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Nitric oxide production inhibitory activity of clerodane diterpenes from Monoon membranifolium.
- Source :
- Natural Product Research; May2022, Vol. 36 Issue 10, p2513-2517, 5p
- Publication Year :
- 2022
-
Abstract
- A new clerodane diterpene, 2β-methoxyhardwickiic acid (1), and four known compounds (2–5) were isolated from the twigs of Monoon membranifolium. The structure of the new compound was determined by extensive spectroscopic methods and ESITOFMS data. The absolute configuration of 1 was established by a comparison of its ECD spectrum and specific rotation with those of related previously reported compounds. All compounds were evaluated for their nitric oxide (NO) production inhibitory activities in RAW264.7 macrophage cells. Compounds 3 and 5 inhibited NO production with IC<subscript>50</subscript> values of 16.1 and 28.9 μM, respectively, which were better than that of standard compound, indomethacin (IC<subscript>50</subscript> = 32.2 μM). [ABSTRACT FROM AUTHOR]
- Subjects :
- CLERODANES
NITRIC oxide
MOLECULAR rotation
TWIGS
INDOMETHACIN
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 36
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 157155807
- Full Text :
- https://doi.org/10.1080/14786419.2021.1912044