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Climate change is the primary environmental threat to subsistence farmers’ productivity in Peru. Adaptation is promoted as the best mechanism to cope with climate change in subsistence agricultural livelihoods. However, climatic adaptability depends on the resources the farmer has access to or can use, which are not always adequate to respond effectively to the speed and aggressiveness of climate change. This study explored the local factors and dynamics (assets) influencing the climate adaptability processes of subsistence farmers in Huayhuay, Peru. Twenty subsistence farmers participated in semi-structured interviews within a basic qualitative design. The results brought to light 18 local factors and dynamics that influence the coping mechanisms of climate adaptability. These findings support other investigations that demonstrate the difficulty of climate change adaptation agricultural communities face. The difficulty of climate change adaptation has rooted the interrelationships of assets of different natures within the same adaptive process. Future research and interventions should encourage the active participation of farmers in local climate action and evaluate the efficiency and effectiveness of farmers' adaptability mechanisms, considering the role of each local-scale factor and dynamic.

Internationalization of higher education’s agricultural disciplines is essential to account for agrifood system trends toward globalization and multiculturalism. Professional and academic associations can play a formative role preparing graduate students for their agricultural careers. Guided by socialization theory, this needs assessment explores graduate students’ perceived needs, expectations, and ideas to optimize engagement with associations focused on international agriculture. A convergent mixed methods design integrated and contrasted quantitative and qualitative data from an online survey—filled by 26 student participants—and qualitative data from a virtual fishbone focus group with seven participants. Students’ perceptions appear responsive to trends toward globalized food systems and demonstrate their desire for socialization to gain internationally focused capacities and connections to opportunities in a variety of global agricultural areas. Findings indicate associations geared toward internationally oriented scholarship and academics should expand to better encompass international development practice. Doing so would provide greater insight into practitioners’ priorities and facilitate alternative career pathways for graduate students interested in practice. Additionally, findings point to needs for student mentoring and communication efforts focused on equitable and inclusive engagement with first generation students and students in developing countries who may be financially inhibited from traveling for in-person socialization activities.

Traditional production of dry salted shrimp enhances cholesterol oxidation and astaxanthin degradation in the product. The aim of this study was to evaluate the effect of addition of the antioxidants butylhydroxytoluene (BHT) and tert-butylhydroquinone (TBHQ) to cooked shrimp on the formation of cholesterol oxidation products (COPs) and astaxanthin degradation during solar drying of shrimp.The added antioxidants significantly inhibited COPs formation after the product was boiled in brine. Smaller amounts of COPs were formed in antioxidant-treated shrimps (~-23%) as compared to untreated samples. The antioxidants continued to significantly inhibit COPs formation (~-39%) during sun drying. Similarly, TBHQ and BHT reduced by 51.3% and 37.2%, respectively, the degradation rate of astaxanthin, favoring a higher retention of this carotenoid in the final product.The use of the antioxidants BHT and TBHQ in the preparation of dry salted shrimp significantly inhibited the formation of COPs after cooking raw shrimp and during direct solar drying. They also protected astaxanthin contained in the cooked shrimp from photodegradation. These results are technologically relevant because it is possible to prepare a product with a higher content of astaxanthin and lower the presence of hazardous COPs. © 2022 Society of Chemical Industry.

Coated polycrystalline cubic boron nitride (PcBN) tools are increasingly used for industrial applications with stringent requirements. However, information on the mechanical integrity of these systems is quite limited. Within this context, the adhesion strength of two TiN/TiAlN-coated and microstructurally different PcBN substrates – high- and low-cBN content grades with metallic and ceramic binders, respectively – is investigated by means of Rockwell C indentation testing. In doing so, special attention is paid to substrate microstructure effects on emergence and evolution of damage as applied load is increased. For both coated systems, it is found that damage scenario evolves from early adhesive delamination within the contact area towards radial cracking and spalling outside the residual imprint. However, critical loads for transition between damage stages are discerned to depend on microstructural assemblage of the substrate. Higher resistance to radial cracking and delamination is exhibited by the high cBN-content grade, in agreement with its higher hardness and toughness. Failure micromechanisms associated with cracking and spalling are similar for both coated-PcBN systems. Very interesting, delamination outside the residual imprint is determined to be of cohesive nature within the substrate, an experimental fact resulting from interaction among indentation-induced radial, cone-like and lateral fissures in PcBN.

Introduction /Objectives: The objectives were to conduct a survey of cardiologists on their recent experiences with cats that have dilated cardiomyopathy (DCM), and to retrospectively review individual cases of feline DCM. Animals, Materials and Methods Part One: A survey was distributed to cardiologists with questions regarding caseload and clinical management of cats with DCM diagnosed over the past two years. Part Two: Cardiologists completing the survey were invited to submit data from cats recently diagnosed with DCM. Data on signalment, clinical signs, diet, echocardiographic measurements, and outcome were recorded. Results Part One: From 52 completed surveys, many cardiologists responded that measuring and supplementing taurine and recommending a diet change in cats with DCM are common practices. Few (15%) cardiologists reported an increase in number of feline DCM cases over the past two years, although some had cases that improved even if taurine deficiency was not present. Part Two: Twenty of 37 (54%) cats ate low pea/lentil (low PL) diets and 14/37 (38%) ate high pea/lentil (high PL) diets at the time of diagnosis; three had incomplete diet information. Two of 13 cats (15%) in which taurine was measured had levels below the reference range. After adjusting for other variables, cats eating high PL diets that changed diets post-diagnosis had a significantly longer survival time compared to cats eating high PL diets that did not change diets post-diagnosis (P=0.025). Conclusions Additional research is warranted to determine whether there could be a possible association between diet and DCM in cats.

Resume Introduction Les residents en EHPAD sont une population fragile dont l’acces aux soins est limite. Ces dernieres annees, la telemedecine s’est developpee dans plusieurs specialites, dont l’ophtalmologie. L’objectif principal de notre etude est la validation d’un protocole de teleexpertise d’ophtalmologie en EHPAD. Materiel et methodes Il s’agit d’une etude retrospective, multicentrique et descriptive incluant 4 EHPAD autour de l’agglomeration de Rennes. Un orthoptiste examinait les residents une demi-journee par semaine. L’examen se faisait directement dans la chambre du patient, au lit ou au fauteuil, avec du materiel portable. Les examens sont interpretes a distance et en differe par un ophtalmologiste du service dans un delai de 7 jours. Une prise en charge adaptee medicale ou chirurgicale est alors proposee au patient selon le diagnostic. Resultats Nous avons inclus 113 residents. Un examen complet et interpretable a ete realise dans 84,1 % des cas. Une ou plusieurs pathologies ophtalmologiques ont ete diagnostiquees chez 57,5 % des residents. Parmi les residents ayant effectue une consultation au CHU, 65 % d’entre eux ont eu un acte chirurgical ou un laser programme. L’acuite visuelle a ete significativement amelioree apres la teleexpertise. Discussion Le taux de reussite d’un examen complet et interpretable nous permet, a ce jour, de valider notre procedure d’examen en EHPAD. En plus d’apporter un grand nombre d’informations initialement inconnues au personnel medical et paramedical de la structure, la teleexpertise d’ophtalmologie permet une amelioration significative de l’acuite visuelle. Conclusion Ce projet a permis de valider la faisabilite d’une teleexpertise d’ophtalmologie dans les EHPAD. Cette activite semble egalement pouvoir s’ouvrir a d’autres centres de soins (centres penitenciers, etablissement de sante mentale…).

From its origins in social media usage, the term “sharing” has become an umbrella term for socio-technological competency. Even though sharing is a multifaceted construct – influenced by user motivations, expectations, and particularly the intrinsic and extrinsic social benefits to be gained – there are few definitions that approach it around these terms. We analyze these benefits in terms of what we call sociability affordances - i.e., social network site (SNS) affordances that arise outside either the merely material or imagined affordances - which enable individuals to take social actions toward social integration and interaction. Semi-structured interviews with young Chileans from three representative social media use typologies showed that each were closely linked with the performance of sharing actions for intrinsic and extrinsic social integration and interaction gains. Coding of interviews found four main sociability affordances from sharing practices: social visibility; audience engagement; social strengthening and enduring intra-personal communication. Based on U&G and self-determination theories, and rooted in an affordance approach, this study finds that online sharing behaviors are carefully weighed upon to achieve either factual or imagined social gains.

Background Organisms in the wild can acquire disease- and stress-resistance traits that outstrip the programs endogenous to humans. Finding the molecular basis of such natural resistance characters is a key goal of evolutionary genetics. Standard statistical-genetic methods toward this end can perform poorly in organismal systems that lack high rates of meiotic recombination, like Caenorhabditis worms. Results Here we discovered unique ER stress resistance in a wild Kenyan C. elegans isolate, which in inter-strain crosses was passed by hermaphrodite mothers to hybrid offspring. We developed an unbiased version of the reciprocal hemizygosity test, RH-seq, to explore the genetics of this parent-of-origin-dependent phenotype. Among top-scoring gene candidates from a partial-coverage RH-seq screen, we focused on the neuronally-expressed, cuticlin-like gene cutl-24 for validation. In gene-disruption and controlled crossing experiments, we found that cutl-24 was required in Kenyan hermaphrodite mothers for ER stress tolerance in their inter-strain hybrid offspring; cutl-24 was also a contributor to the trait in purebred backgrounds. Conclusions These data establish the Kenyan strain allele of cutl-24 as a determinant of a natural stress-resistant state, and they set a precedent for the dissection of natural trait diversity in invertebrate animals without the need for a panel of meiotic recombinants.

Because climate change has severely impacted global bee populations by depleting their habitats and food sources, beekeepers must implement management practices to adapt to changing climates. However, beekeepers in El Salvador lack information about necessary climate change adaptation strategies. This study explored Salvadoran beekeepers’ experiences adapting to climate change. The researchers used a phenomenological case study approach and conducted semi-structured interviews with nine Salvadoran beekeepers who were members of The Cooperative Association for Marketing, Production, Savings, and Credit of Beekeepers of Chalatenango (ACCOPIDECHA). The beekeepers perceived water and food scarcity, as well as extreme weather events (e.g., increasing temperature, rain, winds), as the leading climate change-induced challenges to their production. Such challenges have augmented their honey bees’ physiological need for water, limited their movement patterns, decreased apiary safety, and increased the incidence of pests and diseases, all of which have led to honey bee mortality. The beekeepers shared adaptation strategies, including box modification, apiary relocation, and food supplementation. Although most beekeepers accessed climate change information using the internet, they struggled to understand and apply pertinent information unless they received it from trusted ACCOPIDECHA personnel. Salvadoran beekeepers require information and demonstrations to improve their climate change adaptation strategies and implement new ones to address the challenges they experience.

Dysgeusia is a common but understudied complication in patients undergoing autologous hematopoietic cell transplantation (auto-HCT). We assessed the feasibility of using chemical gustometry (CG) to measure dysgeusia and explored its associations with symptom burden, nutrition, chemotherapy pharmacokinetics (PK), and the oral microbiome.We conducted a single-center, prospective feasibility study (NCT03276481) of patients with multiple myeloma undergoing auto-HCT. CG was performed longitudinally testing five flavors (sweet, sour, salty, bitter, umami) to calculate a total taste score (maximum score, 30). We measured caloric intake and patient-reported symptoms, assessing their correlation with oral microbiota composition and salivary and blood melphalan PK exposure.Among all 45 patients, 39 (87%) completed at least four (60%) and 22 (49%) completed all six CG assessments. Median total CG scores remained stable over time but were lowest at day +7 (27, range 24-30) with recovery by day +100. Symptom burden was highest by day +10 (area under the curve, 2.9; range, 1.0-4.6) corresponding with the lowest median overall caloric intake (1624 kcal; range, 1345-2267). Higher serum/salivary melphalan levels correlated with higher patient-reported dysgeusia and lower caloric intake. Oral microbiota α-diversity was stable early and increased slightly by day +100.Assessment of dysgeusia by CG is feasible after auto-HCT. Most dysgeusia, symptom burden, and lowest caloric intake occurred during the blood count nadir. Higher melphalan concentrations correlated with more dysgeusia and poorer caloric intake. Future studies will aim to modulate melphalan exposure by PK-targeted dosing and characterize patient taste preferences to personalize diets for improved nutritional intake.Taste changes after cancer treatments are very common. We used chemical gustometry (taste testing) to study taste changes and to better understand why patients with multiple myeloma experience this symptom after autologous hematopoietic cell transplantation. We found that taste testing was feasible, taste changes peaked when blood counts were lowest, and most patients recovered their taste by 100 days after transplantation. Taste changes correlated with lower food intake and with higher levels of chemotherapy in the body. Future work will focus on using personalized chemotherapy doses to reduce taste changes and to match patients' individual taste preferences with their diets.

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The reduction of nitrites in cooked meat products is becoming a topic of primary importance, both for manufacturers and for consumers. However, their complete or partial replacement with a single natural compound is a challenge, due to the multifunctional characteristics of nitrites. One possible approach is the use of natural antioxidants from Mediterranean vegetal sources, such as olives and their processing by-products, which are rich in phenolic compounds. In particular, olive mill wastewaters (OMWW) generated during virgin olive oil production contain the majority of hydrophilic phenols (mainly secoiridoids and its derivates, which are found exclusively in the Oleaceae family), which are known to have high antioxidant and antimicrobial activities. Thus, if phenols are extracted from OMWW and purified by suitable membrane technology, they can be used for the formulation of healthier cooked meat products, with a reduced content of nitrate salts. The aim of this study was to evaluate the effect of an extract rich in phenols (PE), obtained from OMWW, on the oxidative stability and sensory characteristics of steam-cooked and grilled würstels during storage. The steam cooked würstels were prepared with beef (50%), lean pork (20%) and lard (30%), ice (20%), salt (1.25%), ascorbic acid (0.02%), aromas (0.33%) and liquid smoke (0.05%). The ingredients were homogenized until complete emulsion and, the dough was then divided into four batches: Control (NO2 150 mg/kg) and 3 PE-enriched samples (W1, W2 and W3, with PE 200 mg/kg + NO2 35/150/0 mg/kg). The emulsion was bagged into a collagen bowel and cooked in a steam oven until 72°C. After cooling in the blast chiller, würstels were peeled, vacuum-packed, pasteurized at 75°C for 20 min and stored under alternating exposure to fluorescent light at 4±2°C for 30 days. Steam cooked würstels were sampled at fixed time periods (0, 15 and 30 days of storage) and frozen at -80°C. At the same sampling times, the same number of steam cooked würstels from each batch were grilled at 200°C for 3.30 min per side until 70°C was reached at core. After processing and grilling, about 60% of total phenols were retained in PE samples. Regarding primary lipid oxidation, peroxide value (PV) in the control sample tripled in 30 days, while in W1 and W3 samples the final PV were 74% and 71% lower, respectively. Furthermore, no significant effect of storage on the PV of PE samples was observed. The steam-cooked control sample showed an increase in both conjugated dienes and trienes during storage, while these parameters remained almost constant in ungrilled PE samples. After grilling, all samples showed the classical bell-shape behavior of primary oxidation products. Regarding secondary lipid oxidation, VOCS largely confirmed the role of PE in limiting the increase of C5 and C6 saturated aldehydes that derive from lipid oxidation, being up to 36% lower in PE samples than in the control after 30-day storage, and up to 25% lower after grilling. In addition, grilled samples had TBARs values that were about 2 times higher than those of steam-cooked würstels, confirming the pro-oxidant effect of grilling. However, TBARs in both steam-cooked and grilled control würstels were lower than those of the PE samples during storage. Regarding COPs and COR%, no significative differences were found between PE and control steam-cooked würstel samples. No taste anomalies were detected for all products, confirming their stability during chilled displaying. Samples were only discriminated by a grayer color, which is due to the addition of a lower quantity of NO2 in the formulation of PE samples. This study confirms that it is possible to produce healthier low-nitrate würstels with improved oxidative stability by using PE from OMWW, thus representing a good strategy to valorize by-products of the olive oil food chain and to promote industrial symbiosis.

During olive oil mechanical extraction process, two by-products (vegetation waters and paste) are generated, which are sources of high-added value molecules to produce new foods and/or ingredients with higher functionality. For both food industry and consumer is of great interest to replace synthetic additives (i.e. nitrite/nitrate salts and colorants) with natural compounds (such as biophenols). Moreover, the utilization of natural compounds extracted from agri-food by-products increases the food chain sustainability, promoting the development of healthier food products as well. The phenolic extract from olive vegetation water is of particular interest, as it has a high concentration of secoiridoids’ derivatives and verbascoside, so its addition in cooked meat products can exert an antioxidant action towards lipids and myoglobin, thus contributing to the reduction of the use of nitrites in their formulation. The aim of this study was to evaluate the effect of an extract rich in phenols (PE) obtained from olive vegetation water on the oxidative stability and the sensory characteristics of cooked ham during storage. Cooked ham was prepared using fresh pork meat. The injected brine contained: i) sodium chloride (1.5%), ii) glucose (0.2%), iii) ascorbic acid (0.02%), iv) flavours (0.15%), v) PE + NO2 at different levels (S1, S2 and S3, PE 200 mg/kg + NO2 150/35/0 mg/kg; Control + NO2 150 mg/kg). After the brine injection, meat was kneaded, kept at 4 °C and cooked up to an internal temperature of 69 °C. After slicing and packaging in ATM made of N2 (80%) and CO2 (20%), samples were stored in a refrigerated cabinet where they were exposed to fluorescent light (11 h/day) and sampled at 0, 15 and 30 days. During the 30-day storage, more than 35% of the added phenols were still retained in all formulations (S1, S2 and S3). Regarding secondary lipid oxidation, S1 showed the best oxidative stability, with TBARs below 1.0 mg MDA/kg of meat (reference value for rancidity development in cooked pork meat), while the control sample had significantly higher TBARs values (less than 3.79 mg MDA/kg of meat). S2 and S3 displayed a similar oxidative trend, with TBARs values below 1.4 mg MDA/kg of meat; therefore, it is possible to hypothesize that the antioxidant activity in both S2 and S3 was mainly due to phenols, while nitrites in S1 were more involved in the color development. The volatile organic compounds (VOCs) showed a general raise in C5 and C6 saturated aldehydes, reaching an increase of more than 400% in control sample, 300% in S1, 100% in S2 and 200% in S3 after 30 days of storage. Total cholesterol oxidation products (COPs) and its oxidation ratio (OR%) were particularly low (less than 4 mg/kg of meat and 0.4%, respectively) in all cooked ham samples. Taste and flavor attributes were not negatively affected by PE, whilst the pink color was positively protected by PE in combination with the lowest concentration of NO2. This study confirms that PE obtained from OMWW is able to improve lipid oxidation in low-nitrate cooked ham, being a good strategy to produce healthier meat products with a circular economy approach.

The dynamics facing rural development and school policy in New Mexico has limited merging and redistricting efforts in small schools in isolated rural communities. This has created a situation where small schools exist in several rural communities in the state. These programs often include school-based agricultural education as a program offering. The dynamics of the schools can impact how the total program approach commonly used in agricultural education can be implemented. The purpose of the study was to explore how agriculture teachers in small schools in New Mexico developed their own institutional polices and worked with the policies established by the school to involve students in the total program. A qualitative case study with six teachers was conducted. The themes emphasized the nuanced nature of the programs as well as the importance of relationships with students, parents, community members, and school staff to implement these programs. The teachers faced challenges related to balancing student time and working with athletics for scheduling. Successful programs cater to the context of the school and community by getting to know the students they serve. Advice and best practices provided by the teachers were discussed. Recommendations were provided related to establishing and maintaining relationships.

Virtual reality (VR) is an emerging tool to reduce pain and anxiety during procedures. Although VR's clinical benefits are reported, biometric data quantifying VR's effect on pain tolerance is lacking. We used time-lapse, subjective, and biometric data to evaluate VR's effect on modulating pain.Randomized, controlled crossover within-subject clinical trial.This study was conducted in the Chariot Lab at Lucile Packard Children's Hospital and outdoors at Stanford University School of Medicine.156 healthy volunteers were included.Participants underwent pain-inducing ice immersions while connected to biometric sensors. Participants were randomized to immerse their dominant or non-dominant hand with VR or control (no VR) for one immersion, and then crossed-over to the other hand for the second immersion. We instructed participants to submerge their hand until they reached their pain tolerance or until four minutes elapsed.Outcomes included ice immersion duration, perceived pain scores, and skin conductance response density (SCRD), a marker of sympathetic arousal. We used survival analysis and mixed effects models to compare measurements with and without VR.153 participants were included in the analysis. Participants with VR were 64% less likely to remove their hands from the ice bath throughout the immersion's duration compared to control (P 0.001). Participants with VR reported significantly lower pain scores after controlling for dominant hand treatment assignment, VR vs. no VR treatment order, and gender (P 0.001). SCRD increased as time progressed for both VR and control groups (P = 0.047 combined), with no significant mean group differences.Participants with VR were more likely to survive the 4-min ice bath challenge longer and with lower levels of pain perception, supporting VR's effectiveness as a distraction tool during painful procedures. We observed no differences in sympathetic response when comparing VR to no VR.

The incidence of acute kidney injury (AKI) in hospitalized patients with COVID-19 is variable, being associated with worse outcomes. The objectives of the study were to evaluate the incidence, risk factors (considering demographic characteristics, comorbidities, initial clinical presentation and associated complications) and impact of AKI in subjects hospitalized for COVID-19 in two third-level hospitals in Córdoba, Argentina. A retrospective cohort study was conducted. We included 448 adults who were consecutively hospitalized for COVID-19 between March 3 and October 31, 2020 and were followed throughout the hospitalization. The incidence of AKI was 19% (n = 85; stage I = 43, stage II = 17, and stage III = 25, 18 required renal replacement therapy). In the multivariate analysis, the variables that were independently associated with AKI were: age (for every 10 years, adjusted odd ratio [95%CI] = 1.30 [1.04-1.63], p = 0.022), history of chronic kidney disease -CKD- (9.92 [4.52-21.77], p0.001), blood neutrophil count at admission -BNCA- (for every increase of 1000 BNCA, 1.09 [1.01-1.18], p = 0.037) and requirement for mechanical ventilation -MV- (6.69 [2.24-19.90], p = 0.001). AKI was associated with longer hospitalization, higher admission (63.5 vs. 29.7%; p0.001) and longer stay in the intensive care unit, a positive association with respiratory bacterial superinfection, sepsis, respiratory distress syndrome, MV requirement and mortality (mortality without AK I = 12.4% vs with AKI = 47.1%; stage I = 26%, stage II = 41% and stage III = 88%; p0.001). AKI was independently associated with higher mortality (3.32 [1.6-6.9], p = 0.001). In conclusion, the incidence of AKI in adults hospitalized for COVID-19 was 19% and had a clear impact on morbidity and mortality. The independent risk factors for AKI were: Age, CKD, BNCA and MV.Los objetivos del estudio fueron evaluar la incidencia, los factores de riesgo (considerando características demográficas, comorbilidades, presentación clínica inicial y complicaciones asociadas) y el impacto de la lesión renal aguda ‐LRA‐ en sujetos hospitalizados por COVID-19 en dos instituciones de alta complejidad de Córdoba, Argentina. Se realizó un estudio de cohorte retrospectivo. Se incluyeron 448 adultos que fueron hospitalizados por COVID-19 entre el 3 de marzo y el 31 de octubre del 2020 con seguimiento durante toda la hospitalización. La incidencia de LRA fue 19% (estadio I = 43, estadio II = 17 y estadío III = 25, 18 requirieron diálisis). Las variables que se asociaron de manera independiente con el LRA fueron: edad (por cada 10 años, odd ratio ajustado [IC95%] = 1.30 [1.04-1.63], p = 0.022), enfermedad renal crónica ‐ERC‐ (9.92 [4.52-21.77], p0.001), recuento de neutrófilos sanguíneos al ingreso ‐NSI‐ (por cada incremento de 1000 NSI, 1.09 [1.01‐1.18], p = 0.037) y asistencia respiratoria mecánica ‐ARM‐ (6.69 [2.24‐19.90], p = 0.001). Los sujetos con LRA presentaron una internación más prolongada, mayor requerimiento (63.5 vs. 29.7%; p0.001) y estadía más prolongada en unidad de cuidados intensivos, una asociación positiva con sobreinfección respiratoria bacteriana, sepsis, síndrome de distrés respiratorio, requerimiento de ARM y mortalidad (mortalidad sin LRA 12.4% vs. con LRA 47.1%; estadio I = 26%, estadio II = 41% y estadio III = 88%; p0.001). LRA se asoció de manera independiente a mayor mortalidad (3.3 [1.6‐6.9], p = 0.001). En conclusión, la incidencia de LRA en adultos hospitalizados por COVID-19 fue del 19% y tuvo un claro impacto en la morbi-mortalidad. Los factores de riesgo independientes de LRA fueron: edad, ERC, NSI y ARM.

At the Fermilab Tevatron proton-antiproton ($p\bar{p}$) collider, high-mass electron-neutrino ($e\nu$) pairs are produced predominantly in the process $p \bar{p} \rightarrow W(\rightarrow e\nu) + X$. The asymmetry of the electron and positron yield as a function of their pseudorapidity constrain the slope of the ratio of the $u$- to $d$-quark parton distributions versus the fraction of the proton momentum carried by the quarks. This paper reports on the measurement of the electron-charge asymmetry using the full data set recorded by the Collider Detector at Fermilab in 2001--2011 and corresponding to 9.1~fb$^{-1}$ of integrated luminosity. The measurement significantly improves the precision of the Tevatron constraints on the parton-distribution functions of the proton. Numerical tables of the measurement are provided.

In Peru, subsistence farmers experience firsthand the direct and indirect impacts of climate change (CC). To understand how farmers adapt their livelihoods to climatic variability, this mixed methods study explored their perceptions and climate adaptability strategies implemented in Huayhuay, Peru. Twenty farmers participated in semi-structured interviews, and 103 completed a survey questionnaire. The results indicated that most farmers perceive changes in temperature, precipitation, and drought that negatively affect agricultural production and local natural resources. To deal with CC, farmers are implementing twenty-six climate adaptation strategies. Diversifying agricultural products and practices, and exploring new economic activities were adaptability strategies identified in this study that the literature has previously documented as having positive implications for agricultural livelihoods. However, some farmers reported that adaptability strategies are failed attempts at local climate action. The results, along with the adaptability literature, revealed that farmers implement locally accessible adaptability strategies based on their climate variability perceptions. Therefore, this study recommends exploring CC perceptions and adaptability strategies with a site-based approach. It is also recommended that future research, local climate planning, and action must focus on the efficiency and inclusiveness of strategies rather than their frequency or levels of adoption. Finally, strengthening the technical capacities and knowledge of CC among subsistence farmers must be a priority for authorities and practitioners in Huayhuay, Peru.

This article compares the exergetic cost of cooling of an Adiabatic Demagnetization Refrigerator (ADR) providing 1 W of refrigeration at 4.2 K, with two different magnetic field sources: a Nb3Sn superconducting (SC) magnet and a NdFeB permanent magnet (PM) Halbach cylinder. The total cost of the system is assumed to be comprised of two components: the cost of the magnetocaloric material (MCM), which is a function of the total volume of the MCM, and the cost of the magnetic system, which depends on the MCM volume and the peak magnetic field. The exergetic cost of cooling for different values of mass (volume) of MCM and hot source temperatures are shown in the article, assuming a specific cost of the SC wire of 890$/kg, 3500$/kg for the MCM, and 100$/kg for the PM. The SC appear to be the most cost-effective solution for the system. However, if large temperatures spans are required between the hot source and the cold source PMs emerge as a better option.

Prevalence of Parkinson's Disease (PD) in the Philippines has been estimated to be 1 % based on a 2007 nationwide survey conducted by the Philippine Neurological Association, but without case ascertainment. Since there is still paucity of data, we aim to determine the prevalence of PD in a rural community and the possible predisposing factors on the development of the disease.This is a two-phase descriptive study which investigated the prevalence of PD and associated risk factors in a randomly selected rural community in Candelaria, Quezon Province. A validated screening questionnaire was utilized, and case ascertainment was done in eligible respondents.A total of 365 respondents aged ≥ 20 years were randomly surveyed from 2016 to 2017. Two cases of PD aged ≥ 60 years were reported. Thus, the prevalence of PD in the community was 0.55 %. Age-specific prevalence of PD among individuals ≥ 60 years was 4.35 %.Insecticide use was infrequent in the community and was recorded in one PD patient. Protective factors like smoking and drinking tea were not observed in both cases whereas coffee intake was reported in one PD patient.This community-based epidemiologic study on PD is consistent with a nationwide study. The study portrayed certain demographic and environmental features inherent in a community, which are potential confounding variables in PD development. Future larger population studies be recommended to establish PD in the advancing age and to further support the link of various factors with PD.

The objective of this study was to evaluate the effects of soybean lecithin in broiler diets formulated with either fried or non-fried soybean oils (as an energy source), on growth performance, digestibility, and some serum parameters. A total of 600 broilers (50% male) were assigned to 4 experimental groups (with 10 replicates of 15 birds each): (i) group (S) fed with soybean oil only, (ii) group (SL) fed with soybean oil + lecithin (0.035% in feed), (iii) group (F) fed with fried soybean oil only, and iv) group (FL) fed with fried soybean oil + lecithin (0.035% in feed). The results showed that fried soybean oil in broilers diets had the same effects on the analysed parameters as the non-fried oil. Broilers that received lecithin with fried soybean oil (group FL) exhibited significantly higher body weights (1.228 vs. 1.210, p

Aortic aneurysm; Bicuspid aortic valve; Computed tomography Aneurisma aòrtic; Vàlvula aòrtica bicúspide; Tomografia computada Aneurisma aórtico; Válvula aórtica bicúspide; Tomografía computada Multimodality imaging is the basis of the diagnosis, follow-up, and surgical management of bicuspid aortic valve (BAV) patients. Transthoracic echocardiography (TTE) is used in our clinical routine practice as a first line imaging for BAV diagnosis, valvular phenotyping and function, measurement of thoracic aorta, exclusion of other aortic malformations, and for the assessment of complications such are infective endocarditis and aortic. Nevertheless, TTE is less useful if we want to assess accurately other aortic segments such as mid-distal ascending aorta, where computed tomography (CT) and magnetic resonance (CMR) could improve the precision of aorta size measurement by multiplanar reconstructions. A major advantage of CT is its superior spatial resolution, which affords a better definition of valve morphology and calcification, accuracy, and reproducibility of ascending aorta size, and allows for coronary artery assessment. Moreover, CMR offers the opportunity of being able to evaluate aortic functional properties and blood flow patterns. In this setting, new developed sequences such as 4D-flow may provide new parameters to predict events during follow up. The integration of all multimodality information facilitates a comprehensive evaluation of morphologic and dynamic features, stratification of the risk, and therapy guidance of this cohort of patients.

This study aims at evaluating the effect of a phenol-rich extract obtained from the concentration and purification of olive mill wastewaters (added at a ratio of 87.5 and 175 mg of phenols/kg meat) on the stability and sensory quality of beef hamburgers packed under modified atmosphere and stored under alternating exposure to fluorescent light at 4 ± 2 °C for 9 days. The hamburgers were sampled at different times (0, 6, and 9 days) and grilled at 200 °C. After 9 days, more than 56% of the added phenols in the raw burgers and more than 20% the grilled ones were retained. The results show that both concentrations of phenolic extract proved to effectively reduce primary and secondary lipid oxidation, as well as cholesterol oxidation products (COPs), during the shelf-life of raw hamburgers. Peroxide value, thiobarbituric acid reactive substances, and total COPs were up to 1.4-, 4.5-, and 8.8-fold lower in phenol-enriched raw hamburgers, respectively, than in the control samples; a similar trend was noted also in phenol-enriched cooked hamburgers (1.3-, 5.7-, and 4-fold lower). The sensory analysis also confirmed the effectiveness of the addition of phenolic extract, resulting in a positive effect on the red color intensity (raw product) and thus reducing browning during storage.

The aim of this study was to assess the impact of in vitro digestion on the antioxidant activity of three extracts rich in phenols (two purified organic extracts (A20, A21) and one powdered extract stabilized with maltodextrins (SP)) obtained from olive mill wastewaters (OMWW). The content and composition of phenols and antioxidant activity was determined before and after in vitro digestion. The phenol content of the A20 and A21 samples were higher (>75%) than that of the SP sample before in vitro digestion. After the entire in vitro digestion, 89.3, 76.9, and 50% loss of phenols was found in A20, A21 and SP, respectively. ABTS•+ and ORAC values decreased during in vitro digestion of A20 and A21 samples, while they remained almost constant in SP. IC50 increased during digestion of A20 and A21, evidencing a loss of antioxidant capacity after the intestinal phase; an opposite IC50 trend was noted in SP, confirming the protective role of maltodextrins. For these reasons, SP represents a promising formulation to be used in the food field.