10 results on '"Minesh Khashu"'
Search Results
2. Prenatal maternal mental health and resilience in the United Kingdom during the SARS-CoV-2 pandemic: a cross- national comparison
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Swarali Datye, Marko Smiljanic, Rohan Shetti, Alison MacRae-Miller, Edwin van Teijlingen, Latha Vinayakarao, Eva M. J. Peters, Catherine Lebel, Lianne Tomfohr-Madsen, Gerald Giesbrecht, Minesh Khashu, and Melanie L. Conrad
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pregnancy ,maternal mental health ,depression ,anxiety ,resilience ,social support ,Psychiatry ,RC435-571 - Abstract
IntroductionPrenatal mental health problems are associated with morbidity for the pregnant person, and their infants are at long-term risk for poor health outcomes. We aim to explore how the SARS-CoV-2 pandemic affected the mental health of pregnant people in the United Kingdom (UK), and to further identify resilience factors which may have contributed to varying mental health outcomes. We also aim to examine the quality of antenatal care provided during the pandemic in the UK and to identify potential inadequacies to enhance preparedness for future events.MethodsDuring June-November 2020, we recruited 3666 individuals in the UK for the EPPOCH pregnancy cohort (Maternal mental health during the COVID-19 pandemic: Effect of the Pandemic on Pregnancy Outcomes and Childhood Health). Participants were assessed for depression, anxiety, anger and pregnancy-related anxiety using validated scales. Additionally, physical activity, social support, individualized support and personal coping ability of the respondents were assessed as potential resilience factors.ResultsParticipants reported high levels of depression (57.05%), anxiety (58.04%) and anger (58.05%). Higher levels of social and individualized support and personal coping ability were associated with lower mental health challenges. Additionally, pregnant individuals in the UK experienced higher depression during the pandemic than that reported in Canada. Finally, qualitative analysis revealed that restrictions for partners and support persons during medical appointments as well as poor public health communication led to increased mental health adversities and hindered ability to make medical decisions.DiscussionThis study revealed increased mental health challenges among pregnant individuals in the UK during the SARS-CoV-2 pandemic. These results highlight the need for reassessing the mental health support measures available to pregnant people in the UK, both during times of crisis and in general.
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- 2024
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3. Correction: Investigating Father or Partner Involvement in Family Integrated Care in Neonatal Units: Protocol for a Prospective, Multicenter, Multiphase Study
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Rupa Rubinstein, Katie Gallagher, John Ho, Julian Bose, Minesh Khashu, and Narendra Aladangady
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Medicine ,Computer applications to medicine. Medical informatics ,R858-859.7 - Published
- 2024
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4. Investigating Father or Partner Involvement in Family Integrated Care in Neonatal Units With TARGET (Fathers and Partners in Family Integrated Care): Protocol for a Prospective, Multicenter, Multiphase Study
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Rupa Rubinstein, Katie Gallagher, John Ho, Julian Bose, Minesh Khashu, and Narendra Aladangady
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Medicine ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundNeonatal unit (NU) admissions for premature babies can last for months, which can significantly impact parental mental health (MH) with symptoms of depression, stress, and anxiety. Literature suggests fathers experience comparable MH symptoms to mothers. Family integrated care (FICare) is a culture where parents are collaborators and partners in caring for their hospitalized newborns. FICare improves infant outcomes and maternal MH. Similar reports on fathers are limited. ObjectiveThe primary aim of this study is to investigate the impact of supporting father or partner engagement in FICare of preterm infants on their MH up to 6 weeks postdischarge. The secondary aim is to investigate the impact on maternal MH. MethodsThis is a 2-phase study: phase 1 to gather baseline information and phase 2 to assess the impact of enhanced father or partner engagement in FICare on their MH, involving 2 NUs (tertiary and level 2). Enhanced FICare will be developed and introduced (eg, information booklet, workbook, classes, and a father peer-support group) alongside standard FICare practices. Father or partner MH will be assessed with semistructured qualitative interviews and validated questionnaires: Generalized Anxiety Disorder Assessment, Patient Health Questionnaire, and Parental Stressor Scale: Neonatal Intensive Care Unit from NU admission to 6 weeks postdischarge. Mothers will be assessed by focus groups and the same questionnaires. Descriptive statistics and appropriate comparative tests, such as the 2-tailed t test, will be used to analyze and compare phase 1 and 2 data. Qualitative data will be coded line by line with the use of NVivo (Lumivero) and thematically analyzed. Simultaneously, systematic reviews (SRs) of fathers’ experiences of FICare and their MH outcomes will be conducted. The study was approved by the National Research Ethics Committee (22/EM/0140) in August 2022. A parent advisory group was formed to advise on the study methodology, materials, involvement of participant parents, and dissemination of study findings. ResultsA recent SR demonstrated that data saturation is likely to be achieved by interviewing 9 to 17 participants. We will study a maximum of 20 parents of infants born at less than 33 weeks’ gestation in each phase. As of October 2023, the study was ongoing. The SR studies are registered with the PROSPERO database (324275 and 306760). The projected end date for data collection is July 2024; data analysis will be conducted in November 2024 and publication will occur in 2025. ConclusionsThe study aims to demonstrate the feasibility of using a father or partner-sensitive FICare model for parents of premature babies with a positive impact on their MH. It will demonstrate the feasibility of providing FICare to extremely premature babies receiving intensive care. This study may support the development of inclusive FICare guidelines for nonbirthing parents and their extremely premature infants. Trial RegistrationClinicalTrials.gov: NCT06022991; https://classic.clinicaltrials.gov/ct2/show/NCT06022991 International Registered Report Identifier (IRRID)DERR1-10.2196/53160
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- 2024
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5. Editorial: Recent advances in our understanding of NEC pathogenesis, diagnosis, and treatment
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Misty Good and Minesh Khashu
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necrotizing enterocolitis (NEC) ,artificial intelligence ,breast milk ,probiotics ,neonate ,intestine ,Pediatrics ,RJ1-570 - Published
- 2023
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6. It is high time we reduce 'routine' blood work in neonatal units
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Michael Narvey and Minesh Khashu
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neonatal ,NICU ,bloods ,bloodtests ,testing ,Pediatrics ,RJ1-570 - Published
- 2023
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7. Postnatal corticosteroid use for prevention or treatment of bronchopulmonary dysplasia in England and Wales 2012–2019: a retrospective population cohort study
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Neena Modi, Chris Gale, Iyad Al-Muzaffar, Jonathan Cusack, Victoria Nesbitt, Sanjay Salgia, Matthew Babirecki, Aashish Gupta, L M Wong, Anita Mittal, Ahmed Hassan, Karin Schwarz, Graham Whincup, Abdul Hasib, Mehdi Garbash, David Gibson, Pauline Adiotomre, Abby Deketelaere, Stanley Zengeya, Cath Seagrave, Hilary Dixon, Narendra Aladangady, Hassan Gaili, Matthew James, M Lal, Lawrence Miall, Venkatesh Kairamkonda, J Kefas, Jennifer Birch, Gail Whitehead, I Misra, Subodh Gupta, Steven Wardle, Eleri Adams, Minesh Khashu, Charlotte Groves, Christos Zipitis, Peter De Halpert, Joanne Fedee, Stephen Jones, Kirsten Mack, Charlotte Huddy, Salim Yasin, Ngozi Edi-osagie, Carrie Heal, Jacqeline Birch, Hari Kumar, Chris Rawlingson, Delyth Webb, Sankara Narayanan, Elizabeth Eyre, Caroline Sullivan, Wynne Leith, Vimal Vasu, Katia Vamvakiti, Megan Eaton, Ambalika Das, Katharine Mcdevitt, Anna Gregory, Shu-Ling Chuang, Sabita Uthaya, Cheryl Battersby, Imran Ahmed, Chris Warren, Tristan Bate, Mark Johnson, Sunil Reddy, Rashmi Gandhi, Nitin Goel, Richard Hearn, Cheentan Singh, Faith Emery, Vineet Gupta, Yee Aung, Vennila Ponnusamy, Pinki Surana, Anand Kamalanathan, Kavi Aucharaz, Lindsay Halpern, Matt Nash, Alex Allwood, Nigel Brooke, Jennifer Holman, Geraint Lee, Sobia Balal, Poornima Pandey, Ravindra Bhat, Simon Rhodes, Savi Sivashankar, Michael Grosdenier, Ajay Reddy, Prakash Thiagarajan, Chinnappa Reddy, Lidia Tyszcuzk, Glynis Rewitzky, Bushra Abdul-Malik, Dominic Muogbo, Angela D'Amore, John McIntyre, Lucinda Winckworth, Jim Baird, Akinsola Ogundiya, Pamela Cairns, Porus Bastani, Marice Theron, Siba Paul, Giles Kendall, Puneet Nath, Ros Garr, Sundeep Sandhu, Michael Cronin, Alison Bedford Russell, Ruchika Gupta, Archana Mishra, Oluseun Tayo, Priya Muthukumar, Brendan Harrington, Victoria Sharp, Nicola Johnson, Sam Wallis, Prashanth Bhat, Lee Abbott, Raju Narasimhan, Kate Creese, Divyen Shah, Clare Cane, Ghada Ramadan, Sijia Yao, Alistair Ewing, Penelope Young, Ramona Onita, Joanne Dangerfield, Jocelyn Morris, Toria Klutse, Sonia Spathis, Sathish Krishnan, Samar Sen, Jez Jones, Geedi Farah, Prem Pitchaikani, Jonathan Filkin, Ashok Karupaiah, Richard Heaver, Mohammad Alam, Tiziana Fragapane, Jess Reynolds, Khadija Ben-Sasi, Patricia Cowley, Shilpa Ramesh, Julia Croft, Soma Sengupta, Nagendra Venkata, Anitha Vayalakkad, Ben Obi, Anjali Petkar, Arun Ramachandran, Se-Yeon Park, Sue Bird, Jageer Mohammed, and Sanjay Jaisal
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Medicine - Abstract
Objective Describe the population of babies who do and do not receive postnatal corticosteroids for prevention or treatment of bronchopulmonary dysplasia (BPD).Design Retrospective cohort study using data held in the National Neonatal Research Database.Setting National Health Service neonatal units in England and Wales.Patients Babies born less than 32 weeks gestation and admitted to neonatal units from 1 January 2012 to 31 December 2019.Main outcomes Proportion of babies given postnatal corticosteroid; type of corticosteroid; age at initiation and duration, trends over time.Secondary outcomes Survival to discharge, treatment for retinopathy of prematurity, BPD, brain injury, severe necrotising enterocolitis, gastrointestinal perforation.Results 8% (4713/62019) of babies born
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- 2022
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8. Need for standardized vancomycin dosing for coagulase-negative staphylococci in hospitalized infants
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Eleanor J. Harvey, Diane Ashiru-Oredope, Louise F. Hill, Alicia Demirjian, Karthik Paranthaman, Elita Jauneikaite, Yu Wan, Russell Hope, Andrew Robb, Louise Thorn, Paul Fleming, Bruno Pichon, Derren Ready, Mustafa Elsayed, Heather Felgate, Ginny Moore, Santosh Pattnayak, Sakina Ali, Ted Gasiorowski, Timothy Watts, Louise Wooster, Vicky Payne, Colin Brown, Alleyna Claxton, Christina Kortsalioudaki, Mitul Patel, Nabeela Mughal, Olga Moncayo, Sujoy Banerjee, Liz McKechnie, Rashmi Gandhi, Rhys DCosta, Minesh Khashu, Natasha Ratnaraja, Kavita Sethi, Simon Drysdale, and Bharat Patel
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Microbiology (medical) ,Infectious Diseases ,General Medicine - Published
- 2023
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9. Single Nucleotide Polymorphisms in Neonatal Necrotizing Enterocolitis
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Keyur T, Donda, Benjamin A, Torres, Minesh, Khashu, and Akhil, Maheshwari
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Enterocolitis, Necrotizing ,Pediatrics, Perinatology and Child Health ,Infant, Newborn ,Humans ,Polymorphism, Single Nucleotide ,Infant, Newborn, Diseases ,digestive system diseases - Abstract
Abstract: The etiopathogenesis of necrotizing enterocolitis (NEC) remains unclear, but increasing information suggests that the risk and severity of NEC may be influenced by single nucleotide polymorphisms in many genes. In this article, we have reviewed gene variations that have either been specifically identified in NEC or have been noted in other inflammatory bowel disorders with similar histopathological abnormalities. We present evidence from our own peer-reviewed laboratory studies and data from an extensive literature search in the databases PubMed, EMBASE, and Scopus. To avoid bias in the identification of existing studies, search keywords were short-listed both from our own studies and from PubMed’s Medical Subject Heading (MeSH) thesaurus.
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- 2022
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10. Current Understanding of Transfusion-associated Necrotizing Enterocolitis: Review of Clinical and Experimental Studies and a Call for More Definitive Evidence
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Minesh, Khashu, Christof, Dame, Pascal M, Lavoie, Isabelle G, De Plaen, Parvesh M, Garg, Venkatesh, Sampath, Atul, Malhotra, Michael D, Caplan, Praveen, Kumar, Pankaj B, Agrawal, Giuseppe, Buonocore, Robert D, Christensen, and Akhil, Maheshwari
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The association between red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC), so-called transfusion-associated NEC (ta-NEC), was first described in 1987. However, further work is needed to confirm a causal relationship, elucidate underlying mechanisms, and develop possible strategies for prevention. We performed an extensive literature search in the databases PubMed, EMBASE, and Scopus.Although multiple retrospective human studies have strongly suggested an association between blood transfusions and subsequent occurrence of NEC, meta-analyses of randomized controlled trials (RCTs) testing RBC transfusion thresholds or the use of recombinant erythropoiesis-stimulating growth factors did not confirm an association of anemia with ta-NEC. These conflicting data necessitated the development of an animal model to elucidate mechanisms and causal factors. Data from this recent mouse model of ta-NEC highlighted the importance of sequential exposure to severe anemia followed by transfusion for development of ta-NEC.This review summarizes current human and experimental data, highlights open questions, and suggests avenues for further research aimed at preventing ta-NEC in preterm infants. Further studies are required to delineate whether there is a tipping point, in terms of the level and duration of anemia, and to develop an effective strategy for blood management and the quality of RBC transfusions.
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- 2022
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