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Your search keyword '"Maneerat, Tharakorn"' showing total 24 results
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24 results on '"Maneerat, Tharakorn"'

6. Tetrahydroxanthene-1,3(2H)-diones and Oxidized Hexadiene Derivatives from Uvaria leptopoda and Their Biological Activities

Author

Teerapongpisan, Passakorn, primary, Monkantha, Thanakorn, additional, Yimklan, Saranphong, additional, Mah, Siau Hui, additional, Gunter, Natalie Vivien, additional, Promnart, Phunrawie, additional, Deachathai, Suwanna, additional, Maneerat, Tharakorn, additional, Duangyod, Thidarat, additional, Charoensup, Rawiwan, additional, Baka, Abdulromea, additional, Andersen, Raymond J., additional, and Laphookhieo, Surat, additional

Published
2024
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9. Styryl lactone derivatives and aristolactam alkaloids from Goniothalamus tapis Miq. and their α-glucosidase inhibitory activity

Author

Phukhatmuen, Piyaporn, primary, Teerapongpisan, Passakorn, additional, Suthiphasilp, Virayu, additional, Maneerat, Tharakorn, additional, Duangyod, Thidarat, additional, Charoensup, Rawiwan, additional, Cheenpracha, Sarot, additional, Zhu, Jin-Lin, additional, Wang, Yan Alexander, additional, Deachathai, Suwanna, additional, Andersen, Raymond J., additional, and Laphookhieo, Surat, additional

Published
2024
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10. Chemical Composition of the Essential Oils from Goniothalamus tortilipetalus M.R.Hend. and Their Antioxidant and Antibacterial Activities.

Author

Anatachodwanit, Aknarin, Promnart, Phunrawie, Deachathai, Suwanna, Maneerat, Tharakorn, Charoensup, Rawiwan, Duangyod, Thidarat, and Laphookhieo, Surat

Subjects
ESSENTIAL oils, ANTIBACTERIAL agents, GAS chromatography/Mass spectrometry (GC-MS), MICROCOCCUS luteus, SHIGELLA flexneri, TERPENES
Abstract

This work was the first investigation of the essential oil composition of Goniothalamus tortilipetalus M.R.Hend. The aim of this study is to investigate the essential oil composition extracted from different parts of Goniothalamus tortilipetalus M.R.Hend., including flowers, leaves, and twigs, and to evaluate their antioxidant and antibacterial activities. The Clevenger apparatus was used for hydrodistillation to prepare the essential oils. The essential oils were investigated using gas chromatography–mass spectrometry (GC-MS). The three major compounds of the flowers were bicyclogermacrene (15.81%), selin-11-en-4-α-ol (14.68%), and E-caryophyllene (7.02%), whereas the leaves were p-cymene (39.57%), ascaridole (9.39%), and α-copaene (9.12%). In the case of the twigs, α-copaene (10.34%), selin-11-en-4-α-ol (8.85%), and p-cymene (7.76%) were the major compounds. The flower essential oil showed antioxidant activities with IC50 values of 725.21 µg/mL and 123.06 µg/mL for DPPH and ABTS assays, respectively. The flower essential oil also displayed antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Salmonella typhimurium, and Shigella flexneri, with the same MIC value of 640 µg/mL. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Antidiabetic and Cytotoxic Activities of Rotenoids and Isoflavonoids Isolated from Millettia pachycarpa Benth

Author

Suthiphasilp, Virayu, primary, Rujanapun, Narawadee, additional, Kumboonma, Pakit, additional, Chaiyosang, Boonyanoot, additional, Tontapha, Sarawut, additional, Maneerat, Tharakorn, additional, Patrick, Brian O, additional, Andersen, Raymond J, additional, Duangyod, Thidarat, additional, Charoensup, Rawiwan, additional, and Laphookhieo, Surat, additional

Published
2022
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18. Isoprenylated chromones from the stems of Harrisonia perforata

Author

Cheenpracha, Sarot, primary, Chokchaisiri, Ratchanaporn, additional, Ganranoo, Lucksagoon, additional, Maneerat, Tharakorn, additional, Rujanapun, Narawadee, additional, Charoensup, Rawiwan, additional, Laphookhieo, Surat, additional, Injan, Natcha, additional, and Nokbin, Somkiat, additional

Published
2022
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19. Xanthones from the latex and twig extracts of Garcinia nigrolineata Planch. ex T. Anderson (Clusiaceae) and their antidiabetic and cytotoxic activities.

Author

Phukhatmuen, Piyaporn, Suthiphasilp, Virayu, Rujanapan, Narawadee, Duangyod, Thidarat, Maneerat, Tharakorn, Charoensup, Rawiwan, and Laphookhieo, Surat

Subjects
GARCINIA, CLUSIACEAE, ALPHA-glucosidases, LATEX, TWIGS, HYPOGLYCEMIC agents
Abstract

A new geranylated xanthone, nigrolineaxanthone AA (1) together with 18 known compounds (2–19) were isolated from latex and twig extracts of Garcinia nigrolineata Planch. ex T. Anderson. Some of the isolated compounds were assessed for their antidiabetic activities and cytotoxicity against three cancer cell lines. Of these, compounds 12 (IC50 value of 25.8 ± 0.2 µM), 16 (IC50 value of 124.8 ± 0.7 µM), and 17 (IC50 value of 44.4 ± 1.1 µM) exhibited the highest α-glucosidase inhibitory, α-amylase inhibitory, and glycation inhibition activities, respectively. Compound 11 showed glucose consumption and glucose uptake with IC50 values of 14.2 ± 0.8 µM and 3.1-fold. Compound 10 displayed cytotoxic activity against colon cancer (SW480) with an IC50 value of 4.3 ± 0.1 µM), while compound 2 showed cytotoxicity against leukemic cancer (K562) with IC50 value of 4.4 ± 0.3 µM. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Nitric oxide production inhibitory activity of clerodane diterpenes from Monoon membranifolium.

Author

Polbuppha, Isaraporn, Suthiphasilp, Virayu, Maneerat, Tharakorn, Charoensup, Rawiwan, Limtharakul, Thunwadee, Cheenpracha, Sarot, Pyne, Stephen G., and Laphookhieo, Surat

Subjects
CLERODANES, NITRIC oxide, MOLECULAR rotation, TWIGS, INDOMETHACIN
Abstract

A new clerodane diterpene, 2β-methoxyhardwickiic acid (1), and four known compounds (2–5) were isolated from the twigs of Monoon membranifolium. The structure of the new compound was determined by extensive spectroscopic methods and ESITOFMS data. The absolute configuration of 1 was established by a comparison of its ECD spectrum and specific rotation with those of related previously reported compounds. All compounds were evaluated for their nitric oxide (NO) production inhibitory activities in RAW264.7 macrophage cells. Compounds 3 and 5 inhibited NO production with IC50 values of 16.1 and 28.9 μM, respectively, which were better than that of standard compound, indomethacin (IC50 = 32.2 μM). [ABSTRACT FROM AUTHOR]

Published
2022
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23. Tetrahydroxanthene-1,3(2H)-diones and Oxidized Hexadiene Derivatives from Uvaria leptopodaand Their Biological Activities

Author

Teerapongpisan, Passakorn, Monkantha, Thanakorn, Yimklan, Saranphong, Mah, Siau Hui, Gunter, Natalie Vivien, Promnart, Phunrawie, Deachathai, Suwanna, Maneerat, Tharakorn, Duangyod, Thidarat, Charoensup, Rawiwan, Baka, Abdulromea, Andersen, Raymond J., and Laphookhieo, Surat

Abstract

The first phytochemical investigation of the twig extract of Uvaria leptopodaresulted in the isolation and identification of three new tetrahydroxanthene-1,3(2H)-diones, uvarialeptones A–C, two new oxidized hexadiene derivatives, uvarialeptols A and B, together with ten known compounds. Their structures were elucidated by spectroscopic techniques and mass spectrometry. Uvarialeptones A and B were unprecedented tetrahydroxanthene-1,3(2H)-dione dimers which exhibited a cyclobutane ring via [2 + 2] cycloaddition from uvarialeptone C and 9a-O-methyloxymitrone, respectively. The structure of uvarialeptone A was confirmed by X-ray diffraction analysis using Mo Kα radiation. Compound 3inhibited NO production at an IC50value of 6.7 ± 0.1 μM.

Published
2024
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24. Tetrahydroxanthene-1,3(2 H )-diones and Oxidized Hexadiene Derivatives from Uvaria leptopoda and Their Biological Activities.

Author

Teerapongpisan P, Monkantha T, Yimklan S, Mah SH, Gunter NV, Promnart P, Deachathai S, Maneerat T, Duangyod T, Charoensup R, Baka A, Andersen RJ, and Laphookhieo S

Subjects
Molecular Structure, Animals, Nitric Oxide biosynthesis, Mice, Xanthenes pharmacology, Xanthenes chemistry, Crystallography, X-Ray, Oxidation-Reduction, RAW 264.7 Cells, Uvaria chemistry
Abstract

The first phytochemical investigation of the twig extract of Uvaria leptopoda resulted in the isolation and identification of three new tetrahydroxanthene-1,3(2 H )-diones, uvarialeptones A-C, two new oxidized hexadiene derivatives, uvarialeptols A and B, together with ten known compounds. Their structures were elucidated by spectroscopic techniques and mass spectrometry. Uvarialeptones A and B were unprecedented tetrahydroxanthene-1,3(2 H )-dione dimers which exhibited a cyclobutane ring via [2 + 2] cycloaddition from uvarialeptone C and 9a- O -methyloxymitrone, respectively. The structure of uvarialeptone A was confirmed by X-ray diffraction analysis using Mo Kα radiation. Compound 3 inhibited NO production at an IC 50 value of 6.7 ± 0.1 μM.

Published
2024
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