37 results on '"Schranz, Dietmar"'
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2. Duct Stenting in Duct-Dependent Systemic Blood Flow, Past, Present, and Future
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Schranz, Dietmar
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- 2024
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3. Treatment Strategies for Dilated Cardiomyopathy in Children: Scientific Statement from the American Heart Association—A Real Advance! But Please More Specific!
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Schranz, Dietmar
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- 2024
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4. A Global Perspective on PDA Management in the Extremely Premature: Shifting Trend Toward Transcatheter Closure.
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Sathanandam, Shyam, McNamara, Patrick, Pedra, Carlos, Toyoshima, Katsuaki, Malekzadeh-Milani, Sophie, Patkai, Juliana, Baspinar, Osman, Uslu, Hasan, Promphan, Worakan, Khorana, Meera, Wang, Jieh-Neng, Lin, Yung-Chieh, Fujii, Takanari, Mainzer, Gur, Salazar-Lizárraga, David, Márquez-Gonzalez, Horacio, Popat, Himanshu, Mervis, Jonathan, Hong, Neoh, Alwi, Mazeni, Wonwandee, Ratthapon, Schranz, Dietmar, Stanimir, Georgiev, Philip, Ranjit, and Ing, Frank
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global perspective ,patent ductus arteriosus ,prematurity ,transcatheter occlusion - Abstract
Patent ductus arteriosus (PDA) is a frequently encountered defect in infants born extremely premature (≤26 weeks gestation). Historically, closure of the PDA was performed using cyclooxygenase inhibitor medications or by surgical ligations. However, the benefits of PDA closure using these therapies have never been demonstrated, albeit studies have previously not focused on the extremely premature infants. Therefore, there was a worldwide trend toward conservative management of the PDA. With improved survival of extremely premature infants, comorbidities associated with the PDA has increased, resulting in finding alternate treatments such as transcatheter patent ductus arteriosus closure (TCPC) for this population. Currently, there is a renewed interest toward selective treatment of the PDA in this high-risk cohort of small infants. This Comprehensive Review article inspects the globally changing trends in the management of the PDA in premature infants, with a special focus on the rising adoption of TCPC. Moreover, this article compiles data from several neonatal networks worldwide to help understand the problem at hand. Understanding the current management of premature infants and their outcomes is fundamentally essential if pediatric cardiologists are to offer TCPC as a viable therapeutic option for this population. This article aims to serve as a guide for pediatric cardiologists on this topic by compiling the results on landmark clinical trials on PDA management and the controversies that arise from these trials. Comparative outcomes from several countries are presented, including interpretations and opinions of the data from experts globally. This is a step toward coming to a global consensus in PDA management in premature infants.
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- 2023
5. Way of Planning a Complex Interventional Treatment with Support of a 3-Dimensional Printed Heart Model in a Patient with Interrupted Aortic Arch Type A
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Martens, Sabrina, Schranz, Dietmar, Kehl, Hans-Gerd, and Kiski, Daniela
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- 2023
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6. Can Pediatric Heart Failure Therapy Be Improved? Yes It Can, But…
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Schranz, Dietmar
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- 2022
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7. Reintervention and Survival After Transcatheter Pulmonary Valve Replacement
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McElhinney, Doff B., Zhang, Yulin, Levi, Daniel S., Georgiev, Stanimir, Biernacka, Elżbieta Katarzyna, Goldstein, Bryan H., Shahanavaz, Shabana, Qureshi, Athar M., Cabalka, Allison K., Bauser-Heaton, Holly, Torres, Alejandro J., Morray, Brian H., Armstrong, Aimee K., Millan-Iturbe, Oscar, Peng, Lynn F., Aboulhosn, Jamil A., Rużyłło, Witold, Berger, Felix, Sondergaard, Lars, Schranz, Dietmar, Cheatham, John P., Jones, Thomas K., Ewert, Peter, and Schubert, Stephan
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- 2022
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8. Plädoyer für eine alters- und ursachenbezogene Therapie der Herzinsuffizienz im Kindesalter
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Schranz, Dietmar
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- 2023
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9. A developmentally based proposal for neonates with hypoplastic left heart: What a great progress! But please don't stop here! A broad result is emerging
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Schranz, Dietmar, primary
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- 2023
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10. Life-threatening PPHN refractory to NO: therapeutic algorithm
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Schranz, Dietmar, Schrewe, Roland, and Esmaeili, Anoosh
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- 2022
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11. Left Ventricular Physiology and Ventricular‐Vascular Interactions in Young Patients After Heart Transplantation
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Latus, Heiner, primary, Raap, Ramona, additional, Klingel, Karin, additional, Happel, Christoph, additional, Moysich, Axel, additional, Khalil, Markus, additional, Kerst, Gunter, additional, Milla, Jakob, additional, Skrzypek, Susanne, additional, Thul, Josef, additional, Jux, Christian, additional, Schranz, Dietmar, additional, and Apitz, Christian, additional
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- 2023
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12. A developmentally based proposal for neonates with hypoplastic left heart: what a great progress! But please don’t stop here! A broad result is emerging
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Schranz, Dietmar and Schranz, Dietmar
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- 2023
13. Hybrid Procedures for Congenital Heart Disease
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Akintuerk, Hakan, primary, Schranz, Dietmar, additional, and Voelkel, Norbert, additional
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- 2023
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14. Functional regeneration of dilated cardiomyopathy by transcatheter bilateral pulmonary artery banding: first-in-human case series
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Schranz, Dietmar, primary, Krause, Ulrich, additional, Kerst, Gunter, additional, Esmaeili, Anoosh, additional, and Paul, Thomas, additional
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- 2023
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15. Plädoyer für eine alters- und ursachenbezogene Therapie der Herzinsuffizienz im Kindesalter
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Schranz, Dietmar, primary
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- 2022
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16. Way of Planning a Complex Interventional Treatment with Support of a 3-Dimensional Printed Heart Model in a Patient with Interrupted Aortic Arch Type A
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Martens, Sabrina, primary, Schranz, Dietmar, additional, Kehl, Hans-Gerd, additional, and Kiski, Daniela, additional
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- 2022
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17. Hypoplastic Left Ventricle: Left Ventricular Recruitment With Hybrid Approach
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Akintürk, Hakan, primary, Yörüker, Uygar, additional, Müller, Matthias, additional, and Schranz, Dietmar, additional
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- 2022
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18. Hypoplastic Left Heart Syndrome Palliation: Technical Aspects and Common Pitfalls of the Hybrid Approach
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Akintürk, Hakan, primary, Yörüker, Uygar, additional, and Schranz, Dietmar, additional
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- 2022
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19. Impact of Right Ventricular Pressure Load After Repair of Tetralogy of Fallot
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Latus, Heiner, primary, Stammermann, Jana, additional, Voges, Inga, additional, Waschulzik, Birgit, additional, Gutberlet, Matthias, additional, Diller, Gerhard‐Paul, additional, Schranz, Dietmar, additional, Ewert, Peter, additional, Beerbaum, Philipp, additional, Kühne, Titus, additional, Sarikouch, Samir, additional, Kerst, Gunter, additional, Kanaan, Majed, additional, Lebherz, Corinna, additional, Rüffer, André, additional, Gkalpakiotis, Dimitrios, additional, Schedifka, Andrea, additional, Buheitel, Gernot, additional, Streble, Joachim, additional, Willing, Rainer, additional, Schubert, Stephan, additional, Laser, Kai Thorsten, additional, Sandica, Eugen, additional, Trusen, Burkhard, additional, Berger, Felix, additional, Miera, Oliver, additional, Ovroutski, Stanislav, additional, Schmitt, Katharina, additional, Photiadis, Joachim, additional, Opgen‐Rhein, Bernd, additional, Weiss, Katja, additional, Klaassen, Sabine, additional, Berns, Christoph, additional, Boeckel, Thomas, additional, Haverkämper, Guido, additional, Kästner, Andreas, additional, Koch, Heike, additional, Peters, Björn, additional, Schmidt, Florian, additional, Timme, Jens, additional, Engel, Konstanze, additional, Franzbach, Birgit, additional, Senft, Gabriela, additional, Beyer, Frank, additional, Winter, Klaus, additional, Breuer, Johannes, additional, Schneider, Martin, additional, Bahlmann, Jens, additional, Griese, Eberhard, additional, Lê, Trong Phi, additional, Hebe, Joachim, additional, Nürnberg, Jan‐Hendrik, additional, Magsaam, Annette, additional, Müller, Ronald, additional, Potthoff, Ludger, additional, Voigt, Renate, additional, Krüger, Tim, additional, Gerleve, Hubert, additional, Kleideiter, Ulrich, additional, Schneider‐Kulla, Dirk, additional, Krülls‐Münch, Jürgen, additional, Menke, Thomas, additional, Lehn, Martin, additional, Heilmann, Antje, additional, Tomczak, Helge, additional, Tarusinov, Gleb, additional, Scheid, Michael, additional, Mayatepek, Ertan, additional, Pillekamp, Frank, additional, Lichtenberg, Artur, additional, Terpeluk, Christiane, additional, Kolterer, Bruno, additional, Dittrich, Sven, additional, Gundlach, Ulrike, additional, Cesnjevar, Robert, additional, Müntjes, Carsten, additional, Morf, Geert, additional, Esmaeili, Anoosh, additional, Backhoff, Stephan, additional, Stiller, Brigitte, additional, Beyersdorf, Friedhelm, additional, Kroll, Johannes, additional, Häffner, Nicole, additional, Siaplaouras, Jannos, additional, Masri‐Zada, Antje, additional, Jux, Christian, additional, Böning, Andreas, additional, Akintürk, Hakan, additional, Paul, Thomas, additional, Sigler, Matthias, additional, Tirilomis, Theodor, additional, Schürer, Gabriele, additional, Hartmann, Johannes, additional, Grabitz, Ralph, additional, Liebaug, Uta, additional, Rotzsch, Claudius, additional, Kozlik‐Feldmann, Rainer, additional, Rickers, Carsten, additional, Mir, Thomas, additional, Hübler, Michael, additional, Sachweh, Jörg, additional, Renz, Stefan, additional, Schemm, Andreas, additional, Friedrich, Bernd, additional, Schlobohm, Otmar, additional, Böthig, Dietmar, additional, Wermter, Burkhard, additional, Kelter‐Klöpping, Andrea, additional, Horke, Alexander, additional, Bauersachs, Johann, additional, Westhoff‐Bleck, Mechthild, additional, Gorenflo, Matthias, additional, Karck, Matthias, additional, Loukanov, Tsvetomir, additional, Schrüfer, Hermann, additional, Wilken, Martin, additional, Abdul‐Khaliq, Hashim, additional, Rädle‐Hurst, Tanja, additional, Rentzsch, Axel, additional, Schäfers, Hans‐Joachim, additional, Reichert, Hagen, additional, Vilser, Daniel, additional, Kriebel, Thomas, additional, Boysen, Arnulf, additional, Uebing, Anselm, additional, Attmann, Tim, additional, Cremer, Joachim Thomas, additional, Scheewe, Jens, additional, Buchholz‐Berdau, Regina, additional, Möller, Peter, additional, Horter, Thorsten, additional, Brockmeier, Konrad, additional, Bennink, Gerardus B. W. E, additional, Baldus, Stephan, additional, Gillor, Alex, additional, Niehues, Tim, additional, Lawrenz, Wolfgang, additional, Leidig, Steffen, additional, Dähnert, Ingo, additional, Riede, Frank‐Thomas, additional, Kostelka, Martin, additional, Kändler, Liane, additional, Bethge, Martin, additional, Köster, Stefan, additional, Schröder, Christoph, additional, Karstedt, Jens, additional, Seitz, Uwe, additional, Kampmann, Christoph, additional, Dohle, Daniel‐Sebastian, additional, Stahl, Frank, additional, Abedini, Mojtaba, additional, Müller‐Scholden, Joachim, additional, Hager, Alfred, additional, Huntgeburth, Michael, additional, Kaemmerer, Harald, additional, Nagdyman, Nicole, additional, Schoetzau, Jörg, additional, Tutarel, Oktay, additional, Lange, Rüdiger, additional, Hörer, Jürgen, additional, Haas, Nikolaus A, additional, Hauser, Michael, additional, Roithmaier, Alexander, additional, Kehl, Hans‐Gerd, additional, Lammers, Astrid, additional, Malec, Edward, additional, Baumgartner, Helmut, additional, Diller, Gerhard, additional, Bahle, Roswitha, additional, Hofner, Gerald, additional, Zink, Stefan, additional, Reif, Roland, additional, Singer, Helmut, additional, Parlasca, Christoph, additional, Freund, Matthias W, additional, Schumacher, Michael, additional, Dewald, Oliver, additional, Darrelmann, Christine, additional, Willmann, Olaf, additional, Schmiedl, Norbert, additional, Quick, Peter, additional, Hillebrand, Dirk, additional, Michele Eiselt, Stephan, additional, Nekarda, Torsten, additional, Eberhard, Michael, additional, Baier, Georg, additional, Uhlemann, Frank, additional, Tzanavaros, Ioannis, additional, Beyer, Alexander, additional, Binz, Gudrun, additional, Hess, Steffen, additional, Teufel, Thomas, additional, Handke, Ronald‐Peter, additional, Hofbeck, Michael, additional, Kaulitz, Renate, additional, Sieverding, Ludger, additional, Schlensak, Christian, additional, Apitz, Christian, additional, Kaestner, Michael, additional, Holtvogt, Jürgen, additional, Wippermann, Carl‐Friedrich, additional, Hinz, Sönke, additional, Heusch, Andreas, additional, Wirbelauer, Johannes, additional, and Brosi, Wolfgang, additional
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- 2022
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20. A highly virulent variant of HIV-1 circulating in the Netherlands
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Wymant, Chris, Bezemer, Daniela, Blanquart, François, Ferretti, Luca, Gall, Astrid, Hall, Matthew, Golubchik, Tanya, Bakker, Margreet, Ong, Swee Hoe, Zhao, Lele, Bonsall, David, de Cesare, Mariateresa, MacIntyre-Cockett, George, Abeler-Dörner, Lucie, Albert, Jan, Bannert, Norbert, Fellay, Jacques, Grabowski, M Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F, Kivelä, Pia, Kouyos, Roger D, Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, Ristola, Matti, van Sighem, Ard, Berkhout, Ben, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B Martinez, Marzolini, C, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Weber, R, Yerly, S, van der Valk, M, Geerlings, S E, Goorhuis, A, Hovius, J W, Lempkes, B, Nellen, F J B, van der Poll, T, Prins, J M, Reiss, P, van Vugt, M, Wiersinga, W J, Wit, F W M N, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A M H, Pijnappel, F J J, Smalhout, S Y, Weijsenfeld, A M, Jurriaans, S, Back, N K T, Zaaijer, H L, Berkhout, B, Cornelissen, M T E, Schinkel, C J, Wolthers, K C, Peters, E J G, van Agtmael, M A, Autar, R S, Bomers, M, Sigaloff, K C E, Heitmuller, M, Laan, L M, Ang, C W, van Houdt, R, Jonges, M, Kuijpers, T W, Pajkrt, D, Scherpbier, H J, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Looff, L, Buiting, A, Reuwer, A, Veenemans, J, Wintermans, B, Pronk, M J H, Ammerlaan, H S M, van den Bersselaar, D N J, de Munnik, E S, Deiman, B, Jansz, A R, Scharnhorst, V, Tjhie, J, Wegdam, M C A, van Eeden, A, Nellen, J, Brokking, W, Elsenburg, L J M, Nobel, H, van Kasteren, M E E, Berrevoets, M A H, Brouwer, A E, Adams, A, van Erve, R, de Kruijf-van de Wiel, B A F M, Keelan-Phaf, S, van der Ven, B, Buiting, A G M, Murck, J L, de Vries-Sluijs, T E M S, Bax, H I, van Gorp, E C M, de Jong-Peltenburg, N C, de Mendonç A Melo, M, van Nood, E, Nouwen, J L, Rijnders, B J A, Rokx, C, Schurink, C A M, Slobbe, L, Verbon, A, Bassant, N, van Beek, J E A, Vriesde, M, van Zonneveld, L M, de Groot, J, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Fraaij, P L A, van Rossum, A M C, Vermont, C L, van der Knaap, L C, Visser, E, Branger, J, Douma, R A, Cents-Bosma, A S, Duijf-van de Ven, C J H M, Schippers, E F, van Nieuwkoop, C, van Ijperen, J M, Geilings, J, van der Hut, G, van Burgel, N D, Leyten, E M S, Gelinck, L B S, Mollema, F, Davids-Veldhuis, S, Tearno, C, Wildenbeest, G S, Heikens, E, Groeneveld, P H P, Bouwhuis, J W, Lammers, A J J, Kraan, S, van Hulzen, A G W, Kruiper, M S M, van der Bliek, G L, Bor, P C J, Debast, S B, Wagenvoort, G H J, Kroon, F P, de Boer, M G J, Jolink, H, Lambregts, M M C, Roukens, A H E, Scheper, H, Dorama, W, van Holten, N, Claas, E C J, Wessels, E, den Hollander, J G, El Moussaoui, R, Pogany, K, Smit, J V, Struik-Kalkman, D, van Niekerk, T, Pontesilli, O, Lowe, S H, Oude Lashof, A M L, Posthouwer, D, van Wolfswinkel, M E, Ackens, R P, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I H M, Havenith, T R A, van Vonderen, M G A, Kampschreur, L M, Faber, S, Steeman-Bouma, R, Al Moujahid, A, Kootstra, G J, Delsing, C E, van der Burg-van de Plas, M, Scheiberlich, L, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F A, Cohen Stuart, J W T, Jansen, E R, Hoogewerf, M, Rozemeijer, W, van der Reijden, W A, Sinnige, J C, Brinkman, K, van den Berk, G E L, Blok, W L, Lettinga, K D, de Regt, M, Schouten, W E M, Stalenhoef, J E, Veenstra, J, Vrouenraets, S M E, Blaauw, H, Geerders, G F, Kleene, M J, Kok, M, Knapen, M, van der Meché, I B, Mulder-Seeleman, E, Toonen, A J M, Wijnands, S, Wttewaal, E, Kwa, D, van Crevel, R, van Aerde, K, Dofferhoff, A S M, Henriet, S S V, Ter Hofstede, H J M, Hoogerwerf, J, Keuter, M, Richel, O, Albers, M, Grintjes-Huisman, K J T, de Haan, M, Marneef, M, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F F, Burger, D, Gisolf, E H, Hassing, R J, Claassen, M, Ter Beest, G, van Bentum, P H M, Langebeek, N, Tiemessen, R, Swanink, C M A, van Lelyveld, S F L, Soetekouw, R, van der Prijt, L M M, van der Swaluw, J, Bermon, N, Jansen, R, Herpers, B L, Veenendaal, D, Verhagen, D W M, Lauw, F N, van Broekhuizen, M C, van Wijk, M, Bierman, W F W, Bakker, M, Kleinnijenhuis, J, Kloeze, E, Middel, A, Postma, D F, Schölvinck, E H, Stienstra, Y, Verhage, A R, Wouthuyzen-Bakker, M, Boonstra, A, de Groot-de Jonge, H, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Knoester, M, Hoepelman, A I M, Arends, J E, Barth, R E, Bruns, A H W, Ellerbroek, P M, Mudrikova, T, Oosterheert, J J, Schadd, E M, van Welzen, B J, Aarsman, K, Griffioen-van Santen, B M G, de Kroon, I, van Berkel, M, van Rooijen, C S A M, Schuurman, R, Verduyn-Lunel, F, Wensing, A M J, Bont, L J, Geelen, S P M, Loeffen, Y G T, Wolfs, T F W, Nauta, N, Rooijakkers, E O W, Holtsema, H, Voigt, R, van de Wetering, D, Alberto, A, van der Meer, I, Rosingh, A, Halaby, T, Zaheri, S, Boyd, A C, Bezemer, D O, van Sighem, A I, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Brétin, N, Djoechro, E, Groters, M, Kruijne, E, Lelivelt, K J, Lodewijk, C, Lucas, E, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnörr, P, Scheigrond, A, Tuijn, E, Veenenberg, L, Visser, K M, Witte, E C, Van Frankenhuijsen, Maartje, Allegre, Thierry, Makhloufi, Djamila, Livrozet, Jean-Michel, Chiarello, Pierre, Godinot, Mathieu, Brunel-Dalmas, Florence, Gibert, Sylvie, Trepo, Christian, Peyramond, Dominique, Miailhes, Patrick, Koffi, Joseph, Thoirain, Valérie, Brochier, Corinne, Baudry, Thomas, Pailhes, Sylvie, Lafeuillade, Alain, Philip, Gisèle, Hittinger, Gilles, Assi, Assi, Lambry, Véronique, Rosenthal, Eric, Naqvi, Alissa, Dunais, Brigitte, Cua, Eric, Pradier, Christian, Durant, Jacques, Joulie, Aline, Quinsat, Denis, Tempesta, Serge, Ravaux, Isabelle, Martin, Isabelle Poizot, Faucher, Olivia, Cloarec, Nicolas, Champagne, Hélène, Pichancourt, Gilles, Morlat, Philippe, Pistone, Thierry, Bonnet, Fabrice, Mercie, Patrick, Faure, Isabelle, Hessamfar, Mojgan, Malvy, Denis, Lacoste, Denis, Pertusa, Marie-Carmen, Vandenhende, Marie-Anne, Bernard, Noëlle, Paccalin, François, Martell, Cédric, Roger-Schmelz, Julien, Receveur, Marie-Catherine, Duffau, Pierre, Dondia, Denis, Ribeiro, Emmanuel, Caltado, Sabrina, Neau, Didier, Dupont, Michel, Dutronc, Hervé, Dauchy, Frédéric, Cazanave, Charles, Vareil, Marc-Olivier, Wirth, Gaétane, Le Puil, Séverine, Pellegrin, Jean-Luc, Raymond, Isabelle, Viallard, Jean-François, Chaigne de Lalande, Severin, Garipuy, Daniel, Delobel, Pierre, Obadia, Martine, Cuzin, Lise, Alvarez, Muriel, Biezunski, Noemie, Porte, Lydie, Massip, Patrice, Debard, Alexa, Balsarin, Florence, Lagarrigue, Myriam, Prevoteau du Clary, François, Aquilina, Christian, Reynes, Jacques, Baillat, Vincent, Merle, Corinne, Lemoing, Vincent, Atoui, Nadine, Makinson, Alain, Jacquet, Jean Marc, Psomas, Christina, Tramoni, Christine, Aumaitre, Hugues, Saada, Mathieu, Medus, Marie, Malet, Martine, Eden, Aurélia, Neuville, Ségolène, Ferreyra, Milagros, Sotto, Albert, Barbuat, Claudine, Rouanet, Isabelle, Leureillard, Didier, Mauboussin, Jean-Marc, Lechiche, Catherine, Donsesco, Régine, Cabie, André, Abel, Sylvie, Pierre-Francois, Sandrine, Batala, Anne-Sophie, Cerland, Christophe, Rangom, Camille, Theresine, Nadine, Hoen, Bruno, Lamaury, Isabelle, Fabre, Isabelle, Schepers, Kinda, Curlier, Elodie, Ouissa, Rachida, Gaud, Catherine, Ricaud, Carole, Rodet, Roland, Wartel, Guillaume, Sautron, Carmele, Beck-Wirth, Geneviève, Michel, Catherine, Beck, Charles, Halna, Jean-Michel, Kowalczyk, Jakub, Benomar, Meryem, Drobacheff-Thiebaut, Christine, Chirouze, Catherine, Faucher, Jean-François, Parcelier, François, Foltzer, Adeline, Haffner-Mauvais, Cécile, Hustache Mathieu, Mathieu, Proust, Aurélie, Piroth, Lionel, Chavanet, Pascal, Duong, Michel, Buisson, Marielle, Waldner, Anne, Mahy, Sophie, Gohier, Sandrine, Croisier, Delphine, May, Thierry, Delestan, Mikael, Andre, Marie, Zadeh, Mahsa Mohseni, Martinot, Martin, Rosolen, Béatrice, Pachart, Anne, Martha, Benoît, Jeunet, Noëlle, Rey, David, Cheneau, Christine, Partisani, Maria, Priester, Michèle, Bernard-Henry, Claudine, Batard, Marie-Laure, Fischer, Patricia, Berger, Jean-Luc, Kmiec, Isabelle, Robineau, Olivier, Huleux, Thomas, Ajana, Faïza, Alcaraz, Isabelle, Allienne, Christophe, Baclet, Véronique, Meybeck, Agnès, Valette, Michel, Viget, Nathalie, Aissi, Emmanuelle, Biekre, Raphael, Cornavin, Pauline, Merrien, Dominique, Seghezzi, Jean-Christophe, Machado, Moise, Diab, Georges, Raffi, François, Bonnet, Bénédicte, Allavena, Clotilde, Grossi, Olivier, Reliquet, Véronique, Billaud, Eric, Brunet, Cecile, Bouchez, Sabelline, Morineau-Le Houssine, Pascale, Sauser, Fabienne, Boutoille, David, Besnier, Michel, Hue, Hervé, Hall, Nolwenn, Brosseau, Delphine, Souala, Faouzi, Michelet, Christian, Tattevin, Pierre, Arvieux, Cédric, Revest, Matthieu, Leroy, Helene, Chapplain, Jean-Marc, Dupont, Matthieu, Fily, Fabien, Patra-Delo, Solène, Lefeuvre, Céline, Bernard, Louis, Bastides, Frédéric, Nau, Pascale, Verdon, Renaud, de la Blanchardiere, Arnaud, Martin, Anne, Feret, Philippe, Geffray, Loïk, Daniel, Corinne, Rohan, Jennifer, Fialaire, Pascale, Chennebault, Jean Marie, Rabier, Valérie, Abgueguen, Pierre, Rehaiem, Sami, Luycx, Odile, Niault, Mathilde, Moreau, Philippe, Poinsignon, Yves, Goussef, Marie, Mouton-Rioux, Virginie, Houlbert, Dominique, Alvarez-Huve, Sandrine, Barbe, Frédérique, Haret, Sophie, Perre, Philippe, Leantez-Nainville, Sophie, Esnault, Jean-Luc, Guimard, Thomas, Suaud, Isabelle, Girard, Jean-Jacques, Simonet, Véronique, Debab, Yasmine, Schmit, Jean-Luc, Jacomet, Christine, Weinberck, Pierre, Genet, Claire, Pinet, Pauline, Ducroix, Sophie, Durox, Hélène, Denes, Éric, Abraham, Bruno, Gourdon, Florence, Antoniotti, Odile, Molina, Jean-Michel, Ferret, Samuel, Lascoux-Combe, Caroline, Lafaurie, Matthieu, Colin de Verdiere, Nathalie, Ponscarme, Diane, De Castro, Nathalie, Aslan, Alexandre, Rozenbaum, Willy, Pintado, Claire, Clavel, François, Taulera, Olivier, Gatey, Caroline, Munier, Anne-Lise, Gazaigne, Sandrine, Penot, Pauline, Conort, Guillaume, Lerolle, Nathalie, Leplatois, Anne, Balausine, Stéphanie, Delgado, Jeannine, Timsit, Julie, Tabet, Magda, Gerard, Laurence, Girard, Pierre-Marie, Picard, Odile, Tredup, Jürgen, Bollens, Diane, Valin, Nadia, Campa, Pauline, Bottero, Julie, Lefebvre, Benedicte, Tourneur, Muriel, Fonquernie, Laurent, Wemmert, Charlotte, Lagneau, Jean-Luc, Yazdanpanah, Yazdan, Phung, Bao, Pinto, Adriana, Vallois, Dorothée, Cabras, Ornella, Louni, Françoise, Pialoux, Gilles, Lyavanc, Thomas, Berrebi, Valérie, Chas, Julie, Lenagat, Sophie, Rami, Agathe, Diemer, Myriam, Parrinello, Maguy, Depond, Audrey, Salmon, Dominique, Guillevin, Loïc, Tahi, Tassadit, Belarbi, Linda, Loulergue, Pierre, Zak Dit Zbar, Olivier, Launay, Odile, Silbermann, Benjamin, Leport, Catherine, Alagna, Laura, Pietri, Marie-Pierre, Simon, Anne, Bonmarchand, Manuela, Amirat, Naouel, Pichon, François, Kirstetter, Myriam, Katlama, Christine, Valantin, Marc Antoine, Tubiana, Roland, Caby, Fabienne, Schneider, Luminita, Ktorza, Nadine, Calin, Ruxandra, Merlet, Audrey, Ben Abdallah, Saadia, Weiss, Laurence, Buisson, Martin, Batisse, Dominique, Karmochine, Marina, Pavie, Juliette, Minozzi, Catherine, Jayle, Didier, Castel, Philippe, Derouineau, Jean, Kousignan, Pascale, Eliazevitch, Murielle, Pierre, Isabelle, Collias, Lio, Viard, Jean-Paul, Gilquin, Jacques, Sobel, Alain, Slama, Laurence, Ghosn, Jade, Hadacek, Blanka, Thu-Huyn, Nugyen, Nait-Ighil, Lella, Cros, Agnes, Maignan, Aline, Duvivier, Claudine, Consigny, Paul Henri, Lanternier, Fanny, Shoai-Tehrani, Michka, Touam, Fatima, Jerbi, Saadia, Bodard, Loïc, Jung, Corinne, Goujard, Cécile, Quertainmont, Yann, Duracinsky, Martin, Segeral, Olivier, Blanc, Arnaud, Peretti, Delphine, Cheret, Antoine, Chantalat, Christelle, Dulucq, Marie Josée, Levy, Yves, Lelievre, Jean Daniel, Lascaux, Anne Sophie, Dumont, Cécile, Boue, François, Chambrin, Véronique, Abgrall, Sophie, Kansau, Imad, Raho-Moussa, Mariem, De Truchis, Pierre, Dinh, Aurélien, Davido, Benjamin, Marigot, Dhiba, Berthe, Huguette, Devidas, Alain, Chevojon, Pierre, Chabrol, Amélie, Agher, Nouara, Lemercier, Yvon, Chaix, Fabrice, Turpault, Isabelle, Bouchaud, Olivier, Honore, Patricia, Rouveix, Elisabeth, Reimann, Evelyne, Belan, Alix Greder, Godin Collet, Claire, Souak, Safia, Mortier, Emmanuel, Bloch, Martine, Simonpoli, Anne-Marie, Manceron, Véronique, Cahitte, Isabelle, Hiraux, Emmanuel, Lafon, Erik, Cordonnier, François, Zeng, Ai-Feng, Zucman, David, Majerholc, Catherine, Bornarel, Dominique, Uludag, Agnès, Gellen-Dautremer, Justine, Lefort, Agnès, Bazin, Christine, Daneluzzi, Vincent, Gerbe, Juliette, Jeantils, Vincent, Coupard, Mélissa, Patey, Olivier, Bantsimba, Jonas, Delllion, Sophie, Paz, Pauline Caraux, Cazenave, Benoit, Richier, Laurent, Garrait, Valérie, Delacroix, Isabelle, Elharrar, Brigitte, Vittecoq, Daniel, Bolliot, Claudine, Lepretre, Annie, Genet, Philippe, Masse, Virginie, Perrone, Véronique, Boussard, Jean-Luc, Chardon, Patricia, Froguel, Eric, Simon, Philippe, Tassi, Sylvie, Avettand Fenoel, Véronique, Barin, Francis, Bourgeois, Christine, Cardon, Fanny, Chaix, Marie-Laure, Delfraissy, Jean François, Essat, Asma, Fischer, Hugues, Lecuroux, Camille, Petrov-Sanchez, Ventzislava, Rouzioux, Christine, Saez-Cirion, Asier, Seng, Rémonie, Kuldanek, Kristin, Mullaney, Scott, Young, Carmel, Zucchetti, Antonella, Bevan, Margaret-Ann, McKernan, Sinead, Wandolo, Emily, Richardson, Celia, Youssef, Elaney, Green, Pippa, Faulkner, Sue, Faville, Rebecca, Herman, Sandra, Care, Christine, Blackman, Helen, Bellenger, Katharine, Fairbrother, Keith, Phillips, Andrew, Babiker, Abdel, Delpech, Valerie, Fidler, S, Clarke, Mindy, Fox, Julie, Gilson, R, Goldberg, David, Hawkins, David, Johnson, Anne, Johnson, Margaret, McLean, Ken, Nastouli, Eleni, Post, Frank, Kennedy, N, Pritchard, J, Andrady, U, Rajda, N, Donnelly, C, McKernan, S, Drake, S, Gilleran, G, White, D, Ross, J, Harding, J, Faville, R, Sweeney, J, Flegg, P, Toomer, S, Wilding, H, Woodward, R, Dean, G, Richardson, C, Perry, N, Gompels, M, Jennings, L, Bansaal, D, Browing, M, Connolly, L, Stanley, B, Estreich, S, Magdy, A, O'Mahony, C, Fraser, P, Jebakumar, S P R, David, L, Mette, R, Summerfield, H, Evans, M, White, C, Robertson, R, Lean, C, Morris, S, Winter, A, Faulkner, S, Goorney, B, Howard, L, Fairley, I, Stemp, C, Short, L, Gomez, M, Young, F, Roberts, M, Green, S, Sivakumar, K, Minton, J, Siminoni, A, Calderwood, J, Greenhough, D, DeSouza, C, Muthern, Lisa, Orkin, C, Murphy, S, Truvedi, M, McLean, K, Hawkins, D, Higgs, C, Moyes, A, Antonucci, S, McCormack, S, Lynn, W, Bevan, M, Fox, J, Teague, A, Anderson, J, Mguni, S, Post, F, Campbell, L, Mazhude, C, Russell, H, Carrick, G, Ainsworth, J, Waters, A, Byrne, P, Johnson, M, Kuldanek, K, Mullaney, S, Lawlor, V, Melville, R, Sukthankar, A, Thorpe, S, Murphy, C, Wilkins, E, Ahmad, S, Green, P, Tayal, S, Ong, E, Meaden, J, Riddell, L, Loay, D, Peacock, K, Blackman, H, Harindra, V, Saeed, A M, Allen, S, Natarajan, U, Williams, O, Lacey, H, Care, C, Bowman, C, Herman, S, Devendra, S V, Wither, J, Bridgwood, A, Singh, G, Bushby, S, Kellock, D, Young, S, Rooney, G, Snart, B, Currie, J, Fitzgerald, M, Arumainayyagam, J, Chandramani, S, Rajamanoharan, S, Robinson, T, Taylor, B, Brewer, C, Mayr, Christoph, Schmidt, Wolfgang, Speidel, Andrea, Strohbach, Frank, Arastéh, Keikawus, Cordes, Christiane, Stündel, Manfred, Claus, Jörg, Baumgarten, Axel, Carganico, Andreas, Ingiliz, Patrick, Dupke, Stephan, Freiwald, Matthias, Rausch, Michael, Moll, Arend, Schleehauf, Dorothea, Hintsche, Bettina, Klausen, Gerd, Jessen, Heiko, Jessen, Arne, Köppe, Siegfried, Kreckel, Peter, Schranz, Dietmar, Fischer, Klaus, Schulbin, Hubert, Speer, Miriam, Glaunsinger, Tobias, Wicke, Thomas, Bieniek, Bernhard, Hillenbrand, Heribert, Schlote, Frank, Lauenroth-Mai, Elke, Schuler, Christoph, Schürmann, Dirk, Wesselmann, Hans, Brockmeyer, Norbert, Gehring, Peter, Schmalöer, Dirk, Hower, Martin, Spornraft-Ragaller, Petra, Häussinger, Dieter, Reuter, Stefan, Esser, Stefan, Markus, Rudolf, Kreft, Burkhard, Berzow, Dirk, Christl, Andreas, Meyer, Andreas, Plettenberg, Andreas, Stoehr, Albrecht, Graefe, Katrin, Lorenzen, Thore, Adam, Axel, Schewe, Knut, Weitner, Lutwin, Fenske, Stefan, Hansen, Stefan, Stellbrink, Hans-Jürgen, Wiemer, Dorothea, Hertling, Sandra, Schmidt, Reinhold, Arbter, Peter, Claus, Bernd, Galle, Peter, Jäger, Hans, Jä Gel-Guedes, Eva, Postel, Nils, Fröschl, Monika, Spinner, Christoph, Bogner, Johannes, Salzberger, Bernd, Schölmerich, Jürgen, Audebert, Franz, Marquardt, Ties, Schaffert, Andreas, Schnaitmann, Eiko, Trein, Andreas, Frietsch, Bernhard, Müller, Marcus, Ulmer, Albrecht, Detering-Hübner, Barbara, Kern, Peter, Schubert, Franz, Dehn, Günther, Schreiber, Maria, Güler, Cengiz, Schmidt, Daniel, Meixenberger, Karolin, Medical Microbiology & Infectious Diseases, Internal Medicine, Virology, Pediatrics, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Global Health, Infectious diseases, APH - Aging & Later Life, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Internal medicine, VU University medical center, Surgery, AMS - Rehabilitation & Development, APH - Quality of Care, Psychiatry, Pediatric surgery, Neurology, Public and occupational health, APH - Mental Health, Pathology, Cardiology, ACS - Heart failure & arrhythmias, Anesthesiology, IOO, Rehabilitation medicine, Obstetrics and gynaecology, General practice, Gastroenterology and hepatology, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Medical oncology laboratory, Hematology, Epidemiology and Data Science, Physiology, Microbes in Health and Disease (MHD), University of Oxford, Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Amsterdam UMC - Amsterdam University Medical Center, The Wellcome Trust Sanger Institute [Cambridge], Karolinska Institutet [Stockholm], Robert Koch Institute [Berlin] (RKI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Johns Hopkins University (JHU), Universität Zürich [Zürich] = University of Zurich (UZH), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University College of London [London] (UCL), Kymab Ltd, Cambridge, England, Institut Pasteur [Paris] (IP), This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment., We thank K. Fransen and G. Vanham for help with the Belgian data, O. Ratmann for help in identifying the Dutch clusters, K. Kusejko for testing for additional VB individuals in the SHCS, B. Foley for help with genome sharing, B. Dearlove and L. Thomson for help with software, and J. Herbeck and three other reviewers for helpful suggestions., Contributors and affiliations are listed in the supplementary materials., Department of Medicine, University of Helsinki, Infektiosairauksien yksikkö, HUS Inflammation Center, and Clinicum
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Adult ,Male ,HIV-1/genetics ,Genotype ,Anti-HIV Agents ,Evolution ,[SDV]Life Sciences [q-bio] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,HIV Infections/drug therapy ,selection ,HIV Infections ,Genome, Viral ,heritability ,epidemic ,human-immunodeficiency-virus ,Evolution, Molecular ,SDG 3 - Good Health and Well-being ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Humans ,Viral ,Phylogeny ,Netherlands ,Multidisciplinary ,Genome ,model ,Virulence ,transmission ,Molecular ,setpoint viral load ,reverse-transcriptase ,dynamics ,Viral Load ,CD4 Lymphocyte Count ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,3121 General medicine, internal medicine and other clinical medicine ,Anti-HIV Agents/therapeutic use ,Mutation ,HIV-1 ,Female ,progression - Abstract
Comment in Does HIV-1 virulence matter in the ART era? Lewitus E, Rolland M. Med (N Y). 2022 Apr 8;3(4):217-219. doi: 10.1016/j.medj.2022.03.003. PMID: 35590149; International audience; We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
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21. Exercise-dependent changes in ventricular–arterial coupling and aortopulmonary collateral flow in Fontan patients: a real-time CMR study
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Latus, Heiner, primary, Hofmann, Lucas, additional, Gummel, Kerstin, additional, Khalil, Markus, additional, Yerebakan, Can, additional, Waschulzik, Birgit, additional, Schranz, Dietmar, additional, Voges, Inga, additional, Jux, Christian, additional, and Reich, Bettina, additional
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22. Fetal Echocardiography in Predicting Postnatal Outcome in Borderline Left Ventricle.
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Vorisek, Carina Nina, Bischofsberger, Lucy, Kurkevych, Andrii, Yürökür, Uygar, Wolter, Aline, Gembruch, Ulrich, Berg, Christoph, Hudel, Helge, Thul, Josef, Jux, Christian, Akintürk, Hakan, Schranz, Dietmar, and Axt-Fliedner, Roland
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- 2023
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23. Exercise-dependent changes in ventricular–arterial coupling and aortopulmonary collateral flow in Fontan patients: a real-time CMR study.
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Latus, Heiner, Hofmann, Lucas, Gummel, Kerstin, Khalil, Markus, Yerebakan, Can, Waschulzik, Birgit, Schranz, Dietmar, Voges, Inga, Jux, Christian, and Reich, Bettina
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PULMONARY circulation ,VENA cava superior ,COLLATERAL circulation ,MAGNETIC resonance imaging ,EXERCISE ,RESEARCH funding ,EMPLOYEES' workload ,AORTA ,CARDIOPULMONARY bypass ,ERGOMETRY ,VENA cava inferior ,HEMODYNAMICS ,HEART failure - Abstract
Aims Inefficient ventricular–arterial (V–A) coupling has been described in Fontan patients and may result in adverse haemodynamics. A varying amount of aortopulmonary collateral (APC) flow is also frequently present that increases volume load of the single ventricle. The aim of the study was to assess changes in V–A coupling and APC flow during exercise CMR. Methods and results Eighteen Fontan patients (age 24 ± 3 years) and 14 controls (age 23 ± 4 years) underwent exercise CMR using a cycle ergometer. Ventricular volumetry and flow measurements in the ascending aorta (AAO), inferior (IVC), and superior (SVC) vena cava were assessed using real-time sequences during stepwise increases in work load. Measures of systemic arterial elastance Ea, ventricular elastance Ees, and V–A coupling (Ea/Ees) were assessed. APC flow was quantified as AAO − (SVC + IVC). Ea remained unchanged during all levels of exercise in both groups (P = 0.39 and P = 0.11). Ees increased in both groups (P = 0.001 and P < 0.001) with exercise but was lower in the Fontan group (P = 0.04). V–A coupling was impaired in Fontan patients at baseline (P = 0.04). Despite improvement during exercise (P = 0.002) V–A coupling remained impaired compared with controls (P = 0.001). Absolute APC flow in Fontan patients did not change during exercise even at maximum work load (P = 0.98). Conclusions Inefficient V–A coupling was already present at rest in Fontan patients and aggravated during exercise due to a limited increase in ventricular contractility which demonstrates the importance of a limited functional reserve of the single ventricle. APC flow remained unchanged suggesting no further increase in volume load during exercise. [ABSTRACT FROM AUTHOR]
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24. Hypoplastic left heart syndrome: Hybrid approach?
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Schranz, Dietmar
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HYPOPLASTIC left heart syndrome , *ATRIAL septum , *CARDIAC surgery - Abstract
The article discusses the use of the Hybrid procedure in newborns with hypoplastic left heart syndrome (HLHS). The authors question the rationale behind the increased use of the Hybrid procedure at a specific institution, despite a decline in the total number of Norwood operations. They highlight the need for clarity regarding the adoption of the Hybrid approach and the technical details of the procedure. The article emphasizes the importance of understanding the technical nuances of the Hybrid procedure and conducting comparative studies to inform decision-making in pediatric cardiac surgery. The authors also suggest that percutaneous transcatheter techniques may soon replace surgical approaches. [Extracted from the article]
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- 2024
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25. Late presentation of chronic hepatitis C patients in the era of direct‐acting antivirals—Data from the German Hepatitis C‐Registry.
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Bischoff, Jenny, Mauss, Stefan, Lutz, Thomas, Cordes, Christiane, Klausen, Gerd, Scholten, Stefan, Hillenbrand, Heribert, Cornberg, Markus, Baumgarten, Axel, Rockstroh, Jürgen K., Fenske, Stefan, Deterding, Katja, Zamani, Carsten, Knechten, Heribert, Bohr, Ulrich, Schuler, Christoph, Merle, Ute, Stephan, Christoph, Schranz, Dietmar, and Buggisch, Peter
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CHRONIC hepatitis C ,HEPATITIS C ,ANTIVIRAL agents ,VIRAL hepatitis ,HEPATITIS ,INTRAVENOUS drug abuse ,HEPATITIS C virus - Abstract
Keywords: advanced liver disease; HCV; HIV coinfection; late presentation; viral hepatitis EN advanced liver disease HCV HIV coinfection late presentation viral hepatitis 1660 1664 5 10/19/21 20211101 NES 211101 Abbreviations ALT Alanine-aminotransferase APRI Aspartate-aminotransferase-to-platelet-ratio-index ART Antiretroviral therapy BMI Body mass index DAA Direct acting antiviral DHC-R German Hepatitis C-Registry GECCO German Hepatitis C Cohort GT Genotype HBV Hepatitis B virus HCC Hepatocellular carcinoma HCV Hepatitis C virus HIV Human immunodeficiency virus IVDA intravenous drug abuse LP Late presentation for viral hepatitis MSM Men who have sex with men OST Opioid substitution therapy PrEP Pre-Exposure prophylaxis RNA Ribonucleic acid SVR Sustained virological response WHO World Health Organization INTRODUCTION Chronic liver disease due to hepatitis C virus (HCV) infection is a major public health burden with an estimated 71 million people worldwide suffering from replicative HCV infection.1 Even if diagnosed in an early stage of disease, missing linkage to care or reluctance to treat might defer treatment until progression to an advanced stage of liver disease. Has increased rollout of direct acting antiviral therapy decreased the burden of late presentation and advanced liver disease in patients starting hepatitis C virus therapy in Germany? We aimed to investigate the extent of LP since unrestricted access to DAA therapy in Germany for HCV monoinfected and HIV/HCV coinfected patients in the period 2014-2018. Treatment uptake was about 3 times higher in 2015 compared to 2014 (1100 patients vs. 3055 patients), which reflects most likely the effect of the implementation of DAAs for HCV treatment and unrestricted access in Germany. [Extracted from the article]
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26. Hybrid approach to hypoplastic left heart syndrome
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Schranz, Dietmar and Akintuerk, Hakan
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27. Fibrotic myocardial remodeling in children and adolescents after cardiac transplantation - a CMR native T1 mapping study.
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Latus, Heiner, Voges, Inga, Blank, Eva, Gummel, Kerstin, Reich, Bettina, Klingel, Karin, Khalil, Markus, Kerst, Gunter, Skrzypek, Susanne, Schranz, Dietmar, and Jux, Christian
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28. Univentricular (hypoplastic left heart syndrome) palliation: perioperative care.
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Schranz, Dietmar
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HYPOPLASTIC left heart syndrome , *PERIOPERATIVE care , *NEONATAL surgery , *VENOUS pressure , *SURGICAL intensive care - Abstract
It is noteworthy that some statistically different haemodynamic variables were associated with LOS in ICU; however, that changes in surgical techniques, including switching from hypothermic cardio-circulatory arrest to selective cerebral perfusion or other surgical modifications, had no apparent outcome effects. Parent's consent to the foetal and neonatal treatment of their children with single-ventricle physiology, especially HLHS, will in future depend on the survivors' somatic and cognitive outcome being almost normal. Keywords: HLHS; Norwood; Perioperative care EN HLHS Norwood Perioperative care 1281 1282 2 05/31/22 20220601 NES 220601 In this week's issue of I EJCTS i , Staehler I et al. i [[1]] report a retrospective single-centre study in which perioperative data from a large cohort of 322 newborns with hypoplastic left heart syndrome (HLHS) and variants were analysed who underwent a Norwood procedure in a period of 18 years between 2001 and 2019. [Extracted from the article]
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29. COVID-19 in children: acute endotheliopathy, but forgotten prostacyclin replacement?
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Schranz, Dietmar
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30. A rare origin of atrial flutter in a girl with congenital heart disease: 3D-electromapping guided radiofrequency ablation of the left atrial ceiling.
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Gülgün, Mustafa, Gonzales, Maria, Schranz, Dietmar, and Kerst, Gunter
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31. Non-surgical stage I to avoid neonatal surgeries in newborns with HLHS and HLHC.
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Lang, Nora, Hübler, Michael, Schranz, Dietmar, Sachweh, Jörg, Müller, Götz, Kehl, Torben, Weinknecht, Judith, Grafmann, Maria, Biermann, Daniel, and Feldmann, Rainer Kozlik
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32. Perioperative anesthetic management of patients with hypoplastic left heart syndrome undergoing the comprehensive stage II surgery—A review of 148 cases.
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Müller, Matthias, Lurz, Florian, Zajonz, Thomas, Edinger, Fabian, Yörüker, Uygar, Thul, Josef, Schranz, Dietmar, and Akintürk, Hakan
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HYPOPLASTIC left heart syndrome , *TRANSITION flow , *INTRAVENOUS therapy , *CARDIAC surgery , *BLOOD flow - Abstract
Background Methods Results Conclusion Trial Registration Patients with hypoplastic left heart syndrome undergo the comprehensive stage 2 procedure as the second stage in the hybrid approach toward Fontan circulation. The complexity of comprehensive stage 2 procedure is considered a potential limitation, and limited information is available on its anesthetic management. This study aims to address this gap.A single‐center retrospective cohort study analyzed 148 HLHS patients who underwent comprehensive stage 2 procedure, divided into Group A (stable condition, n = 116) and Group B (requiring preoperative intravenous inotropic therapy, n = 32). Demographic data, intraoperative hemodynamics, anesthetic management, and postoperative outcomes were collected.Etomidate (40%) was the most common induction agent, followed by esketamine (24%), midazolam (16%), and propofol (13%). Inhaled induction was rarely necessary (2%), occurring only in Group A patients. No statistical differences were found between groups for induction drug choice. Post‐cardiopulmonary bypass management included moderate hypoventilation, inhaled nitric oxide (100%), and hemodynamic support with milrinone (97%) and norepinephrine (77%). Group B patients more frequently required additional levosimendan (20%) and epinephrine (18%). Extracorporeal membrane oxygenation was necessary in 8 patients (5%) with no between‐group differences. Switching from fentanyl to remifentanil reduced postoperative ventilation time overall. However, Group B experienced significantly longer ventilation (6.3 vs. 3.5 h) and ICU stay (22 vs. 14 days). In‐hospital mortality was 5% overall (Group A: 4%, Group B: 9%). Long‐term survival analysis revealed a significant advantage for Group A.The use of short‐acting opioids and adjusted ventilation modes enables optimal pulmonary blood flow and rapid transition to spontaneous breathing. Differentiated hemodynamic support with milrinone, norepinephrine, supplemented by levosimendan and epinephrine in high‐risk patients, can mitigate the effects on the preoperatively volume‐loaded right ventricle. However, differences in long‐term survival probability were observed between groups.Local ethics committee, Medical Faculty, Justus‐Liebig‐University‐Giessen (Trial Code Number: 216/14). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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33. Pulmonary artery banding for cardiomyopathy in young children: First trial in China.
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Dou Z, He Q, Ma K, Wang X, Zeng M, Pang K, Zhang B, Rui L, Mao F, Yuan J, Wu D, Liu Y, Schranz D, and Li S
- Abstract
Aims: Heritable dilated cardiomyopathy (DCM) or DCM associated with congenital or acquired left ventricular diseases carries a significant mortality risk. Pulmonary artery banding (PAB) has been proposed as an alternative to heart transplantation. This study aimed to delineate the clinical development, ventricular reverse remodelling, and functional regeneration of the dilated left ventricle, presenting as a pioneering approach in China., Methods and Results: This prospective study was initiated in November 2021, involving paediatric patients with a significant dilated left ventricle and preserved right ventricle who underwent surgical PAB. The baseline characteristics and clinical information during follow-up were collected. Seven patients (five boys) with a median age of 240 (148, 1028) days have been included thus far. No procedural or follow-up mortality was observed. The modified Ross functional class improved from treatment to follow-up of 348 (200, 629) days, and the median left ventricular ejection fraction increased from 27.0 (15.0, 34.0) % before surgery to 61.0 (52.0, 68.0) % (P < 0.05); the median left ventricular end-diastolic diameter and corresponding Z-scores decreased from 43.0 (40.0, 55.0) mm [+9.4 (+7.7, +11.7)] to 33.0 (29.0, 39.0) mm [+1.8 (+1.3, +3.8)] (P < 0.05). Functional regeneration of the left ventricle was observed in five patients. Three of them underwent balloon dilation of the PAB to relieve excessively elevated right ventricular pressures., Conclusions: The application of PAB should adhere to strict criteria. Initial results are promising for infants and even toddlers with a dilated left ventricle and limited probability of spontaneous recovery. PAB can be an alternative when there is a shortage of donor transplants and assist devices, especially for low- and middle-income countries., (© 2024 The Author(s). ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
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- 2024
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34. Fetal Echocardiography in Predicting Postnatal Outcome in Borderline Left Ventricle.
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Vorisek CN, Bischofsberger L, Kurkevych A, Yürökür U, Wolter A, Gembruch U, Berg C, Hudel H, Thul J, Jux C, Akintürk H, Schranz D, and Axt-Fliedner R
- Subjects
- Pregnancy, Female, Humans, Retrospective Studies, Prospective Studies, ROC Curve, Ultrasonography, Prenatal methods, Heart Ventricles, Echocardiography methods
- Abstract
Objectives: Prenatal prediction of postnatal univentricular versus biventricular circulation in patients with borderline left ventricle (bLV) remains challenging. This study investigated prenatal fetal echocardiographic parameters and postnatal outcome of patients with a prenatally diagnosed bLV., Methods: We report a retrospective study of bLV patients at four prenatal centers with a follow-up of one year. BLV was defined as z-scores of the left ventricle (LV) between -2 and -4. Single-ventricle palliation (SVP), biventricular repair (BVR), and no surgical or catheter-based intervention served as the dependent outcome. Prenatal ultrasound parameters were used as independent variables. Cut-off values from receiver operating characteristic curves (ROC) were determined for significant discrimination between outcomes., Results: A total of 54 patients were diagnosed with bLV from 2010 to 2018. All were live births. Out of the entire cohort, 8 (15 %) received SVP, 34 (63 %) BVR, and 12 (22 %) no intervention. There was no significant difference with regard to genetic or extracardiac anomalies. There were significantly more patients with endocardial fibroelastosis (EFE) in the SVP group compared to the BVR group (80 % vs. 10 %), (p < 0.001). Apex-forming LV (100 % vs. 70 %) and lack of retrograde arch flow (20 % vs. 80 %) were associated with no intervention (p < 0.001). With respect to BVR vs. SVP, the LV sphericity index provided the highest specificity (91.7 %) using a cutoff value of ≤ 0.5., Conclusion: The majority of bLV patients maintained biventricular circulation. EFE, retrograde arch flow, and LV sphericity can be helpful parameters for counseling parents and further prospective studies can be developed., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)
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- 2023
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35. Functional regeneration of dilated cardiomyopathy by transcatheter bilateral pulmonary artery banding: first-in-human case series.
- Author
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Schranz D, Krause U, Kerst G, Esmaeili A, and Paul T
- Abstract
Background: Dilated cardiomyopathy (DCM) is a leading cause of heart transplantation (HTx) in children. Surgical pulmonary artery banding (PAB) is used worldwide to achieve functional heart regeneration and remodelling., Case Summary: We report for the first-time successful bilateral transcatheter implantation of bilateral pulmonary artery flow restrictors in a case series of three infants with severe DCM based on left-ventricular non-compaction morphology associated with Barth syndrome in one and a non-classified syndrome in another. Functional cardiac regeneration was observed in two patients after almost 6 months of endoluminal banding, and in the neonate with Barth syndrome already after 6 weeks. Accompanied by an improvement in functional class (Class IV to Class I), the left ventricular end-diastolic dimensions z -score normalized, as did the elevated serum brain natriuretic peptide levels. A listing for HTx could be avoided., Discussion: Percutaneous bilateral endoluminal PAB is a novel minimally invasive approach that enables functional cardiac regeneration in infants with severe DCM and preserved right ventricular function. Interruption of the ventriculo-ventricular interaction, the key mechanism for recovery, is avoided. Intensive care for these critically ill patients is reduced to a minimum. However, investing in 'heart regeneration to avoid transplantation' remains a challenge., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2023
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36. Exercise-dependent changes in ventricular-arterial coupling and aortopulmonary collateral flow in Fontan patients: a real-time CMR study.
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Latus H, Hofmann L, Gummel K, Khalil M, Yerebakan C, Waschulzik B, Schranz D, Voges I, Jux C, and Reich B
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- Humans, Young Adult, Adult, Arteries, Heart Ventricles, Hemodynamics, Aorta, Fontan Procedure
- Abstract
Aims: Inefficient ventricular-arterial (V-A) coupling has been described in Fontan patients and may result in adverse haemodynamics. A varying amount of aortopulmonary collateral (APC) flow is also frequently present that increases volume load of the single ventricle. The aim of the study was to assess changes in V-A coupling and APC flow during exercise CMR., Methods and Results: Eighteen Fontan patients (age 24 ± 3 years) and 14 controls (age 23 ± 4 years) underwent exercise CMR using a cycle ergometer. Ventricular volumetry and flow measurements in the ascending aorta (AAO), inferior (IVC), and superior (SVC) vena cava were assessed using real-time sequences during stepwise increases in work load. Measures of systemic arterial elastance Ea, ventricular elastance Ees, and V-A coupling (Ea/Ees) were assessed. APC flow was quantified as AAO - (SVC + IVC). Ea remained unchanged during all levels of exercise in both groups (P = 0.39 and P = 0.11). Ees increased in both groups (P = 0.001 and P < 0.001) with exercise but was lower in the Fontan group (P = 0.04). V-A coupling was impaired in Fontan patients at baseline (P = 0.04). Despite improvement during exercise (P = 0.002) V-A coupling remained impaired compared with controls (P = 0.001). Absolute APC flow in Fontan patients did not change during exercise even at maximum work load (P = 0.98)., Conclusions: Inefficient V-A coupling was already present at rest in Fontan patients and aggravated during exercise due to a limited increase in ventricular contractility which demonstrates the importance of a limited functional reserve of the single ventricle. APC flow remained unchanged suggesting no further increase in volume load during exercise., Competing Interests: Conflict of interest: none declared., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2022
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37. Please not again: Recommendations after five negative cases!
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Schranz D
- Subjects
- Humans, Treatment Outcome, Paclitaxel
- Published
- 2022
- Full Text
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