General Medicine
Abstract: Since most sports in Indonesia are imported products from other countries, it has resulted in a large number of Indonesian sports terms that are derived from other languages. This includes volleyball which originated in the United States. Therefore, a lot of volleyball terms in Indonesian are derived from English. This research focuses on the translation of sports terms from English into Indonesian in the translation of FIVB Official Volleyball Rules 2017-2020 into PBVSI Peraturan Resmi Bolavoli 2017-2020. Its aim is to identify the strategy used by the translator to find out how sports terms are translated from English into Indonesian. The research shows that three of Chesterman’s translation strategies, namely syntactic, semantic, and pragmatic strategies are used in the translation of Official Volleyball Rules from English into Indonesian. Of all 30 strategies from loan to other pragmatic strategies, 10 of them are used in the translation. The most frequently used strategies are unit shift, distribution change, loan, and calque. Meanwhile, the least used strategies are clause structure change, abstraction change, paraphrase, and cultural filtering.
Published: 2022
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8. Association between osteoarthritis burden and advanced lumbar degeneration in patients undergoing spine surgery

Author: Schonnagel, L., primary, Camino-Willhuber, G., additional, Braun, S., additional, Caffard, T., additional, Zhu, J., additional, Guven, A.E., additional, Tani, S., additional, Bendersky, M., additional, Lebl, D.R., additional, Haffer, H., additional, Muellner, M., additional, Shue, J., additional, Duculan, R., additional, Cammisa, F.P., additional, Girardi, F.P., additional, Sama, A.A., additional, Mancuso, C.A., additional, and Hughes, A.P., additional
Published: 2023
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9. The utility of clavicle cortex index as a screening tool for low bone mineral density among spine surgery patients

Author: Dodo, Y., primary, Okano, I., additional, Tsuchiya, K., additional, Tani, S., additional, Hayakawa, C., additional, Yamamura, R., additional, Maruyama, H., additional, and Kudo, Y., additional
Published: 2023
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10. Predicting postoperative outcomes in lumbar spinal fusion: A machine learning approach

Author: Schonnagel, L., primary, Caffard, T., additional, Vu-Han, T.L., additional, Nathoo, I., additional, Finos, K., additional, Zhu, J., additional, Guven, A.E., additional, Tani, S., additional, Camino-Willhuber, G., additional, Haffer, H., additional, Muellner, M., additional, Shue, J., additional, Duculan, R., additional, Zippelius, T., additional, Sama, A.A., additional, Cammisa, F.P., additional, Mancuso, C.A., additional, and Hughes, A.P., additional
Published: 2023
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11. Abdominal aortic calcification is independently associated with lumbar endplate changes

Author: Schonnagel, L., primary, Zhu, J., additional, Muellner, M., additional, Guven, A.E., additional, Camino-Willhuber, G., additional, Tani, S., additional, Caffard, T., additional, Haffer, H., additional, Suwalski, P., additional, Chiapparelli, E., additional, Arzani, A., additional, Amoroso, K., additional, Moser, M., additional, Shue, J., additional, Tan, E.T., additional, Carrino, J.A., additional, Sama, A.A., additional, Cammisa, F.P., additional, Girardi, F.P., additional, and Hughes, A.P., additional
Published: 2023
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12. Decision-making algorithm for the surgical treatment of degenerative lumbar spondylolisthesis of L4/L5

Author: Schonnagel, L., primary, Caffard, T., additional, Zhu, J., additional, Tani, S., additional, Camino-Willhuber, G., additional, Amini, D. Adl, additional, Haffer, H., additional, Muellner, M., additional, Arzani, A., additional, Chiapparelli, E., additional, Amoroso, K., additional, Shue, J., additional, Duculan, R., additional, Zippelius, T., additional, Sama, A.A., additional, Cammisa, F.P., additional, Girardi, F.P., additional, Mancuso, C.A., additional, and Hughes, A.P., additional
Published: 2023
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13. Strategies in Translating English Sports Terms into Indonesian in Official Volleyball Rules

Author: Lestari, Tani S., primary
Published: 2022
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14. Coverage and Cost-of-CareLinks: Addressing Financial Toxicity Among Patients With Hematologic Cancer and Their Caregivers

Author: Edward, Jean S., McLouth, Laurie E., Rayens, Mary Kay, Eisele, Lori P., Davis, Tani S., and Hildebrandt, Gerhard
Published: 2023
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15. COMPARISON OF POSTOPERATIVE WOUND INFECTION IN CONTROLLED DIABETIC AND NON-DIABETIC PATIENTS IN ELECTIVE OPERATIONS.

Author: AHAMAD F. U., HASSAN M. M., KHAN MAUK, MOST. FATEMA B., HABIB M. A., DAS P. K., HA HAKIM N., and TANI S. A.
Subjects: DIABETES, HYPERGLYCEMIA, SURGICAL site infections, ASEPTIC & antiseptic surgery, ELECTIVE surgery
Abstract: Background: Diabetes mellitus (DM) is a systemic disease that alters the metabolism of blood sugar. Poorly controlled diabetes or hyperglycaemia is associated with an array of micro-vascular, macro-vascular, and neuropathic complications. There is a widely held belief that infections are usually more frequent and severe in diabetic patients. Diabetes prevalence is increasing in the developed & developing countries, and the appropriate management of patients with diabetes has become increasingly important for the prevention of hospital-acquired infections. Postoperative wound infection continues to be a major source of morbidity and mortality in developing countries despite recent advances in aseptic techniques. There is little information regarding postoperative wound infection in controlled diabetic patients undergoing elective operation. Objectives: The aim of our study was to evaluate the postoperative wound infection in controlled diabetic and non-diabetic patients in elective operations. Materials & method: This cross sectional comparative study was conducted in Department of Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, during the period of October 2011 to March 2012. A total seventy three patients with controlled diabetics and seventy three non-diabetics were selected. Inclusion criteria were patients undergoing clean and cleancontaminated elective operations. Un-controlled diabetes, patient undergoing contaminated and dirty operation, patient with tuberculosis, jaundice, uraemia, having cortico-steroids /chemoradiation and operated for malignancies were excluded. After preoperative preparation specific operation was done. All patients were followed up for 30 days of post operative period for development of any postoperative wound infection. All information recorded in data collection sheet. Data was processed and analysed with the help of computer program SPSS-16 and Microsoft excel. Quantitative data expressed as mean and standard deviation and qualitative data as frequency and percentage. Result: The patients of diabetic group [31 male, 42 female; mean age, 44.5 (SD 8.2) years] and non-diabetic group [40 male, 33 female; mean age, 43.1 (SD 9.4) years] were similar in age and sex (p>0.05 each). The rate of postoperative wound infection after elective abdominal surgery was 7.5% [in controlled diabetic group was 12.3% and that of non-diabetic group was 2.7% (p<0.05)] and the patients of diabetic group were 5.0 times more likely to develop wound infection as compared to that of non-diabetic group (OR=4.992; 95% of CI=1.040--23.971) in clean and clean contaminated elective abdominal surgery. The length of postoperative hospital stay was significantly more in diabetic group than that of non-diabetic group (8.2 (SD ± 2.9) vs 6.8 (SD ± 3.2) days; p<0.01). Conclusion: Postoperative wound infection was higher in controlled diabetic patients than that of non-diabetic. These results support the consideration of diabetes as an independent risk factor for SSIs after elective surgery. Continued efforts are needed to improve surgical outcomes for diabetic patients. [ABSTRACT FROM AUTHOR]
Published: 2022
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16. P-296 Pain management in pancreatic cancer

Author: Tani, S. Chaibdra, Saidi, A., and Ghomari-Bezzar, S.
Published: 2023
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17. P-328 Dihydropyrimidine dehydrogenase deficiency frequency and its impact on 5-fluorouracil (5-FU) based chemotherapy toxicity

Author: Lakhdari, H., Belhadj, A., Mkedder, N., Tani, S. Chaibdra, and Ghomari-Bezzar, S.
Published: 2023
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18. Association of Glycated Hemoglobin Level with Self-Reported Chewing Problems in Elderly Community-Dwelling Individuals in Japan

Author: Fujishiro M, Tanaka S, Watanabe K, Imatake K, Suzuki Y, Ishihara H, and Tani S
Subjects: chewing, community dwellers, diabetes mellitus, elderly, glycated hemoglobin, Medicine (General), R5-920
Abstract: Midori Fujishiro,1,2 Sho Tanaka,1,3 Kentaro Watanabe,1 Kazuhiro Imatake,4 Yasuyuki Suzuki,4– 6 Hisamitsu Ishihara,1 Shigemasa Tani4– 6 1Division of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan; 2Department of Internal Medicine, Nihon University Hospital, Tokyo, Japan; 3Amemiya Internal Medicine Clinic, Kanagawa, Japan; 4Department of Health Planning Center, Nihon University Hospital, Tokyo, Japan; 5Department of Cardiology, Nihon University Hospital, Tokyo, Japan; 6Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanCorrespondence: Sho Tanaka, Division of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan, Tel +81-3-3972-8111, Fax +81-3-3959-9775, Email tanaka.sho@nihon-u.ac.jpPurpose: Chewing problems are associated with increased mortality, geriatric syndromes and poor activities of daily living. Starting in 2018, in Japan, a self-reported questionnaire investigating chewing status was implemented in the annual health checkup program. Considering the bidirectional association between hyperglycemia and poor oral health, it is hypothesized that people with self-reported chewing problems will have relatively poor glycemic profiles. We investigated the metabolic characteristics of elderly community dwellers with self-reported chewing problems, as well as the association between the problems and HbA1c levels.Patients and Methods: This was a retrospective, cross-sectional study. We reviewed the data of 1018 adults ≥ 65 years of age who had undergone an annual health checkup at Nihon University Hospital during the period from January 2019 through December 2019. The presence of chewing problems was investigated using a self-reported questionnaire constructed based on guidance provided by the Japanese government.Results: In the 1018 participants, the overall prevalence of chewing problems was 10.4%. Participants with chewing problems showed significantly higher levels and worse categories of HbA1c than those without such problems (HbA1c < 6.0%, 42.5% vs 54.8%; HbA1c 6.0– 6.9%, 41.5% vs 37.0%; HbA1c ≥ 7.0%, 16.0% vs 8.2%, p = 0.008). Participants with HbA1c ≥ 7.0% have a significantly increased risk of chewing problems as compared to those with HbA1c < 6.0% (odds ratio 2.76, p = 0.002), even after adjusting for the effects of age, sex, body mass index, eating behaviors, and history of diabetes mellitus.Conclusion: HbA1c ≥ 7.0% is associated with self-reported chewing problems in elderly Japanese community-dwellers. We thus recommend a proactive assessment of oral conditions for this population.Keywords: chewing, community dwellers, diabetes mellitus, elderly, glycated hemoglobin
Published: 2023

19. Risk factors of early recurrence after radical resection for pancreatic cancer.

Author: Maehira, H., Mori, H., Nitta, N., Ishikawa, H., Maekawa, T., Tani, S., Takebayashi, K., Kojima, M., Kaida, S., Miyake, T., and Tani, M.
Published: 2024
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20. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Author: Global Health Research Unit on Global Surgery, National Institute for Health and Care Research, Adisa, Adewale, Bahrami-Hessari, Michael, Bhangu, Aneel, George, Christina, Ghosh, Dhruv, Glasbey, James, Haque, Parvez, Ingabire, J C Allen, Kamarajah, Sivesh Kathir, Kudrna, Laura, Ledda, Virginia, Li, Elizabeth, Lillywhite, Robert, Mittal, Rohin, Nepogodiev, Dmitri, Ntirenganya, Faustin, Picciochi, Maria, Simões, Joana Filipa Ferreira, Booth, L, Elliot, R, Kennerton, A S, Pettigrove, K L, Pinney, L, Richard, H, Tottman, R, Wheatstone, P, Wolfenden, John W D, Smith, A, Sayed, A Emad, Goswami, Aakansha Giri, Malik, Aamer, Mclean, Aaron Lawson, Hassan, Abbas, Nazimi, Abd Jabar, Aladna, Abdallah, Abdelgawad, Abdalrahman, Saed, Abdel, Abdelmageed, Abdelfatah, Ghannam, Abdelilah, Mahmoud, Abdelrahman, Alvi, Abdul, Ismail, Abdulaziz, Adesunkanmi, Abdulhafiz, Ebrahim, Abdulla, Al-Mallah, Abdullah, Alqallaf, Abdullah, Durrani, Abdullah, Gabr, Abdullah, Kirfi, Abdullahi Musa, Altaf, Abdulmalik, Almutairi, Abdulmjeed, Sabbagh, Abdulrahman J, Ajiya, Abdulrazak, Haddud, Abdurrahman, Alnsour, Abed Alfattah Mahmoud, Singh, Abhinav, Mittal, Abhishek, Semple, Abigail, Adeniran, Abiodun, Negussie, Abraham, Oladimeji, Abraham, Muhammad, Abubakar Bala, Yassin, Abubaker, Gungor, Abuzer, Tarsitano, Achille, Soibiharry, Adaiah, Dyas, Adam, Frankel, Adam, Peckham-Cooper, Adam, Truss, Adam, Issaka, Adamu, Ads, Adel Mohamed, Aderogba, Adeleke Akeem, Adeyeye, Ademola, Ademuyiwa, Adesoji, Sleem, Adham, Papa, Adrian, Cordova, Adriana, Appiah-Kubi, Adu, Meead, Adullah, Nacion, Aeris Jane D, Michael, Afieharo, Forneris, Agustin Albani, Duro, Agustin, Gonzalez, Agustin Rodriguez, Altouny, Ahmad, Ghazal, Ahmad, Khalifa, Ahmad, Ozair, Ahmad, Quzli, Ahmad, Haddad, Ahmad, Othman, Ahmad Faidzal, Yahaya, Ahmad Shuib, Elsherbiny, Ahmed, Nazer, Ahmed, Tarek, Ahmed, Abu-Zaid, Ahmed, Al-Nusairi, Ahmed, Azab, Ahmed, Elagili, Ahmed, Elkazaz, Ahmed, Kedwany, Ahmed, Nuhu, Ahmed Mohammed, Sakr, Ahmed, Shehta, Ahmed, Shirazi, Ahmed, Mohamed, Ahmed Mohamed Ibrahim, Sherif, Ahmed Elshawadfy, Awad, Ahmed K, Abbas, Ahmed M, Abdelrahman, Ahmed Saber, Ammar, Ahmed Siddique, Azzam, Ahmed Y, Ciftci, Ahmet Burak, Dural, Ahmet Cem, Sanli, Ahmet Necati, Rahy-Martín, Aida Cristina, Tantri, Aida Rosita, Khan, Aimal, Al-Touny, Aiman, Tariq, Aiman, Gmati, Aimen, Costas-Chavarri, Ainhoa, Auerkari, Aino, Landaluce-Olavarria, Aitor, Puri, Ajay, Radhakrishnan, Ajay, Ubom, Akaninyene Eseme, Pradhan, Akhilesh, Turna, Akif, Adepiti, Akinfolarin, Kuriyama, Akira, Kassam, Al-Faraaz, Hassouneh, Ala, El-Hussuna, Alaa, Habeebullah, Alaa, Ads, Alaa Mohamed, Mousli, Alaa, Biloslavo, Alan, Hoang, Alan, Kirk, Alan, Santini, Alasdair, Melero, Alba Vazquez, Calvache, Albaro José Nieto, Baduell, Albert, Chan, Albert, Abrate, Alberto, Balduzzi, Alberto, Sánchez, Alberto Cabañero, Navarrete-Peón, Alberto, Porcu, Alberto, Brolese, Alberto, Barranquero, Alberto G, Saibene, Alberto Maria, Adam, Albushra Altayeb, Vagge, Aldo, Maquilón, Alejandra Jara, Leon-Andrino, Alejandro, Sekulić, Aleksandar, Trifunovski, Aleksandar, Mako, Aleksandro, Bedada, Alemayehu Ginbo, Broglia, Alessandro, Coppola, Alessandro, Giani, Alessandro, Grandi, Alessandro, Iacomino, Alessandro, Moro, Alessandro, D’amico, Alessia, Malagnino, Alessia, Tang, Alethea, Doyle, Alex, Alfieri, Alex, Haynes, Alex, Wilkins, Alex, Baldwin, Alexander, Heriot, Alexander, Laird, Alexander, Lazarides, Alexander, O'connor, Alexander, Trulson, Alexander, Rokohl, Alexander Christopher, Caziuc, Alexandra, Triantafyllou, Alexandra, Anesi, Alexandre, Nikova, Alexandrina, Andrianakis, Alexandros, Charalabopoulos, Alexandros, Tsolakidis, Alexandros, Chirca, Alexandru, Arnaud, Alexis P, Narvaez-Rojas, Alexis Rafael, Kavalakat, Alfie, Spina, Alfio, Recordare, Alfonso, Annicchiarico, Alfredo, Conti, Alfredo, Mohammed, Alhassan Datti, Kocataş, Ali, Almhimid, Ali, Arnaout, Ali, Fahmy, Ali, Mangi, Ali, Modabber, Ali, Ulas, Ali Bilal, Mohamedahmed, Ali Yasen Y, Frontali, Alice, Moynihan, Alice, Yunus, Alif, Ahmad, Aline, Kent, Alistair J, Khamees, Almu'atasim, Ugwu, Aloy Okechukwu, Turan, Alparslan, Mohammed, Alsnosy Abdullah Khalefa, Navarro-Barrios, Alvaro, Yebes, Alvaro, De Sousa, Álvaro Francisco Lopes, Moreno, Amabelle, Sethi, Aman, Dawson, Amanda Caroline, Othman, Amani Alsayd Abdulsalam, Kaur, Amanjot, Wolde, Amanuel, Antonelli, Amedeo, Scifo, Amedeo, Alhamad, Ameen, Davis, Amelia, Alderazi, Amer, Harky, Amer, Mohammed-Durosinlorun, Amina, Seguya, Amina, Okhakhu, Amina, Chamakhi, Amine, Sebai, Amine, Souadka, Amine, Asla, Amir, Agrawal, Amit, Persad, Amit, Gupta, Amit, Elgazar, Amr, Kulkarni, Amruta, Coates, Amy, Bellés, Ana Ciscar, Hadzibegovic, Ana Danic, Jotic, Ana, Kowark, Ana, Martins, Ana, Pineda, Ana Mejía, Peral, Ana, Gollarte, Ana Sánchez, Senent-Boza, Ana, Camarena, Ana Isabel Avellaneda, Castaño-Leon, Ana M, Bravo, Ana Maria Minaya, Moro, Ana María Gimeno, Musina, Ana-Maria, Tapia-Herrero, Ana-María, Kothari, Anai, Gupta, Anand, Raja, Anand, Aljaiuossi, Anas, Taha, Anas, Majbar, Anass Mohammed, Prodromidou, Anastasia, Kanatas, Anastasios, Gupte, Anaya, Zakaria, Andee Dzulkarnaen, Balla, Andrea, Barberis, Andrea, Bondurri, Andrea, Bottari, Andrea, Costantino, Andrea, Figus, Andrea, Lauretta, Andrea, Mingoli, Andrea, Romanzi, Andrea, Sagnotta, Andrea, Scacchi, Andrea, Picchetto, Andrea, Valadez, Andrea Estefania Cueto, Luzzi, Andrea-Pierre, Älgå, Andreas, Fontalis, Andreas, Hecker, Andreas, Demetriades, Andreas K, Serban, Andreea-Madalina, Văcărașu, Andrei Bogdan, Cokan, Andrej, Isaza-Restrepo, Andres, Beamish, Andrew, Schache, Andrew, Stevenson, Andrew, Yiu, Andrew, Cockbain, Andrew J, Litvin, Andrey, Abad-Motos, Ane, Becerra, Angel, Ramos, Ángel Cilleruelo, Chiaradia, Angela, Dell, Angela, Romano, Angela, Pascale, Angelo, Marra, Angelo Alessandro, Dimas, Angelos, Kolias, Angelos, Cerovac, Anis, Koneru, Anish, Tidjane, Anisse, Agbeko, Anita Eseenam, Bajaj, Ankur, Gosain, Ankush, Allan, Anna, 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Subjects: general surgery, acute care surgery, Settore MED/18 - CHIRURGIA GENERALE, climate change, trauma, Settore MED/40 - Ginecologia E Ostetricia, environmental impact, surgery, Settore MED/31 - Otorinolaringoiatria, None, Medicine and Health Sciences, Surgery, operating theatre, environment
Abstract: Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low-middle-income countries. Results: In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of 'single-use' consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low-middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion: This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high- and low-middle-income countries.
Published: 2023

21. Two types of arteriopathies, arteriomegaly and aneurysms, frequently develop at diverse locations in vertebrobasilar dolichoectasia patients: A retrospective analysis and a meta-analysis.

Author: Shimizu K, Tani S, Fukumitsu R, Goto M, Imamura H, Ohta T, and Sakai N
Subjects: Humans, Retrospective Studies, Male, Female, Intracranial Aneurysm diagnostic imaging, Intracranial Aneurysm epidemiology, Intracranial Aneurysm pathology, Aged, Middle Aged, Vertebrobasilar Insufficiency diagnostic imaging
Abstract: Background: Past studies have reported that vertebrobasilar dolichoectasia (VBD) patients may develop similar arteriopathies other than the vertebrobasilar system. However, the details of these VBD-related arteriopathies are still unclear., Methods: We retrospectively enrolled patients diagnosed with VBD at two stroke centers in Japan between January 2012 and December 2023. Arteries of the brain and the trunk were assessed for arteriopathies resembling VBD by computed tomography angiography. Vessel sizes were defined as the maximum diameter measured on the cross-sectional plane. Age, sex, and race-matched stroke patients were recruited as a control group. Arterial ectasias were subdivided into arteriomegaly, which was defined as diffuse ectasia more than 1.5 times the mean size of the controls, or focal ectasia (i.e., aneurysms). A systematic review of PubMed and Scopus was performed between the date of the databases' inception and June 2024 using the keywords (vertebrobasilar OR basilar OR vertebral) AND (dolichoectasia OR dolichoectatic OR serpentiform OR serpentine OR "fusiform aneurysm"). The prevalences of VBD-related vasculopathy at each anatomical location were meta-analyzed by a random-effect model., Results: Nineteen VBD patients were enrolled. Radiological data of the brain and the trunk were available in 19 and 7 patients. The median VBD size was 13.4 (IQR, 11.3-19.6) mm. The vessel sizes of the anterior circulation were significantly larger in VBD patients than in the controls [internal carotid artery (ICA), 6.7 (IQR, 5.4-7.8) vs. 3.8 (IQR, 3.5-4.0) mm; M1 segment, 3.2 (IQR 2.9-4.2) vs. 2.5 (IQR 2.4-2.6) mm; P < 0.0001 in both]. These arterial sizes significantly correlated to contralateral counterparts [ICA, ρ = 0.86, P < 0.0001; M1, ρ = 0.62, P = 0.0049]. At the trunk, arteriomegaly or aneurysms were identified in five (71.4 %) patients. The systematic review identified 11 case series, including ours, that reported the prevalences of arteriopathies outside the vertebrobasilar system. The prevalences of arteriomegaly or aneurysms at the anterior circulation have been most frequently reported in 7 case series followed by those at the aorta and coronary artery in 6 and 2, respectively. Meta-analyses corroborated the high prevalences of arteriopathies at the anterior circulation (23 %; 95 % CI, 10-39 %), aorta (37 %; 95 % CI, 21-54 %), and coronary artery (43 %; 95 % CI, 23-65 %)., Conclusions: Our study suggests that the pathogenesis underlying VBD affects diverse arterial regions and causes two types of arterial remodeling, arteriomegaly and aneurysms., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 Elsevier Ltd. All rights reserved.)
Published: 2025
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22. Impact of Lumbar Degenerative Changes on Vertebral Bone Strength: A Finite Element Analysis.

Author: Tani S, Ishikawa K, Chiapparelli E, Camino-Willhuber G, Schönnagel L, Caffard T, Amoroso K, Guven AE, Shue J, Alman BA, Carrino JA, Girardi FP, Sama AA, Cammisa FP, and Hughes AP
Abstract: Assessing the bone condition in patients with spinal disease is clinically valuable. However, evaluating bone strength in the presence of spine degenerative changes is challenging. Quantitative computed tomography (QCT) and finite element analysis (FEA) have been proposed as methods for more accurate bone quality assessment. This study investigates the relationship between bone strength predicted by FEA and other relevant biological parameters. This retrospective cross-sectional study included 127 patients with spinal disease who underwent preoperative CT scans between 2014 and 2020. Baseline patient characteristics, volumetric bone mineral density (vBMD) measured by QCT, and vertebral bone strength predicted by FEA were collected. The degree of degeneration was evaluated by classifying osteophyte formation, disc height narrowing, vertebral sclerosis, and spondylolisthesis into a grading scale ranging from 0 to 2. Multiple linear regression analysis was conducted to assess the effect of each factor on bone strength predicted by FEA. Of 127 patients, 120 patients (median age was 62 years) were included. The median vBMD and vertebral strength were 114.3 mg/cm 3 and 7892.9 N, respectively. After adjusting for age, sex, body mass index, smoking status, diabetes mellitus, vBMD, and degenerative changes, multiple linear regression analysis revealed that sex, vBMD, and degree of degeneration independently increased the vertebral strength measured by FEA. This study suggests that in patients with spinal disease, vertebral bone strength is affected not only by sex and bone mineral density but also by degenerative changes. Thus, bone strength could be predicted more accurately in patients with spinal disease using FEA., (© 2025 Orthopaedic Research Society.)
Published: 2025
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23. Osseous Sarcoid-like Reaction in Sigmoid Colon Cancer Requiring Differentiation from Bone Metastasis: A Case Report.

Author: Higashi A, Inoue H, Matsumoto H, Tani S, Isokawa K, Aoyama H, Shintani S, Imai T, Ohno M, Kimura H, Miyake T, Nishida A, Kushima R, Tani M, and Inatomi O
Abstract: Although sarcoid-like reactions are uncommon in colorectal cancer, they can coexist with other cancers. We herein report a 50-year-old woman with sigmoid adenocarcinoma and osseous sarcoid-like reactions that resembled metastases. Positron emission tomography-computed tomography revealed an uptake in the iliac bone and para-aortic lymph nodes. The depth of invasion indicates non-metastatic lesions. Bone and lymph node biopsies revealed epithelioid non-caseating granulomas with bone trabeculae, resulting in a final diagnosis of pathological T2N2aM0, Stage IIIB. When the expected depth of invasion differs from that of typical bone metastases, colorectal cancer-associated bone lesions should be evaluated for sarcoid-like reactions.
Published: 2025
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24. The Modified 5-Factor Frailty Score May Not be Useful in Predicting Complications and Unplanned Readmission After 1-Level or 2-Level Anterior Cervical Decompression and Fusion.

Author: Camino-Willhuber G, Tani S, Schonnagel L, Caffard T, Chiapparelli E, Amoroso K, Verna B, Arzani A, Zhu J, Shue J, Zelenty WD, Sokunbi G, Lebl DR, Cammisa FP, Girardi FP, Hughes AP, and Sama AA
Abstract: Background: The modified frailty index (mFI-5) has been shown to be a reliable risk stratification tool in different spine procedures. Its usefulness to predict complications after 1-level or 2-level anterior cervical decompression and fusion (ACDF) has not been studied extensively., Purpose: We aimed to assess the usefulness of the mFI-5 in 1-level or 2-level ACDF surgery by asking the following questions: (1) Is the mFI-5 a reliable tool to predict complications after 1-level or 2-level ACDF? (2) Is the mFI-5 useful in predicting prolonged hospital stay after 1-level or 2-level ACDF? (3) Is the mFI-5 useful in predicting readmission after 1-level or 2-level ACDF?, Methods: We performed a retrospective analysis of the medical records of patients who underwent 1-level or 2-level ACDF at our institution. The mFI-5 was calculated based on the presence of 5 comorbidities: (1) congestive heart failure, (2) diabetes mellitus, (3) chronic obstructive pulmonary disease, (4) partially or totally dependent functional status, and (5) hypertension requiring medication. Patients were classified in 3 groups: not frail (mFI-5 items = 0), pre-frail (mFI-5 items = 1), and frail (mFI-5 items ≥2). Postoperative complications, length of stay, and readmission were recorded., Results: In the 662 patients included (mean age 51.4 ± 10.4 years), surgical and medical complications were not significantly different among groups. Lengths of stay and readmission rates were both significantly higher in the pre-frail group., Conclusion: Our study findings suggest that the mFI-5 might not be reliable to assess preoperative risk after 1-level or 2-level ACDF., Competing Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Gbolabo Sokunbi, MD, reports relationships with Stryker and Camber Spine. Alexander P. Hughes, MD, reports relationships with Kuros Biosciences AG, NuVasive, Inc., and Kuros Biosciences BV. Federico P. Girardi, MD, reports relationships with Lanx, Inc., Ortho Development Corp., BCIMD, and Healthpoint Capital Partners, LP. Frank P. Cammisa, MD, reports relationships with NuVasive, Inc., Accelus, 4WEB Medical/4WEB, Inc., Healthpoint Capital Partners, LP; ISPH II, LLC; ISPH 3 Holdings, LLC; Ivy Healthcare Capital Partners, LLC; Medical Device Partners II, LLC; Medical Device Partners III, LLC; Orthobond Corporation; Spine Biopharma, LLC; Tissue Differentiation Intelligence, LLC; VBVP VI, LLC; VBVP X, LLC; Woven Orthopedics Technologies; DePuy Synthes, Spine Biopharma, LLC, Mallinckrodt Pharmaceuticals, Camber Spine, and Centinel Spine. Andrew. A. Sama, MD, reports relationships with Ortho Development, Corp., Vestia Ventures MiRUS Investment, LLC, IVY II, LLC, ISPH II, LLC, ISPH 3, LLC, HSS ASC Development Network, LLC, Centinel Spine (Vbros Venture Partners V), Depuy Synthes Products, Inc., Clariance, Inc., Kuros Biosciences AG, Ortho Development Corp., and Spinal Kinetics, Inc. The other authors declared no potential conflicts of interest., (© The Author(s) 2024.)
Published: 2025
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25. CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis.

Author: Miyahara J, Omata Y, Chijimatsu R, Okada H, Ishikura H, Higuchi J, Tachibana N, Nagata K, Tani S, Kono K, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Iwanaga Y, Terashima A, Yano F, Seki M, Suzuki Y, Baron R, Tanaka S, and Saito T
Subjects: Humans, Phenotype, Male, Female, Middle Aged, Aged, Fibroblasts metabolism, Fibroblasts pathology, Synovial Membrane metabolism, Synovial Membrane pathology, Osteoarthritis, Knee pathology, Osteoarthritis, Knee metabolism, Osteoarthritis, Knee genetics, Antigens, CD34 metabolism, Fibrosis
Abstract: Osteoarthritis (OA) shows various clinical manifestations depending on the status of its joint components. We aimed to identify the synovial cell subsets responsible for OA pathophysiology by comprehensive analyses of human synovium samples in single-cell resolution. Two distinct OA synovial tissue groups were classified by gene expression profiles in RNA-Seq: inflammatory and fibrotic. The inflammatory group exhibited high expression of inflammatory cytokines, histologically inflammatory infiltrate, and a more severe pain score. The fibrotic group showed higher expression of fibroblast growth factor (FGFs) and bone morphogenetic proteins (BMPs), showed histologically perivascular fibrosis, and showed a lower pain score. In single-cell RNA-Seq (scRNA-Seq) of synovial cells, MERTKloCD206lo macrophages and CD34hi fibroblasts were associated with the inflammatory and fibrotic groups, respectively. Among the 3 fibroblast subsets, CD34loTHY1lo and CD34loTHY1hi fibroblasts were influenced by synovial immune cells, whereas CD34hi fibroblasts were influenced by mural and endothelial cells. Particularly, in CD34hi fibroblast subsets, CD34hiCD70hi fibroblasts promoted proliferation of Tregs, potentially suppressing synovitis and protecting articular cartilage. Elucidation of the mechanisms underlying the regulation of these synovial cell subsets may lead to novel strategies for OA therapeutics.
Published: 2025
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26. High incidence of radiation-induced brain necrosis in the periventricular deep white matter: stereotactic radiotherapy for brain metastases using volumetric modulated arc therapy.

Author: Ohguri T, Itamura H, Tani S, Shiba E, and Yamamoto J
Subjects: Humans, Male, Retrospective Studies, Female, Middle Aged, Aged, Incidence, Adult, Aged, 80 and over, Radiotherapy Dosage, Brain Neoplasms radiotherapy, Brain Neoplasms secondary, Radiotherapy, Intensity-Modulated adverse effects, Radiotherapy, Intensity-Modulated methods, Necrosis etiology, Radiosurgery adverse effects, Radiosurgery methods, Radiation Injuries etiology, Radiation Injuries pathology, Radiation Injuries epidemiology, White Matter radiation effects, White Matter pathology
Abstract: Purpose: In this retrospective study, we aimed to evaluate the efficacy and incidence of radiation-induced brain necrosis (RBN) after volumetric modulated arc therapy-based stereotactic irradiation (VMAT-STI) for brain metastases., Methods: In the 220 brain metastatic lesions included between January 2020 and June 2022, there were 1-9 concurrently treated lesions (median 1). A biologically effective dose (BED)10 of 80 Gy and a reduced BED10 of 50 Gy were prescribed to the gross tumor volume (GTV) and planning target volume (PTV) (PTV = GTV + 3 mm) margins, respectively. The number of fractions was adjusted from 3 to 15 to accommodate different GTV sizes; for larger tumor volumes, this was increased while maintaining the BED10 values comparable to those for GTV and PTV margins., Results: Of the total patients, 16 (7%) exhibited locally progressive lesions; local tumor recurrence was observed in 2 (1%) patients, while RBN was noted in 14 (6%) patients. RBN was significantly more prevalent in the deep white matter around the lateral ventricles (DWM-LV) than in other sites, occurring in 9/22 (41%) lesions of metastases in the DWM-LV. The 2-year actuarial incidence risk of developing RBN was significantly higher in the DWM-LV (69%) than at other sites (5%)., Conclusion: The recurrence rate of brain metastases was low, and the incidence of RBN was lower in tumor sites other than the DWM-LV. However, the frequency of RBN was significantly higher in the DWM-LV region. Additional VMAT-STI-prescribed dose protocols are necessary to reduce RBN incidence in DWM-LVs., Competing Interests: Declarations. Ethics approval and consent to participate: Our study was reviewed and approved by the Ethics Committee of University of Occupational and Environmental health. Consent for publication: Not applicable. Human Ethics declaration: Not applicable. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)
Published: 2025
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27. HMB/Arg/Gln may improve short-term outcomes after esophagectomy in patients with thoracic esophageal cancer.

Author: Takebayashi K, Kaida S, Otake R, Fukuo A, Miyake T, Kojima M, Tani S, Maehira H, Mori H, Ishikawa H, and Tani M
Subjects: Humans, Male, Female, Aged, Middle Aged, Retrospective Studies, Aged, 80 and over, Adult, Treatment Outcome, Dietary Supplements, Postoperative Complications etiology, Postoperative Complications epidemiology, Wound Healing, Esophagectomy methods, Esophagectomy adverse effects, Esophageal Neoplasms surgery, Arginine therapeutic use, Valerates administration & dosage, Valerates therapeutic use, Glutamine administration & dosage, Glutamine therapeutic use
Abstract: Background: The wound healing effects of a specialized amino acid supplement containing calcium beta-hydroxy-beta-methylbutyrate, L-arginine, and L-glutamine (HMB/Arg/Gln) have been reported. This study aimed to investigate the effectiveness of HMB/Arg/Gln in the perioperative management of patients with thoracic esophageal cancer., Methods: This retrospective cohort study included 131 patients who underwent esophagectomy for thoracic esophageal cancer between January 2016 and November 2023. Postoperative infectious complications (PICs) were compared between patients who received HMB/Arg/Gln for 7 days before surgery (n = 95) and those who did not (control group, n = 36)., Results: Among the 111 male and 20 female patients (median age 68 years, range 38-84 years), stage I disease was found in 37 patients, stage II in 26, stage III in 61, and stage IVa in 7. Of the 131 patients, 36 (27.5%) had PICs, with PICs occurring in 20 (21%) of the HMB/Arg/Gln group and 16 (44.4%) of the control group. The PIC rate was significantly lower in the HMB/Arg/Gln than in the control group (p = 0.007). Propensity score matching analysis showed lower rates of anastomotic leakage (5.5% vs. 22.2%; p = 0.04) and Clavien-Dindo grade III or higher PICs (5.5% vs. 27.8%; p = 0.011) in the HMB/Arg/Gln than in the control group. The healing time for anastomotic leakage was shorter in the HMB/Arg/Gln (18 days, range 7-25 days) than in the control group (25 days, range 21-56 days) (p = 0.033)., Conclusions: HMB/Arg/Gln supplementation was associated with reduced risk of anastomotic leakage and PIC severity following esophagectomy., (© The Author(s) 2025. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus.)
Published: 2025
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28. Modeling of skeletal development and diseases using human pluripotent stem cells.

Author: Hojo H, Tani S, and Ohba S
Subjects: Humans, Bone Diseases pathology, Bone and Bones metabolism, Bone and Bones embryology, Animals, Pluripotent Stem Cells metabolism, Pluripotent Stem Cells cytology, Models, Biological, Bone Development
Abstract: Human skeletal elements are formed from distinct origins at distinct positions of the embryo. For example, the neural crest produces the facial bones, the paraxial mesoderm produces the axial skeleton, and the lateral plate mesoderm produces the appendicular skeleton. During skeletal development, different combinations of signaling pathways are coordinated from distinct origins during the sequential developmental stages. Models for human skeletal development have been established using human pluripotent stem cells (hPSCs) and by exploiting our understanding of skeletal development. Stepwise protocols for generating skeletal cells from different origins have been designed to mimic developmental trails. Recently, organoid methods have allowed the multicellular organization of skeletal cell types to recapitulate complicated skeletal development and metabolism. Similarly, several genetic diseases of the skeleton have been modeled using patient-derived induced pluripotent stem cells and genome-editing technologies. Model-based drug screening is a powerful tool for identifying drug candidates. This review briefly summarizes our current understanding of the embryonic development of skeletal tissues and introduces the current state-of-the-art hPSC methods for recapitulating skeletal development, metabolism, and diseases. We also discuss the current limitations and future perspectives for applications of the hPSC-based modeling system in precision medicine in this research field., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research.)
Published: 2024
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29. Relevance of Lumbar Subcutaneous Edema and Local Lordosis.

Author: Doi K, Okazaki T, Shibamoto K, Tani S, and Mizuno J
Subjects: Humans, Male, Female, Middle Aged, Retrospective Studies, Aged, Adult, Aged, 80 and over, Subcutaneous Tissue diagnostic imaging, Subcutaneous Tissue pathology, Age Factors, Edema diagnostic imaging, Edema etiology, Lordosis diagnostic imaging, Lumbar Vertebrae diagnostic imaging, Magnetic Resonance Imaging
Abstract: Lumbar subcutaneous edema (LSE) is sometimes found within the deep subcutaneous or perifascial tissue on magnetic resonance imaging (MRI) via short-tau inversion recovery or fat-suppressed T2-weighted imaging. It is more likely to occur in older patients and those with obesity. However, no studies have focused on the association between LSE and local alignment. Therefore, the present study aimed to elucidate such an association. This retrospective study included 111 adult symptomatic patients who underwent lumbar plain MRI in a single institution. Patient demographics and the radiographical characteristics of the LSE and non-LSE groups were analyzed. LSE was detected in 30 (27.0%) patients. The L1-S1 angle was significantly lower in the LSE group (P = 0.033), whereas the sacral slope was not different between the groups (P > 0.05). As previously reported, the patients in the LSE group were older (P < 0.001) and had lower body weight (P = 0.015). This study demonstrates that older age and age-related hypolordosis were associated with a significantly higher frequency of LSE.
Published: 2024
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30. Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid.

Author: Kesharwani A, Tani S, Nishikawa M, Sakai Y, Okada H, Ohba S, Chung UI, and Hojo H
Abstract: Vascular interactions play a crucial role in embryogenesis, including skeletal development. During endochondral ossification, vascular networks are formed as mesenchymal cells condense and later invade skeletal elements to form the bone marrow. We and other groups developed a model of endochondral ossification by implanting human embryonic stem cell (hESC)-derived sclerotome into immunodeficient mice. However, in vitro models of endochondral ossification, particularly vascular interaction with mesenchymal cells at its initial stage, are yet to be established. Therefore, we developed a method to model the initial stage of endochondral ossification using a microfluidic chip-based platform, with a particular focus on the vascular interaction. On the chip, we found that the fibrin gel helped align mCherry-expressing human umbilical vein endothelial cells (HUVECs) better than the collagen-I gel, suggesting that the fibrin gel is more suitable for the formation of a vascular-like network. The perfusability of the vascular-like networks was partially confirmed using fluorescein isothiocyanate (FITC)-dextran and fluorescent microbeads. We then mixed hESC-derived sclerotome with enhanced green fluorescent protein (EGFP)-expressing HUVECs and applied this mixture on the chip. We named this mixture of cells SH organoids. The SH organoids showed superior abilities to maintain the vascular-like network, which was formed by the mCherry-expressing HUVECs, compared with the sclerotome spheroids on the chip. The EGFP-expressing HUVECs migrated from the SH organoid, formed a vascular-like networks, and partially interacted with the mCherry-expressing vascular-like networks on the chip. Histological analysis showed that SRY-box transcription factor 9 (SOX9) and type I collagen were expressed mutually exclusively in the condensed mesenchymal cells and perichondrial-like cells, respectively. This study demonstrates that our SH organoid-on-a-chip method reproduces vascular networks that are formed at the initial stage of endochondral ossification. This model may provide insights into human endochondral ossification and has potential applications in bone disease modeling and drug screening., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)
Published: 2024
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31. Association of aerobic exercise habits with higher albumin-globulin ratio and lower cellular immune-inflammatory markers: implication of the preventive effect of aerobic exercise on atherosclerotic cardiovascular disease.

Author: Tani S, Imatake K, Suzuki Y, Yagi T, and Takahashi A
Abstract: Aerobic exercise habits have shown promising potential in reducing inflammation. Several studies have suggested that a higher albumin-globulin ratio (AGR), a key indicator of the immune-inflammatory response, could potentially suppress the progression of atherosclerosis. In this study, we investigated the relationship between aerobic exercise and atherosclerotic cardiovascular disease (ASCVD) predictors, specifically, AGR and cellular immune-inflammatory markers. We conducted a cross-sectional study involving 8381 participants (average age, 46.7 ± 13.0 years; 59% men) with no history of ASCVD registered at the Health Planning Center, Nihon University Hospital between 2019 and 2020. We defined aerobic exercise habits as 30 min of sweating at least twice a week for over a year, per the guideline for conducting specific health examinations according to Japan's Ministry of Health, Labour and Welfare. Participants who engaged in habitual aerobic exercise (n = 2159) had a significantly higher AGR than those who did not (n = 6220) [1.70 (1.55/1.86) vs. 1.67 (1.53/1.84), P < 0.0001]. Cellular immune-inflammatory markers, including neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune-inflammation index (neutrophil/lymphocyte × platelet count), were significantly lower in participants who engaged in habitual aerobic exercise than in those who did not (all P < 0.0001). Furthermore, lower cellular immune-inflammatory markers were associated with a higher AGR. Causal mediation analysis revealed that cellular immune-inflammatory markers partially mediated the association between aerobic exercise and AGR. In conclusion, aerobic exercise habits may be associated with a higher AGR and lower cellular immune-inflammatory markers. Moreover, the lower immune-inflammatory response related to aerobic exercise may partially mediate the higher AGR. These associations may explain the attenuating effects of aerobic exercise on the risk of ASCVD., Competing Interests: Declarations. Conflict of interest: The Authors declare that there is no conflict of interest. Ethical approval: This study was reviewed and approved by the Nihon University Hospital Ethics Committee (approval number: 20230601). All the participants provided written informed consent to participate in this study. This study was conducted in accordance with the guidelines of the World Medical Association Declaration of Helsinki. This study was registered with the UMIN ( http://www.umin.ac.jp/ ). Study ID: ( http://www.umin.ac.jp/ ; December 25, 2023; study ID: UMIN000053207)., (© 2024. Springer Nature Japan KK, part of Springer Nature.)
Published: 2024
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32. [A Case of Needle Tract Seeding Discovered Three Years after Pancreatic Cancer Surgery and Treated with Local Gastrectomy].

Author: Naito S, Maehira H, Mori H, Ishikawa H, Nitta N, Maekawa T, Tani S, Kojima M, Otake R, Takebayashi K, Kaida S, Miyake T, Shintani S, Inatomi O, and Tani M
Subjects: Humans, Male, Aged, Time Factors, Adenocarcinoma surgery, Adenocarcinoma drug therapy, Adenocarcinoma pathology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Pancreatectomy, Neoplasm Seeding, Stomach Neoplasms surgery, Stomach Neoplasms pathology, Stomach Neoplasms drug therapy, Endosonography, Gastrectomy, Pancreatic Neoplasms surgery, Pancreatic Neoplasms pathology, Pancreatic Neoplasms drug therapy
Abstract: A 70s-year-old man with pancreatic body cancer underwent evaluation by endoscopic-ultrasound guided tissue acquisition(EUS-TA), followed by distal pancreatectomy. Histopathological findings showed a well differentiated pT3N0M0 adenocarcinoma. Adjuvant S-1 chemotherapy was completed, and annual upper gastrointestinal endoscopy was performed. Three years postoperatively, a type 0-Ⅱc lesion was detected at the posterior gastric wall, at the location where the EUS-TA was performed. The initial biopsy showed no obvious malignant findings, but a repeat biopsy 6 months later revealed a well-differentiated adenocarcinoma. Therefore, we performed 4 courses of gemcitabine+nab-paclitaxel, subsequently performed partial gastrectomy. Histopathological findings of the resected stomach specimen showed a well differentiated adenocarcinoma extending from the subserosa to the submucosa. Then, we diagnosed as needle tract seeding(NTS)of pancreatic cancer. Twelve months after partial gastrectomy, there were no signs of recurrence. EUS-TA is a useful method for diagnosing pancreatic tumor. However, knowledge regarding NTS of pancreatic cancer due to EUS-TA is limited by the fact that this is a rare event. We herein report a case of NTS due to EUS-TA, which was performed partial gastrectomy.
Published: 2024

33. [Simultaneous Robotic Surgery for Synchronous Multiple Cancers with Gastric Cancers-Three Case Reports].

Author: Matsunaga T, Kaida S, Miyake T, Takebayashi K, Otake R, Kojim M, Tani S, Maehira H, Mori H, Nitta N, Takenaka Y, Naito S, Ishikawa H, Shimizu T, and Tani M
Subjects: Humans, Male, Aged, Kidney Neoplasms surgery, Kidney Neoplasms pathology, Middle Aged, Female, Lymph Node Excision, Stomach Neoplasms surgery, Stomach Neoplasms pathology, Robotic Surgical Procedures methods, Neoplasms, Multiple Primary surgery, Gastrectomy methods
Abstract: Synchronous gastric cancer(GC)is rare. We performed simultaneous robotic surgery in 2 cases of colorectal cancer and one case of renal cancer with GC. In case 1(GC cStage Ⅰ, rectal cancer[RC]cStage ⅡB, and descending colon cancer cStage ⅢB), peritoneal dissemination of RC was observed during surgery. Robotic high anterior resection, left hemicolectomy, and D3 lymph node dissection(LND)were performed, followed by distal gastrectomy and D1 LND. The operation time was 600 minutes, with an estimated blood loss of 0 mL. In case 2(GC cStage ⅡA, RC cStage ⅡB), robotic distal gastrectomy, D2 LND, low anterior resection, and D3 LND were performed. The operation time was 648 minutes, with an estimated blood loss of 0 mL. In case 3(right renal cancer cStage Ⅰ, GC 1: cStage ⅡA, and GC 2: cStage ⅡA), a robotic partial right nephrectomy, total gastrectomy, and D2 LND were performed. The operation time was 926 minutes, with an estimated blood loss of 447 mL. Discussion: Although simultaneous surgery for multiple cancers is lengthy and highly invasive, it avoids the risk of tumor growth during the waiting period and adhesion during reoperation. These procedures were performed safely and proved to be beneficial in terms of operating room utilization and cost. Conclusion: Simultaneous robotic surgery for GC is a viable option for patients with synchronous cancers.
Published: 2024

34. A Component of the Septation Initiation Network Complex, SepL, Participates in the Cellobiose-Responsive Expression of Cellulolytic Enzyme Genes in Aspergillus aculeatus.

Author: Sawada K, Kikuya S, Shiga Y, Kawaguchi T, and Tani S
Abstract: The production of cellulolytic enzymes in Aspergillus aculeatus is regulated at transcriptional levels in response to inducers and various physiological signals. In this study, we identified that a component of the septation initiation network complex, SepL, a putative protein kinase, was involved in the expression of carbohydrate-active enzyme (CAZyme) encoding genes. The deletion of sepL (ΔsepL) in A. aculeatus resulted in a deficiency in both septation and conidiation and sensitivity to Congo red. These phenotypes of ΔsepL are conserved in Aspergillus. In addition to the conserved function of SepL in Aspergillus, we found that SepL in A. aculeatus was necessary for the inducible expression of the CAZyme genes in response to cellobiose, whereas the inducible expression of these genes in response to 1,4-β-mannobiose was significantly reduced but not abolished. Combining the results of the present functional analysis of SepL with previous evidence that the expression of the CAZyme genes, which is responsive to both cellobiose and 1,4-β-mannobiose, is regulated by a transcription factor ManR in A. aculeatus, indicates that SepL in A. aculeatus is involved in the selective expression of the cellobiose-responsive CAZyme genes under the control of ManR., (© 2024 Wiley‐VCH GmbH.)
Published: 2024
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35. Total serum bilirubin levels as mediators of anti-atherosclerosis mechanisms with consideration of smoking status.

Author: Tani S, Imatake K, Suzuki Y, Yagi T, and Takahashi A
Abstract: Introduction: Cigarette smoking is a significant risk factor for atherosclerotic cardiovascular diseases (ASCVDs). Mildly elevated total serum bilirubin (TSB) levels can exert anti-atherosclerotic effects and may regulate inflammation. We explore the relationship between TSB levels, smoking, and inflammation., Methods: This cross-sectional study evaluated health screening participants with no history of ASCVD between 1 April 2019 and 31 March 2020. TSB was compared between non-smokers and smokers using the Kruskal-Wallis test, and the influencing factors of TSB levels were identified using multivariable logistic regression with TSB levels above the 75th percentile set as the dependent variable. Mediation analysis was performed to determine whether TSB levels mediated the association between smoking and inflammation., Results: A total of 8337 participants (mean age: 46.6 ± 13.0 years; 58.9% men) were included. TSB levels were significantly lower in smokers (n=1353) than in non-smokers (n=6984) [median (IQR): 0.72 (0.56-0.92) vs 0.76 (0.60-0.97) mg/dL, p<0.0001]. Multivariable logistic regression analysis demonstrated that smoking was an independent determinant of lower TSB levels (adjusted odds ratio, AOR=0.81; 95% CI: 0.70-0.93, p=0.003). Leukocyte counts and C-reactive protein levels significantly decreased as TSB levels increased (p<0.0001). Moreover, the relationship between the duration of smoking cessation and TSB levels showed a positive correlation. Mediation analysis indicated that cigarette smoking had significant indirect effects on higher leukocyte counts and higher CRP levels (coefficient=0.014; 95% CI: 0.008-0.021; and coefficient=0.002; 95% CI: 0.001-0.003, respectively]., Conclusions: Lower TSB levels related to a smoking habit may be associated with higher inflammation, thereby increasing the ASCVD risk. TSB may regulate inflammation and exert antioxidant effects. Furthermore, smoking cessation may lead to higher TSB levels and lower inflammation., Competing Interests: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none was reported., (© 2024 Tani S. et al.)
Published: 2024
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36. Diagnosis and evaluation of cervical ossification of the posterior longitudinal ligament on Zero-Echo Time Magnetic Resonance Imaging: an illustrative case series.

Author: Caffard T, Chiapparelli E, Arzani A, Tani S, Camino-Willhuber G, Finos K, Burkhard MD, Zippelius T, Breighner RE, Carrino JA, Dalton D, and Hughes AP
Subjects: Humans, Retrospective Studies, Male, Female, Middle Aged, Aged, Adult, Ossification of Posterior Longitudinal Ligament diagnostic imaging, Magnetic Resonance Imaging methods, Cervical Vertebrae diagnostic imaging, Tomography, X-Ray Computed methods
Abstract: Purpose: Computed tomography (CT) scans are widely used clinically in the diagnosis of ossification of the posterior longitudinal ligament (OPLL). Conventionally acquired magnetic resonance imaging (MRI) is limited by insufficient signal intensity within bone tissue. Osseus conspicuity may be enhanced by applying sequences with "CT-like" bone contrast zero-echo time (ZTE) MRI. This is a case series aimed to understand if ZTE-MRI is sensitive in detecting cervical OPLL and if this modality is suitable for evaluating OPLL morphology., Methods: A retrospective review was performed to identify adult patients with available cervical ZTE-MRI and CT scans. ZTE-MRI and CT were evaluated for their ability to detect OPLL by 2 attending spine surgeons, 1 spine surgery clinical fellow, and 1 senior orthopedic resident. The phenotype of OPLL was then described and compared between the two modalities., Results: A total of 50 patients were reviewed. All clinicians detected 4 cases of OPLL on CT, and the same cases were independently found on ZTE-MRI. The modalities were then compared to assess the phenotype of OPLL., Conclusion: ZTE-MRI may have the potential to obviate the need for concurrent CT scans in diagnosing OPLL. When OPLL was suspected on MRI, ZTE-MRI could confirm the OPLL diagnosis. With conventional MRI sequences that include additional post-processed ZTE-MRI, clinicians can also assess OPLL morphology and the resulting spinal cord change to make a complete diagnosis and identify patients at higher risk for progression or complications. ZTE-MRI avoids CT-related radiation, can improve diagnosis, and decrease health costs., Competing Interests: Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. Dr. Carrino reports consulting for Pfizer, Inc; Eli-Lilly; Globus Medical, Inc.; Regeneron; AstraZeneca; scientific advisory board/other office position with Carestream; Image Analysis Group; Image Biopsy Lab. Dr. Hughes reports research support from Kuros Biosciences AG and Expanding Innovations, Inc.; private investments in Tissue Connect Systems, Inc.; and fellowship support from NuVasive, Inc. outside the submitted work. Ethics approval: This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Institutional Review Board (IRB) of Hospital for Special Surgery approved this study (#2023–0413). Consent to Participate and Publish: Informed consent was waived due to the retrospective nature of the study., (© 2024. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.)
Published: 2024
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37. Bone Mineral Density Distribution in the Posterior Wall of the Lateral Mass Evaluated by Computed Tomography Osteoabsorptiometry.

Author: Doi K, Inoue N, Tani S, and Mizuno J
Abstract: Objective Cervical open-door laminoplasty using plates and miniscrews is gaining popularity. One of the complications of this procedure is the loosening or back-out of the miniscrews inserted in the lateral mass (LM). Bone mineral density (BMD) measured by computed tomography (CT) has been used as a predictor of bone strength. However, bone density distribution in the LM remains unclear. Materials and Methods We investigated bone density distribution in the posterior wall of the LM. A total of 120 LMs were analyzed from the patients who underwent laminoplasty. The distribution of BMD defined by Hounsfield unit (HU) in the posterior wall of the LM was measured by CT osteoabsorptiometry. The posterior wall was divided into nine zones, which consisted of three columns (lateral, center, and medial) and three rows (cranial, center, and caudal). BMD in each zone was averaged and compared by zones and cervical levels. Results Overall mean ± standard deviation BMD was 1,092 ± 433 HU. Averaged BMD in the entire posterior wall was highest at C4 (1,365 ± 459 HU), second highest at C3 (1,239 ± 435 HU), and lower in the lower levels. BMD in the medial-center zone (1,357 ± 443 HU) was the highest in all zones. BMD in the medial-caudal region at C7 was only 59% of the highest BMD in the medial-center region at C4. Conclusion The medial-center to the cranial region was most suitable for miniscrew fixation for laminoplasty. These biomechanical findings would be useful in the preoperative planning of laminoplasty especially for the determination of the LM screw entry points and in the design of laminoplasty implants., Competing Interests: Conflict of Interest None declared., (Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
Published: 2024
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38. Offline Adaptive Radiotherapy for Large Non-small Cell Lung Cancer With Volumetric Modulated Arc Therapy Replanning After Creation of Dose Distribution Using Cone-Beam Computed Tomographic Images of Image-Guided Radiotherapy.

Author: Ohguri T, Shiba E, Kuroki R, Matsukawa H, Tani S, and Iwai Y
Abstract: There is a paucity of studies reporting the use of automated contouring function on cone-beam computed tomography (CBCT) images acquired during image-guided radiotherapy (IGRT) with offline adaptive radiotherapy for locally advanced non-small cell lung cancer (NSCLC). This case report discusses the use of an automated contouring function on CBCT images acquired during IGRT to quantify the dose distribution variations associated with tumor shrinkage in a patient with large NSCLC. A 72-year-old woman with locally advanced squamous cell carcinoma of the lung (T4N1M0; tumor diameter: 14 cm) underwent chemoradiotherapy. Two offline adaptive radiotherapy sessions were performed, resulting in no evidence of recurrence or distant metastasis, as well as no side effects of Grade 2 or higher toxicity., Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Ohguri et al.)
Published: 2024
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39. Synthesis of tricarbonylated propargylamine and conversion to 2,5-disubstituted oxazole-4-carboxylates.

Author: Iwai K, Hikasa A, Yoshioka K, Tani S, Umezu K, and Nishiwaki N
Abstract: The N , O -acetal derived from diethyl mesoxalate (DEMO) undergoes elimination of acetic acid upon treatment with a base, leading to the formation of N -acylimine in situ. Lithium acetylide readily attacks the imino group to afford N ,1,1-tricarbonylated propargylamines. When the resulting propargylamine reacts with butyllithium, ring closure occurs between the ethynyl and carbamoyl groups, yielding 2,5-disubstituted oxazole-4-carboxylates. This cyclization also occurs when the propargylamine is heated with ammonium acetate, resulting in double activation., (Copyright © 2024, Iwai et al.)
Published: 2024
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40. Combinational manipulation of transcription factors, CreA and ClbR, is a viable strategy to improve cellulolytic enzyme production in Aspergillus aculeatus.

Author: Tani S, Hirose S, and Kawaguchi T
Subjects: Cellobiose metabolism, Gene Expression Regulation, Fungal, Cellulose metabolism, Gene Deletion, Aspergillus genetics, Aspergillus enzymology, Aspergillus metabolism, Cellulase genetics, Cellulase metabolism, Cellulase biosynthesis, beta-Glucosidase genetics, beta-Glucosidase metabolism, beta-Glucosidase biosynthesis, Transcription Factors genetics, Transcription Factors metabolism, Fungal Proteins genetics, Fungal Proteins metabolism, Endo-1,4-beta Xylanases genetics, Endo-1,4-beta Xylanases metabolism, Endo-1,4-beta Xylanases biosynthesis
Abstract: The production of cellulolytic enzymes in response to inducible carbon sources is mainly regulated at the transcriptional level in filamentous fungi. We have identified a cellobiose-response regulator (ClbR) controlling the expression of cellulolytic enzyme-encoding genes in Aspergillus aculeatus. However, the engineering potential of combining the deletion of transcriptional repressors with the overexpression of transcriptional activators to enhance enzyme production has not been analyzed. Here, we investigated the effect of the deletion of the transcriptional repressor creA and the overexpression of the transcriptional activator clbR in enzyme production in A. aculeatus. Here, we verified that a combination of creA deletion and clbR overexpression (Δc&OE) improved cellulase, β-1,4-xylanase, and β-glucosidase production. Cellulase and β-1,4-xylanase production increased 3.4- and 8.0-fold in Δc&OE compared with the host strain (MR12) at 96-h incubation, respectively. β-Glucosidase production in ΔcreA and Δc&OE increased approximately 5.0-fold compared with that in MR12 at 240-h incubation. Transcriptional analysis revealed that the increase in enzyme production was due to increased expression of cellobiohydrolase, endo-β-1,4-glucanase, β-1,4-xylanase, and β-glucosidase 1 (bgl1). Interestingly, bgl1 expression in ΔcreA increased in a dose-dependent manner in response to glucose. Thus, combinational manipulation of transcription factors improved cellulase, xylanase, and β-glucosidase production in A. aculeatus., (Copyright © 2024 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.)
Published: 2024
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41. Colloidal 2D Layered SiC Quantum Dots from a Liquid Precursor: Surface Passivation, Bright Photoluminescence, and Planar Self-Assembly.

Author: Thomas SA, Alharthi NS, Petersen RJ, Aldrees A, Tani S, Anderson KJ, Granlie J, Pringle TA, Payne SA, Choi Y, Kilin DS, and Hobbie EK
Abstract: We report the bottom-up synthesis of colloidal two-dimensional (2D) layered silicon carbide (SiC) quantum dots with a cubic structure, lateral size of 5-10 nm, ⟨110⟩ exfoliation to few atomic layers, and surface passivation with 1-dodecene. Samples shielded from oxygen and plasma-annealed for purity exhibit narrow blue photoluminescence (PL) with quantum yields (QYs) over 60% in exceptional cases, while unshielded nanocrystals (NCs) exhibit broad blue/green/white PL with 10-15% QY. The latter scenario is attributed to excess surface carbon and oxygen accrued during synthesis and processing, with size separation through ultracentrifugation revealing size-dependent impurity emission. In contrast, the shape of the bright narrow blue PL shows little variation with NC size, while in both scenarios, the maximum QY occurs near four atomic layers. When dried under heat, the disk-like NC suspensions are observed to aggregate into microscale domains, with further self-assembly into planar superlattice domains with common crystalline orientation. The results are compared with photophysical simulations and bring clarity to the broad emission commonly reported for top-down approaches, while inspiring bottom-up schemes directed at improved material quality.
Published: 2024
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42. Optimal Targeted Temperature Management for Patients with Post-Cardiac Arrest Syndrome.

Author: Yagi T, Tachibana E, Atsumi W, Kuronuma K, Iso K, Hayashida S, Sugai S, Sasa Y, Shoji Y, Kunimoto S, Tani S, Matsumoto N, and Okumura Y
Subjects: Humans, Male, Female, Middle Aged, Aged, Time Factors, Body Temperature, Retrospective Studies, Heart Arrest therapy, Heart Arrest complications, Hypothermia, Induced methods, Hypothermia, Induced standards, Post-Cardiac Arrest Syndrome complications, Post-Cardiac Arrest Syndrome physiopathology
Abstract: Background : To prevent hypoxic-ischemic brain damage in patients with post-cardiac arrest syndrome (PCAS), international guidelines have emphasized performing targeted temperature management (TTM). However, the most optimal targeted core temperature and cooling duration reached no consensus to date. This study aimed to clarify the optimal targeted core temperature and cooling duration, selected according to the time interval from collapse to return of spontaneous circulation (ROSC) in patients with PCAS due to cardiac etiology. Methods : Between 2014 and 2020, the targeted core temperature was 34 °C or 35 °C, and the cooling duration was 24 h. If the time interval from collapse to ROSC was within 20 min, we performed the 35 °C targeted core temperature (Group A), and, if not, we performed the 34 °C targeted core temperature (Group B). Between 2009 and 2013, the targeted core temperature was 34 °C, and the cooling duration was 24 or 48 h. If the interval was within 20 min, we performed the 24 h cooling duration (Group C), and, if not, we performed the 48 h cooling duration (Group D). Results : The favorable neurological outcome rates at 30 days following cardiac arrest were 45.7% and 45.5% in Groups A + B and C + D, respectively ( p = 0.977). In patients with ROSC within 20 min, the favorable neurological outcome rates at 30 days following cardiac arrest were 75.6% and 86.4% in Groups A and C, respectively ( p = 0.315). In patients with ROSC ≥ 21 min, the favorable neurological outcome rates at 30 days following cardiac arrest were 29.3% and 18.2% in Groups B and D, respectively ( p = 0.233). Conclusions : Selecting the optimal target core temperature and the cooling duration for TTM, according to the time interval from collapse to ROSC, may be helpful in patients with PCAS due to cardiac etiology.
Published: 2024
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43. Spontaneous spinal epidural hematoma in children: a case report and literature review.

Author: Tombeng MA, Doi K, Mahadewa TGB, Tani S, and Mizuno J
Abstract: Background: Spontaneous spinal epidural hematoma (SSEH) is a hematoma within the spinal epidural space without the underlying causes of trauma or iatrogenic and is considered a very rare neurosurgical emergency disease in children that can cause spinal cord compression and neurological dysfunction. This article provides useful information and guidance to the clinician about SSEH in children regarding its specific characteristics, clinical presentation, and management strategy to achieve a better outcome., Case Description: A 14-year-old boy presented with an acute onset of neck pain radiating to the right shoulder and progressive right hemiparesis. The cervical spine magnetic resonance imaging (MRI) revealed a right posterolateral hyperacute spinal epidural hematoma at C4-C7. The patient underwent an emergent open-door laminoplasty (C5-C6) with partial laminectomy (C4 and C7) and complete evacuation of the hematoma. The patient had a complete recovery after surgery with no neurological deficits. A literature search in the PubMed electronic database was performed to identify published English articles between January 2000 to December 2023 focusing on SSEH in children. We have found 81 articles with a total of 95 cases of SSEH in children, providing comparison data on sex, age, clinical presentation, etiology, location of the hematoma, treatment modalities, and outcomes., Conclusions: SSEH in children is a very rare neurosurgical emergency disease. Prompt and proper examination is essential to establish the diagnosis and early surgical decompression. Adequate surgical decompression may reduce intradural pressure and increase the blood perfusion to the spinal cord, thus, this will eventually reduce ischemia and prevent secondary spinal injury. As a result, complete recovery can be expected., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jss.amegroups.com/article/view/10.21037/jss-24-49/coif). The authors have no conflicts of interest to declare., (2024 AME Publishing Company. All rights reserved.)
Published: 2024
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44. A Case Report of Long-Term Survival Achieved by Nivolumab and Hyperthermia With Multiple Local Therapies for the Peritoneal Dissemination of Gastric Cancer.

Author: Ohguri T, Tani S, Kawarada Y, and Kitahara M
Abstract: A 60-year-old male with recurrent metastatic gastric cancer achieved long-term survival with nivolumab, hyperthermia, and local multisite therapy. The patient had a history of multiple relapses despite receiving standard treatment. After the failure of multiple lines of chemotherapy, nivolumab and hyperthermia were initiated. During this combination therapy, local treatments including surgery and radiation therapy were administered to treat the progressive disease. Remarkably, the patient achieved more than five years of overall survival time after starting nivolumab and external repeated hyperthermia with local therapies and has shown no measurable disease on imaging for the past 24 months. This case suggests that a combination of nivolumab, hyperthermia, and local therapies may offer a potential therapeutic strategy for patients with advanced gastric cancer., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Ohguri et al.)
Published: 2024
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45. ASO Author Reflections: A Novel Microwave Scissors-Based Sutureless Laparoscopic Partial Nephrectomy Technique with a Less Technically Demanding Procedure.

Author: Nguyen HN, Yamada A, Naka S, Murakami K, Tani S, and Tani T
Subjects: Humans, Surgical Instruments, Sutureless Surgical Procedures methods, Nephrectomy methods, Laparoscopy methods, Microwaves therapeutic use, Kidney Neoplasms surgery
Published: 2024
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46. Microwave Scissors-Based Sutureless Laparoscopic Partial Nephrectomy Versus Conventional Open Partial Nephrectomy in a Porcine Model: Usefulness and Complications.

Author: Nguyen HN, Yamada A, Naka S, Murakami K, Tani S, and Tani T
Subjects: Animals, Swine, Postoperative Complications etiology, Kidney Neoplasms surgery, Kidney Neoplasms pathology, Operative Time, Female, Surgical Instruments, Nephrectomy methods, Laparoscopy methods, Microwaves therapeutic use
Abstract: Background: This study aimed to compare the benefits and safety of microwave scissors-based sutureless laparoscopic partial nephrectomy (MSLPN) with those of conventional open partial nephrectomy (cOPN)., Methods: Each kidney in nine pigs underwent MSLPN using microwave scissors (MWS) via transperitoneal laparoscopy or cOPN via retroperitoneal open laparotomy. The kidney's lower and upper poles were resected under temporary hilar-clamping. The renal calyces exposed during renal resections were sealed and transected using MWS in MSLPN and were sutured in cOPN. For MWS, the generator's power output was 60 W. Data on procedure time (PT), ischemic time (IT), blood loss (BL), normal nephron loss (NNL), and extravasation during retrograde pyelogram were compared between the two techniques., Results: The authors successfully performed 22 MSLPNs and 10 cOPNs. Compared with cOPN, MSLPN was associated with significantly lower PT (median, 9.2 vs 13.0 min; p = 0.026), IT (median, 5.9 vs 9.0 min; p < 0.001), BL (median, 14.4 vs 38.3 mL; p = 0.043), and NNL (median, 7.6 vs 9.4 mm; p = 0.004). However, the extravasation rate was higher in the MSLPN group than in the cOPN group (54.5 % [n = 12] vs 30.0 % [n = 3]), albeit without a significant difference (p = 0.265). Pelvic stenosis occurred in one MSLPN procedure that involved deep lower pole resection near the kidney hilum., Conclusions: The study data show that MSLPN can improve intraoperative outcomes while reducing technical demands for selected patients with non-hilar-localized renal tumors. However, renal calyces, if violated, should be additionally sutured to prevent urine leakage., (© 2024. The Author(s).)
Published: 2024
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47. Liquid-Crystalline Photonic Sandwich: Electroresponsive Colloids of Clay Nanosheets Loading Photofunctional Dyes.

Author: Nakato T, Watanabe T, Harada T, Shintaku M, Mouri E, Tani S, Suzuki Y, Miyata H, Breu J, and Kawamata J
Abstract: Colloidal clay nanosheets obtained by the delamination of layered crystals of smectite-type clay minerals in water form liquid crystals because of their shape anisotropy. Loading of organic dyes onto the liquid crystalline clay nanosheets will enable novel photonic materials, where photofunctions of the loaded dye are controlled by the liquid crystallinity of the clay nanosheets. However, adsorption of organic dyes onto the nanosheets renders the nanosheet surfaces hydrophobic, and consequently, colloidal stability of the nanosheets is lost. In this study, this drawback is overcome by sandwiching cationic stilbazolium dyes between a pair of synthetic fluorohectorite nanosheets. This is realized by the preparation of stilbazolium-clay second-stage intercalation compounds characterized by intercalation of dye cations into every other interlayer space of the hectorite clay, where nonintercalated interlayer spaces are occupied by Na + ions. The second-stage intercalation compounds are obtained by partial ion exchange of mother clay mineral incorporating Na + ions in all of the interlayer spaces and delaminated from the Na + -containing interlayer spaces to form clay nanosheets sandwiching the dye molecules. Aqueous colloids of the dye-sandwiching clay nanosheets form colloidal liquid crystals, and the dye-sandwiching liquid crystalline clay nanosheets respond to an applied AC electric field to be aligned parallel to the electric field. The assembled structure of the dye-sandwiching clay nanosheets under the electric field is characterized by aligned discrete clay platelets, which is somewhat different from that of a colloidal liquid crystal of clay nanosheets without dye loading characterized by macroscopic liquid crystalline domains up to submillimeters. The electric alignment of the clay nanosheets induces alteration of light absorption of the sandwiched stilbazolium molecules, which verifies a strategy of constructing stimuli-responsive photonic materials of clay-organic hybrids.
Published: 2024
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48. The potential effect of romosozumab on perioperative management for instrumentation surgery.

Author: Ishikawa K, Tani S, Toyone T, Tsuchiya K, Towatari T, Oshita Y, Yamamura R, Wada K, Nagai T, Shirahata T, Inagaki K, and Yoshifumi K
Abstract: Background: Age-related changes in bone health increase the risk for complications in elderly patients undergoing orthopedic surgery. Osteoporosis is a key therapeutic target that needs to be addressed to ensure successful instrumentation surgery. The effectiveness of pharmacological interventions in orthopedic surgery, particularly the new drug romosozumab, is still unknown. We aim to evaluate the effect of 3-month romosozumab treatment on biomechanical parameters related to spinal instrumentation surgery, using the Quantitative Computed Tomography (QCT)-based Finite Element Method (FEM)., Methods: This open-labeled, prospective study included 81 patients aged 60 to 90 years, who met the osteoporosis criteria and were scheduled for either romosozumab or eldecalcitol treatment. Patients were assessed using blood samples, dual-energy absorptiometry (DXA), and QCT. Biomechanical parameters were evaluated using FEM at baseline and 3 months post-treatment. The primary endpoints were biomechanical parameters at 3 months, while secondary endpoints included changes in regional volumetric bone mineral density around the pedicle (P-vBMD) and vertebral body (V-vBMD)., Results: Romosozumab treatment led to significant gains in P-vBMD, and V-vBMD compared to eldecalcitol at 3 months. Notably, the romosozumab group showed greater improvements in all biomechanical parameters estimated by FEM at 3 months compared to the eldecalcitol group., Conclusion: Romosozumab significantly increased the regional vBMD as well as biomechanical parameters, potentially offering clinical benefits in reducing post-operative complications in patients with osteoporosis undergoing orthopedic instrumentation surgery. This study highlights the novel advantages of romosozumab treatment and advocates further research on its effectiveness in perioperative management., Competing Interests: Koji Ishikawa and Takashi Nagai received a speaking fee from Amgen. Soji Tani, Toyone Tomoaki, Koki Tsuchiya, Tomoko Towatari, Yusuke Oshita, Ryo Yamamura, Kazuki Wada, Toshiyuki Shirahata, Katsunori Inagaki, and Yoshifumi Kudo declare that they have no competing interests related to this study., (© 2024 The Author(s). JOR Spine published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.)
Published: 2024
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49. Examining the Role of Paraspinal Musculature in Postoperative Disability After Lumbar Fusion Surgery for Degenerative Spondylolisthesis.

Author: Schönnagel L, Guven AE, Camino-Willhuber G, Caffard T, Tani S, Zhu J, Haffer H, Muellner M, Zadeh A, Sanchez LA, Shue J, Duculan R, Schömig F, Sama AA, Cammisa FP, Girardi FP, Mancuso CA, and Hughes AP
Subjects: Humans, Male, Female, Middle Aged, Aged, Retrospective Studies, Disability Evaluation, Treatment Outcome, Postoperative Complications etiology, Decompression, Surgical methods, Decompression, Surgical adverse effects, Spondylolisthesis surgery, Spondylolisthesis diagnostic imaging, Spinal Fusion methods, Spinal Fusion adverse effects, Paraspinal Muscles diagnostic imaging, Lumbar Vertebrae surgery, Lumbar Vertebrae diagnostic imaging
Abstract: Study Design: Retrospective analysis of prospectively enrolled patients., Objective: To evaluate the relationship between paraspinal muscle (PM) atrophy and Oswestry Disability Index (ODI) improvement after spinal fusion surgery for degenerative lumbar spondylolisthesis., Background: Atrophy of the PM is linked to multiple spinal conditions, sagittal malalignment, and increased postoperative complications. However, only limited evidence for the effect on patient-reported outcomes exists., Methods: Patients with degenerative lumbar spondylolisthesis undergoing decompression and fusion surgery were analyzed. Patients with missing follow-up, no imaging, or inadequate image quality were excluded. The ODI was assessed preoperatively and two years postoperatively. A cross-sectional area of the PM was measured on a T2-weighted magnetic resonance imaging sequence at the upper endplate of L4. On the basis of the literature, a 10-point improvement cutoff was defined as the minimum clinically important difference. Patients with a baseline ODI below the minimum clinically important difference were excluded. Logistic regression was used to calculate the association between fatty infiltration (FI) of the PM and improvement in ODI, adjusted for age, sex, and body mass index., Results: A total of 133 patients were included in the final analysis, with only two lost to follow-up. The median age was 68 years (IQR 62-73). The median preoperative ODI was 23 (IQR 17-28), and 76.7% of patients showed improvement in their ODI score by at least 10 points. In the multivariable regression, FI of the erector spinae and multifidus increased the risk of not achieving clinically relevant ODI improvement ( P =0.01 and <0.001, respectively). No significant association was found for the psoas muscle ( P =0.158)., Conclusions: This study demonstrates that FI of the erector spinae and multifidus is significantly associated with less likelihood of clinically relevant ODI improvement after decompression and fusion. Further research is needed to assess the effect of interventions., Competing Interests: A.A.S. reports royalties from Ortho Development, Corp.; private investments for Vestia Ventures MiRUS Investment, LLC, IVY II, LLC, ISPH II, LLC, ISPH 3, LLC, HS2, LLC, HSS ASC Development Network, LLC, and Centinel Spine (Vbros Venture Partners V); consulting fee from Depuy Synthes Products Inc., Clariance Inc., Kuros Biosciences AG, Ortho Development Corp., Medical Device Business Service Inc.; speaking and teaching arrangements of DePuy Synthes Products Inc.; membership of scientific advisory board of Depuy Synthes Products Inc., Clariance Inc., and Kuros Biosciences AG; Medical Device Business Service Inc. and trips/travel of Medical Device Business; research support from Spinal Kinetics Inc., outside the submitted work. Cammisa reports royalties from NuVasive Inc. Accelus; ownership interest for 4WEB Medical/4WEB Inc.; Healthpoint Capital Partners, LP; ISPH II, LLC; ISPH 3 Holdings, LLC; Ivy Healthcare Capital Partners, LLC; Medical Device Partners II, LLC; Medical Device Partners III, LLC; Orthobond Corporation; Spine Biopharma, LLC; Tissue Differentiation Intelligence, LLC; VBVP VI, LLC; VBVP X, LLC; Woven Orthopedics Technologies; consulting fees from 4WEB Medical/4WEB Inc., DePuy Synthes, NuVasive Inc., Spine Biopharma, LLC, and Synexis, LLC, Accelus; membership of scientific advisory board/other office of Healthpoint Capital Partners, Medical Device Partners II, LLC, Orthobond Corporation, Spine Biopharma, LLC, and Woven Orthopedic Technologies; and research support from 4WEB Medical/4WEB Inc., Mallinckrodt Pharmaceuticals, Camber Spine, and Centinel Spine, outside the submitted work. F.P.G. reports royalties from Lanx Inc., and Ortho Development Corp.; private investments for BCIMD; and stock ownership of Healthpoint Capital Partners, LP, outside the submitted work. A.P.H. reports research support from Kuros Biosciences AG and fellowship support from NuVasive Inc. and Kuros Biosciences BV, outside the submitted work. The remaining authors report no conflicts of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Published: 2024
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50. Stent Retriever Deployment Tracing Susceptibility Vessel Sign in the M2 Branch Predicts the Effective First-Pass Reperfusion in Thrombectomy for M1 Occlusion.

Author: Yoshida S, Fujimoto M, Shimizu K, Ogata H, Yamashita H, Akiyama Y, and Tani S
Subjects: Humans, Male, Female, Aged, Retrospective Studies, Middle Aged, Ischemic Stroke surgery, Ischemic Stroke diagnostic imaging, Aged, 80 and over, Treatment Outcome, Magnetic Resonance Imaging, Infarction, Middle Cerebral Artery surgery, Infarction, Middle Cerebral Artery diagnostic imaging, Thrombectomy methods, Stents, Reperfusion methods
Abstract: Background and Purpose: Successful first-pass reperfusion is associated with better functional outcomes after mechanical thrombectomy (MT) for acute ischemic stroke, but its treatment strategies remain unclear., Materials and Methods: We retrospectively recruited patients who underwent MT for M1 occlusion between December 2020 and May 2023 at our institution. The locations of susceptibility vessel sign (SVS) on magnetic resonance imaging were classified into M1 only, M1 to single M2 branch, or M1 to both M2 branches. Patients were included in the SVS tracing group when the stent retriever of the first pass covered the entire SVS length. Successful reperfusion was defined as a modified Thrombolysis in Cerebral Infarction scale 2b-3. Any intracranial hemorrhage detected at 24-hour postoperatively was included as a hemorrhagic complication., Results: The SVS was detected in M1 only, M1 to single M2 branch, and M1 to both M2 branches in 8, 22, and 4 patients, respectively. Among the 34 patients, 27 were included in the SVS-tracing group. Successful first-pass reperfusion was significantly more frequent in the SVS-tracing group compared with the non-SVS tracing group (odds ratio, 14.4; 95% confidence interval, 2.0 - 101; P = 0.007). The procedural time was significantly reduced in the SVS tracing group (median, 29 [interquartile range, 22 - 49] minute vs. 63 [43 - 106] minute; P = 0.043). There was a trend toward less frequent hemorrhagic complications in the SVS tracing group (odds ratio, 0.17; 95% confidence interval, 0.029 - 1.0; P = 0.052)., Conclusions: This study provides a thrombus imaging-based MT strategy to efficiently achieve first-pass reperfusion in M1 occlusion., (Copyright © 2024 Elsevier Inc. All rights reserved.)
Published: 2024
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