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1. The impacts of social determinants of health and cardiometabolic factors on cognitive and functional aging in Colombian underserved populations.

Author

Santamaria-Garcia, Hernando, Moguilner, Sebastian, Rodriguez-Villagra, Odir, Botero-Rodriguez, Felipe, Pina-Escudero, Stefanie, ODonovan, Gary, Albala, Cecilia, Matallana, Diana, Schulte, Michael, Slachevsky, Andrea, Possin, Katherine, Ndhlovu, Lishomwa, Al-Rousan, Tala, Corley, Michael, Kosik, Kenneth, Muniz-Terrera, Graciela, Miranda, J, Ibanez, Agustin, and Yokoyama, Jennifer

Subjects
Cardiometabolic factors, Cognition, Functionality, National Aging Population Survey, Social determinants of Health, Humans, Social Factors, Social Determinants of Health, Cross-Sectional Studies, Colombia, Vulnerable Populations, Aging, Cognition, Cardiovascular Diseases
Abstract

Global initiatives call for further understanding of the impact of inequity on aging across underserved populations. Previous research in low- and middle-income countries (LMICs) presents limitations in assessing combined sources of inequity and outcomes (i.e., cognition and functionality). In this study, we assessed how social determinants of health (SDH), cardiometabolic factors (CMFs), and other medical/social factors predict cognition and functionality in an aging Colombian population. We ran a cross-sectional study that combined theory- (structural equation models) and data-driven (machine learning) approaches in a population-based study (N = 23,694; M = 69.8 years) to assess the best predictors of cognition and functionality. We found that a combination of SDH and CMF accurately predicted cognition and functionality, although SDH was the stronger predictor. Cognition was predicted with the highest accuracy by SDH, followed by demographics, CMF, and other factors. A combination of SDH, age, CMF, and additional physical/psychological factors were the best predictors of functional status. Results highlight the role of inequity in predicting brain health and advancing solutions to reduce the cognitive and functional decline in LMICs.

Published
2023

2. Heterogeneous factors influence social cognition across diverse settings in brain health and age-related diseases

Author

Fittipaldi, Sol, Legaz, Agustina, Maito, Marcelo, Hernandez, Hernan, Altschuler, Florencia, Canziani, Veronica, Moguilner, Sebastian, Gillan, Claire M., Castillo, Josefina, Lillo, Patricia, Custodio, Nilton, Avila-Funes, José Alberto, Cardona, Juan Felipe, Slachevsky, Andrea, Henriquez, Fernando, Fraile-Vazquez, Matias, Cruz de Souza, Leonardo, Borroni, Barbara, Hornberger, Michael, Lopera, Francisco, Santamaria-Garcia, Hernando, Matallana, Diana, Reyes, Pablo, Gonzalez-Campo, Cecilia, Bertoux, Maxime, and Ibanez, Agustin

Published
2024
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3. Biomarkers for dementia in Latin American countries: Gaps and opportunities.

Author

Parra, Mario, Orellana, Paulina, Leon, Tomas, Victoria, Cabello, Henriquez, Fernando, Gomez, Rodrigo, Avalos, Constanza, Damian, Andres, Slachevsky, Andrea, Ibañez, Agustin, Zetterberg, Henrik, Tijms, Betty, Yokoyama, Jennifer, Piña-Escudero, Stefanie, Cochran, J, Matallana, Diana, Acosta, Daisy, Allegri, Ricardo, Arias-Suárez, Bianca, Barra, Bernardo, Behrens, Maria, Brucki, Sonia, Busatto, Geraldo, Caramelli, Paulo, Castro-Suarez, Sheila, Contreras, Valeria, Custodio, Nilton, Dansilio, Sergio, la Cruz-Puebla, Myriam, de Souza, Leonardo, Diaz, Monica, Duque, Lissette, Farías, Gonzalo, Ferreira, Sergio, Guimet, Nahuel, Kmaid, Ana, Lira, David, Lopera, Francisco, Meza, Beatriz, Miotto, Eliane, Nitrini, Ricardo, Nuñez, Alberto, ONeill, Santiago, Ochoa, John, Pintado-Caipa, Maritza, Resende, Elisa, Risacher, Shannon, Rojas, Luz, Sabaj, Valentina, Schilling, Lucas, Sellek, Allis, Sosa, Ana, Takada, Leonel, Teixeira, Antonio, Unaucho-Pilalumbo, Martha, and Duran-Aniotz, Claudia

Subjects
Humans, Latin America, Dementia
Abstract

Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.

Published
2023

4. Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study

Author

Maito, Marcelo Adrián, Santamaría-García, Hernando, Moguilner, Sebastián, Possin, Katherine L, Godoy, María E, Avila-Funes, José Alberto, Behrens, María I, Brusco, Ignacio L, Bruno, Martín A, Cardona, Juan F, Custodio, Nilton, García, Adolfo M, Javandel, Shireen, Lopera, Francisco, Matallana, Diana L, Miller, Bruce, de Oliveira, Maira Okada, Pina-Escudero, Stefanie D, Slachevsky, Andrea, Ortiz, Ana L Sosa, Takada, Leonel T, Tagliazuchi, Enzo, Valcour, Victor, Yokoyama, Jennifer S, and Ibañez, Agustín

Subjects
Health Services and Systems, Health Sciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative, Acquired Cognitive Impairment, Clinical Research, Aging, Behavioral and Social Science, Brain Disorders, Neurosciences, Alzheimer's Disease Related Dementias (ADRD), Machine Learning and Artificial Intelligence, Dementia, Alzheimer's Disease, Frontotemporal Dementia (FTD), 4.2 Evaluation of markers and technologies, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Good Health and Well Being, Alzheimer?s Disease, Frontotemporal dementia, Underrepresented samples, Machine learning, Alzheimer’s Disease
Abstract

BackgroundGlobal brain health initiatives call for improving methods for the diagnosis of Alzheimer's disease (AD) and frontotemporal dementia (FTD) in underrepresented populations. However, diagnostic procedures in upper-middle-income countries (UMICs) and lower-middle income countries (LMICs), such as Latin American countries (LAC), face multiple challenges. These include the heterogeneity in diagnostic methods, lack of clinical harmonisation, and limited access to biomarkers.MethodsThis cross-sectional observational study aimed to identify the best combination of predictors to discriminate between AD and FTD using demographic, clinical and cognitive data among 1794 participants [904 diagnosed with AD, 282 diagnosed with FTD, and 606 healthy controls (HCs)] collected in 11 clinical centres across five LAC (ReDLat cohort).FindingsA fully automated computational approach included classical statistical methods, support vector machine procedures, and machine learning techniques (random forest and sequential feature selection procedures). Results demonstrated an accurate classification of patients with AD and FTD and HCs. A machine learning model produced the best values to differentiate AD from FTD patients with an accuracy = 0.91. The top features included social cognition, neuropsychiatric symptoms, executive functioning performance, and cognitive screening; with secondary contributions from age, educational attainment, and sex.InterpretationResults demonstrate that data-driven techniques applied in archival clinical datasets could enhance diagnostic procedures in regions with limited resources. These results also suggest specific fine-grained cognitive and behavioural measures may aid in the diagnosis of AD and FTD in LAC. Moreover, our results highlight an opportunity for harmonisation of clinical tools for dementia diagnosis in the region.FundingThis work was supported by the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat), funded by NIA/NIH (R01AG057234), Alzheimer's Association (SG-20-725707-ReDLat), Rainwater Foundation, Takeda (CW2680521), Global Brain Health Institute; as well as CONICET; FONCYT-PICT (2017-1818, 2017-1820); PIIECC, Facultad de Humanidades, Usach; Sistema General de Regalías de Colombia (BPIN2018000100059), Universidad del Valle (CI 5316); ANID/FONDECYT Regular (1210195, 1210176, 1210176); ANID/FONDAP (15150012); ANID/PIA/ANILLOS ACT210096; and Alzheimer's Association GBHI ALZ UK-22-865742.

Published
2023

5. The Latin American Brain Health Institute, a regional initiative to reduce the scale and impact of dementia.

Author

Duran-Aniotz, Claudia, Sanhueza, Jorge, Grinberg, Lea T, Slachevsky, Andrea, Valcour, Victor, Robertson, Ian, Lawlor, Brian, Miller, Bruce, and Ibáñez, Agustín

Subjects
Brain, Humans, Dementia, Latin America, brain health, capacity building, dementia, networking, translational research, Aging, Neurodegenerative, Brain Disorders, Neurosciences, Acquired Cognitive Impairment, Neurological, Clinical Sciences, Geriatrics
Abstract

Latin American and Caribbean countries face complex challenges to improve brain health and reduce the impact of dementia. Regional hubs devoted to research, capacity building, implementation science, and education are critically needed. The Latin American Brain Health Institute represent an important step to address many of these needs.

Published
2022

6. Multi-feature computational framework for combined signatures of dementia in underrepresented settings.

Author

Moguilner, Sebastian, Birba, Agustina, Fittipaldi, Sol, Gonzalez-Campo, Cecilia, Tagliazucchi, Enzo, Reyes, Pablo, Matallana, Diana, Parra, Mario, Slachevsky, Andrea, Farías, Gonzalo, Cruzat, Josefina, García, Adolfo, Eyre, Harris, La Joie, Renaud, Rabinovici, Gil, Whelan, Robert, and Ibáñez, Agustín

Subjects
feature selection, harmonization, machine learning, multimodal neuroimaging, neurodegeneration, Alzheimer Disease, Bayes Theorem, Biomarkers, Brain, Frontotemporal Dementia, Humans, Magnetic Resonance Imaging, Neuropsychological Tests
Abstract

Objective.The differential diagnosis of behavioral variant frontotemporal dementia (bvFTD) and Alzheimers disease (AD) remains challenging in underrepresented, underdiagnosed groups, including Latinos, as advanced biomarkers are rarely available. Recent guidelines for the study of dementia highlight the critical role of biomarkers. Thus, novel cost-effective complementary approaches are required in clinical settings.Approach. We developed a novel framework based on a gradient boosting machine learning classifier, tuned by Bayesian optimization, on a multi-feature multimodal approach (combining demographic, neuropsychological, magnetic resonance imaging (MRI), and electroencephalography/functional MRI connectivity data) to characterize neurodegeneration using site harmonization and sequential feature selection. We assessed 54 bvFTD and 76 AD patients and 152 healthy controls (HCs) from a Latin American consortium (ReDLat).Main results. The multimodal model yielded high area under the curve classification values (bvFTD patients vs HCs: 0.93 (±0.01); AD patients vs HCs: 0.95 (±0.01); bvFTD vs AD patients: 0.92 (±0.01)). The feature selection approach successfully filtered non-informative multimodal markers (from thousands to dozens).Results. Proved robust against multimodal heterogeneity, sociodemographic variability, and missing data.Significance. The model accurately identified dementia subtypes using measures readily available in underrepresented settings, with a similar performance than advanced biomarkers. This approach, if confirmed and replicated, may potentially complement clinical assessments in developing countries.

Published
2022

7. The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds

Author

Prado, Pavel, Medel, Vicente, Gonzalez-Gomez, Raul, Sainz-Ballesteros, Agustín, Vidal, Victor, Santamaría-García, Hernando, Moguilner, Sebastian, Mejia, Jhony, Slachevsky, Andrea, Behrens, Maria Isabel, Aguillon, David, Lopera, Francisco, Parra, Mario A., Matallana, Diana, Maito, Marcelo Adrián, Garcia, Adolfo M., Custodio, Nilton, Funes, Alberto Ávila, Piña-Escudero, Stefanie, Birba, Agustina, Fittipaldi, Sol, Legaz, Agustina, and Ibañez, Agustín

Published
2023
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8. Impact of cardiometabolic factors and blood beta-amyloid on the volume of white matter hyperintensities in dementia-free subjects with cognitive complaints

Author

Riquelme-Contreras, Patricio, primary, Hornberger, Michael, additional, Khondoker, Mizanur, additional, Henriquez, Fernando, additional, Gonzalez-Campo, Cecilia, additional, Altschuler, Florencia, additional, Fraile-Vazquez, Matias, additional, Lukasewicz Ferreira, Pamela, additional, Bellaver, Bruna, additional, Pascoal, Tharick, additional, Muniz-Terrera, Graciela, additional, Okuma, Cecilia, additional, Gonzalez-Billault, Christian, additional, Court, Felipe, additional, Cerda, Mauricio, additional, Lillo, Patricia, additional, and Slachevsky, Andrea, additional

Published
2024
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10. Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City

Author

Sosa, Ana Luisa, primary, Brucki, Sonia MD, additional, Crivelli, Lucia, additional, Lopera, Francisco Javier, additional, Acosta, Daisy M, additional, Acosta‐Uribe, Juliana, additional, Aguilar, Diego, additional, Aguilar‐Navarro, Sara G, additional, Allegri, Ricardo F, additional, Bertolucci, Paulo HF, additional, Calandri, Ismael L, additional, Carrillo, Maria C, additional, Mendez, Patricio Alexis Chrem, additional, Cornejo‐Olivas, Mario, additional, Custodio, Nilton, additional, Damian, Andrés, additional, de Souza, Leonardo Cruz, additional, Duran‐Aniotz, Claudia, additional, García, Adolfo M, additional, García‐Peña, Carmen, additional, Gonzales, Mitzi M, additional, Grinberg, Lea T, additional, Ibanez, Agustin M, additional, Illanes‐Manrique, Maryenela Zaida, additional, Jack, Clifford R, additional, Leon‐Salas, Jorge Mario, additional, Llibre‐Guerra, Jorge J, additional, Luna‐Muñoz, José, additional, Matallana, Diana, additional, Miller, Bruce L, additional, Naci, Lorina, additional, Parra, Mario A, additional, Pericak‐Vance, Margaret, additional, Piña‐Escudero, Stefanie D, additional, França Resende, Elisa de Paula, additional, Ringman, John M, additional, Sevlever, Gustavo, additional, Slachevsky, Andrea, additional, Suemoto, Claudia Kimie, additional, Valcour, Victor, additional, Villegas‐Lanau, Andres, additional, Yassuda, Mônica S, additional, Mahinrad, Simin, additional, and Sexton, Claire, additional

Published
2024
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12. Impact of the Pandemic Time on the Mental Health of People with Dementia and Their Family Caregivers in Brazil and Chile: One-Year Follow-Up

Author

Olavarría, Loreto, primary, Caramelli, Paulo, additional, Lema, José, additional, Andrade, Caíssa Bezerra de, additional, Pinto, Alejandra, additional, Azevedo, Lílian Viana dos Santos, additional, Thumala, Daniela, additional, Vieira, Maria Carolina Santos, additional, Rossetti, Adriana Peredo, additional, Generoso, Alana Barroso, additional, Carmona, Karoline Carvalho, additional, Sepúlveda-Loyola, Walter, additional, Pinto, Ludmilla Aparecida Cardoso, additional, Barbosa, Maira Tonidandel, additional, and Slachevsky, Andrea, additional

Published
2024
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13. Neurocognitive correlates of semantic memory navigation in Parkinson’s disease

Author

Toro-Hernández, Felipe Diego, primary, Migeot, Joaquín, additional, Marchant, Nicolás, additional, Olivares, Daniela, additional, Ferrante, Franco, additional, González-Gómez, Raúl, additional, González Campo, Cecilia, additional, Fittipaldi, Sol, additional, Rojas-Costa, Gonzalo M., additional, Moguilner, Sebastian, additional, Slachevsky, Andrea, additional, Chaná Cuevas, Pedro, additional, Ibáñez, Agustín, additional, Chaigneau, Sergio, additional, and García, Adolfo M., additional

Published
2024
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14. Author Correction: The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds

Author

Prado, Pavel, primary, Medel, Vicente, additional, Gonzalez-Gomez, Raul, additional, Sainz-Ballesteros, Agustín, additional, Vidal, Victor, additional, Santamaría-García, Hernando, additional, Moguilner, Sebastian, additional, Mejia, Jhony, additional, Slachevsky, Andrea, additional, Behrens, Maria Isabel, additional, Aguillon, David, additional, Lopera, Francisco, additional, Parra, Mario A., additional, Matallana, Diana, additional, Maito, Marcelo Adrián, additional, Garcia, Adolfo M., additional, Custodio, Nilton, additional, Funes, Alberto Ávila, additional, Piña-Escudero, Stefanie, additional, Birba, Agustina, additional, Fittipaldi, Sol, additional, Legaz, Agustina, additional, and Ibañez, Agustín, additional

Published
2024
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15. A Multidimensional, Person-Centered Framework for Functional Assessment in Dementia: Insights from the 'What', 'How', 'To Whom', and 'How Much' Questions.

Author

Slachevsky, Andrea, Grandi, Fabrissio, Thumala, Daniela, Baez, Sandra, Santamaria-García, Hernando, Schmitter-Edgecombe, Maureen, and Parra, Mario A.

Subjects
*FUNCTIONAL assessment, *DEMENTIA, *MILD cognitive impairment, *NEUROBEHAVIORAL disorders, *ACTIVITIES of daily living
Abstract

Dementia is a syndrome characterized by cognitive and neuropsychiatric symptoms associated with progressive functional decline (FD). FD is a core diagnostic criterion for dementia, setting the threshold between its prodromal stages and the full-blown disease. The operationalization of FD continues to generate a great deal of controversy. For instance, the threshold of FD for the diagnosis of dementia varies across diagnostic criteria, supporting the need for standardization of this construct. Moreover, there is a need to reconsider how we are measuring FD to set boundaries between normal aging, mild cognitive impairment, and dementia. In this paper, we propose a multidimensional framework that addresses outstanding issues in the assessment of FD: i) What activities of daily living (ADLs) are necessary to sustain an independent living in aging? ii) How to assess FD in individuals with suspected neurocognitive disorders? iii) To whom is the assessment directed? and iv) How much does FD differentiate healthy aging from mild and major neurocognitive disorders? Importantly, the To Whom Question introduces a person-centered approach that regards patients and caregivers as active agents in the assessment process of FD. Thus, once impaired ADLs have been identified, patients can indicate how significant such impairments are for them in daily life. We envisage that this new framework will guide future strategies to enhance functional assessment and treatment of patients with dementia and their caregivers. [ABSTRACT FROM AUTHOR]

Published
2024
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16. miRNAs peripheral biomarkers for early diagnosis of AD in Latinamerican population

Author

Orellana, Paulina, primary, Caviedes, Ariel, additional, Gonzalez, Carolina, additional, Salcidua, Stefanny, additional, Henriquez, Fernando, additional, Cabello, Victoria, additional, Lillo, Patricia, additional, Villagra, Roque, additional, Cerda, Mauricio, additional, Zitko, Pedro, additional, Thumala, Daniela, additional, Gonzalez, Christian, additional, Ibanez, Agustin, additional, de la Cruz, Rolando, additional, Slachevsky, Andrea, additional, and Duran‐Aniotz, Claudia, additional

Published
2023
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20. Factors associated with emotional and social loneliness among Latin American family care partners of people with dementia and other long‐term conditions during Covid‐19

Author

Tapia‐Muñoz, Thamara, primary, Leon, Tomas, additional, Slachevsky, Andrea, additional, Beber, Bárbara Costa, additional, Nubia, Carla, additional, Vilar‐Compte, Mireya, additional, Gaitan, Pablo, additional, Olavarria, Loreto, additional, Castro, Loreto, additional, Pinto, Alejandra, additional, Chen, Yaohua Sophie, additional, Grycuk, Emilia, additional, Leroi, Iracema, additional, Lawlor, Brian, additional, Duran‐Aniotz, Claudia, additional, O'Sullivan, Roger, additional, and Miranda‐Castillo, Claudia, additional

Published
2023
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21. Dimensions of activities of daily living in subjective cognitive complaint elderly. The GERO Cohort

Author

Slachevsky, Andrea, primary, Lillo, Patricia, additional, Sepúlveda Loyola, Walter, additional, Demanet, Michele, additional, Cerda, Mauricio, additional, Henriquez, Fernando, additional, Parrao, Teresa, additional, Zitko, Pedro, additional, Martínez‐Pernía, David, additional, Villagra, Roque, additional, Amieva, Helene, additional, and Thumala, Daniela, additional

Published
2023
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22. First genome‐wide association study on Alzheimer’s disease in the Argentinian and the Chilean populations

Author

Dalmasso, Maria Carolina, primary, de Rojas, Itziar, additional, Olivar, Natividad, additional, Muchnik, Carolina, additional, Angel, Bárbara, additional, Gogler, Sergio, additional, Sanchez‐Avalos, Mariana S, additional, Chacon, Maria Victoria, additional, Aránguiz, Rafael, additional, Orellana, Paulina, additional, Cuesta, Carolina, additional, Galeano, Pablo, additional, Campanelli, Lorenzo, additional, Novack, Gisella V, additional, Medel, Nancy, additional, Lisso, Julieta, additional, Sevillano, Zulma, additional, Irureta, Nicolas, additional, Castaño, Eduardo M, additional, Montrreal, Laura, additional, Heilmann‐Heimbach, Stefanie, additional, Mintz, Ines, additional, Villella, Ivana, additional, Lambert, Jean‐Charles, additional, Solis, Patricia, additional, Politis, Daniel, additional, Mangone, Carlos A, additional, Gonzalez‐Billault, Christian, additional, Boada, Mercè, additional, Tárraga, Lluís, additional, Slachevsky, Andrea, additional, Albala, Cecilia, additional, Fuentes, Patricio, additional, Kochen, Silvia, additional, Brusco, Luis Ignacio, additional, Ruiz, Agustin, additional, Morelli, Laura, additional, and Ramirez, Alfredo, additional

Published
2023
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23. Heterogenous factors modulate social cognition across diverse settings in brain health and disease

Author

Fittipaldi, Sol, primary, Legaz, Agustina, additional, Maito, Marcelo Adrian, additional, Hernandez, Hernan, additional, Altschuler, Florencia, additional, Canziani, Veronica, additional, Moguilner, Sebastian, additional, Castillo, Josefina, additional, Lillo, Patricia, additional, Slachevsky, Andrea, additional, Henriquez, Fernando, additional, Fraile‐Vazquez, Matias, additional, Santamaria‐Garcia, Hernando, additional, Campo, Cecilia Gonzalez, additional, Bertoux, Maxime, additional, and Ibanez, Agustin, additional

Published
2023
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24. Functionality and socio‐demographic factors in chilean’s community‐dwelling elderly with subjective cognitive complaints . The GERO Cohort

Author

Loyola, Walter Sepúlveda, primary, Lillo, Patricia, additional, Zitko, Pedro, additional, Cerda, Mauricio, additional, Villagra, Roque, additional, Parrao, Teresa, additional, Gomez, Rodrigo, additional, Barría, Silvia, additional, Demanet, Michele, additional, Amieva, Helene, additional, Thumala, Daniela, additional, Henriquez, Fernando, additional, and Slachevsky, Andrea, additional

Published
2023
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26. The first genome‐wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease

Author

Dalmasso, Maria Carolina, primary, de Rojas, Itziar, additional, Olivar, Natividad, additional, Muchnik, Carolina, additional, Angel, Bárbara, additional, Gloger, Sergio, additional, Sanchez Abalos, Mariana Soledad, additional, Chacón, María Victoria, additional, Aránguiz, Rafael, additional, Orellana, Paulina, additional, Cuesta, Carolina, additional, Galeano, Pablo, additional, Campanelli, Lorenzo, additional, Novack, Gisela Vanina, additional, Martinez, Luis Eduardo, additional, Medel, Nancy, additional, Lisso, Julieta, additional, Sevillano, Zulma, additional, Irureta, Nicolás, additional, Castaño, Eduardo Miguel, additional, Montrreal, Laura, additional, Thoenes, Michaela, additional, Hanses, Claudia, additional, Heilmann‐Heimbach, Stefanie, additional, Kairiyama, Claudia, additional, Mintz, Inés, additional, Villella, Ivana, additional, Rueda, Fabiana, additional, Romero, Amanda, additional, Wukitsevits, Nancy, additional, Quiroga, Ivana, additional, Gona, Cristian, additional, Lambert, Jean‐Charles, additional, Solis, Patricia, additional, Politis, Daniel Gustavo, additional, Mangone, Carlos Alberto, additional, Gonzalez‐Billault, Christian, additional, Boada, Mercè, additional, Tàrraga, Lluís, additional, Slachevsky, Andrea, additional, Albala, Cecilia, additional, Fuentes, Patricio, additional, Kochen, Silvia, additional, Brusco, Luis Ignacio, additional, Ruiz, Agustín, additional, Morelli, Laura, additional, and Ramírez, Alfredo, additional

Published
2023
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28. Transferability of a European-derived Alzheimer’s Disease Genetic Risk Score across Multi-Ancestry Populations

Author

Nicolas, Aude, primary, Grenier-Boley, Benjamin, additional, Sherva, Richard, additional, Kim, Yoontae, additional, Kikuchi, Masataka, additional, de Rojas, Itziar, additional, Dalmasso, Carolina, additional, Zhou, Xiaopu, additional, Guen, Yann Le, additional, Arboleda-Bustos, Carlos E, additional, Camargos Bicalho, Maria Aparecida, additional, Guerchet, Maëlenn, additional, van der Lee, Sven, additional, Goss, Monica, additional, Castillo, Atahualpa, additional, Bellenguez, Céline, additional, Küçükali, Fahri, additional, Satizabal Barrera, Claudia, additional, Fongang, Bernard, additional, yang, Qiong, additional, Peters, Oliver, additional, Schneider, Anja, additional, Dichgans, Martin, additional, Rujescu, Dan, additional, Scherbaum, Norbert, additional, Deckert, Jürgen, additional, Riedel-Heller, Steffi, additional, Hausner, Lucrezia, additional, Molina Porcel, Laura, additional, Düzel, Emrah, additional, Grimmer, Timo, additional, Wiltfang, Jens, additional, Heilmann-Heimbach, Stefanie, additional, Moebus, Susanne, additional, Tegos, Thomas, additional, Scarmeas, Nikolaos, additional, Dols-Icardo, Oriol, additional, Moreno, Fermin, additional, Pérez-Tur, Jordi, additional, Bullido, María J., additional, Pastor, Pau, additional, Sánchez-Valle, Raquel, additional, Álvarez, Victoria, additional, Cao, Han, additional, Ip, Nancy Y., additional, Fu, Amy K. Y., additional, Ip, Fanny C. F., additional, Olivar, Natividad, additional, Muchnik, Carolina, additional, Cuesta, Carolina, additional, Campanelli, Lorenzo, additional, Solis, Patricia, additional, Politis, Daniel Gustavo, additional, Kochen, Silvia, additional, Brusco, Luis Ignacio, additional, Boada, Mercè, additional, García-González, Pablo, additional, Puerta, Raquel, additional, Mir, Pablo, additional, Real, Luis M, additional, Piñol-Ripoll, Gerard, additional, María García-Alberca, Jose, additional, Luís Royo, Jose, additional, Rodriguez-Rodriguez, Eloy, additional, Soininen, Hilkka, additional, Heikkinen, Sami, additional, de Mendonça, Alexandre, additional, Mehrabian, Shima, additional, Traykov, Latchezar, additional, Hort, Jakub, additional, Vyhnalek, Martin, additional, Rasmussen, Katrine Laura, additional, Qvist Thomassen, Jesper, additional, Pijnenburg, Yolande A.L., additional, Holstege, Henne, additional, van Swieten, John, additional, Ramakers, Inez, additional, Verhey, Frans, additional, van der Lugt, Aad, additional, Scheltens, Philip, additional, Ortega-Rojas, Jenny, additional, Concha Mera, Ana Gabriela, additional, Mahecha, Maria F., additional, Pardo, Rodrogo, additional, Arboleda, Gonzalo, additional, Graff, Caroline, additional, Papenberg, Goran, additional, Giedraitis, Vilmantas, additional, Boland, Anne, additional, Deleuze, Jean-François, additional, Armando de Marco, Luiz, additional, Nunes de Moraes, Edgar, additional, de Viana, Bernardo, additional, Túlio Gualberto Cintra, Marco, additional, Grsiwold, Anthony, additional, Forund, Tatiana, additional, Cruchaga, Carlos, additional, Haines, Jonathan, additional, Farrer, Lindsay, additional, DeStefano, Anita, additional, Wijsman, Ellen, additional, Mayeux, Richard, additional, Pericak-Vance, Margaret, additional, Kunkle, Brian, additional, Goate, Alison, additional, Schellenberg, Gerard D., additional, Vardarajan, Badri, additional, Wang, Li-San, additional, Leung, Yuk Yee, additional, Dalgard, Clifton, additional, Nicolas, Gael, additional, Wallon, David, additional, Dufouil, Carole, additional, Pasquier, Florence, additional, Hanon, Olivier, additional, Debette, Stéphanie, additional, Grünblatt, Edna, additional, Popp, Julius, additional, Angel, Bárbara, additional, Golger, Sergio, additional, Victoria Chacon, Maria, additional, Aranguiz, Rafael, additional, Orellana, Paulina, additional, Slachevsky, Andrea, additional, Gonzalez-Billault, Christian, additional, Albala, Cecilia, additional, Fuentes, Patricio, additional, Porter, Tenielle, additional, Laws, Simon M, additional, Sachdev, Perminder, additional, Mather, Karen, additional, Hauger, Richard L., additional, Merritt, Victoria, additional, Panizzon, Matthew, additional, Zhang, Rui, additional, Gaziano, Michael, additional, Ghidoni, Roberta, additional, Galimberti, Daniela, additional, Arosio, Beatrice, additional, Mecocci, Patrizia, additional, Solfrizzi, Vincenzo, additional, Parnetti, Lucilla, additional, Squassina, Alessio, additional, Tremolizzo, Lucio, additional, Borroni, Barbara, additional, Nacmias, Benedetta, additional, Caffarra, Paolo, additional, Seripa, Davide, additional, Rainero, Innocenzo, additional, Daniele, Antonio, additional, Piras, Fabrizio, additional, Miyashita, Akinori, additional, Hara, Norikazu, additional, Ozaki, Kouichi, additional, Niida, Shumpei, additional, Williams, Julie, additional, Masullo, Carlo, additional, Amouyel, Philippe, additional, Preux, Pierre-Marie, additional, Mbelesso, Pascal, additional, Bandzouzi, Bébène, additional, Saykin, Andy, additional, Jessen, Frank, additional, Kehoe, Patrick, additional, Van Duijn, Cornelia, additional, Gim, Jungsoo, additional, Ben Salem, Nesrine, additional, Frikke-Schmidt, Ruth, additional, Cherni, Lofti, additional, Greicius, Michael D., additional, Tsolaki, Magda, additional, Sánchez-Juan, Pascual, additional, Romano Silva, Marco Aurélio, additional, Sleegers, Kristel, additional, Ingelsson, Martin, additional, Dartigues, Jean-François, additional, Seshadri, Sudha, additional, Rossi, Giacomina, additional, Morelli, Laura, additional, Hiltunen, Mikko, additional, Sims, Rebecca, additional, van der Flier, Wiesje, additional, Andreassen, Ole, additional, Arboleda, Humberto, additional, Escott-Price, Valentina, additional, Ruiz, Agustín, additional, Lee, Kun Ho, additional, Ikeuchi, Takeshi, additional, Ramirez, Alfredo, additional, Logue, Mark, additional, and Lambert, Jean-Charles, additional

Published
2023
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29. Multivariate word properties in fluency tasks reveal markers of Alzheimer's dementia

Author

Ferrante, Franco J., primary, Migeot, Joaquín, additional, Birba, Agustina, additional, Amoruso, Lucía, additional, Pérez, Gonzalo, additional, Hesse, Eugenia, additional, Tagliazucchi, Enzo, additional, Estienne, Claudio, additional, Serrano, Cecilia, additional, Slachevsky, Andrea, additional, Matallana, Diana, additional, Reyes, Pablo, additional, Ibáñez, Agustín, additional, Fittipaldi, Sol, additional, Campo, Cecilia Gonzalez, additional, and García, Adolfo M., additional

Published
2023
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30. Multivariate word properties in fluency tasks reveal markers of Alzheimer's dementia.

Author

Ferrante, Franco J., Migeot, Joaquín, Birba, Agustina, Amoruso, Lucía, Pérez, Gonzalo, Hesse, Eugenia, Tagliazucchi, Enzo, Estienne, Claudio, Serrano, Cecilia, Slachevsky, Andrea, Matallana, Diana, Reyes, Pablo, Ibáñez, Agustín, Fittipaldi, Sol, Campo, Cecilia Gonzalez, and García, Adolfo M.

Abstract

INTRODUCTION: Verbal fluency tasks are common in Alzheimer's disease (AD) assessments. Yet, standard valid response counts fail to reveal disease‐specific semantic memory patterns. Here, we leveraged automated word‐property analysis to capture neurocognitive markers of AD vis‐à‐vis behavioral variant frontotemporal dementia (bvFTD). METHODS: Patients and healthy controls completed two fluency tasks. We counted valid responses and computed each word's frequency, granularity, neighborhood, length, familiarity, and imageability. These features were used for group‐level discrimination, patient‐level identification, and correlations with executive and neural (magnetic resonanance imaging [MRI], functional MRI [fMRI], electroencephalography [EEG]) patterns. RESULTS: Valid responses revealed deficits in both disorders. Conversely, frequency, granularity, and neighborhood yielded robust group‐ and subject‐level discrimination only in AD, also predicting executive outcomes. Disease‐specific cortical thickness patterns were predicted by frequency in both disorders. Default‐mode and salience network hypoconnectivity, and EEG beta hypoconnectivity, were predicted by frequency and granularity only in AD. DISCUSSION: Word‐property analysis of fluency can boost AD characterization and diagnosis. Highlights: We report novel word‐property analyses of verbal fluency in AD and bvFTD.Standard valid response counts captured deficits and brain patterns in both groups.Specific word properties (e.g., frequency, granularity) were altered only in AD.Such properties predicted cognitive and neural (MRI, fMRI, EEG) patterns in AD.Word‐property analysis of fluency can boost AD characterization and diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Heterogeneous factors influence social cognition across diverse settings in brain health and age-related diseases

Author

Fittipaldi, Sol, primary, Legaz, Agustina, additional, Maito, Marcelo, additional, Hernandez, Hernan, additional, Altschuler, Florencia, additional, Canziani, Veronica, additional, Moguilner, Sebastian, additional, Gillan, Claire, additional, Castillo, Josefina, additional, Lillo, Patricia, additional, Custodio, Nilton, additional, Avila-Funes, José, additional, Cardona, Juan, additional, Slachevsky, Andrea, additional, Henriquez, Fernando, additional, Fraile-Vazquez, Matias, additional, de Souza, Leonardo Cruz, additional, Borroni, Barbara, additional, Hornberger, Michael, additional, Lopera, Francisco, additional, Santamaria-Garcia, Hernando, additional, Matallana, Diana, additional, Reyes, Pablo, additional, Gonzalez-Campo, Cecilia, additional, Bertoux, Maxime, additional, and Ibanez, Agustin, additional

Published
2023
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34. Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

Author

Moguilner, Sebastian, Baez, Sandra, Hernandez, Hernan, Migeot, Joaquín, Legaz, Agustina, Gonzalez-Gomez, Raul, Farina, Francesca R., Prado, Pavel, Cuadros, Jhosmary, Tagliazucchi, Enzo, Altschuler, Florencia, Maito, Marcelo Adrián, Godoy, María E., Cruzat, Josephine, Valdes-Sosa, Pedro A., Lopera, Francisco, Ochoa-Gómez, John Fredy, Hernandez, Alfredis Gonzalez, Bonilla-Santos, Jasmin, Gonzalez-Montealegre, Rodrigo A., Anghinah, Renato, d’Almeida Manfrinati, Luís E., Fittipaldi, Sol, Medel, Vicente, Olivares, Daniela, Yener, Görsev G., Escudero, Javier, Babiloni, Claudio, Whelan, Robert, Güntekin, Bahar, Yırıkoğulları, Harun, Santamaria-Garcia, Hernando, Lucas, Alberto Fernández, Huepe, David, Di Caterina, Gaetano, Soto-Añari, Marcio, Birba, Agustina, Sainz-Ballesteros, Agustin, Coronel-Oliveros, Carlos, Yigezu, Amanuel, Herrera, Eduar, Abasolo, Daniel, Kilborn, Kerry, Rubido, Nicolás, Clark, Ruaridh A., Herzog, Ruben, Yerlikaya, Deniz, Hu, Kun, Parra, Mario A., Reyes, Pablo, García, Adolfo M., Matallana, Diana L., Avila-Funes, José Alberto, Slachevsky, Andrea, Behrens, María I., Custodio, Nilton, Cardona, Juan F., Barttfeld, Pablo, Brusco, Ignacio L., Bruno, Martín A., Sosa Ortiz, Ana L., Pina-Escudero, Stefanie D., Takada, Leonel T., Resende, Elisa, Possin, Katherine L., de Oliveira, Maira Okada, Lopez-Valdes, Alejandro, Lawlor, Brain, Robertson, Ian H., Kosik, Kenneth S., Duran-Aniotz, Claudia, Valcour, Victor, Yokoyama, Jennifer S., Miller, Bruce, and Ibanez, Agustin

Abstract

Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex and neurodegeneration) on the brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American and Caribbean countries (LAC) and 8 non-LAC countries). Based on higher-order interactions, we developed a brain-age gap deep learning architecture for functional magnetic resonance imaging (2,953) and electroencephalography (2,353). The datasets comprised healthy controls and individuals with mild cognitive impairment, Alzheimer disease and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (functional magnetic resonance imaging: mean directional error = 5.60, root mean square error (r.m.s.e.) = 11.91; electroencephalography: mean directional error = 5.34, r.m.s.e. = 9.82) associated with frontoposterior networks compared with non-LAC models. Structural socioeconomic inequality, pollution and health disparities were influential predictors of increased brain-age gaps, especially in LAC (R² = 0.37, F² = 0.59, r.m.s.e. = 6.9). An ascending brain-age gap from healthy controls to mild cognitive impairment to Alzheimer disease was found. In LAC, we observed larger brain-age gaps in females in control and Alzheimer disease groups compared with the respective males. The results were not explained by variations in signal quality, demographics or acquisition methods. These findings provide a quantitative framework capturing the diversity of accelerated brain aging.

Published
2024
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35. Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research

Author

Franzen, Sanne, Nuytemans, Karen, Bourdage, Renelle, Caramelli, Paulo, Ellajosyula, Ratnavalli, Finger, Elizabeth, Illán-Gala, Ignacio, Loi, Samantha M., Morhardt, Darby, Pijnenburg, Yolande, Rascovsky, Katya, Williams, Monique M., Yokoyama, Jennifer S., Alladi, Suvarna, Ayhan, Yavuz, Broce, Iris, Castro-Suarez, Sheila, Coleman, Kristy, de Souza, Leonardo Cruz, Dacks, Penny A., de Boer, Sterre C.M., de Leon, Jessica, Dodge, Shana, Grasso, Stephanie, Gupta, Veer, Gupta, Vivek, Ghoshal, Nupur, Kamath, Vidyulata, Kumfor, Fiona, Matias-Guiu, Jordi A., Narme, Pauline, Nielsen, T. Rune, Okhuevbie, Daniel, Piña-Escudero, Stefanie D., Garcia, Ramiro Ruiz, Scarioni, Marta, Slachevsky, Andrea, Suarez-Gonzalez, Aida, Tee, Boon Lead, Tsoy, Elena, Ulugut, Hülya, Babulal, Ganesh M., Onyike, Chiadi U., Erasmus MC other, Psychiatry, Neurology, and Pediatrics

Subjects
SDG 3 - Good Health and Well-being
Abstract

Frontotemporal dementia (FTD) is one of the leading causes of dementia before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, and other socioeconomic factors; current research and clinical practice, however, is mainly based on studies conducted in North America and Western Europe. Changes in diagnostic criteria and procedures as well as new or adapted cognitive tests are likely needed to take into consideration global diversity. This perspective paper by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment examines how increasing global diversity impacts the clinical presentation, screening, assessment, and diagnosis of FTD and its treatment and care. It subsequently provides recommendations to address immediate needs to advance global FTD research and clinical practice.

Published
2023

36. Assessing subjective cognitive decline in older adults attending primary health care centers: what question should be asked?

Author

Molina-Donoso, Matías, primary, Parrao, Teresa, additional, Meillon, Céline, additional, Thumala, Daniela, additional, Lillo, Patricia, additional, Villagra, Roque, additional, Ibañez, Agustín, additional, Cerda, Mauricio, additional, Zitko, Pedro, additional, Amieva, Hélène, additional, and Slachevsky, Andrea, additional

Published
2023
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37. The limitations and challenges in the assessment of executive dysfunction associated with real-world functioning: The opportunity of serious games

Author

Martínez-Pernía, David, primary, Olavarría, Loreto, additional, Fernández-Manjón, Baltasar, additional, Cabello, Victoria, additional, Henríquez, Fernando, additional, Robert, Philippe, additional, Alvarado, Luís, additional, Barría, Silvia, additional, Antivilo, Andrés, additional, Velasquez, Juan, additional, Cerda, Mauricio, additional, Farías, Gonzalo, additional, Torralva, Teresa, additional, Ibáñez, Agustín, additional, Parra, Mario A., additional, Gilbert, Sam, additional, and Slachevsky, Andrea, additional

Published
2023
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38. Moral Emotions and Their Brain Structural Correlates Across Neurodegenerative Disorders

Author

Baez, Sandra, primary, Trujillo-Llano, Catalina, additional, de Souza, Leonardo Cruz, additional, Lillo, Patricia, additional, Forno, Gonzalo, additional, Santamaría-García, Hernando, additional, Okuma, Cecilia, additional, Alegria, Patricio, additional, Huepe, David, additional, Ibáñez, Agustín, additional, Decety, Jean, additional, and Slachevsky, Andrea, additional

Published
2023
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40. Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: a cross sectional observational study

Author

Maito, Marcelo Adrián, primary, Santamaría-García, Hernando, additional, Moguilner, Sebastián, additional, Possin, Katherine L., additional, Godoy, María E., additional, Avila-Funes, José Alberto, additional, Behrens, María I., additional, Brusco, Ignacio L., additional, Bruno, Martín A., additional, Cardona, Juan F., additional, Custodio, Nilton, additional, García, Adolfo M., additional, Javandel, Shireen, additional, Lopera, Francisco, additional, Matallana, Diana L., additional, Miller, Bruce, additional, Okada de Oliveira, Maira, additional, Pina-Escudero, Stefanie D., additional, Slachevsky, Andrea, additional, Sosa Ortiz, Ana L., additional, Takada, Leonel T., additional, Tagliazuchi, Enzo, additional, Valcour, Victor, additional, Yokoyama, Jennifer S., additional, and Ibañez, Agustín, additional

Published
2023
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42. A task force for diagnosis and treatment of people with Alzheimer's disease in Latin America.

Author

Lopera, Francisco, Custodio, Nilton, Rico-Restrepo, Mariana, Allegri, Ricardo F., Barrientos, José Domingo, Garcia Batres, Estuardo, Calandri, Ismael L., Calero Moscoso, Cristian, Caramelli, Paulo, Duran Quiroz, Juan Carlos, Jansen, Angela Marie, Mimenza Alvarado, Alberto José, Nitrini, Ricardo, Parodi, Jose F., Ramos, Claudia, Slachevsky, Andrea, and Dozzi Brucki, Sonia María

Subjects
ALZHEIMER'S disease, GERIATRICIANS, TASK forces, NEUROLOGISTS, MEDICAL personnel, SOCIAL determinants of health, COGNITIVE testing
Abstract

Alzheimer's disease (AD) represents a substantial burden to patients, their caregivers, health systems, and society in Latin America and the Caribbean (LAC). This impact is exacerbated by limited access to diagnosis, specialized care, and therapies for AD within and among nations. The region has varied geographic, ethnic, cultural, and economic conditions, which create unique challenges to AD diagnosis and management. To address these issues, the Americas Health Foundation convened a panel of eight neurologists, geriatricians, and psychiatrists from Argentina, Brazil, Colombia, Ecuador, Guatemala, Mexico, and Peru who are experts in AD for a three-day virtual meeting to discuss best practices for AD diagnosis and treatment in LAC and create a manuscript offering recommendations to address identified barriers. In LAC, several barriers hamper diagnosing and treating people with dementia. These barriers include access to healthcare, fragmented healthcare systems, limited research funding, unstandardized diagnosis and treatment, genetic heterogeneity, and varying social determinants of health. Additional training for physicians and other healthcare workers at the primary care level, region-specific or adequately adapted cognitive tests, increased public healthcare insurance coverage of testing and treatment, and dedicated search strategies to detect populations with gene variants associated with AD are among the recommendations to improve the landscape of AD. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Risk factors for loneliness in family caregivers of people with dementia and enduring mental health conditions during the COVID‐19 pandemic in Latin America

Author

Leon, Tomas, primary, Miranda‐Castillo, Claudia, additional, Slachevsky, Andrea, additional, Tapia‐Muñoz, Thamara, additional, Olavarria, Loreto, additional, Castro, Loreto, additional, Pinto, Alejandra, additional, Chen, Yaohua Sophie, additional, Leroi, Iracema, additional, Lawlor, Brian, additional, Duran‐Aniotz, Claudia, additional, Grycuk, Emilia, additional, Beber, Bárbara Costa, additional, Peres, Fernando Aguzzoli, additional, Nubia, Carla, additional, Gaitan, Pablo, additional, Vilar‐Compte, Mireya, additional, and O'Sullivan, Roger, additional

Published
2022
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44. Pandemic‐Related Stress, Coping, and Wellbeing in an International and Multi‐Ethnic Cohort of Older Adults

Author

Medina, Luis D, primary, Franco, Idalid, additional, Thumala, Daniela, additional, Miranda‐Castillo, Claudia, additional, Acosta, Daisy M, additional, Aguero, Cinthya, additional, Aguilar‐Navarro, Sara Gloria, additional, Baena, Ana Y., additional, Brucki, Sonia, additional, Bustin, Julian, additional, Duque, Lissette, additional, Velazquez, Ivonne Z. Jimenez, additional, Marquine, Maria J., additional, Slachevsky, Andrea, additional, Soto‐Añari, Marcio, additional, and Quiroz, Yakeel T., additional

Published
2022
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46. Cohort Profile: The Community‐based Cohort of Functional Decline in Subjective Cognitive Complaint elderly study of the Geroscience Center for Brain Health and Metabolisms (GERO)

Author

Slachevsky, Andrea, primary, Peters, Anne, additional, Zitko, Pedro, additional, Lillo, Patricia, additional, Thumala, Daniela, additional, Demanet, Michele, additional, Villagra, Roque, additional, Cerda, Mauricio, additional, Ibáñez, Agustin, additional, and Gonzalez, Christian, additional

Published
2022
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47. Does culture shape our understanding of others’ thoughts and emotions? An investigation across 12 countries.

Author

Quesque, François, primary, Coutrot, Antoine, additional, Cox, Sharon, additional, de Souza, Leonardo Cruz, additional, Baez, Sandra, additional, Cardona, Juan Felipe, additional, Mulet-Perreault, Hannah, additional, Flanagan, Emma, additional, Neely-Prado, Alejandra, additional, Clarens, Maria Florencia, additional, Cassimiro, Luciana, additional, Musa, Gada, additional, Kemp, Jennifer, additional, Botzung, Anne, additional, Philippi, Nathalie, additional, Cosseddu, Maura, additional, Trujillo-Llano, Catalina, additional, Grisales-Cardenas, Johan Sebastián, additional, Fittipaldi, Sol, additional, Magrath Guimet, Nahuel, additional, Calandri, Ismael Luis, additional, Crivelli, Lucia, additional, Sedeno, Lucas, additional, Garcia, Adolfo M., additional, Moreno, Fermin, additional, Indakoetxea, Begoña, additional, Benussi, Alberto, additional, Brandão Moura, Millena Vieira, additional, Santamaria-Garcia, Hernando, additional, Matallana, Diana, additional, Pryanishnikova, Galina, additional, Morozova, Anna, additional, Iakovleva, Olga, additional, Veryugina, Nadezda, additional, Levin, Oleg, additional, Zhao, Lina, additional, Liang, Junhua, additional, Duning, Thomas, additional, Lebouvier, Thibaud, additional, Pasquier, Florence, additional, Huepe, David, additional, Barandiaran, Myriam, additional, Johnen, Andreas, additional, Lyashenko, Elena, additional, Allegri, Ricardo F., additional, Borroni, Barbara, additional, Blanc, Frederic, additional, Wang, Fen, additional, Yassuda, Mônica Sanches, additional, Lillo, Patricia, additional, Teixeira, Antônio Lúcio, additional, Caramelli, Paulo, additional, Hudon, Carol, additional, Slachevsky, Andrea, additional, Ibáñez, Agustin, additional, Hornberger, Michael, additional, and Bertoux, Maxime, additional

Published
2022
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49. Biomarkers for dementia in Latin American countries: Gaps and opportunities

Author

Parra, Mario A., primary, Orellana, Paulina, additional, Leon, Tomas, additional, Victoria, Cabello G., additional, Henriquez, Fernando, additional, Gomez, Rodrigo, additional, Avalos, Constanza, additional, Damian, Andres, additional, Slachevsky, Andrea, additional, Ibañez, Agustin, additional, Zetterberg, Henrik, additional, Tijms, Betty M., additional, Yokoyama, Jennifer S., additional, Piña‐Escudero, Stefanie D., additional, Cochran, J. Nicholas, additional, Matallana, Diana L., additional, Acosta, Daisy, additional, Allegri, Ricardo, additional, Arias‐Suárez, Bianca P., additional, Barra, Bernardo, additional, Behrens, Maria Isabel, additional, Brucki, Sonia M. D., additional, Busatto, Geraldo, additional, Caramelli, Paulo, additional, Castro‐Suarez, Sheila, additional, Contreras, Valeria, additional, Custodio, Nilton, additional, Dansilio, Sergio, additional, la Cruz‐Puebla, Myriam De, additional, de Souza, Leonardo Cruz, additional, Diaz, Monica M., additional, Duque, Lissette, additional, Farías, Gonzalo A., additional, Ferreira, Sergio T., additional, Guimet, Nahuel Magrath, additional, Kmaid, Ana, additional, Lira, David, additional, Lopera, Francisco, additional, Meza, Beatriz Mar, additional, Miotto, Eliane C., additional, Nitrini, Ricardo, additional, Nuñez, Alberto, additional, O'Neill, Santiago, additional, Ochoa, John, additional, Pintado‐Caipa, Maritza, additional, Resende, Elisa de Paula França, additional, Risacher, Shannon, additional, Rojas, Luz Angela, additional, Sabaj, Valentina, additional, Schilling, Lucas, additional, Sellek, Allis F., additional, Sosa, Ana, additional, Takada, Leonel T., additional, Teixeira, Antonio L., additional, Unaucho‐Pilalumbo, Martha, additional, and Duran‐Aniotz, Claudia, additional

Published
2022
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50. Allostatic-Interoceptive Overload in Frontotemporal Dementia

Author

Birba, Agustina, primary, Santamaría-García, Hernando, additional, Prado, Pavel, additional, Cruzat, Josefina, additional, Ballesteros, Agustín Sainz, additional, Legaz, Agustina, additional, Fittipaldi, Sol, additional, Duran-Aniotz, Claudia, additional, Slachevsky, Andrea, additional, Santibañez, Rodrigo, additional, Sigman, Mariano, additional, García, Adolfo M., additional, Whelan, Robert, additional, Moguilner, Sebastián, additional, and Ibáñez, Agustín, additional

Published
2022
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